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Check prices for these dates

Tonight
14 Nov - 15 Nov
Tomorrow
15 Nov - 16 Nov
Next weekend
20 Nov - 22 Nov
In two weeks
27 Nov - 29 Nov

Our top choices for Mississippi Delta business-friendly hotels

A spacious living area with a wooden floor, a sofa, a coffee table, and a dining area visible through a glass door.

1. Cotton House, Cleveland, a Tribute Portfolio Hotel

Cotton House, Cleveland, a Tribute Portfolio Hotel
3.5 star property
Cleveland
9.0 out of 10, Wonderful, (728 reviews)
"Everything was beautiful I enjoyed my stay. The staff was friendly and very catering to my needs. The rooms are beautiful."
United States
Monica
The price is £115
includes taxes & fees
22 Nov - 23 Nov
Cotton House, Cleveland, a Tribute Portfolio Hotel
A modern restaurant with brick walls, multiple seating areas, and pendant lighting.

2. Lyric Hotel West End, Trademark Collection by Wyndham

Lyric Hotel West End, Trademark Collection by Wyndham
3.0 star property
Cleveland
8.4 out of 10, Very good, (350 reviews)
"Everything was good. Staff extremely helpful to me and my family especially with accommodations. I would definitely stay again"
United States
LaShanda
The price is £103
includes taxes & fees
22 Nov - 23 Nov
Lyric Hotel West End, Trademark Collection by Wyndham
A buffet with labeled sections for omelets and cheese.

3. Holiday Inn Express Hotel & Suites Cleveland by IHG

Holiday Inn Express Hotel & Suites Cleveland by IHG
2.5 star property
Cleveland
7.8 out of 10, Good, (1,000 reviews)
"The room was clean and the staff there are very nice."
United States
Linda
The price is £89
includes taxes & fees
28 Nov - 29 Nov
Holiday Inn Express Hotel & Suites Cleveland by IHG
A modern lounge area with leather sofas, a glass-top coffee table, and a brick wall with a fireplace.

4. Quality Inn Indianola

Quality Inn Indianola
2.5 star property
Indianola
7.6 out of 10, Good, (177 reviews)
"Clean"
United States
Dennis
The price is £51
includes taxes & fees
5 Dec - 6 Dec
Quality Inn Indianola
Breakfast area

5. Hotel 27

Hotel 27
2.0 star property
Greenville
9.0 out of 10, Wonderful, (384 reviews)
"Love the Hotel great location quiet and clean. Just need to upgrade to a better breakfast and stronger coffee. Great hotel love it...."
United States
Atwood
The price is £85
includes taxes & fees
16 Nov - 17 Nov
Hotel 27
A hotel room with a large bed, a desk, a chair, a TV, and a window with curtains.

6. Super 8 by Wyndham Indianola

Super 8 by Wyndham Indianola
2.0 star property
Indianola
7.4 out of 10, Good, (418 reviews)
"Staff was helpful and parking was plentiful breakfast was okay, a cut back from previous stay."
United States
Mary
The price is £68
includes taxes & fees
6 Dec - 7 Dec
Super 8 by Wyndham Indianola
A person sitting by a pool with clear blue water, wearing a white bikini and a large straw hat.

7. Harlow's Casino Resort & Spa

Harlow's Casino Resort & Spa
3.5 star property
Greenville
7.8 out of 10, Good, (1,001 reviews)
"I loved the everything about this place"
United States
Latasha
The price is £97
includes taxes & fees
15 Nov - 16 Nov
Harlow's Casino Resort & Spa
A modern living room with two grey sofas, a coffee table, and a decorative wall unit with a vase.

8. Hampton Inn Greenwood

Hampton Inn Greenwood
2.5 star property
Greenwood
8.2 out of 10, Very good, (544 reviews)
"Everyone was professional and friendly. The breakfast was excellent and hearty."
United States
Silvia
The price is £117
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn Greenwood
An indoor swimming pool with a brick column, a staircase, and a balcony with chairs.

9. SureStay Plus Hotel by Best Western Greenwood

SureStay Plus Hotel by Best Western Greenwood
2.5 star property
Greenwood
8.2 out of 10, Very good, (792 reviews)
"enjoyed my stay"
United States
James
The price is £104
includes taxes & fees
13 Dec - 14 Dec
SureStay Plus Hotel by Best Western Greenwood
A modern bathroom with a large bathtub, a mirror, and a vanity.

10. Best Western Gateway Inn

Best Western Gateway Inn
2.5 star property
Yazoo City
8.0 out of 10, Very good, (388 reviews)
"This was my second stay at the Best Western in Yazoo City, and visit was just as great as the first. The staff was friendly, the room had all the amenities I needed, and the breakfast was filling. Looking forward to returning."
United States
Cyrus
The price is £107
includes taxes & fees
16 Nov - 17 Nov
Best Western Gateway Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi Delta Hotel Reviews

A two-story brick building with large windows and a green door, featuring outdoor seating and a signboard.
Travelers Hotel

Travelers Hotel

Travelers Hotel
Clarksdale

10/10 Excellent

I loved the quirkiness of the hotel The host was really helpful. The facilities and guest area have everything you need with a kitchen area which has a stocked fridge with yogurts fruit sauces butter etc. Coffee making and selection of teas. Relaxing lounge with self-service bar and honesty payment. Great location for blues fans. The location has a gritty feel and is quite run down but full of live music venues and bars including the famous ground zero blues club and Reds.
United Kingdom
Loraine
Reviewed October 25, 2026
Travelers Hotel

Frequently Asked Questions

How much do business hotels in Mississippi Delta cost?

Prepare to pay between £51 and £116 per night for business hotels in Mississippi Delta. Awesome deals on stays that are suitable for work-related guests are just a few clicks away on Expedia. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

How many business hotels are there in Mississippi Delta?

Mississippi Delta has 177 business hotels to pick from. Whether you're hosting a conference or meeting or working remotely, these properties come with everything you need to be productive.

Why book your business hotel in Mississippi Delta with Expedia?

Here at Expedia, it's our job to help you locate a suitable stay at the right price. From 5-star corporate-friendly getaways to affordable motor inns filled with handy amenities, you'll have your next work trip booked in a few simple clicks.

How can I find cheap business hotels in Mississippi Delta?

When work takes you on the road in Mississippi Delta, our "business friendly" filter will help you find the right hotel. From free WiFi and included breakfast to computer stations and concierge services, they have the amenities you need to get down to business. You can also narrow your search by your budget and preferred star rating to view the most affordable options.

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