Title: Looe Key National Marine Sanctuary in United States of America | Expedia.co.uk [Looe Key National Marine Sanctuary Hotels](https://expedia.co.uk/Looe-Key-National-Marine-Sanctuary-Hotels.0-l553248621533115813-0.Travel-Guide-Filter-Hotels)[Flights to United States of America](https://expedia.co.uk/Destinations-In-United-States-Of-America.d201.Flight-Destinations)[Looe Key National Marine Sanctuary Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Looe-Key-National-Marine-Sanctuary.d553248621533115813.Car-Hire-Guide)[United States of America Holidays](https://expedia.co.uk/United-States-Of-America.d201.Holidays-City-Breaks) # Looe Key National Marine Sanctuary ## Visit Looe Key National Marine Sanctuary Activities --- --- ## Plan a trip to see Looe Key National Marine Sanctuary Price found within the past 48 hours. Click for updated prices. ![Palazzo Lakeside Hotel](https://images.trvl-media.com/lodging/1000000/20000/14800/14701/f253be82_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Palazzo Lakeside Hotel £730 per person 3 Jun - 10 Jun found 1 day ago Return flight included London (LHR) to Orlando (MCO) 8.2/10 Very Good! (5,182 reviews) The hotel was extremely clean. I loved the Bible verses posted throughout the building. The staff were friendly as well. All questions were answered. I would highly recommend this place to others. 👍💯 Reviewed on 2 Apr 2026 ![Encore Inn Inglewood ](https://images.trvl-media.com/lodging/119000000/118100000/118098300/118098292/41a368f2_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Encore Inn Inglewood Lockhaven £881 per person 23 Jun - 30 Jun found 23 hours ago Return direct flight included London (LGW) to Los Angeles (LAX) 6.4/10 (144 reviews) Clean room w/ a shower. Reviewed on 2 Jan 2026 ![The Retreat Collection at 1 Hotel & Homes South Beach](https://images.trvl-media.com/lodging/13000000/12320000/12316600/12316590/e518a34f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Retreat Collection at 1 Hotel & Homes South Beach South Beach £8,048 per person 4 Jun - 10 Jun found 1 day ago Return flight included London (LHR) to Miami (MIA) 8/10 Very Good! (1 review) ### Popular places to visit ![Aerial view from Venture Out on Cudjoe Key Florida., Shutterstock ID 757510879, Purchase Order: Wave 0 First Batch, Order Number: , Client/Licensee: Hotels.com / BEX, Other: Mixed Budget](https://images.trvl-media.com/place/553248635976496782/a20a9413-7e85-4fd2-95ee-846207681027.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Florida Keys Beaches 4.5/5(12 reviews) Nothing says holiday like spending a care-free day in Florida Keys Beaches, a popular beach in Long Beach Estates. [](https://expedia.co.uk/Florida-Keys-Beaches-Florida.d553248635976496782.Attraction) ![Sugarloaf Beach](https://images.trvl-media.com/place/553248635983994028/1d746f78-98d9-4591-8682-e70514df330b.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Sugarloaf Beach Why not spend a lazy afternoon at Sugarloaf Beach during your trip to Summerland Key? [](https://expedia.co.uk/Sugarloaf-Beach-Sugarloaf-Key.d553248635983994028.Attraction) #### Munson Island Commune with nature and explore the great outdoors at Munson Island during your travels in Big Pine Key. While you're in the area, stroll along the beaches. [](https://expedia.co.uk/Munson-Island-Big-Pine-Key.d874556621345521664.Attraction) #### Big Munson Island Commune with nature and explore the great outdoors at Big Munson Island during your travels in Big Pine Key. While you're in the area, stroll along the beaches. [](https://expedia.co.uk/Big-Munson-Island-Big-Pine-Key.d874555262665744384.Attraction) #### Newfound Harbor Keys Commune with nature and explore the great outdoors at Newfound Harbor Keys during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [](https://expedia.co.uk/Newfound-Harbor-Keys-Big-Pine-Key.d874556615670603776.Attraction) #### Hopkins Island Commune with nature and explore