Mytilene Holidays from £401

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Your Mytilene Holiday

Unforgettable adventures await when you lock in a Mytilene holiday package. Whether you're a history buff, foodie or just a traveller who loves to see new places, there's something for everyone in this exciting city. A trip to Mytilene is an excellent opportunity to do some sightseeing. Be sure to visit popular attractions like Mytilini Castle, University of the Aegean and Museum of the Memorial of the Refugees of 1922. Your Mytilene holiday is just clicks away. Explore hotels, airfares and more on Expedia for a trip that's tailored to suit your travel style.

Top Mytilene Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Hotel Iris

Hotel Iris

£401
per person
17 Oct - 21 Oct
found 1 day ago
Return direct flight included
London (LON) to Mytilene (MJT)
10/10 Exceptional! (4 reviews)
Eressian Hotel & Hammam Spa

Eressian Hotel & Hammam Spa

£1,362
per person
17 Oct - 21 Oct
found 1 day ago
Return direct flight included
London (LON) to Mytilene (MJT)
10/10 Exceptional! (4 reviews)
Very friendly and informative welcome. Calm from the minute you walk through the door. Only 4 rooms so felt very special. Such lovely staff.

Reviewed on 18 Aug 2024

Loriet Hotel

Loriet Hotel

£445
per person
17 Oct - 21 Oct
found 1 day ago
Return direct flight included
London (LON) to Mytilene (MJT)
8.4/10 Very good! (91 reviews)
Our vacation at the Loriet Hotel in Mithilini was amazing. Everything was perfect. We really had very good time in there. Thanks for the hospitality and the hygiene conditions. Having new plans for coming back again.

Reviewed on 27 Jun 2026

Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat

£456
per person
17 Oct - 21 Oct
found 1 day ago
Return direct flight included
London (LON) to Mytilene (MJT)
8.6/10 Excellent! (58 reviews)
Panselinos Hotel

Panselinos Hotel

£411
per person
17 Oct - 21 Oct
found 1 day ago
Return direct flight included
London (LON) to Mytilene (MJT)
8.6/10 Excellent! (43 reviews)
The hotel staff were very friendly and helpful. Many thanks to them. We had no problems with cleanliness either. Breakfast was also adequate. The hotel is a bit far from Molyvos, so a car is necessary

Reviewed on 4 Sept 2026

Mytilene Beach Holiday

Get set to live out those beachy daydreams on your upcoming Mytilene holiday. Set off on a lovely stroll, take in the sweeping ocean views and collect unique seashells during your trip to Mytilene. Located just 6 miles from the city centre, Thermi Beach is the place to be for many travellers. Look through our Mytilene packages and watch your travel budget stretch further!

Things You Should Know About Mytilene

  • If you want that beachside lifestyle, have a look at our Mytilene beach hotels. Beautiful water views and refreshing sea air — what more could anyone want?
  • Take a look at Sunrise Resort Hotel and Elysion Hotel. These hotels might just be perfect for your holiday in Mytilene.
  • There are plenty of activities that keep the 28,300 or so residents of Mytilene busy. A quick look at our Mytilene things to do page will let you in on everything this place has to offer.
  • If you're searching for things to do while you're in town, add University of the Aegean, Thermi Beach and Port of Mytilene to your travel schedule. Also, take a look at our Mytilene holiday deals to save money on your experiences, hotels and more.

Mytilene Essential Information

Language
Greek
Currency
Euros
Local Welcome
Ya su
Local Goodbye
Yiá sou
Closest Airport
Mytilene Intl. Airport (MJT)
Population
28,300
Max Temp Winter
13ºC
Max Temp Summer
29ºC
Top Sights
Thermi Beach, Museum of the Memorial of the Refugees of 1922 and Olive-press Museum of Archipelagos Society

Top hotels in Mytilene

Akti Vigla Premium

Akti Vigla Premium

Vigla Lesvos Lesvos
£58
2 Oct - 3 Oct
includes taxes & fees
Akti Vigla Premium
Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat

Agrilia Lesvos
£87
10 Oct - 11 Oct
includes taxes & fees
Mythical Coast Wellness Retreat
Hotel Lesvion

Hotel Lesvion

P. Kountourioti 27A Lesvos
£71
1 Oct - 2 Oct
includes taxes & fees
9.6/10 Exceptional! (127 reviews)
"Amazing stay! From the location and view, the amenities, the delicious and extensive breakfast choices and to the incredible staff who helped me so kindly scanning documents and book a courier service for me. Beyond grateful for their help! I 100% recommend this hotel and will stay again in the ..."

