Isernia Holidays from £154

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Your Isernia Holiday

Skip the stress of planning your next great adventure with a Isernia holiday package. Whether you're here for its food, history, art or other highlights, there's an inexhaustible array of experiences to be had. If your trip to Isernia includes a little sightseeing, visit famous attractions like Basilica Minore dellAddolorata, National Museum of the Paleolithic and Cathedral of Isernia. Expedia will help you escape your daily routine. Tailor your holiday to Isernia to match your travel style, whatever that may be!

Top Isernia Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Villa Michelangelo

Villa Michelangelo

4 out of 5
Price was £184, price is now £154 per person
£154
per person
25 Sept - 27 Sept
found 1 day ago
Return flight included
London (LON) to Pescara (PSR)
8.6/10 Excellent! (30 reviews)
Absolutely amazing choice for our stop from north to south Italy!!! The pool is unbelievable for the whole family with amazing shape and great fresh water that brings you back to life. The room super clean and great bathroom with many many towels for everyone. Breakfast also something amazing just as we wanted.

Reviewed on 3 Jul 2026

LH Mion Hotel

LH Mion Hotel

4 out of 5
Save 100% on your flight
Price was £262, price is now £174 per person
£174
per person
25 Sept - 27 Sept
found 1 day ago
Return flight included
London (LON) to Pescara (PSR)
8.8/10 Excellent! (25 reviews)

Hotel Prestige

Hotel Prestige

3 out of 5
Price was £378, price is now £309 per person
£309
per person
17 Sept - 24 Sept
found 1 day ago
Return flight included
Liverpool (LPL) to Pescara (PSR)
8.8/10 Excellent! (254 reviews)
We had an absolutely fantastic stay and couldn't have asked for a better experience. The hotel itself was excellent – a charming, authentic hotel full of character and situated in a beautiful location. What really made our stay special, however, was the staff. They were genuinely the nicest, friendliest, and most helpful hotel staff we have ever come across. Nothing was ever too much trouble, and they always went above and beyond to make sure we were comfortable and enjoying our stay. The warm hospitality, wonderful atmosphere, and perfect location made this a truly memorable trip. We felt welcomed from the moment we arrived and were sad to leave. We would highly recommend this hotel to anyone looking for an authentic and enjoyable stay, and we will definitely be returning in the future.

Reviewed on 4 Jun 2026

Hotel Saint Tropez

Hotel Saint Tropez

3 out of 5
Price was £313, price is now £265 per person
£265
per person
6 Sept - 12 Sept
found 1 day ago
Return flight included
London (LON) to Pescara (PSR)
9.6/10 Exceptional! (28 reviews)
What a great find! The staff at this hotel are amazing! They embody the true spirit of hospitality. They made our group feel like family and did everything possible to ensure we enjoyed our stay. There is a great little bar on site and the hotel offers a dinner menu nightly. Sit on the porch and enjoy ocean breezes and a spritz or walk down to their reserved beach area. We would highly recommend this property.

Reviewed on 21 Sept 2025

HOTEL SETTIBI

HOTEL SETTIBI

3 out of 5
Price was £307, price is now £267 per person
£267
per person
6 Sept - 12 Sept
found 1 day ago
Return flight included
London (LON) to Pescara (PSR)
9.4/10 Exceptional! (25 reviews)
Rooms were clean. You need a swimming cap for the pool! No where else in the world that we have traveled to, required a swimming cap to wear in the pool - there is no health reason just a money grab 3 euro each! Ridiculous. They advertise a private beach? What is that? They are across the road from the beach, that has chairs from another hotel! Breakfast was OK, the tables are numbered with your room, no one told us, we got a very un-welcome greeting and a shake of the head when we were found to be sitting in the wrong spot. The whole visit made us feel awkward. Would not stay there again.

Reviewed on 2 Jul 2026

Isernia Essential Information

Language
Italian
Currency
Euros
Local Welcome
Ciao
Local Goodbye
Ciao
Population
16,900
Max Temp Winter
10ºC
Max Temp Summer
27ºC
Top Sights
Campitello Matese Ski Resort, Pandone Castle National Museum and Pandone Castle

Top hotels in Isernia

Central Isernia

Central Isernia

Via XXIV Maggio n. 235 Isernia IS
The price is £62 per night from 9 Aug to 10 Aug
£62
9 Aug - 10 Aug
includes taxes & fees
9/10 Wonderful! (6 reviews)
"It was a great place to spend a night and continue my travels."

