Mesopotamia Holidays from £267

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to £335 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Packages with flights are ATOL protected

Your Mesopotamia Holiday

Our holiday packages to Mesopotamia let you create your own adventure. Tailor your getaway to your style and interests and make the most of your time in this wonderful city. Fill your schedule with tours of Kastoria Lake, Kastoria Aquarium and Holy Prophet Elias Church, some of the top attractions you really should see during a trip to Mesopotamia. Your ideal Mesopotamia holiday is a few clicks away. Search airfares, hotels and more on Expedia for an adventure that's tailored to suit your style.

Top Mesopotamia Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Mirabilia Boutique Hotel

Mirabilia Boutique Hotel

3 out of 5
Save 100% on your flight
per person
30 Sept - 5 Oct
found 23 hours ago
Return flight included
London (LON) to Thessaloniki (SKG)
9.6/10 Exceptional! (50 reviews)
Wow !! This place is just amazing… everything (staff-room-location-service-breakfast was 5star ) we highly recommend and we will be back for sure !! Thank you guys for everything!

Reviewed on 17 Aug 2024

Domes Noruz Kassandra - Adults Only, Halkidiki

Domes Noruz Kassandra - Adults Only, Halkidiki

5 out of 5
Save 100% on your flight
per person
30 Aug - 5 Sept
found 1 day ago
Return direct flight included
Bristol (BRS) to Thessaloniki (SKG)
9.4/10 Exceptional! (110 reviews)
Everything about this property from the moment you get to the gate is excellent. Checkin was smooth, property is beautiful! Extended my stay twice

Reviewed on 1 Jul 2025

Wellness Santa Hotel - Adults Only

Wellness Santa Hotel - Adults Only

5 out of 5
Save 100% on your flight
per person
5 Sept - 12 Sept
found 1 day ago
Return direct flight included
Bristol (BRS) to Thessaloniki (SKG)
8.6/10 Excellent! (174 reviews)
liked this hotel in general

Reviewed on 7 Jul 2025

Sandy Seaside Suites

Sandy Seaside Suites

4 out of 5
Save 100% on your flight
per person
8 Sept - 15 Sept
found 1 day ago
Return flight included
London (LGW) to Thessaloniki (SKG)
10/10 Exceptional! (1 review)
This hotel exceeded every expectation that I had! There are lots I could talk about; the cleanliness, the beautiful rooms, the superb breakfast but what really makes this hotel is the amazing staff who all go over and above to help and genuinely invest in making your stay as positive as possible.

Reviewed on 30 Jul 2025

Sani Polyastron Hotel & Spa

Sani Polyastron Hotel & Spa

4 out of 5
Save 100% on your flight
per person
2 Sept - 7 Sept
found 1 day ago
Return flight included
London (LON) to Thessaloniki (SKG)
8.6/10 Excellent! (4 reviews)

Mesopotamia Essential Information

Language
Greek
Currency
Euros
Local Welcome
Ya su
Local Goodbye
Yiá sou
Closest Airport
Kastoria (KSO-Aristoteles)
Population
2,100
Max Temp Winter
4ºC
Max Temp Summer
27ºC
Top Sights
Kastoria Aquarium, Folklore Museum of Kastoria and Byzantine Museum of Kastoria

Top hotels in Mesopotamia

To Spiti tis Sofias

To Spiti tis Sofias

Mesopotamia, Kastoria, Western Macedonia
Fully refundableReserve now, pay when you stay
The price is £58 per night from 14 Aug to 15 Aug
£58
14 Aug - 15 Aug
includes taxes & fees
To Spiti tis Sofias
Limneon Resort & Spa

Limneon Resort & Spa

4 out of 5
4th km National Road Kastoria Athens, Kastoria
Fully refundableReserve now, pay when you stay
The price is £106 per night from 6 Aug to 7 Aug
£106
6 Aug - 7 Aug
includes taxes & fees
9.2/10 Wonderful! (184 reviews)
"Incredibly beautiful property. The view is stunning, the pools are amazing! The rooms were nice and quiet, well sound proofed and the curtains were nice and darkened if you needed to sleep in late. Unfortunately I wasn't able to visit the spa but it looked amazing and I'm sure, like everything else ..."

Reviewed on 29 Jul 2025

Limneon Resort & Spa
Hotel Anastassiou

Hotel Anastassiou

2 out of 5
1st km Highway Kastoria-Athens, Kastoria, Western Macedonia
Fully refundableReserve now, pay when you stay
The price is £38 per night from 9 Aug to 10 Aug
£38
9 Aug - 10 Aug
includes taxes & fees
7.8/10 Good! (65 reviews)
"Nice simple stay."

Reviewed on 13 Mar 2025

Hotel Anastassiou
See all 44 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Popular places to visit

Holy Prophet Elias Church

Learn about the local history of Kastoria with a stop at Holy Prophet Elias Church. While you're in the area, stroll along the lakeside.

Holy Prophet Elias Church

Byzantine Museum of Kastoria

You can spend an afternoon studying the exhibits at Byzantine Museum of Kastoria during your trip to Kastoria. While you're in the area, stroll along the lakeside.

Byzantine Museum of Kastoria

What to do in Mesopotamia

Archery Odyssey Traditional Archery Experience

Archery Odyssey Traditional Archery Experience

£52
per adult
Archery Odyssey Traditional Archery Experience
See all activities in Mesopotamia

Frequently asked questions

Why should I book my Mesopotamia holiday with Expedia?
With great-value airfares, car hire and hotel options all in one place, Expedia makes booking your Mesopotamia holiday a cinch. Moreover, we can help you bundle your bookings into a package holiday so you can save even more. Select from fabulous stays, add your flights and/or a car hire (and maybe even some exciting activities!) and land unbeatable prices. Need to change plans? Expedia has a flexible cancellation policy for many reservations. To find out more, head over to our Customer Service Portal link.
When is the best time of year to holiday in Mesopotamia?
Mesopotamia is very popular in May, August and September. If you're not a fan of crowds and prefer a quieter pace, book your getaway for November, December and January. Plan your trip to Mesopotamia based on what type of holiday you're looking for. January is the coolest time of year, when daytime temperatures average 0ºC. In July, the warmest period, expect averages of 22ºC during the day.
What is the top hotel for my holiday in Mesopotamia?
Orologopoulos Mansion is the perfect base for a fabulous trip to Mesopotamia, offering all the conveniences you need and more.
How do I get a cheap holiday to Mesopotamia?
Bundle your hotel and flight bookings, add extras such as activities, and save with a Mesopotamia holiday. You won't just score big discounts on your adventure — you'll have loads of choice within your reach too. When you book with Expedia, you can choose from more than 400 airlines and 321,000 properties throughout the world. Your unforgettable holiday starts right here, right now! Learn more about how you can save money on your holiday when you book a flight and hotel together with Expedia.
What should I do on my Mesopotamia holiday?
Make sure your next holiday in Mesopotamia is a memorable one by stopping by its best attractions. Kastoria Lake, Kastoria Aquarium, Neolithic Lakeside Settlement and Holy Monastery of Panagias Mauriotissas are among the things worth discovering while you're in the city.
Do I need a visa for my Mesopotamia holiday?
Check the latest information on official government websites. Your nationality and whether you're travelling for leisure, study or business will determine if you need a visa for Mesopotamia. Get familiar with the application process, including the required documentation, turnaround times and fees. Start your application well in advance to allow enough time for processing. Some visas may take weeks or even months to obtain, depending on the country.
What should I wear on my Mesopotamia holiday?
Do some research into the sorts of clothing people in Mesopotamia wear, and consider browsing fashion pages on social media for inspiration. Try to create a versatile travel wardrobe full of pieces that work for your destination and showcase your personal style. Pack your bags with confidence by checking the weather forecast in Mesopotamia. July brings the warmest temperatures, with daytime averages of 22ºC, while January days average 0ºC, making it the coolest month.
What does an Expedia Mesopotamia holiday include?
Select from any combination of flights, hotels and hire cars. Once you've made your booking, add some tours and activities. Want to pick your fare class? That's possible too. The choice is yours when it comes to organising your dream Mesopotamia trip. Expedia allows you the freedom and flexibility to tailor the holiday of your dreams your way.
Does Expedia offer Book Now, Pay Later Mesopotamia holidays?
Expedia has joined forces with online lender Klarna to make booking your next getaway easier on your bank balance. Paying in instalments means you can spread the costs of your next dream escape, leaving you with more money to play with while you're travelling. Klarna has several payment plans to choose from, so you're sure to find something that suits your budget. Consider these flexible payment options:

  • Pay monthly holidays: If paying in multiple transactions works for you, Klarna can help. Paying in convenient monthly instalments will make that dream getaway possible.
  • No-deposit holidays: Clicking on the "book now" button is easier with this plan. With no deposit required for your getaway, you can Book Now, Pay Later and get on your way.

Can I choose my airline with a Mesopotamia Expedia holiday?
Yes — that's the beauty of an Expedia package. You're the boss! We have more than 400 partner airlines worldwide, so you have options galore when creating your Mesopotamia escape.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.