Name: Hotel Anastassiou
Price range: £38
Rating: 7.8

Your Mesopotamia Holiday

Our holiday packages to Mesopotamia let you create your own adventure. Tailor your getaway to your style and interests and make the most of your time in this wonderful city. Fill your schedule with tours of Kastoria Lake, Kastoria Aquarium and Holy Prophet Elias Church, some of the top attractions you really should see during a trip to Mesopotamia. Your ideal Mesopotamia holiday is a few clicks away. Search airfares, hotels and more on Expedia for an adventure that's tailored to suit your style.

Top Mesopotamia Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.

Acrotel Athena Pallas

£293

per person

18 Oct - 22 Oct

found 4 hours ago

Return flight included

London (LHR) to Thessaloniki (SKG)

8.8/10 Excellent! (118 reviews)

Fabulous hotel with absolutely wonderful staff. Guest relations are brilliant at helping with taxi reservations, horse riding bookings to recommending places to eat in the 2 two towns a 15 mins away by taxi either side of the hotel. Hotel and area is very quiet. Would recommend car hire as there are only 2 walkable tavernas nearby one 5 mins and one about 15 mins away for a change of scenery. Food at the hotel is exquisite. Access to private beach and crystal clear waters just done some steps. WiFi access great Super comfy beds There's no poolside entertainment or blaring music or sun lounger hogging. Would he highly recommend for a relaxing wholesome break.

Reviewed on 7 Aug 2025

Ajul Luxury Hotel & Spa Resort, a Registry Collection Hotel

Save 100% on your flight

£657

per person

25 Oct - 30 Oct

found 1 day ago

Return flight included

London (LON) to Thessaloniki (SKG)

8/10 Very Good! (8 reviews)

Lazart Hotel, Trademark Collection by Wyndham

Stavroupoli

£616

per person

24 Oct - 31 Oct

found 1 day ago

Return direct flight included

London (LON) to Thessaloniki (SKG)

8.8/10 Excellent! (214 reviews)

I want to clarify that my negative feedback is directed solely at the hotel management—not the staff. We visited Thessaloniki in early September, when temperatures were still around 30°C, and were surprised to find the pool closed. While I understand the Expedia listing mentions the pool closes at the end of August, it also states that pool availability is subject to weather conditions. Given the heat, I believe it would have been reasonable for management to extend pool access. We stayed at other 4- and 5-star hotels in the area during our trip, and all had their pools open. It’s hard to accept that Wyndham couldn’t do the same. I don’t think my request was excessive or inconvenient—just a simple expectation for a summer-like experience in Greece. The hotel staff were kind and understanding, and even offered us a bottle of wine as a gesture—which I truly appreciated. However, I still find it hard to accept that the only 5-star hotel we stayed at in Thessaloniki had its pool closed during such high temperatures in early September. It seems like that the Wyndham has a poor Management. It was our first stay at a Wyndham hotel and i think also our last one.

Reviewed on 8 Sept 2025

The Excelsior Small Luxury Hotels of the World

Thessaloniki City Centre

Save 100% on your flight

£699

per person

24 Oct - 31 Oct

found 1 day ago

Return direct flight included

London (LON) to Thessaloniki (SKG)

9.6/10 Exceptional! (389 reviews)

Excelsior was a beautifully renovated property with a lovely welcome and excellent service.

Reviewed on 20 Aug 2025

Domes Noruz Kassandra - Adults Only, Halkidiki

£737

per person

25 Oct - 31 Oct

just found

Return direct flight included

Leeds (LBA) to Thessaloniki (SKG)

9.4/10 Exceptional! (119 reviews)

From the moment we arrived at Domes Noruz Kassandra, we knew we had stepped into something extraordinary. This is not just a hotel – it’s an experience designed to indulge, relax, and completely immerse you in the beauty of Halkidiki. The Atmosphere The adults-only vibe creates an intimate, chic, and serene setting. The design is contemporary yet warm, blending seamlessly with the natural beauty of the coastline. Every detail, from the stylish architecture to the thoughtfully curated spaces, radiates luxury and sophistication without ever feeling pretentious. The Service What truly sets this place apart is the incredible staff. They manage to anticipate your needs before you even realise them yourself. Always warm, genuinely friendly, and professional – they strike that rare balance of making you feel pampered yet completely at home. The Culinary Journey Dining here was a revelation. Every dish felt like a celebration of Greek flavors with a modern twist – fresh, vibrant, and beautifully presented. Whether it was the elegant breakfast spread, beachside cocktails, or fine dining in the evening, each meal was unforgettable. The Beach & Pool The private beach is stunning, with crystal-clear waters and luxurious loungers that invite you to spend endless hours under the sun. The pool area is equally perfect – chic, vibrant, and with the perfect mix of energy and relaxation.

Reviewed on 26 Aug 2025

Things to do in Mesopotamia

Mesopotamia offers a delightful blend of outdoor adventures, romantic settings, and rich cultural experiences. Visitors can embark on guided tours to explore local rituals and festive processions, immersing themselves in the vibrant traditions of the area. Group tours provide an excellent opportunity to connect with fellow travellers while enjoying the unique cultural heritage that Mesopotamia has to offer. Whether you're seeking relaxation or enrichment, this charming destination has something for everyone.

