The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West - 2026 Updated Prices

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A breakfast table with various food items and drinks, a pool in the background, and a tiled wall.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.6 mi from Florida Keys National Marine Sanctuary

Teresa

£204

includes taxes & fees

1 Nov - 2 Nov

A tropical outdoor area with palm trees, hanging plants, and string lights.

A wooden deck with lush greenery and a pool area.

An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.

A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.6 mi from Florida Keys National Marine Sanctuary

Maricela

£116

includes taxes & fees

29 Oct - 30 Oct

A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.

A colonial-style building with a porch, surrounded by lush tropical vegetation.

A bar area with a counter, chairs, and a clock.

A couple walking along a poolside pathway surrounded by lush greenery.

3. The Gardens Hotel

Downtown Key West, 0.5 mi from Florida Keys National Marine Sanctuary

Gisele

£188

includes taxes & fees

27 Oct - 28 Oct

A modern outdoor area with a pool, lounge chairs, and a bar area.

A modern hotel with a prominent glass facade, palm trees, and a clear sky.

An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

A modern hotel room with a bed, sofa, coffee table, and artwork.

4. H2O Suites - Adults Only

Uptown - Upper Duval, 0.7 mi from Florida Keys National Marine Sanctuary

Kimberly

£302

includes taxes & fees

28 Oct - 29 Oct

A pool area with lounge chairs and a table, surrounded by palm trees.

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

5. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.5 mi from Florida Keys National Marine Sanctuary

ben

£204

includes taxes & fees

1 Nov - 2 Nov

A modern interior with a staircase, a sofa set, a wooden table, and a television.

A spacious room with a large bed, a sofa, a chair, a small table, and a television.

A pathway flanked by lush green foliage leading to a gated entrance.

A pool area with a clear view of a house in the background, surrounded by palm trees and greenery.

6. Simonton Court Historic Inn & Cottages

Historic Seaport, 0.6 mi from Florida Keys National Marine Sanctuary

William

£125

includes taxes & fees

27 Oct - 28 Oct

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

A spacious living room with a sofa, chairs, and a dining table. There are large windows with blinds, a door leading to a patio, and a ceiling with exposed beams.

A narrow room with a bed, a potted plant, and a window with blinds.

A spacious living room with a wooden ceiling, white sofas, a patterned armchair, a glass coffee table, and a large painting on the wall.

7. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.1 mi from Florida Keys National Marine Sanctuary

Nestor

£235

includes taxes & fees

28 Oct - 29 Oct

A two-story house with a covered porch, a brick pathway, and a large tree.

A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.

A poolside area with a swimming pool, a staircase leading to a deck, and a building with multiple windows and balconies.

8. The Marquesa Hotel

Old Town Key West, 0.6 mi from Florida Keys National Marine Sanctuary

Josh

£420

includes taxes & fees

10 Nov - 11 Nov

A porch with a white railing, a bench, and a flag.

A spacious bedroom with a large bed, a sitting area with a sofa and armchairs, and a dining area with a table and chairs.

A two-story white house with green shutters, a wooden door, and a white picket fence.

A pool area with lounge chairs and a dining table, surrounded by palm trees and a house with a porch.

9. The Conch House Heritage Inn

Old Town Key West, 0.7 mi from Florida Keys National Marine Sanctuary

Jennifer

£260

includes taxes & fees

27 Oct - 28 Oct

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.

A covered walkway with a wooden ceiling, white railings, and a brick path.

A garden with a pond, rocks, and various plants.

10. Island City House Hotel

Historic Seaport, 0.8 mi from Florida Keys National Marine Sanctuary

Elise

£158

includes taxes & fees

28 Oct - 29 Oct

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.

A bedroom with a bed, nightstand, lamp, air conditioning unit, and a no smoking sign.

A covered outdoor area with a wooden staircase, seating, and potted plants.

11. The Grand Guesthouse

Old Town Key West, 1 mi from Florida Keys National Marine Sanctuary

Justyn

£149

includes taxes & fees

27 Oct - 28 Oct

A pool area with lounge chairs and palm trees.

A modern outdoor seating area with a sofa, chairs, and a small table, surrounded by glass doors and a view of greenery.

A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

A modern indoor space with a curved sofa, a small round table, and a staircase.

12. Santa Maria Suites

Uptown - Upper Duval, 0.8 mi from Florida Keys National Marine Sanctuary

Anthony

£302

includes taxes & fees

27 Oct - 28 Oct

A room with a bed, a ceiling fan, and a window with blinds.

A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

A poolside area with lounge chairs, a covered seating area, and a small pool.

A cozy outdoor seating area with a wooden bench and a table, surrounded by potted plants and a coffee and tea sign.

13. The Mermaid & Alligator

Old Town Key West, 0.8 mi from Florida Keys National Marine Sanctuary

Adam

£187

includes taxes & fees

27 Oct - 28 Oct

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.

A two-story building with a white picket fence, a mailbox, and a small tree in front.

14. Duval House

Downtown Key West, 0.5 mi from Florida Keys National Marine Sanctuary

Cathrine

£124

includes taxes & fees

27 Oct - 28 Oct

A green house with a white porch, a flag, and a sign advertising a property for sale.