Reviewed on 18 Jul 2026

Central Isernia
Moon Resort & Spa

Moon Resort & Spa

Via G. Tedeschi, 85 Isernia IS
Get rates
Moon Resort & Spa
Hotel Ai 4 Camosci

Hotel Ai 4 Camosci

3 out of 5
Via Nazionale, 25 Civitella Alfedena AQ
The price is £90 per night from 31 Aug to 1 Sept
£90
31 Aug - 1 Sept
includes taxes & fees
9/10 Wonderful! (118 reviews)
"Good for a night stopover"

Reviewed on 16 Oct 2023

Hotel Ai 4 Camosci
See all 335 properties in Isernia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Stay near popular Isernia attractions

Cathedral of Isernia

10.0/10 (2 reviews)
You can find out about the history of Isernia with a stop at Cathedral of Isernia. You can enjoy the restaurants while in the area.
See properties

Frequently asked questions

Why should I book my Isernia holiday with Expedia?
Choose Expedia to plan your next big escape simply and all in one convenient place. Our insider tip for scoring a terrific deal on an Isernia getaway? Bundle your accommodation, airfares and/or hire car into a package holiday. Then throw in a few exciting tours and activities. Many bookings also include flexible cancellation policies, so there's no need to panic if you have to switch up your travel plans. Round-the-clock assistance with amending and cancelling your trip is available via our Customer Service Portal link.
When is the best time of year to holiday in Isernia?
Isernia is at its busiest in June, July and August. If you want a more laid-back holiday, head there in January, April and December. Arrange your visit to Isernia based on what kind of adventure you're looking for. January is the coolest time of year, when average daytime temperatures are 3ºC. In August, the warmest period, expect temperatures of around 23ºC during the day.
What is the top hotel for my holiday in Isernia?
Centrum Palace sets the stage for an epic adventure in Isernia, offering all the comforts and amenities you need and more.
How do I get a cheap holiday to Isernia?
If you love getting an amazing deal, bundle your bookings into an Isernia holiday. Whether you're looking for hotels, flights, activities or hire cars, you can book everything in one place. You'll have plenty of choice at your fingertips too. Expedia has over 400 air carriers and 321,000 hotels around the globe to take your pick of. Fly with who you prefer, find a room where you like and save some cash — now that's the perfect holiday! Learn more about how you can save money on your next holiday when you book a flight and hotel together with Expedia.
What should I do on my Isernia holiday?
Offering popular attractions like Tibetan Bridge and Basilica Minore dellAddolorata, a holiday in Isernia promises plenty of fun places to visit. National Museum of the Paleolithic and Cathedral of Isernia are two other sights worth checking out.
What is the best area to stay in when on holiday in Isernia?
A getaway to Isernia isn't complete without stopping by National Museum of the Paleolithic. Why not stay close to this popular attraction?
Do I need a visa for my Isernia holiday?
Official government websites are the best source of information on visa requirements, application procedures and any necessary documentation. Your nationality and reason for travelling, whether it be for work or pleasure, will determine if you need a visa for Isernia. Also check that your passport is up to date and has at least six months validity remaining beyond your planned date of return. Do all your travel planning well ahead of time to avoid any last-minute surprises.
What should I wear on my Isernia holiday?
Although everyone's fashion style varies, it can be useful to have some guidelines for what type of clothes to bring on your holiday in Isernia. We recommend looking up style blogs before you leave for inspiration on fashion trends or dress codes. Check the local weather forecast so you can pack appropriately. The warmest month in Isernia is August, with average daytime temperatures of 23ºC. If you plan to travel during the coolest month of January, the mercury hovers around 3ºC during the day.
What does an Expedia Isernia holiday include?
Expedia has everything you need to lock in your Isernia getaway, but how your package is structured is totally up to you. Choose from a combination of flights, hire cars and hotels. In search of some activities or tours to fill in your time? Once you've made your booking, you can add them too. Whatever your style or budget, there's a deal to meet your needs. Bed & breakfasts and apartments are a few of the most popular property types in Isernia. No matter your preference or size of your group, you can count on Expedia for the freedom and flexibility to tailor your next escape.
Does Expedia offer Book Now, Pay Later Isernia holidays?
Your bank balance shouldn't get in the way of taking a holiday, so Expedia has devised a solution to help. Now that we've formed a partnership with online lender Klarna, it's easier than ever to book a fabulous getaway without exhausting your savings. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your trip. Consider one of these flexible payment options:

  • Pay monthly holidays: Klarna offers payments in multiple transactions that suit all types of budgets, so you can book that well-deserved holiday now.
  • No-deposit holidays: When you want to grab an unbeatable deal but your budget doesn't quite go that far, Klarna's no-deposit holiday plan will allow you to Book Now, Pay Later to lock it in.

Can I choose my airline with an Isernia Expedia holiday?
Yes — and it's simple too. Expedia has access to more than 400 partner airlines worldwide. Our holiday packages give you the freedom to take your pick of available flight, hotel or activity options that fit your needs.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.