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If you're arriving at Murcia del Carmen Train Station Airport, Orihuela is about 14 miles to the northeast. Alternatively, it's 30 miles to the southwest of the city's heart.
College of Santo Domingo and Orihuela Cathedral are two nearby tourist sites you'll want to see first. Check out Vistabella Golf and Santa Lucia Plaza if you have time to spare. Neighboring communities, like Bigastro and Hurchillo, are worth your time.
The Alicante city center contains a range of entertaining things to do. Castle of Santa Barbara is an option you won't want to skip.
We recommend that you make reservations for a hotel in advance, since Expedia's Orihuela hotels guide currently doesn't show a huge range of accommodations.