Lake Nona Medical City Holidays from £778

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Your Lake Nona Medical City Holiday

Our Lake Nona Medical City holiday packages are a simple and practical way to organise and reserve your next escape. Uncover the true character of this unique neighbourhood without the fuss of planning everything yourself. Not sure what to do and see during your trip to Lake Nona Medical City? Nearby attractions such as Austin-Tindall Regional Park, University of Central Florida College of Medicine and Eagle Creek Golf Club are excellent places to start. Expedia will help you turn your ideal Lake Nona Medical City holiday into reality, whatever your budget or travel plans.

Price found within the past 48 hours. Click for updated prices.
Seasons Florida Resort

Seasons Florida Resort

£778
per person
23 Dec - 30 Dec
found 1 day ago
Return direct flight included
London (LHR) to Orlando (MCO)
9/10 Wonderful! (3,974 reviews)
Esta muy bueno por el precio serca de todo limpio y fueron amables me volveria a quedar

Reviewed on 14 Oct 2026

Palazzo Lakeside Hotel

Palazzo Lakeside Hotel

£805
per person
21 Nov - 28 Nov
found 22 hours ago
Return flight included
London (LHR) to Orlando (MCO)
8.4/10 Very good! (5,343 reviews)
I love this place

Reviewed on 14 Oct 2026

Margaritaville Cottages Orlando by Vstays with H2O Waterpark

Margaritaville Cottages Orlando by Vstays with H2O Waterpark

Save 100% on your flight
£1,138
per person
23 Dec - 30 Dec
found 1 day ago
Return direct flight included
London (LHR) to Orlando (MCO)
9.2/10 Wonderful! (1,001 reviews)
The Delaney Hotel

The Delaney Hotel

South Orange
Save 100% on your flight
£977
per person
23 Dec - 30 Dec
found 1 day ago
Return direct flight included
London (LHR) to Orlando (MCO)
9.6/10 Exceptional! (1,213 reviews)
Very friendly and helpful staff and very clean. Highly recommend this motel. 5 Stars ⭐️⭐️⭐️⭐️⭐️

Reviewed on 14 Oct 2026

Westgate Palace Hotel / Universal / I-Drive

Westgate Palace Hotel / Universal / I-Drive

International Drive District
£913
per person
18 Dec - 24 Dec
found 7 hours ago
Return direct flight included
Manchester (MAN) to Orlando (MCO)
9/10 Wonderful! (1,334 reviews)
Very clean grounds and rooms. Outdoor pool was well maintained. Love the in room laundry. The only downfall was not having somewhere for late night food.

Reviewed on 13 Oct 2026

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas and neighborhoods for the activities you enjoy most. Learn more about Lake Nona Medical City
A traditional Japanese torii gate with a dragon sculpture in front, overlooking a calm lake with a distant view of a spherical building.

Bay Lake

4 out of top 10 points of interest in this area

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

Find hotels in Bay Lake
A theme park with a large rock formation, Old-Town sign, and various food and restaurant signs.

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

Find hotels in International Drive District
A city skyline with modern buildings, a lake with swans, and a fountain.

Florida Center

2 out of top 10 points of interest in this area

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

Find hotels in Florida Center
A large Ferris wheel with blue lighting, surrounded by a parking lot and buildings.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

Find hotels in Champions Gate
A golf course with sand bunkers, a water hazard, and a clubhouse in the background.

Reunion

The top golf courses and fun-filled water parks are top of the list for many visitors to Reunion. A stop by Reunion Resort Golf Course or Jack Nicklaus Course might round out your trip.

