Title: TOP Luxury Hotels in Isla Santa Maria for 2026 - Isla Santa Maria Upscale Hotels | Expedia.co.uk [Isla Santa Maria Travel Guide](https://expedia.co.uk/Isla-Santa-Maria.dx6101241)[Hotels in Isla Santa Maria](https://expedia.co.uk/Isla-Santa-Maria-Hotels.d6101241.Travel-Guide-Hotels)[Holiday Rentals in Isla Santa Maria](https://expedia.co.uk/Isla-Santa-Maria-Holiday-Rentals.d6101241.Travel-Guide-HolidayRentals)[Flights to Isla Santa Maria](https://expedia.co.uk/Cheap-Flights-To-Isla-Santa-Maria.d6101241.Travel-Guide-Flights)[Isla Santa Maria Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Isla-Santa-Maria.d6101241.Car-Hire-Guide)[Isla Santa Maria Holidays](https://expedia.co.uk/Isla-Santa-Maria.d6101241.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/luxury.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Isla Santa Maria - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Isla Santa Maria Luxury Hotels Tonight [8 Dec - 9 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6101241&startDate=2025-12-08&endDate=2025-12-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [9 Dec - 10 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6101241&startDate=2025-12-09&endDate=2025-12-10&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [12 Dec - 14 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6101241&startDate=2025-12-12&endDate=2025-12-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6101241&startDate=2025-12-19&endDate=2025-12-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Isla Santa Maria Luxury Hotels No exact matches found, but these alternatives could be just right ## Recommended hotels in Isla Santa Maria ![Front of property](https://images.trvl-media.com/lodging/124000000/123390000/123389700/123389606/1a8bd5ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Triple Room, Patio, Garden View | Desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/124000000/123390000/123389700/123389606/16c92ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/124000000/123390000/123389700/123389606/b681a54c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/124000000/123390000/123389700/123389606/314ab44a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Piedra Cruz Bío Bío £36 9 Dec - 10 Dec [](https://www.expedia.co.uk/Arauco-Hotels-Hotel-Piedra-Cruz.h123389606.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-22&endDate=2025-12-23®ionId=6101241&adults=2&sort=LUXURY&star=50&openPlayBack=true) ## Top Isla Santa Maria Hotel Reviews ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - [5 Star Hotels in Concepción ](https://www.expedia.co.uk/5Star-Concepcion-Hotels.s50-0-d790.Travel-Guide-Filter-Hotels) - [Arauco Hotels ](https://www.expedia.co.uk/Arauco-Hotels.d3000374698.Travel-Guide-Hotels) - [Cabrero Hotels ](https://www.expedia.co.uk/Cabrero-Hotels.d6359030.Travel-Guide-Hotels) - [Cañete Hotels ](https://www.expedia.co.uk/Canete-Hotels.d3000445543.Travel-Guide-Hotels) - [Concepción Hotels ](https://www.expedia.co.uk/Concepcion-Hotels.d790.Travel-Guide-Hotels) - [Contulmo Hotels ](https://www.expedia.co.uk/Contulmo-Hotels.d3000400358.Travel-Guide-Hotels) - [Coronel Hotels ](https://www.expedia.co.uk/Coronel-Hotels.d3000006421.Travel-Guide-Hotels) - [Curanilahue Hotels ](https://www.expedia.co.uk/Curanilahue-Hotels.d3000006418.Travel-Guide-Hotels) - [Biobío Hotels ](https://www.expedia.co.uk/Destinations-In-Biobio.d553248635997965342.Hotel-Destinations) - [Dichato Hotels ](https://www.expedia.co.uk/Dichato-Hotels.d553248635964996671.Travel-Guide-Hotels) - [La Florida Hotels ](https://www.expedia.co.uk/La-Florida-Hotels.d178528.Travel-Guide-Hotels) - [Laja Hotels ](https://www.expedia.co.uk/Laja-Hotels.d3000006374.Travel-Guide-Hotels) - [Laraquete Hotels ](https://www.expedia.co.uk/Laraquete-Hotels.d3000006373.Travel-Guide-Hotels) - [Lebu Hotels ](https://www.expedia.co.uk/Lebu-Hotels.d6252686.Travel-Guide-Hotels) - [Los Angeles Hotels ](https://www.expedia.co.uk/Los-Angeles-Hotels.d500226.Travel-Guide-Hotels) - [Lota Hotels ](https://www.expedia.co.uk/Lota-Hotels.d3000374705.Travel-Guide-Hotels) - [Negrete Hotels ](https://www.expedia.co.uk/Negrete-Hotels.d3000006337.Travel-Guide-Hotels) - [San Pedro de la Paz Hotels ](https://www.expedia.co.uk/San-Pedro-De-La-Paz-Hotels.d3000006271.Travel-Guide-Hotels) - [Tome Hotels ](https://www.expedia.co.uk/Tome-Hotels.d6353212.Travel-Guide-Hotels) - [Yumbel Hotels ](https://www.expedia.co.uk/Yumbel-Hotels.d3000006256.Travel-Guide-Hotels) - [Flights to Los Angeles ](https://www.expedia.co.uk/Cheap-Flights-To-Los-Angeles.d500226.Travel-Guide-Flights) - [Flights to Lota ](https://www.expedia.co.uk/Cheap-Flights-To-Lota.d3000374705.Travel-Guide-Flights) - [Flights from London (LHR) to Concepcion (CCP) ](https://www.expedia.co.uk/lp/flights/lhr/ccp/london-to-concepcion) - [Flights from London (LON) to Concepcion (CCP) ](https://www.expedia.co.uk/lp/flights/lon/ccp/london-to-concepcion) - [Flights from Santiago (SCL) to Concepcion (CCP) ](https://www.expedia.co.uk/lp/flights/scl/ccp/santiago-to-concepcion) - [Visit Cabrero ](https://www.expedia.co.uk/Cabrero.dx6359030) - [Visit Concepción ](https://www.expedia.co.uk/Concepcion.dx790) - [Visit Curanilahue ](https://www.expedia.co.uk/Curanilahue.dx3000006418) - [Estadio Municipal de Concepcion ](https://www.expedia.co.uk/Estadio-Municipal-De-Concepcion-Concepcion.d6101214.Attraction) - [Visit Hualpén ](https://www.expedia.co.uk/Hualpen.dx553248635943692184) - [La Florida Holidays ](https://www.expedia.co.uk/La-Florida.d178528.Holidays-City-Breaks) - [Visit Lebu ](https://www.expedia.co.uk/Lebu.dx6252686) - [Lota Holidays ](https://www.expedia.co.uk/Lota.d3000374705.Holidays-City-Breaks) - [Visit Lota ](https://www.expedia.co.uk/Lota.dx3000374705) - [Visit San Pedro de la Paz ](https://www.expedia.co.uk/San-Pedro-De-La-Paz.dx3000006271) - [Visit Tome ](https://www.expedia.co.uk/Tome.dx6353212) - [Apex Car Rentals Rental Cars in Los Álamos ](https://www.expedia.co.uk/Apex-Car-Rentals-Car-Rentals-In-Los-Alamos.d553248635943692183-c1064.Car-Rental-Guide-Suppliers) - [Car hire Concepción ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Concepcion.d790.Car-Hire-Guide) - [Car hire Lota ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Lota.d3000374705.Car-Hire-Guide) - [Guerin Rental Cars in Los Álamos ](https://www.expedia.co.uk/Guerin-Car-Rentals-In-Los-Alamos.d553248635943692183-c1129.Car-Rental-Guide-Suppliers) - [Sr Rent A Car Rental Cars in Los Álamos ](https://www.expedia.co.uk/SR-Rent-A-Car-Car-Rentals-In-Los-Alamos.d553248635943692183-c1077.Car-Rental-Guide-Suppliers) - [Sicily By Car Rental Cars in Los Álamos ](https://www.expedia.co.uk/Sicily-By-Car-Car-Rentals-In-Los-Alamos.d553248635943692183-c1048.Car-Rental-Guide-Suppliers) - [Thai Cars Rental Cars in Los Álamos ](https://www.expedia.co.uk/Thai-Cars-Car-Rentals-In-Los-Alamos.d553248635943692183-c1027.Car-Rental-Guide-Suppliers) - [La Florida Holiday Rentals ](https://www.expedia.co.uk/La-Florida-Holiday-Rentals.d178528.Travel-Guide-HolidayRentals) - [Los Angeles Holiday Rentals ](https://www.expedia.co.uk/Los-Angeles-Holiday-Rentals.d500226.Travel-Guide-HolidayRentals)