A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Mytilene Holidays from £403

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    Save up to £750 when you book a flight and hotel together*
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Top Mytilene flight + hotel deals

Price found within the past 48 hours. Click for updated prices.
  • 9 Sept - 14 Sept

    Belvedere Aeolis Hotel + Flight

    Lesvos
    4 nights
    3.0 star property
    7.2/10 - Good (15 reviews)
    "Outdated hotel"
    Reviewed July 29, 2026
    Return London (LON) - Lesvos (MJT)
    LHR - MJT1 stop MJT - LHR1 stop
    £438
    £403
    per traveller
    found 1 day ago
    Belvedere Aeolis Hotel
  • 7 Sept - 10 Sept

    Hotel Delfinia + Flight

    Lesvos
    3 nights
    3.0 star property
    7.6/10 - Good (115 reviews)
    Return Birmingham (BHX) - Lesvos (MJT)
    BHX - ATH1 stop ATH - BHX1 stop
    £502
    £412
    per traveller
    found 1 day ago
    Hotel Delfinia
  • 9 Sept - 14 Sept

    Loriet Hotel + Flight

    Lesvos
    4 nights
    4.0 star property
    8.4/10 - Very good (87 reviews)
    "Our vacation at the Loriet Hotel in Mithilini was amazing. Everything was perfect. We really had very good time in there. Thanks for the hospitality and the hygiene conditions. Having new plans for coming back again."
    Reviewed June 27, 2026
    Return London (LON) - Lesvos (MJT)
    LHR - MJT1 stop MJT - LHR1 stop
    £655
    £551
    per traveller
    found 1 day ago
    Loriet Hotel
  • 9 Sept - 14 Sept

    Panselinos Hotel + Flight

    Lesvos
    4 nights
    3.0 star property
    8.8/10 - Excellent (39 reviews)
    "The staff is very friendly, the food is very good."
    Reviewed June 21, 2026
    Return London (LON) - Lesvos (MJT)
    LHR - MJT1 stop MJT - LHR1 stop
    £443
    £408
    per traveller
    found 1 day ago
    Panselinos Hotel
  • 9 Sept - 14 Sept

    Eressian Hotel & Hammam Spa + Flight

    Lesvos
    4 nights
    3.0 star property
    10/10 - Exceptional (4 reviews)
    "Very friendly and informative welcome. Calm from the minute you walk through the door. Only 4 rooms so felt very special. Such lovely staff."
    Reviewed August 18, 2024
    Return London (LON) - Lesvos (MJT)
    LHR - MJT1 stop MJT - LHR1 stop
    £749
    £692
    per traveller
    found 1 day ago
    Eressian Hotel & Hammam Spa

Discover the most popular places to visit in Mytilene

Mytilene Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

Why should I book my Mytilene holiday with Expedia?

With exceptional-value flights, hotel and car hire choices all in the same place, Expedia makes planning your Mytilene getaway a piece of cake. Moreover, we can help you bundle your bookings into a package holiday so you can enjoy even more savings. Choose from amazing properties, add your flights and/or a hire car (and maybe even some fun tours!) and land incredible prices. Want to change your plans? Expedia has a flexible cancellation policy for many bookings. To discover more, check out our Customer Service Portal link.

When is the best time of year to holiday in Mytilene?

Mytilene is at its busiest in January, July and October. If you want a more laid-back escape, visit in February, November and December. To give you an idea of what type of weather you can experience, the average daytime temperature in January, the coolest time of year in Mytilene, is 9ºC. The warmest period here is July, when temperatures are around 26ºC.

What is the top hotel for my holiday in Mytilene?

Offering plenty of amenities and home comforts, Pasiphae Hotel will make the perfect base for your Mytilene escape.

How do I get a cheap holiday to Mytilene?

Bundle your hotels and flights, add on extras such as tours, and save with a Mytilene holiday. You won't just land impressive discounts on your adventure — you'll have lots of choice too. When you book through Expedia, you can choose from more than 400 airlines and 321,000 properties all over the world. Your affordable holiday starts right here, right now! Learn more about how you can save money on your next holiday when you bundle your flight and hotel bookings with Expedia.

What should I do on my Mytilene holiday?

With must-see tourist attractions like Port of Mytilene and Mytilini Castle, a holiday in Mytilene promises plenty of fun places to visit. Monastery of Saint Raphael and Bus Station are two other sights worth discovering.

Do I need a visa for my Mytilene holiday?

Official government websites have all the information you need on visa requirements, application procedures and any necessary documentation. Your nationality and the reason for your visit, whether it be for work or holidays, will determine if you'll need a visa for Mytilene. Also ensure your passport is up to date and has at least six months validity remaining beyond your return date. Finalise all your travel planning well in advance to avoid any last-minute surprises.

What should I wear on my Mytilene holiday?

First, consider the types of activities you'll be doing during your Mytilene holiday and create a travel wardrobe that you can mix and match. For fashion inspiration or even information on dress codes, browse a few style blogs or social media accounts.

What does an Expedia Mytilene holiday include?

Hotels, flights and car hires, or any combination of them — it's up to you! Whether you're exploring Mytilene with the whole family or enjoying a solo break, there's a bundle to fit your budget and style. Once you've made your booking, why not add on some activities? Expedia features different types of properties, with the most popular in Mytilene including apartments and villas. With Expedia, you can expect the freedom and flexibility to personalise your holiday your way.

Does Expedia offer Book Now, Pay Later Mytilene holidays?

We sure do. Expedia has partnered with online lender Klarna to help you conveniently pay for your trip in instalments. Simply click on the payment plan that works for you during the checkout process and take away the stress of budgeting for your trip. Remember to bundle your flights, accommodation and activities with Expedia to get the biggest bang for your travel buck. Browse our flexible payment options below:

  • Pay monthly holidays: Escape on that dream holiday sooner with Klarna's easy payment plans. If paying in multiple transactions sounds right for you, choose this option during the checkout process.
  • No-deposit holidays: Pressing the "book now" button is easier with this option. With no deposit required for your escape, you can Book Now, Pay Later and start packing your bags.

Can I choose my airline with a Mytilene Expedia holiday?

Yes, of course. Expedia has access to more than 400 partner airlines across the globe, so choose the carrier that suits your budget and travelling style.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.