A field with a truck and a power line.

Search Business Hotels in Eastern South Dakota

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Eastern South Dakota Business Hotels

Tonight
17 Oct - 18 Oct
Tomorrow
18 Oct - 19 Oct
Next weekend
23 Oct - 25 Oct
In two weeks
30 Oct - 1 Nov

Our top choices for Eastern South Dakota business-friendly hotels

A hotel room with a large bed, a separate bathroom with a bathtub, and a seating area.
A multi-story American Inn with a prominent sign, a covered entrance, and a landscaped driveway.
A reception desk with a wooden finish and a sign that reads "American Inn." There is a refrigerator stocked with beverages and snacks, and a small shelf with various items.
A hotel hallway with carpeted floors and doors on both sides.

1. AmericInn by Wyndham Hartford SD

AmericInn by Wyndham Hartford SD
Hartford
United States
Laurel
£67
includes taxes & fees
25 Oct - 26 Oct
AmericInn by Wyndham Hartford SD
A compact bathroom with a white sink, a bathtub, and a large mirror.
An indoor swimming pool with clear water, surrounded by wooden walls and a tiled floor. There are chairs and a table near the pool, and a clock on the wall.
A grassy area with several evergreen trees.
A hotel room with two beds, a desk, a chair, a lamp, and artwork on the walls.

2. De Smet Super Deluxe Inn and Suites

De Smet Super Deluxe Inn and Suites
De Smet
United States
T
£82
includes taxes & fees
19 Oct - 20 Oct
De Smet Super Deluxe Inn and Suites
A hotel room with a large bed, a blue sofa, a nightstand with a lamp, and a mural of a waterfall on the wall.
A hotel reception area with a large mural of a mountain and a clear view of the lobby.
A multi-story hotel with a covered entrance, brick facade, and a large tree in front.
A hotel lobby with a fireplace, seating area, and a bar.

3. Clarion Pointe Sioux Falls Airport

Clarion Pointe Sioux Falls Airport
Northwest Sioux Falls
United States
Anita
£73
includes taxes & fees
25 Oct - 26 Oct
Clarion Pointe Sioux Falls Airport
A swimming pool with clear blue water, surrounded by a tiled deck and a seating area with chairs and tables.
A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a clear view of the building's facade.
A modern hotel room with a kitchenette, a sofa, a dining table, a small round table, a bed, and a view of the outdoors.
A hotel room with a bed, a sofa, a desk, and a chair.

4. Comfort Inn & Suites at Sanford Sports Complex

Comfort Inn & Suites at Sanford Sports Complex
Northwest Sioux Falls
United States
Michelle Marie
£86
includes taxes & fees
25 Oct - 26 Oct
Comfort Inn & Suites at Sanford Sports Complex
A spacious living area with a dining set, sofas, and a ceiling fan.
A swimming pool with a fence, trees, and a building in the background.
Two people sitting on Adirondack chairs facing a lake, with picnic tables and benches in the background.
A bed with a grey quilted comforter, a pillow with 'Relax' written on it, and a wooden nightstand with a box on it.

5. Lewis and Clark Resort

Lewis and Clark Resort
Yankton
United States
Jeff
£90
includes taxes & fees
1 Nov - 2 Nov
Lewis and Clark Resort
An outdoor patio area with seating and a fire feature, surrounded by modern architecture and plants.
A modern lobby with a white sofa, pendant lighting, and a gold sculpture.
A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.
A group of people at a social event in a spacious indoor venue with tables and chairs arranged for dining or socializing.

