Title: Pamplico Travel Guide: Best of Pamplico, South Carolina Travel 2026 | Expedia.co.uk [Hotels in Pamplico](https://expedia.co.uk/Pamplico-Hotels.d3000353197.Travel-Guide-Hotels)[Holiday Rentals in Pamplico](https://expedia.co.uk/Pamplico-Holiday-Rentals.d3000353197.Travel-Guide-HolidayRentals)[Pamplico Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Pamplico.d3000353197.Car-Hire-Guide)[Pamplico Holidays](https://expedia.co.uk/Pamplico.d3000353197.Holidays-City-Breaks) # Pamplico Travel Guide ## Tourist Guide ## Visit Pamplico ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=DX_SPRING_PROMO_3000353197) - Top hotels in Pamplico - Top Holiday Rentals in Pamplico ![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfort Inn & Suites Florence Center Area 527 Woody Jones Blvd Florence SC £80 1 Mar - 2 Mar includes taxes & fees Stay at this business-friendly hotel in Florence. Enjoy free breakfast, free Wi-Fi and an outdoor pool. Our guests praise the breakfast and the helpful staff ... 9.2/10 Wonderful! (1,224 reviews) Poor quality of food. No daily maid service. Front desk not staffed Reviewed on 26 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=01%2F03%2F2026&endDate=02%2F03%2F2026&selected=38336321&PinnedHotelID=38336321&HadPinnedHotel=true®ionId=3000353197) ![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Park Inn by Radisson Florence, SC 1729 Mandeville Road Florence SC £71 29 Mar - 30 Mar includes taxes & fees Stay at this business-friendly hotel in Florence. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the helpful ... 9/10 Wonderful! (2,262 reviews) The rooms were clean and it’s so nice having breakfast included with our stay! Reviewed on 26 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=29%2F03%2F2026&endDate=30%2F03%2F2026&selected=47086732&PinnedHotelID=47086732&HadPinnedHotel=true®ionId=3000353197) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Howard Johnson by Wyndham Florence 2038 W Lucas Street Florence SC £58 9 Mar - 10 Mar includes taxes & fees Stay at this business-friendly motel in Florence. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ... 8.6/10 Excellent! (2,569 reviews) room was clean. Staff was helpful Reviewed on 25 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=09%2F03%2F2026&endDate=10%2F03%2F2026&selected=11037&PinnedHotelID=11037&HadPinnedHotel=true®ionId=3000353197) [See all 146 properties in Pamplico](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=27%2F02%2F2026&endDate=28%2F02%2F2026®ionId=3000353197) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/d78ca460_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's Florence SC Stay at this holiday home in Florence. Enjoy a garden, laundry facilities and patios. Popular attractions Regal Swamp Fox and Florence Veterans Park are located ... 10/10 Exceptional! (47 reviews) The house is always super clean and welcoming perfect setup for our family when we visit our son at FMU. Comfy beds, plenty of linens, and great living space to relax. Love being able to cook meals and spend time together! Reviewed on 25 Feb 2026 [](https://expedia.co.uk/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information) ![Walking distance from one of South Carolina's top Medical centers.](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ad5ff8fc_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Walking distance from one of South Carolina's top Medical centers. Florence SC Stay at this holiday home in Florence. Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Old Greenwood Athletic Park and Drs Bruce and Lee ... 9.8/10 Exceptional! (43 reviews) Our third time staying at this home and always have had a great experience. Such a comfy home and very well stocked. Great hosts! Reviewed on 9 Feb 2026 [](https://expedia.co.uk/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information) ![Secret SC Cabin on 100 acres Hot Tub Large Pond](https://images.trvl-media.com/lodging/34000000/33750000/33743000/33742964/281cef30_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Secret SC Cabin on 100 acres Hot Tub Large Pond Marion SC Stay at this family-friendly cabin in Marion. Enjoy a water park, laundry facilities and patios. 9.6/10 Exceptional! (181 reviews) The place was perfectly maintained. Everything was well thought out and worked as it should. The waterfall/pond was really a cool feature. We enjoyed the quietness of being on so much land. Would 100% recommend and will stay again in the future. The host was responsive and accommodating. Reviewed on 15 Feb 2026 [](https://expedia.co.uk/Marion-Hotels-Secret-SC-Cabin-On-100-Acres-Hot-Tub-Large-Pond.h33742964.Hotel-Information) [See all properties in Pamplico](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=3000353197&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Pamplico hotel availability [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000353197&startDate=2026-02-26&endDate=2026-02-27)[26 Feb - 27 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000353197&startDate=2026-02-26&endDate=2026-02-27) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000353197&startDate=2026-02-27&endDate=2026-02-28)[27 Feb - 28 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000353197&startDate=2026-02-27&endDate=2026-02-28) [This weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000353197&startDate=27%2F02%2F2026&endDate=01%2F03%2F2026)[27 Feb - 1 Mar](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000353197&startDate=27%2F02%2F2026&endDate=01%2F03%2F2026) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000353197&startDate=06%2F03%2F2026&endDate=08%2F03%2F2026)[6 Mar - 8 Mar](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000353197&startDate=06%2F03%2F2026&endDate=08%2F03%2F2026) ## Cities near Pamplico ![Charleston skyline from drone, South Carolina](https://images.trvl-media.com/place/8689/320786f2-8a2d-4940-b390-6aca1b71d230.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Marion - Cities near Pamplico [Marion](https://expedia.co.uk/Marion.dx8689) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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