the great outdoors at Hopkins Island during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [](https://expedia.co.uk/Hopkins-Island-Big-Pine-Key.d874555017892454400.Attraction) --- ## Top Hotel Deals ## Check availability on hotels close to Looe Key National Marine Sanctuary [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=2026-04-03&endDate=2026-04-04)[3 Apr - 4 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=2026-04-03&endDate=2026-04-04) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=2026-04-04&endDate=2026-04-05)[4 Apr - 5 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=2026-04-04&endDate=2026-04-05) [This weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026)[3 Apr - 5 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026) ![300’ Private Beach, Pool & Rooftop w Panoramic Ocean Views](https://images.trvl-media.com/lodging/90000000/89060000/89054800/89054710/09b82a09_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 300’ Private Beach, Pool & Rooftop w Panoramic Ocean Views Big Pine Key FL [](https://expedia.co.uk/Big-Pine-Key-Hotels-300-Private-Beach.h89054710.Hotel-Information) ![Barnacle Resort](https://images.trvl-media.com/lodging/91000000/90990000/90989500/90989471/99d053cf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Barnacle Resort 1557 Long Beach Dr Big Pine Key FL [](https://expedia.co.uk/Big-Pine-Key-Hotels-Barnacle-Bed-And-Breakfast.h90989471.Hotel-Information) ![Treehouse Private Village Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152459/a3651a5d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Treehouse Private Village Barnacle Resort Big Pine Key FL [](https://expedia.co.uk/Big-Pine-Key-Hotels-Treehouse-Private-Village.h111152459.Hotel-Information) ![Star Room Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152457/065048f7_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Star Room Barnacle Resort Big Pine Key FL [](https://expedia.co.uk/Big-Pine-Key-Hotels-Star-Room-Barnacle-Resort.h111152457.Hotel-Information) ![Beach View Room Dormitory Room Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111280000/111271600/111271548/37e9f734_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Beach View Room Dormitory Room Barnacle Resort Big Pine Key FL [](https://expedia.co.uk/Big-Pine-Key-Hotels-Beach-View-Room-Barnacle-Bed-And-Breakfast.h111271548.Hotel-Information) ![Ocean View Suite Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152455/3cfd39a9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Ocean View Suite Barnacle Resort Big Pine Key FL [](https://expedia.co.uk/Big-Pine-Key-Hotels-Ocean-View-Room-Barnacle-Bed-And-Breakfast.h111152455.Hotel-Information) ![Beachfront 3B/3B Fishing Oasis](https://images.trvl-media.com/lodging/90000000/89460000/89457100/89457060/aad82c5a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Beachfront 3B/3B Fishing Oasis Ramrod Key FL [](https://expedia.co.uk/Ramrod-Key-Hotels-Beachfront-3B3B-Fishing-Oasis.h89457060.Hotel-Information) ![Looe Key Reef Resort](https://images.trvl-media.com/lodging/5000000/4760000/4759500/4759500/a7994045_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Looe Key Reef Resort 27340 Overseas Highway Summerland Key FL [](https://expedia.co.uk/Ramrod-Key-Hotels-Looe-Key-Reef-Resort.h4759500.Hotel-Information) ![Keys To The Kingdom! Private Oceanfront Retreat with Beach and Pool](https://images.trvl-media.com/lodging/100000000/99110000/99102300/99102202/5cf3f655_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Keys To The Kingdom! Private Oceanfront Retreat with Beach and Pool Big Pine Key FL [](https://expedia.co.uk/Big-Pine-Key-Hotels-Keys-To-The-Kingdom-Private-Oceanfront-Retreat-With-Beach-And-Pool.h99102202.Hotel-Information) [See all 745 properties in Looe Key National Marine Sanctuary](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=553248621533115813) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.