Shopping

In Mesopotamia, you can explore local shops for unique gifts and souvenirs. If you're up for a drive, visit the nearby Katerini Mall, which offers a variety of high street and local brands. Don’t miss the charming local markets for authentic crafts and produce.

Recreation

In Mesopotamia, indulge in rejuvenating treatments at the serene wellness centre, where holistic therapies blend with stunning landscapes. Enjoy yoga sessions amidst nature, followed by soothing massages that rejuvenate the body and mind, creating a perfect escape from daily life.

Adventure

Explore the stunning landscapes of Mesopotamia by hiking the scenic trails, cycling through picturesque villages, or kayaking on the tranquil lakes. Experience the local culture through traditional cooking classes and immerse yourself in the region's rich history at nearby archaeological sites. Adventure awaits around every corner.

Nightlife

Mesopotamia's nightlife offers a vibrant atmosphere with charming tavernas and lively bars. Enjoy traditional Greek music at a local taverna, or sip cocktails at a trendy bar. Dance the night away at popular nightclubs, where the energy and excitement keep you entertained until the early hours.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Mesopotamia

Mesopotamia, nestled in Kastoria, Western Macedonia, Greece, offers a delightful blend of outdoor adventures, romantic experiences, and rich cultural exploration. Visitors can enjoy picturesque lakes, fascinating history museums, and notable landmarks, catering to those seeking cultural, scenic, or beach experiences. Don't miss the chance to learn about the ancient Mesopotamians, their numerous gods, and the vibrant festivals that celebrate their heritage, making for a truly memorable holiday.

Kastoria Lake: Experience the stunning beauty of Kastoria Lake, a serene spot perfect for leisurely walks, picnics, and romantic moments. The picturesque scenery and tranquil waters create an ideal setting for outdoor activities and relaxation.
Folklore Museum of Kastoria: Immerse yourself in the rich culture and history of the region at the Folklore Museum of Kastoria. This captivating museum showcases local traditions, crafts, and artefacts, offering a deep insight into the area's heritage.
Taxiarhia of the Metropolis: Discover the impressive Taxiarhia of the Metropolis, a landmark that blends trendy and luxurious styles. This site offers a unique experience, whether you're exploring its architectural beauty or enjoying its budget-friendly amenities.

Best time to go to Mesopotamia

The best time to visit Mesopotamia is dependant on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are moderately high and weather is sunny with no rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

Calendar Month	Temperature	Precipitation	Cloudiness	Occupancy	Pricing
January	32.5°F (0.3°C)	Light Rain	Mostly Sunny	Moderately Low	Average
February	36.1°F (2.3°C)	Light Rain	Mostly Sunny	Moderately Low	Average
March	41.7°F (5.4°C)	Light Rain	Mostly Sunny	Average	Slightly Low
April	50.2°F (10.1°C)	Light Rain	Mostly Sunny	Average	Slightly High
May	57.9°F (14.4°C)	Light Rain	Mostly Sunny	Average	Average
June	66.0°F (18.9°C)	No Rain	Mostly Sunny	Average	Average
July	72.3°F (22.4°C)	No Rain	Sunny	Moderately High	Slightly High
August	72.5°F (22.5°C)	No Rain	Sunny	Moderately High	Slightly High
September	64.2°F (17.9°C)	No Rain	Mostly Sunny	Moderately High	Average
October	54.1°F (12.3°C)	Light Rain	Mostly Sunny	Average	Slightly Low
November	45.1°F (7.3°C)	Light Rain	Mostly Sunny	Moderately Low	Slightly Low
December	36.3°F (2.4°C)	Light Rain	Mostly Sunny	Average	Average

Tips to save on your trip to Mesopotamia

Combine your flights, hotels and car rentals on Expedia—bundling can result in significant savings.
Consider traveling to Mesopotamia during the low season (March and October to November) for more affordable options.
Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Mesopotamia Essential Information

Language	Greek
Currency	Euros
Local Welcome	Ya su
Local Goodbye	Yiá sou
Closest Airport	Kastoria (KSO-Aristoteles)
Population	2,100
Max Temp Winter	4ºC
Max Temp Summer	27ºC
Top Sights	Kastoria Aquarium, Folklore Museum of Kastoria and Byzantine Museum of Kastoria

Top hotels in Mesopotamia

To Spiti tis Sofias

Mesopotamia, Kastoria, Western Macedonia

Fully refundableReserve now, pay when you stay

£58

29 Sept - 30 Sept

includes taxes & fees

10/10 Exceptional! (1 review)

Le meilleur de notre séjour

"Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin."

Reviewed on 18 Aug 2025

Limneon Resort & Spa

4th km National Road Kastoria Athens, Kastoria

Fully refundableReserve now, pay when you stay

£79

8 Oct - 9 Oct

includes taxes & fees

9.2/10 Wonderful! (190 reviews)

Excellent

"Really pleased and delighted with our stay! Staff were very friendly. Room and facilities were clean and modern. The spa was also lovely. The lake view was absolutely stunning! The pictures dont do justice. You have to see it for yourself!"

Reviewed on 25 Aug 2025

Hotel Anastassiou

1st km Highway Kastoria-Athens, Kastoria, Western Macedonia

Fully refundableReserve now, pay when you stay

£38

6 Oct - 7 Oct

includes taxes & fees

7.8/10 Good! (68 reviews)

"Nice simple stay."

Reviewed on 13 Mar 2025

See all 42 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.