A room with a ceiling fan, an air conditioning unit, a window with blinds, a sofa with patterned cushions, a small round table, and a floor lamp.

A bathroom with a vanity, a mirror, and a window with blinds.

A bedroom with a large bed, a sofa, a nightstand, and a painting on the wall.

15. L'Habitation Guest House - Adults Only

Historic Seaport, 0.5 mi from Florida Keys National Marine Sanctuary

Richard

£122

includes taxes & fees

27 Oct - 28 Oct

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A grand staircase with ornate railings and a chandelier.

A large, two-story house with a prominent tower and a covered porch.

A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

16. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 0.7 mi from Florida Keys National Marine Sanctuary

Janet

£215

includes taxes & fees

27 Oct - 28 Oct

A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.

A hotel room with a bed, a nightstand, a chair, a small table, and a ceiling fan.

A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.

A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.

17. Ambrosia Key West

Old Town Key West, 0.7 mi from Florida Keys National Marine Sanctuary

RICHARD

£116

includes taxes & fees

27 Oct - 28 Oct

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

A bedroom with a bed, two bedside lamps, a ceiling fan, and a view of a balcony with plants.

A poolside area with lounge chairs and a clear blue pool surrounded by lush tropical vegetation.

A two-story house with a white exterior, a green roof, and a staircase leading to the upper floor.

18. Westwinds Inn

Historic Seaport, 0.9 mi from Florida Keys National Marine Sanctuary

Shari

£136

includes taxes & fees

27 Oct - 28 Oct

A poolside area with lounge chairs, umbrellas, and a pergola.

A bright kitchen with white cabinetry, a white island, wicker pendant lights, and geometric patterned backsplash.

A wooden bench with a cushion and a small table, surrounded by bamboo plants and a wooden deck.

A living room with a spiral staircase, a sofa, a chair, a coffee table, and a view of an outdoor seating area.

19. Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.6 mi from Florida Keys National Marine Sanctuary

Lisa and David

£248

includes taxes & fees

27 Oct - 28 Oct

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

A yellow building with a door marked '7'.

A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.

A pool area with a circular pool, lounge chairs, and a gazebo.

20. Alexander Palms Court

Casa Marina, 0.9 mi from Florida Keys National Marine Sanctuary

Brenda

£120

includes taxes & fees

27 Oct - 28 Oct

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,008 reviews	View
Douglas House - Adults Only	9.8 Exceptional 568 reviews	View
The Gardens Hotel	9.8 Exceptional 1,000 reviews	View
H2O Suites - Adults Only	9.8 Exceptional 670 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,003 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Southernmost Beach Resort and Guesthouses

10/10 Excellent

"Our stay at the Southern Most was great! The location is perfect and the staff was wonderful. The beach, the pool the rooms were spotless and the staff couldn’t have been any nicer. Highly recommended."

The Cabana Inn Key West - Adults Only

10/10 Excellent

"A++"

Opal Key Resort & Marina, Key West

10/10 Excellent

"Amazing property located at the tip of the keys. Very convenient to the strip and also a lot of shops."

The Southernmost Inn - Adults Only

8/10 Good

"This is a small, boutique type inn. There are steep steps to the second and third floors so if you have heavy luggage, be careful. The continental breakfast was pretty good, you can make your own waffles. The “happy hour “ was cheese, nuts, some stale crackers and wine. Great location on the island!"

The Reach Key West, Curio Collection by Hilton

10/10 Excellent

"It was welled cared for and the staff was very helpful."

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent

"Breakfast was varied and fresh. Housekeeping did a great job keeping our room clean. Would definitely stay again."

Duval House

10/10 Excellent

"Room was very clean and well maintained. Nice continental breakfast."

Pier House Resort & Spa

10/10 Excellent

"Great parking. Very central. Room was big and staying in the Spa building was quiet and great!"

Douglas House - Adults Only

10/10 Excellent

"Had another fantastic day thank you for your hospitality☀️☀️☀️"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a trip to Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can make plans for a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon browsing the exhibits at USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can do some window-shopping at We Cycle Key West during your stay in Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1487 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveller data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater and Key West Film Society if you're interested in local theatre.

Search Hotels Near Florida Keys National Marine Sanctuary, Key West

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. The Gardens Hotel

4. H2O Suites - Adults Only

5. Orchid Key Inn - Adults Only

6. Simonton Court Historic Inn & Cottages

7. Alexander's Guesthouse - Adult Exclusive

8. The Marquesa Hotel

9. The Conch House Heritage Inn

10. Island City House Hotel

11. The Grand Guesthouse

12. Santa Maria Suites

13. The Mermaid & Alligator

14. Duval House

15. L'Habitation Guest House - Adults Only

16. Southernmost House - Adult Exclusive

17. Ambrosia Key West

18. Westwinds Inn

19. Ella's Cottages - Key West Historic Inns

20. Alexander Palms Court

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Southernmost Beach Resort and Guesthouses

The Cabana Inn Key West - Adults Only

Opal Key Resort & Marina, Key West

The Southernmost Inn - Adults Only

The Reach Key West, Curio Collection by Hilton

Winslow's Bungalows - Key West Historic Inns

Duval House

Pier House Resort & Spa

Douglas House - Adults Only

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions