Title: Mesopotamia Holidays 2026 from £591 | Expedia.co.uk [Mesopotamia Travel Guide](https://expedia.co.uk/Mesopotamia.dx6335336)[Hotels in Mesopotamia](https://expedia.co.uk/Mesopotamia-Hotels.d6335336.Travel-Guide-Hotels)[Holiday Rentals in Mesopotamia](https://expedia.co.uk/Mesopotamia-Holiday-Rentals.d6335336.Travel-Guide-HolidayRentals)[Flights to Mesopotamia](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6335336.Travel-Guide-Flights)[Mesopotamia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesopotamia.d6335336.Car-Hire-Guide) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Mesopotamia Holidays from £591 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected #### Your Mesopotamia Holiday Our holiday packages to Mesopotamia let you create your own adventure. Tailor your getaway to your style and interests and make the most of your time in this wonderful city. Fill your schedule with tours of [Kastoria Lake](https://www.expedia.co.uk/Kastoria-Lake-Kastoria.d553248621532501791.Attraction), [Kastoria Aquarium](https://www.expedia.co.uk/Kastoria-Aquarium-Kastoria.d6334842.Attraction) and [Holy Prophet Elias Church](https://www.expedia.co.uk/Holy-Prophet-Elias-Church-Kastoria.d553248635935219972.Attraction), some of the top attractions you really should see during a trip to Mesopotamia. Your ideal Mesopotamia holiday is a few clicks away. Search airfares, hotels and more on Expedia for an adventure that's tailored to suit your style. ## Top Mesopotamia Flight + Hotel Deals Price found within the past 48 hours. Click for updated prices. ![ON Residence](https://images.trvl-media.com/lodging/74000000/73780000/73771700/73771606/42be8aa2_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### ON Residence Thessaloniki City Centre £591 per person 1 Apr - 8 Apr found 10 hours ago Return direct flight included London (LHR) to Thessaloniki (SKG) 9.8/10 Exceptional! (159 reviews) Beautiful room. Modern and luxurious. Reviewed on 23 Dec 2025 ![The Modernist Thessaloniki](https://images.trvl-media.com/lodging/24000000/23460000/23458400/23458330/ac78d3e5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Modernist Thessaloniki Thessaloniki City Centre £731 per person 7 Apr - 14 Apr found 1 day ago Return flight included London (LGW) to Thessaloniki (SKG) 9.8/10 Exceptional! (583 reviews) The staff are sooooo kind and friendly. They made our stay great. Reviewed on 23 Nov 2025 ![ONOMA Hotel](https://images.trvl-media.com/lodging/68000000/67630000/67624100/67624076/fc93a6a9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### ONOMA Hotel Vardaris £778 per person 7 Apr - 14 Apr found 1 day ago Return flight included London (LGW) to Thessaloniki (SKG) 9.2/10 Wonderful! (144 reviews) Everything! Staff excellent , rainforest showers and great breakfast. Highly recommended Reviewed on 5 Nov 2025 ![City Hotel Thessaloniki](https://images.trvl-media.com/lodging/1000000/90000/83400/83385/d2f1706c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### City Hotel Thessaloniki Thessaloniki City Centre £1,002 per person 14 Mar - 21 Mar found 1 day ago Return direct flight included London (LHR) to Thessaloniki (SKG) 8.6/10 Excellent! (627 reviews) Really enjoyed my stay here. The staff is amazing and the complimentary breakfast was fantastic. It’s centrally located to everything. Reviewed on 17 Jan 2026 ![The Excelsior Small Luxury Hotels of the World](https://images.trvl-media.com/lodging/4000000/3030000/3026600/3026509/b00f672a_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Excelsior Small Luxury Hotels of the World Thessaloniki City Centre £715 per person 7 Apr - 14 Apr found 1 day ago Return flight included London (LGW) to Thessaloniki (SKG) 9.6/10 Exceptional! (398 reviews) Wow! This hotel is amazing. The layout and interior design were breathtaking. The breakfast in the morning was unmatched. The location was right by the water as well as anything you need. I stayed on the first floor and was worried about the sound travel from the nearby restaurants and bars but the rooms are completely sound proofed. Absolutely loved my stay there and if I come back to Thessaloniki, I would choose this hotel again 1000%. Reviewed on 27 Jan 2026 ### Things to do in Mesopotamia Mesopotamia offers a charming blend of scenic beauty and outdoor adventures, perfect for romantic getaways. Visitors can enjoy guided tours showcasing local rituals and cultural experiences, as well as festive processions that highlight the region's rich heritage. Group tours are also available, ensuring a delightful exploration of this enchanting area in Western Macedonia, Greece. **Shopping** In Mesopotamia, visit the local markets for unique crafts and souvenirs. If you're up for a drive, the nearby Kozani Shopping Centre offers a variety of shops and dining options, while further afield, the city of Kastoria features charming