Mesopotamia Holidays from £386

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Your Mesopotamia Holiday

Our holiday packages to Mesopotamia let you create your own adventure. Tailor your getaway to your style and interests and make the most of your time in this wonderful city. Fill your schedule with tours of Kastoria Lake, Kastoria Aquarium and Holy Prophet Elias Church, some of the top attractions you really should see during a trip to Mesopotamia. Your ideal Mesopotamia holiday is a few clicks away. Search airfares, hotels and more on Expedia for an adventure that's tailored to suit your style.

Top Mesopotamia Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
The Met Hotel, a member of Design Hotels

The Met Hotel, a member of Design Hotels

5 out of 5
Price was £480, price is now £386 per person
£386
per person
11 Dec - 15 Dec
found 18 hours ago
Return flight included
London (LON) to Thessaloniki (SKG)
9.2/10 Wonderful! (928 reviews)
When we got off the uber, the driver said this is one of the very nice hotels in town. It is true evertthing about this hotel is perfect. Very nice hotel, rooms are very modern. Our room, the toilet and shower has separate compartments ( with doors). The spa is great, breakfast has a good selection of food. All the staff from front desk, breakfast and the spa are very friendly. It also has shuttle that takes you to city centre and back. It runs every hour, but it’s not all day long, you need to check the schedule at the front desk every day. The negative thing I need to say is the location is a bit out off the way. It is a 18-20 mins walk to the metro. Or you can take the bus #31 across the street into city. The neighborhood is not very nice it is next to some auto repair shops and some abandoned buildings.

Reviewed on 29 Oct 2026

Electra Palace Thessaloniki

Electra Palace Thessaloniki

5 out of 5
Thessaloniki City Centre
Price was £559, price is now £498 per person
£498
per person
11 Dec - 15 Dec
found 18 hours ago
Return flight included
London (LON) to Thessaloniki (SKG)
9.4/10 Exceptional! (1,001 reviews)

Things to do in Mesopotamia

Mesopotamia offers a charming blend of scenic beauty and outdoor adventures, perfect for romantic getaways. Visitors can enjoy guided tours showcasing local rituals and cultural experiences, as well as festive processions that highlight the region's rich heritage. Group tours are also available, ensuring a delightful exploration of this enchanting area in Western Macedonia, Greece.

Shopping

In Mesopotamia, visit the local markets for unique crafts and souvenirs. If you're up for a drive, the nearby Kozani Shopping Centre offers a variety of shops and dining options, while further afield, the city of Kastoria features charming boutiques and traditional stores perfect for gift shopping.

Recreation

In Mesopotamia, the serene wellness retreat at the Spa of Trikala offers rejuvenating treatments and thermal baths. Enjoy yoga sessions surrounded by nature, and explore nearby hiking trails for a refreshing outdoor escape, perfect for unwinding and reconnecting with yourself.

Adventure

In Mesopotamia, explore the stunning landscapes through hiking trails that wind through lush valleys and ancient ruins. Experience adrenaline-pumping activities like river rafting on the nearby rivers and mountain biking along scenic routes, perfect for adventure enthusiasts looking for an unforgettable experience.

Nightlife

Mesopotamia boasts a vibrant nightlife with cosy tavernas and lively bars. Visit the local café for traditional Greek music and dance, or head to a nearby wine bar to sample exquisite local wines. Enjoy the friendly atmosphere as locals and tourists mingle throughout the evening.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Mesopotamia

Mesopotamia offers a perfect blend of scenic beauty and cultural richness, making it ideal for romantic getaways and outdoor adventures. Visitors can explore picturesque lakes, intriguing history museums, and notable landmarks that reflect the region's heritage. Additionally, the area boasts a variety of festivals celebrating ancient Mesopotamian traditions and numerous gods, providing a unique cultural experience for those looking to delve into the fascinating past of this historic locale.

