Title: Midsize Santiago Island Car Hire | Expedia.co.uk ![](https://images.trvl-media.com/place/6336381/e54ac0f5-71d0-4c1f-aaa9-a09eb577a3bd.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Midsize Car Hire Companies in Santiago Island Photo by Jennie Drazan [Become a member for free](https://expedia.co.uk/member-price?rfrr=TG.CM) and get more than just a booking discount. Members also earn points towards their next trip. Compare car suppliers to unlock big savings, and package your flight, hotel, and car to save even more. Enjoy maximum flexibility with penalty-free cancellation on most car rentals. ## Find Cheap Midsize Car Deals for Santiago Island \* Price found within the past 6 days. Click for updated prices. ### Don't see what you're looking for? See all car hire in Santiago Island [View all cars](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santiago%20Island,%20Gal%C3%A1pagos,%20Ecuador&dpln=6336381&date1=22/09/2025&date2=24/09/2025&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ## Midsize Car Hire Information | Car type: | Midsize | | --- | --- | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.co.uk/ground-transfers?rfrr=car.table.AirportTransportation) | - Experience new places with Expedia ### Find Popular Airports close to Santiago Island - [Car hire at Seymour Airport (GPS)](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Seymour.d6024439.Car-Hire-Guide) ### Find Other Car Classes in Santiago Island - [Mini car hire in Santiago Island](https://expedia.co.uk/Mini-Car-Rentals-In-Santiago-Island.d6336381-tMini.Car-Rental-Guide-Class) - [Economy car hire in Santiago Island](https://expedia.co.uk/Economy-Car-Rentals-In-Santiago-Island.d6336381-tEconomy.Car-Rental-Guide-Class) - [Compact car hire in Santiago Island](https://expedia.co.uk/Compact-Car-Rentals-In-Santiago-Island.d6336381-tCompact.Car-Rental-Guide-Class) - [Standard car hire in Santiago Island](https://expedia.co.uk/Standard-Car-Rentals-In-Santiago-Island.d6336381-tStandard.Car-Rental-Guide-Class) - [Fullsize car hire in Santiago Island](https://expedia.co.uk/Fullsize-Car-Rentals-In-Santiago-Island.d6336381-tFullsize.Car-Rental-Guide-Class) - [Premium car hire in Santiago Island](https://expedia.co.uk/Premium-Car-Rentals-In-Santiago-Island.d6336381-tPremium.Car-Rental-Guide-Class) - [Luxury car hire in Santiago Island](https://expedia.co.uk/Luxury-Car-Rentals-In-Santiago-Island.d6336381-tLuxury.Car-Rental-Guide-Class) - [Convertible car hire in Santiago Island](https://expedia.co.uk/Convertible-Car-Rentals-In-Santiago-Island.d6336381-tConvertible.Car-Rental-Guide-Class) - [Minivan car hire in Santiago Island](https://expedia.co.uk/Minivan-Car-Rentals-In-Santiago-Island.d6336381-tMinivan.Car-Rental-Guide-Class) - [Van car hire in Santiago Island](https://expedia.co.uk/Van-Car-Rentals-In-Santiago-Island.d6336381-tVan.Car-Rental-Guide-Class) - [SUV car hire in Santiago Island](https://expedia.co.uk/SUV-Car-Rentals-In-Santiago-Island.d6336381-tSUV.Car-Rental-Guide-Class) - [Pickup car hire in Santiago Island](https://expedia.co.uk/Pickup-Car-Rentals-In-Santiago-Island.d6336381-tPickup.Car-Rental-Guide-Class) - [Sportscar car hire in Santiago Island](https://expedia.co.uk/Sportscar-Car-Rentals-In-Santiago-Island.d6336381-tSportscar.Car-Rental-Guide-Class) ### Expedia's Latest Trends Hotels - [Old Town Riga Hotels](https://expedia.co.uk/Old-Town-Riga-Riga-Hotels.0-n6170999-0.Travel-Guide-Filter-Hotels) - [Atik Hotel](https://expedia.co.uk/Unye-Hotels-Atik-Hotel.h17699257.Hotel-Information) - [Grand Hotel Resort Ma&Ma - Adults Only](https://expedia.co.uk/La-Maddalena-Hotels-Grand-Hotel-Resort-MaMa.h6133280.Hotel-Information) - [Swissotel Al Ghurair](https://expedia.co.uk/Dubai-Hotels-Swissotel-Al-Ghurair.h4595744.Hotel-Information) - [5 Star New York Accommodation](https://expedia.co.uk/5Star-New-York-Hotels.s50-0-d178293.Travel-Guide-Filter-Hotels) - [Hotels in Mytilene](https://expedia.co.uk/Mytilene-Hotels.d6062865.Travel-Guide-Hotels) - [Historic Hotels in Newcastle-upon-Tyne](https://expedia.co.uk/Newcastle-Upon-Tyne-Hotels-Historic-Hotel.0-0-d6084526-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Villas Paxos](https://expedia.co.uk/Paxos-Villas.d6058530-aaVillas.Travel-Guide-Accommodation) - [Hotels in Oistins](https://expedia.co.uk/Oistins-Hotels.d6050167.Travel-Guide-Hotels) - [Corendon Amsterdam New-West, a Tribute Portfolio Hotel](https://expedia.co.uk/Amsterdam-Hotels-Corendon-City-Hotel-Amsterdam.h9726263.Hotel-Information) - [Aparthotel HSM Calas Park - All Inclusive](https://expedia.co.uk/Manacor-Hotels-Apartamentos-HSM-Calas-Park-All-Inclusive.h8183741.Hotel-Information) - [Malmaison Belfast](https://expedia.co.uk/Belfast-Hotels-Malmaison-Belfast.h562202.Hotel-Information) - [Boutique Hotels in Europe](https://expedia.co.uk/Destinations-In-Europe-Boutique-Hotel.0-0-d6022967-tBoutiqueHotel.Hotel-Filter-Destinations) - [Hilton Vilamoura As Cascatas Golf Resort & Spa](https://expedia.co.uk/Vilamoura-Hotels-Hilton-Vilamoura-As-Cascatas-Golf-Resort-Spa.h1671486.Hotel-Information) - [Hotels with Hot Tubs in Worthing](https://expedia.co.uk/Worthing-Hotels-Hotels-With-Hot-Tubs.0-0-d177868-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Atlantica SunGarden Beach](https://expedia.co.uk/Larnaca-Hotels-Atlantica-SunGarden-Beach-All-Inclusive.h1459123.Hotel-Information) Flights - [Flights from Manchester to Washington](https://expedia.co.uk/lp/flights/man/iad/manchester-to-washington) - [O'Hare Intl. 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Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)