Title: Hotels in Greencastle, MO - Best Greencastle Hotels from £54 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Greencastle](https://expedia.co.uk/Greencastle-Holiday-Rentals.d553248634983462000.Travel-Guide-HolidayRentals)[Greencastle Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Greencastle.d553248634983462000.Car-Hire-Guide)[Greencastle Holidays](https://expedia.co.uk/Greencastle.d553248634983462000.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Greencastle, MO from £54 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Greencastle Pet friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Greencastle%2C+Missouri%2C+United+States+of+America®ionId=553248634983462000&latLong=40.262523%2C-92.877981&adults=2&startDate=2026-01-22&d1=2026-01-22&endDate=2026-01-24&d2=2026-01-24&amenities=PETS) ## Check prices for these dates Tonight [8 Jan - 9 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983462000&startDate=2026-01-08&endDate=2026-01-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [9 Jan - 10 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983462000&startDate=2026-01-09&endDate=2026-01-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [9 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983462000&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983462000&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Greencastle hotels ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/17367649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/4be7f63c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/ee47dad5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/a8acc085.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Kirksville - University Area by IHG [](https://www.expedia.co.uk/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information) Kirksville 9.2/10 Wonderful (512) Located near a train station in Kirksville, this hotel offers a refreshing indoor pool and 24-hour fitness centre. Guests praise the complimentary breakfast and attentive staff. Thousand Hills State Park is nearby, with free WiFi and parking included. --- "Excellent service and stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Taylor £99 includes taxes & fees 11 Jan - 12 Jan [](https://www.expedia.co.uk/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/8a5baebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking | Down duvets, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/7d76c669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/b08ddc86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/1e205061.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Kirksville [](https://www.expedia.co.uk/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information) Kirksville 7.6/10 Good (395) Modern rooms complemented by free WiFi and parking await at this convenient Kirksville hotel. Work out in the fitness centre before exploring nearby Thousand Hills State Park. Business travellers appreciate the attentive staff. --- "The staff was friendly and provided excellent service!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Don £67 includes taxes & fees 15 Jan - 16 Jan [](https://www.expedia.co.uk/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/fa987a1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/9afc2091.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/9b5928a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free cots/infant beds, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/a7e2219f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Knights Inn Kirksville [](https://www.expedia.co.uk/Macon-Hotels-Knights-Inn-Kirksville.h22159.Hotel-Information) Kirksville 7.2/10 Good (251) Tranquil accommodation with unique layout ensure no neighbors above or below for ultimate relaxation. Free parking and in-room coffeemakers add convenience, while nearby natural attractions await your exploration. --- "Cozy and cool." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lois £57 includes taxes & fees 10 Jan - 11 Jan [](https://www.expedia.co.uk/Macon-Hotels-Knights-Inn-Kirksville.h22159.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/c19d4fbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/68baa0ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/388c1302.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Refrigerator & Microwave | Hypo-allergenic bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/de278a36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Kirksville [](https://www.expedia.co.uk/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information) Kirksville 9.2/10 Wonderful (581) Located near Thousand Hills State Park, this welcoming hotel offers free breakfast, WiFi, and parking. Enjoy morning swims in the indoor pool or workouts in the fitness centre. Business-friendly amenities and a helpful team ensure a comfortable stay in Missouri. --- "Better than a typical hotel, premium bedding, great lobby space for families to gather." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lynn £100 includes taxes & fees 24 Jan - 25 Jan [](https://www.expedia.co.uk/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/fd2e50c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/d203c711.