Find hotels in Reunion

Top hotels in Lake Nona Medical City

Hyatt Regency Orlando International Airport

Hyatt Regency Orlando International Airport

9300 Jeff Fuqua Boulevard Orlando FL
Fully refundableReserve now, pay when you stay
£186
2 Nov - 3 Nov
includes taxes & fees
Hyatt Regency Orlando International Airport
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

8800 Vistana Centre Dr Orlando FL
£116
5 Nov - 6 Nov
includes taxes & fees
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Marriott's Grande Vista

Marriott's Grande Vista

5925 Avenida Vista Orlando FL
Fully refundableReserve now, pay when you stay
£85
4 Nov - 5 Nov
includes taxes & fees
Marriott's Grande Vista
See all 29,254 properties in Lake Nona Medical City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a Lake Nona Medical City travel package cost?
Our Lake Nona Medical City travel packages, which start at just £778, are the perfect way to save precious money. All you have to do is choose your preferred hotels, flights and rental car to create your dream escape.
If I'm not able to travel, can I cancel my Lake Nona Medical City travel package?
We totally understand that the universe can throw the odd curveball. If you've locked in a Lake Nona Medical City travel package and need to amend or cancel it, we're here to help. It's always worth looking up our Customer Service Portal first for information. But generally speaking, if you've taken out your package within 24 hours, you may be able to change your itinerary at no cost. If it's been more than 24 hours, your airline, hotel or car rental company may charge a fee.
How do I get a cheap travel package to Lake Nona Medical City?
Book everything all in one place with our Lake Nona Medical City travel packages. You'll find bargains on hotels, flights and more that'll keep your hip pocket happy and adventurous side satisfied. And, with more than 550 air carriers and 1,000,000 properties around the globe to select from, there are endless opportunities to mix and match as you like.
Does Expedia offer Book Now, Pay Later Lake Nona Medical City holidays?
Expedia has teamed up with online lender Klarna to make your next trip easier on the purse strings. Paying in instalments means you can spread the costs of your next dream escape, leaving you with more cash to splash while you're travelling. Klarna has several payment plans to choose from, so you're sure to find something that fits your budget. Consider these flexible payment options:
  • Pay monthly holidays: If paying small amounts each month sounds best for you, Klarna can help. Paying in easy monthly instalments will make your holiday dreams possible.
  • Pay in instalments holidays: If you'd like to pay for your escape across multiple transactions, holidays paid in instalments might be the right choice for your Book Now, Pay Later holiday through Klarna.
  • Low deposit holidays: When you want to grab an incredible deal but your budget doesn't quite cover it yet, Klarna's low deposit holiday plan will help you lock it in.
Where should I stay in Lake Nona Medical City?
Most people who visit Lake Nona Medical City put both Walt Disney World® and SeaWorld® Orlando on their must-see lists. Why not consider a hotel that's close to these popular attractions?
What are the top hotels in Lake Nona Medical City?
If it's your very first time in Lake Nona Medical City, reserve a room at Doubletree By Hilton At The Entrance To Universal Orlando or DoubleTree by Hilton Hotel Orlando at SeaWorld. Both hotels have good amenities and are top options with many savvy travellers.
How far in advance should I book my Lake Nona Medical City holiday?
Savvy travellers often reserve their seats early. You can usually browse through international fares on Expedia up to 12 months before your flight. If you're late to book, don't worry. Cheap prices sometimes become available just weeks before departure dates.
What does an Expedia Lake Nona Medical City travel package include?
It all boils down to what kind of escape you're thinking about. Lake Nona Medical City holiday deals can include flights, car rentals and hotels. You can mix and match to find the package that suits your style and budget. You can also add on activities and experiences after you've booked to score even bigger discounts.
What should I know before booking a Lake Nona Medical City travel package?
When you book your hotels, flights and car rentals together, you'll land amazing discounts. Whether you're organising a wilderness getaway in a cabin or prefer to stay in a comfortable hotel in the city, Expedia can make it happen for less.
Can I choose my airline with a Lake Nona Medical City Expedia travel package?
With a travel package, you're the one in charge. Whether you want to fly to Lake Nona Medical City in first class or coach, simply choose from the available airline options. Expedia has access to over 550 partner airlines worldwide.

Things to do

Aquatica Orlando

Aquatica Orlando

£43
per traveller
84% of travellers recommend
Aquatica Orlando
90 Minute Open Jump at a Trampoline Park in Kissimmee

90 Minute Open Jump at a Trampoline Park in Kissimmee

£17
per adult
90 Minute Open Jump at a Trampoline Park in Kissimmee
1 Hour Airboat Everglade Tour

1 Hour Airboat Everglade Tour

£49
per adult
1 Hour Airboat Everglade Tour
See all activities in Orlando

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.