boutiques and traditional stores perfect for gift shopping. **Recreation** In Mesopotamia, the serene wellness retreat at the Spa of Trikala offers rejuvenating treatments and thermal baths. Enjoy yoga sessions surrounded by nature, and explore nearby hiking trails for a refreshing outdoor escape, perfect for unwinding and reconnecting with yourself. **Adventure** In Mesopotamia, explore the stunning landscapes through hiking trails that wind through lush valleys and ancient ruins. Experience adrenaline-pumping activities like river rafting on the nearby rivers and mountain biking along scenic routes, perfect for adventure enthusiasts looking for an unforgettable experience. **Nightlife** Mesopotamia boasts a vibrant nightlife with cosy tavernas and lively bars. Visit the local café for traditional Greek music and dance, or head to a nearby wine bar to sample exquisite local wines. Enjoy the friendly atmosphere as locals and tourists mingle throughout the evening. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Find the best attractions near Mesopotamia Mesopotamia offers a perfect blend of scenic beauty and cultural richness, making it ideal for romantic getaways and outdoor adventures. Visitors can explore picturesque lakes, intriguing history museums, and notable landmarks that reflect the region's heritage. Additionally, the area boasts a variety of festivals celebrating ancient Mesopotamian traditions and numerous gods, providing a unique cultural experience for those looking to delve into the fascinating past of this historic locale. - **[Byzantine Museum of Kastoria: ](https://www.expedia.co.uk/Byzantine-Museum-Of-Kastoria-Kastoria.d6263517.Attraction)** Situated 9.7km from Mesopotamia, this museum offers a fascinating glimpse into the rich history and culture of the Byzantine era. Its impressive collection of artefacts and artwork showcases the artistry and religious significance of the period, making it a must-visit for history enthusiasts. - **Kastoria Lake:** Just 8.0km away, Kastoria Lake is a picturesque destination for outdoor lovers. With its stunning scenery, serene waters, and romantic atmosphere, visitors can enjoy leisurely strolls along the lakeside or partake in various water activities, perfect for a relaxing day out. - **Taxiarhia of the Metropolis:** Located 8.0km from Mesopotamia, this landmark combines trendy architecture with a touch of luxury. It’s an inviting spot for those on a budget seeking a unique experience, featuring vibrant surroundings and a lively atmosphere. ### Best time to go to Mesopotamia The best time to visit Mesopotamia is dependent on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are moderately high and weather is sunny with no rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- | | January | 32.5°F (0.3°C) | Light Rain | Mostly Sunny | Moderately Low | Average | | February | 36.1°F (2.3°C) | Light Rain | Mostly Sunny | Moderately Low | Average | | March | 41.7°F (5.4°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | April | 50.2°F (10.1°C) | Light Rain | Mostly Sunny | Average | Slightly High | | May | 57.9°F (14.4°C) | Light Rain | Mostly Sunny | Average | Average | | June | 66.0°F (18.9°C) | No Rain | Mostly Sunny | Average | Average | | July | 72.3°F (22.4°C) | No Rain | Sunny | Moderately High | Slightly High | | August | 72.5°F (22.5°C) | No Rain | Sunny | Moderately High | Slightly High | | September | 64.2°F (17.9°C) | No Rain | Mostly Sunny | Moderately High | Average | | October | 54.1°F (12.3°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | November | 45.1°F (7.3°C) | Light Rain | Mostly Sunny | Moderately Low | Slightly Low | | December | 36.3°F (2.4°C) | Light Rain | Mostly Sunny | Average | Average | ### Tips to save on your trip to Mesopotamia - Combine your flights, hotels and car rentals on Expedia—bundling can result in significant savings. - Consider traveling during the off-peak season (typically March and October to November) for more affordable package holidays to Mesopotamia. - Use the *Price per traveler* filter on Expedia to find a package deal that suits your budget. - Check the *VIP Access properties* filter to discover outstanding hotels with added member perks at select properties. ## Mesopotamia Essential Information | Language | Greek | | --------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | Euros | | Local Welcome | Ya su | | Local Goodbye | Yiá sou | | Closest Airport | Kastoria (KSO-Aristoteles) | | Population | 2,100 | | Max Temp Winter | 4ºC | | Max Temp Summer | 27ºC | | Top Sights | [Kastoria Aquarium](https://www.expedia.co.uk/Kastoria-Aquarium-Kastoria.d6334842.Attraction), [Folklore Museum of Kastoria](https://www.expedia.co.uk/Folklore-Museum-Of-Kastoria-Kastoria.d6263478.Attraction) and [Byzantine Museum of Kastoria](https://www.expedia.co.uk/Byzantine-Museum-Of-Kastoria-Kastoria.d6263517.Attraction) | ## Top