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/08bb1016.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/9c660a01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Kirksville-University Area [](https://www.expedia.co.uk/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) Kirksville 9.0/10 Wonderful (156) Connected to a golf course in Kirksville, this hotel offers complimentary WiFi, daily buffet breakfast, and free parking. Thousand Hills State Park is nearby, with La Plata Station just 13 minutes away. --- "Great breakfast let me check in early was very nice " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jamie £54 includes taxes & fees 4 Feb - 5 Feb [](https://www.expedia.co.uk/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/9821cb76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/f3c5f510.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/f4cdd5fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/2180aea2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Kirksville [](https://www.expedia.co.uk/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information) Kirksville 6.6/10 (1000) Enjoy a tranquil escape at this Kirksville hotel offering an indoor pool and convenient bar. Located near Thousand Hills State Park with complimentary breakfast, WiFi, and parking. Guests consistently praise the helpful staff and immaculate accommodation. --- "Breakfast was great enjoyed the pool" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dara £54 includes taxes & fees 11 Jan - 12 Jan [](https://www.expedia.co.uk/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-22&endDate=2026-01-23®ionId=553248634983462000&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FGreencastle-Hotels.d553248634983462000.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FGreencastle-Hotels.d553248634983462000.Travel-Guide-Hotels) ## Top Greencastle Hotel Reviews ## More cheap stays in Greencastle ![Super 8 by Wyndham Kirksville-University Area](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/adba1fe4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Super 8 by Wyndham Kirksville-University Area 1101 Country Club Dr Kirksville MO £54 4 Feb - 5 Feb includes taxes & fees 9/10 Wonderful! (155 reviews) [](https://expedia.co.uk/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) ![Days Inn by Wyndham Kirksville](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/9821cb76_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham Kirksville 3805 S Baltimore St Kirksville MO £54 11 Jan - 12 Jan includes taxes & fees 6.6/10 (1,001 reviews) [](https://expedia.co.uk/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information) ![Quality Inn Kirksville](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/2dd82658_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Kirksville 2209 N Baltimore St Kirksville MO £67 15 Jan - 16 Jan includes taxes & fees 7.4/10 Good! (395 reviews) [](https://expedia.co.uk/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information) ![Holiday Inn Express & Suites Kirksville - University Area by IHG](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/17367649_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Kirksville - University Area by IHG 2523 South Franklin St. Kirksville MO £99 11 Jan - 12 Jan includes taxes & fees 9.2/10 Wonderful! (512 reviews) [](https://expedia.co.uk/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information) ![Hampton Inn Kirksville](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/388c1302_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Kirksville 2604 N. Baltimore Street Kirksville MO £100 24 Jan - 25 Jan includes taxes & fees 9/10 Wonderful! (580 reviews) [](https://expedia.co.uk/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information) ![Baymont by Wyndham Kirksville University Area](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/0cfe6b5f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Baymont by Wyndham Kirksville University Area 2702 South Franklin Kirksville MO [Get rates](https://expedia.co.uk/Hotel-Search?startDate=22%2F01%2F2026&endDate=23%2F01%2F2026&selected=125458&PinnedHotelID=125458&HadPinnedHotel=true®ionId=553248634983462000) 7.6/10 Good! (901 reviews) [](https://expedia.co.uk/Macon-Hotels-Baymont-By-Wyndham-Kirksville-University-Area.h125458.Hotel-Information) ## Frequently asked questions ### What's the best place for a stay in Greencastle? ### What are some of the best holiday rentals that Greencastle has to offer? ### If I need to cancel my hotel reservation in Greencastle, will I receive a refund? ### How is it to stay in Greencastle? ### What should I do while I'm visiting Greencastle? ### What's the seasonal weather like in Greencastle? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Spa Hotels in Bethany ](https://www.expedia.co.uk/Bethany-Hotels-Spa-Hotels.0-0-d6897-tSpaHotels.Travel-Guide-Filter-Hotels) - [Brookfield Hotels ](https://www.expedia.co.uk/Brookfield-Hotels.d55605.Travel-Guide-Hotels) - [Callao Hotels ](https://www.expedia.co.uk/Callao-Hotels.d3000444667.Travel-Guide-Hotels) - [Chillicothe Hotels ](https://www.expedia.co.uk/Chillicothe-Hotels.d6058811.Travel-Guide-Hotels) - 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