Reviewed on 1 Sept 2026

Hotel Lesvion
See all 180 properties in Mytilene
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Mytilene attractions

Mytilini Castle

9.0/10 (25 reviews)
Learn about the local history of Mytilene when you spend time at Mytilini Castle. While you're in the area, stroll along the seaside.
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Thermi Beach

7.8/10 (18 reviews)
If a restful holiday is part of your travel plans, Thermi Beach might be the perfect place to visit during your trip to Pirgi Thermis.
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St Hermogenes Charamida Lesvos

Find out about the history of Mytilene when you spend time at St Hermogenes Charamida Lesvos. While you're in the area, stroll along the seaside.
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Roman Aqueduct at Moria

8.0/10 (3 reviews)
You can learn about the history of Mytilene with a trip to Roman Aqueduct at Moria. While you're in the area, stroll along the seaside.
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Thermes Gera Hot Springs

Commune with nature and explore the great outdoors at Thermes Gera Hot Springs during your travels in Mytilene. While you're in the area, stroll along the seaside.
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Archaeological Site of Thermi

Find out about the history of Pirgi Thermis when you spend time at Archaeological Site of Thermi. Wander the seaside and beaches in the area.
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Church of Taxiarches

10.0/10 (1 review)
After visiting Church of Taxiarches, make a plan to see the other sights and activities in Mytilene. While you're in the area, stroll along the seaside.
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Olive-press Museum of Archipelagos Society

You can spend time studying the exhibits at Olive-press Museum of Archipelagos Society in Mytilene. While you're in the area, stroll along the seaside.
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Frequently asked questions

Why should I book my Mytilene holiday with Expedia?
With exceptional-value flights, hotel and car hire choices all in the same place, Expedia makes planning your Mytilene getaway a piece of cake. Moreover, we can help you bundle your bookings into a package holiday so you can enjoy even more savings. Choose from amazing properties, add your flights and/or a hire car (and maybe even some fun tours!) and land incredible prices. Want to change your plans? Expedia has a flexible cancellation policy for many bookings. To discover more, check out our Customer Service Portal link.
When is the best time of year to holiday in Mytilene?
Mytilene is at its busiest in January, July and October. If you want a more laid-back escape, visit in February, November and December. To give you an idea of what type of weather you can experience, the average daytime temperature in January, the coolest time of year in Mytilene, is 9ºC. The warmest period here is July, when temperatures are around 26ºC.
What is the top hotel for my holiday in Mytilene?
Offering plenty of amenities and home comforts, Pasiphae Hotel will make the perfect base for your Mytilene escape.
How do I get a cheap holiday to Mytilene?
Bundle your hotels and flights, add on extras such as tours, and save with a Mytilene holiday. You won't just land impressive discounts on your adventure — you'll have lots of choice too. When you book through Expedia, you can choose from more than 400 airlines and 321,000 properties all over the world. Your affordable holiday starts right here, right now! Learn more about how you can save money on your next holiday when you bundle your flight and hotel bookings with Expedia.
What should I do on my Mytilene holiday?
With must-see tourist attractions like Port of Mytilene and Mytilini Castle, a holiday in Mytilene promises plenty of fun places to visit. Monastery of Saint Raphael and Bus Station are two other sights worth discovering.
Do I need a visa for my Mytilene holiday?
Official government websites have all the information you need on visa requirements, application procedures and any necessary documentation. Your nationality and the reason for your visit, whether it be for work or holidays, will determine if you'll need a visa for Mytilene. Also ensure your passport is up to date and has at least six months validity remaining beyond your return date. Finalise all your travel planning well in advance to avoid any last-minute surprises.
What should I wear on my Mytilene holiday?
First, consider the types of activities you'll be doing during your Mytilene holiday and create a travel wardrobe that you can mix and match. For fashion inspiration or even information on dress codes, browse a few style blogs or social media accounts.
What does an Expedia Mytilene holiday include?
Hotels, flights and car hires, or any combination of them — it's up to you! Whether you're exploring Mytilene with the whole family or enjoying a solo break, there's a bundle to fit your budget and style. Once you've made your booking, why not add on some activities? Expedia features different types of properties, with the most popular in Mytilene including apartments and villas. With Expedia, you can expect the freedom and flexibility to personalise your holiday your way.
Does Expedia offer Book Now, Pay Later Mytilene holidays?
We sure do. Expedia has partnered with online lender Klarna to help you conveniently pay for your trip in instalments. Simply click on the payment plan that works for you during the checkout process and take away the stress of budgeting for your trip. Remember to bundle your flights, accommodation and activities with Expedia to get the biggest bang for your travel buck. Browse our flexible payment options below:
  • Pay monthly holidays: Escape on that dream holiday sooner with Klarna's easy payment plans. If paying in multiple transactions sounds right for you, choose this option during the checkout process.
  • No-deposit holidays: Pressing the "book now" button is easier with this option. With no deposit required for your escape, you can Book Now, Pay Later and start packing your bags.
Can I choose my airline with a Mytilene Expedia holiday?
Yes, of course. Expedia has access to more than 400 partner airlines across the globe, so choose the carrier that suits your budget and travelling style.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.