  • Byzantine Museum of Kastoria: Situated 9.7km from Mesopotamia, this museum offers a fascinating glimpse into the rich history and culture of the Byzantine era. Its impressive collection of artefacts and artwork showcases the artistry and religious significance of the period, making it a must-visit for history enthusiasts.
  • Kastoria Lake: Just 8.0km away, Kastoria Lake is a picturesque destination for outdoor lovers. With its stunning scenery, serene waters, and romantic atmosphere, visitors can enjoy leisurely strolls along the lakeside or partake in various water activities, perfect for a relaxing day out.
  • Taxiarhia of the Metropolis: Located 8.0km from Mesopotamia, this landmark combines trendy architecture with a touch of luxury. It’s an inviting spot for those on a budget seeking a unique experience, featuring vibrant surroundings and a lively atmosphere.

Best time to go to Mesopotamia

The best time to visit Mesopotamia is dependent on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are moderately high and weather is sunny with no rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January32.5°F (0.3°C)Light RainMostly SunnyModerately LowAverage
February36.1°F (2.3°C)Light RainMostly SunnyModerately LowAverage
March41.7°F (5.4°C)Light RainMostly SunnyAverageSlightly Low
April50.2°F (10.1°C)Light RainMostly SunnyAverageSlightly High
May57.9°F (14.4°C)Light RainMostly SunnyAverageAverage
June66.0°F (18.9°C)No RainMostly SunnyAverageAverage
July72.3°F (22.4°C)No RainSunnyModerately HighSlightly High
August72.5°F (22.5°C)No RainSunnyModerately HighSlightly High
September64.2°F (17.9°C)No RainMostly SunnyModerately HighAverage
October54.1°F (12.3°C)Light RainMostly SunnyAverageSlightly Low
November45.1°F (7.3°C)Light RainMostly SunnyModerately LowSlightly Low
December36.3°F (2.4°C)Light RainMostly SunnyAverageAverage

Tips to save on your trip to Mesopotamia

  • Combine your flights, hotels and car rentals on Expedia—bundling can result in significant savings.
  • Consider traveling during the off-peak season (typically March and October to November) for more affordable package holidays to Mesopotamia.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Mesopotamia Essential Information

Language
Greek
Currency
Euros
Local Welcome
Ya su
Local Goodbye
Yiá sou
Closest Airport
Kastoria (KSO-Aristoteles)
Population
2,100
Max Temp Winter
4ºC
Max Temp Summer
27ºC
Top Sights
Kastoria Aquarium, Folklore Museum of Kastoria and Byzantine Museum of Kastoria

Top hotels in Mesopotamia

To Spiti tis Sofias

To Spiti tis Sofias

Mesopotamia Kastoria Western Macedonia
Fully refundableReserve now, pay when you stay
The price is £54 per night from 30 Nov to 1 Dec
£54
30 Nov - 1 Dec
includes taxes & fees
10/10 Exceptional! (2 reviews)
"Very nice and warm welcome from the owner. Quiet atmosphere. Great breakfast with a huge variety of different things. We definitely recommend for a stay."

Reviewed on 22 Sept 2026

To Spiti tis Sofias
Limneon Resort & Spa

Limneon Resort & Spa

5 out of 5
4th km National Road Kastoria Athens Kastoria
Fully refundableReserve now, pay when you stay
The price is £82 per night from 1 Nov to 2 Nov
£82
1 Nov - 2 Nov
includes taxes & fees
9.2/10 Wonderful! (211 reviews)
"We loved our stay very much and will definitely be returning from the staff to the location and simply beautiful views we couldn’t ask for anything better the only suggestion is that they add dresser’s with draws so you can putt your cloths out instead of having to use your suit cases."

Reviewed on 10 Aug 2026

Limneon Resort & Spa
Hotel Anastassiou

Hotel Anastassiou

2 out of 5
1st km Highway Kastoria-Athens Kastoria Western Macedonia
The price is £38 per night from 1 Nov to 2 Nov
£38
1 Nov - 2 Nov
includes taxes & fees
Hotel Anastassiou
See all 48 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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What to do in Mesopotamia

Archery Odyssey Traditional Archery Experience

Archery Odyssey Traditional Archery Experience

£50
per adult
Archery Odyssey Traditional Archery Experience
See all activities in Mesopotamia

Frequently asked questions

Why should I book my Mesopotamia holiday with Expedia?
With great-value airfares, car hire and hotel options all in one place, Expedia makes booking your Mesopotamia holiday a cinch. Moreover, we can help you bundle your bookings into a package holiday so you can save even more. Select from fabulous stays, add your flights and/or a car hire (and maybe even some exciting activities!) and land unbeatable prices. Need to change plans? Expedia has a flexible cancellation policy for many reservations. To find out more, head over to our Customer Service Portal link.
When is the best time of year to holiday in Mesopotamia?
Mesopotamia is very popular in May, August and September. If you're not a fan of crowds and prefer a quieter pace, book your getaway for November, December and January. Plan your trip to Mesopotamia based on what type of holiday you're looking for. January is the coolest time of year, when daytime temperatures average 0ºC. In July, the warmest period, expect averages of 22ºC during the day.
What is the top hotel for my holiday in Mesopotamia?
Orologopoulos Mansion is the perfect base for a fabulous trip to Mesopotamia, offering all the conveniences you need and more.
How do I get a cheap holiday to Mesopotamia?
Bundle your hotel and flight bookings, add extras such as activities, and save with a Mesopotamia holiday. You won't just score big discounts on your adventure — you'll have loads of choice within your reach too. When you book with Expedia, you can choose from more than 400 airlines and 321,000 properties throughout the world. Your unforgettable holiday starts right here, right now! Learn more about how you can save money on your holiday when you book a flight and hotel together with Expedia.
What should I do on my Mesopotamia holiday?
Make sure your next holiday in Mesopotamia is a memorable one by stopping by its best attractions. Kastoria Lake, Kastoria Aquarium, Neolithic Lakeside Settlement and Holy Monastery of Panagias Mauriotissas are among the things worth discovering while you're in the city.
Do I need a visa for my Mesopotamia holiday?
Check the latest information on official government websites. Your nationality and whether you're travelling for leisure, study or business will determine if you need a visa for Mesopotamia. Get familiar with the application process, including the required documentation, turnaround times and fees. Start your application well in advance to allow enough time for processing. Some visas may take weeks or even months to obtain, depending on the country.
What should I wear on my Mesopotamia holiday?
Do some research into the sorts of clothing people in Mesopotamia wear, and consider browsing fashion pages on social media for inspiration. Try to create a versatile travel wardrobe full of pieces that work for your destination and showcase your personal style. Pack your bags with confidence by checking the weather forecast in Mesopotamia. July brings the warmest temperatures, with daytime averages of 22ºC, while January days average 0ºC, making it the coolest month.
What does an Expedia Mesopotamia holiday include?
Select from any combination of flights, hotels and hire cars. Once you've made your booking, add some tours and activities. Want to pick your fare class? That's possible too. The choice is yours when it comes to organising your dream Mesopotamia trip. Expedia allows you the freedom and flexibility to tailor the holiday of your dreams your way.
Does Expedia offer Book Now, Pay Later Mesopotamia holidays?
Expedia has joined forces with online lender Klarna to make booking your next getaway easier on your bank balance. Paying in instalments means you can spread the costs of your next dream escape, leaving you with more money to play with while you're travelling. Klarna has several payment plans to choose from, so you're sure to find something that suits your budget. Consider these flexible payment options:

  • Pay monthly holidays: If paying in multiple transactions works for you, Klarna can help. Paying in convenient monthly instalments will make that dream getaway possible.
  • No-deposit holidays: Clicking on the "book now" button is easier with this plan. With no deposit required for your getaway, you can Book Now, Pay Later and get on your way.

Can I choose my airline with a Mesopotamia Expedia holiday?
Yes — that's the beauty of an Expedia package. You're the boss! We have more than 400 partner airlines worldwide, so you have options galore when creating your Mesopotamia escape.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.