hotels in Mesopotamia ![To Spiti tis Sofias](https://images.trvl-media.com/lodging/101000000/100780000/100775800/100775775/68e1bf42_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### To Spiti tis Sofias Mesopotamia Kastoria Western Macedonia Fully refundableReserve now, pay when you stay £57 15 Feb - 16 Feb includes taxes & fees 10/10 Exceptional! (1 review) Le meilleur de notre séjour Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin. Reviewed on 18 Aug 2025 [](https://expedia.co.uk/Hotel-Search?startDate=15%2F02%2F2026&endDate=16%2F02%2F2026&selected=100775775&PinnedHotelID=100775775&HadPinnedHotel=true®ionId=6335336) ![Limneon Resort & Spa](https://images.trvl-media.com/lodging/14000000/13240000/13236700/13236658/009cc717_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Limneon Resort & Spa 4th km National Road Kastoria Athens Kastoria £82 1 Feb - 2 Feb includes taxes & fees 9/10 Wonderful! (198 reviews) This is an incredible hotel for families - child friendly, clean, and wonderful facilities. There is a small indoor play zone with someone who looks after the kids. The breakfast buffet is fantastic. The indoor pool is lovely. Everyone that works here is the kindest! My family and I had a wonderful ... Reviewed on 22 Jan 2026 [](https://expedia.co.uk/Hotel-Search?startDate=01%2F02%2F2026&endDate=02%2F02%2F2026&selected=13236658&PinnedHotelID=13236658&HadPinnedHotel=true®ionId=6335336) ![Hotel Anastassiou](https://images.trvl-media.com/lodging/7000000/6140000/6136500/6136437/92fd8775_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Anastassiou 1st km Highway Kastoria-Athens Kastoria Western Macedonia Fully refundableReserve now, pay when you stay 7.8/10 Good! (69 reviews) Nice simple stay. Reviewed on 13 Mar 2025 [Get rates](https://expedia.co.uk/Hotel-Search?startDate=13%2F02%2F2026&endDate=14%2F02%2F2026&selected=6136437&PinnedHotelID=6136437&HadPinnedHotel=true®ionId=6335336) [](https://expedia.co.uk/Hotel-Search?startDate=13%2F02%2F2026&endDate=14%2F02%2F2026&selected=6136437&PinnedHotelID=6136437&HadPinnedHotel=true®ionId=6335336) [See all 46 properties in Mesopotamia](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=31%2F01%2F2026&endDate=01%2F02%2F2026®ionId=6335336) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holidays](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![Holiday in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ### Popular places to visit #### Holy Prophet Elias Church After visiting Holy Prophet Elias Church, make a plan to see the other sights and activities in Kastoria. While you're in the area, stroll along the lakeside. [](https://expedia.co.uk/Holy-Prophet-Elias-Church-Kastoria.d553248635935219972.Attraction) #### Byzantine Museum of Kastoria You can spend an afternoon studying the exhibits at Byzantine Museum of Kastoria during your trip to Kastoria. While you're in the area, stroll along the lakeside. [](https://expedia.co.uk/Byzantine-Museum-Of-Kastoria-Kastoria.d6263517.Attraction) ### What to do in Mesopotamia ![Archery Odyssey Traditional Archery Experience](https://mediaim.expedia.com/localexpert/48403815/b4af75d6-0cec-4d50-a540-27608c144545.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Archery Odyssey Traditional Archery Experience £52 per adult [](https://expedia.co.uk/things-to-do/archery-odyssey-traditional-archery-experience.a48403815.activity-details) [See all activities in Mesopotamia](https://expedia.co.uk/things-to-do/search?rid=6335336) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - [4 Star Hotels in Mouriki ](https://www.expedia.co.uk/4Star-Mouriki-Hotels.s40-0-d553248635976431739.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Kastoria ](https://www.expedia.co.uk/5Star-Kastoria-Hotels.s50-0-d1928.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Nymfaio ](https://www.expedia.co.uk/5Star-Nymfaio-Hotels.s50-0-d6335267.Travel-Guide-Filter-Hotels) - 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[Vitsi Holidays ](https://www.expedia.co.uk/Vitsi.d6334824.Holidays-City-Breaks) - [Vlasti Holidays ](https://www.expedia.co.uk/Vlasti.d6335281.Holidays-City-Breaks) - [Voio Holidays ](https://www.expedia.co.uk/Voio.d6334814.Holidays-City-Breaks) - [Visit Voio ](https://www.expedia.co.uk/Voio.dx6334814) - [Car hire Aetos ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Aetos.d6335261.Car-Hire-Guide) - [Car hire Florina ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Florina.d6024959.Car-Hire-Guide) - [Car hire Kastoria ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Kastoria.d1928.Car-Hire-Guide) - [Vevi Holiday Rentals ](https://www.expedia.co.uk/Vevi-Holiday-Rentals.d6335283.Travel-Guide-HolidayRentals) \* Savings based on package bookings compared to the price of the same components booked separately. 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