6. Holiday Inn Express & Suites Sioux City North-Event Center by IHG

Holiday Inn Express & Suites Sioux City North-Event Center by IHG
Dakota Dunes
United States
Dustin and Karen
£77
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express & Suites Sioux City North-Event Center by IHG
A modern bar area with a wooden ceiling, bar stools, and a variety of liquor bottles.
A bar area with a wooden ceiling, multiple shelves of liquor bottles, and bar stools.
A Best Western PLUS hotel with a modern design, featuring a covered entrance and multiple floors.
Room

7. Best Western Plus Lakeview Hotel

Best Western Plus Lakeview Hotel
Madison
United States
Christina
£115
includes taxes & fees
25 Oct - 26 Oct
Best Western Plus Lakeview Hotel
A reception area with a wooden reception desk, a computer, and a chair.
A living room with a fireplace, a clock, and a bookshelf.
A modern kitchen with blue cabinets, a white brick backsplash, and a stainless steel refrigerator.
Exterior

8. Country Inn & Suites by Radisson, Dakota Dunes, SD

Country Inn & Suites by Radisson, Dakota Dunes, SD
Dakota Dunes
United States
James
£64
includes taxes & fees
8 Nov - 9 Nov
Country Inn & Suites by Radisson, Dakota Dunes, SD
A La Quinta Inn & Suites building with a covered entrance and multiple windows.
A swimming pool with a tiled deck, lounge chairs, and a sunroof.
A reception area with a large poster of Sioux Falls, a reception desk, a glass display case, and a shelf with various items.
A hotel lobby with a dining area, seating area, and a TV mounted on the wall.

9. La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls
Mall District
United States
Rex
£79
includes taxes & fees
1 Nov - 2 Nov
La Quinta Inn & Suites by Wyndham Sioux Falls
A hotel lobby with a reception desk, seating area, and a view of the outside.
A hotel room with a bed, a desk with a television, a blue chair, a blue sofa with a red pillow, and a framed picture on the wall.
A swimming pool area with lounge chairs and umbrellas, a tiled floor, and a ceiling with recessed lighting.
A modern kitchen with a central island, bar stools, and pendant lighting.

10. Hampton Inn North Sioux City

Hampton Inn North Sioux City
North Sioux City
United States
Crystal
£73
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn North Sioux City
View all properties

Top Eastern South Dakota Hotel Reviews

Thunderbird Lodge

Thunderbird Lodge

8/10 Good
"Room was clean and breakfast was good"
Tom 1-night trip
Posted 12 hours ago
Thunderbird Lodge
La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls

10/10 Excellent
"For a change we had a Hot Tub that worked and a pool with easy access. Breakfast was good."
Penny 2-night trip
Posted 17 hours ago
La Quinta Inn & Suites by Wyndham Sioux Falls
Clarion Pointe Sioux Falls Airport

Clarion Pointe Sioux Falls Airport

10/10 Excellent
"Nice hotel and friendly staff!"
Pete 1-night trip
Posted 18 hours ago
Clarion Pointe Sioux Falls Airport
The Dakota

The Dakota

8/10 Good
"Pool was wonderful grounds could use improvement"
Christopher 2-night trip
Posted 2 days ago
The Dakota
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

10/10 Excellent
"Pool"
Jamez 1-night trip
Posted 3 days ago
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Baymont by Wyndham Sioux Falls

Baymont by Wyndham Sioux Falls

10/10 Excellent
"I stayed at this hotel numerous times. Very consistent atmosphere and quality. In terms of economics. The amenities included with this hotel our second to none for the price. The breakfast that is offered to the customers is highly valued. Check-in was efficient and professional. Hotel is quiet and was clean."
Victor j 1-night trip
Posted 3 days ago
Baymont by Wyndham Sioux Falls

Frequently asked questions

How much do business hotels in Eastern South Dakota cost?
Expect to pay between £60 and £115 per night for business hotels in Eastern South Dakota. Top deals on stays that are suitable for corporate travellers are just a few clicks away on Expedia. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business hotels are there in Eastern South Dakota?
Eastern South Dakota has 114 business hotels to pick from. Whether you're hosting a conference or meeting or working remotely, these properties come with the services and amenities you need to be productive.
Why book your business hotel in Eastern South Dakota with Expedia?
Here at Expedia, we make it our job to help you locate the perfect stay at the right price. From fancy, corporate-friendly retreats to affordable motor inns loaded with amenities, you'll have your next work trip booked in a few quick clicks.
How can I find cheap business hotels in Eastern South Dakota?
Select the "business friendly" filter, located just under the "traveller experience" heading, to find cheap business hotels in Eastern South Dakota. Then refine your search by your per-night budget. Choosing a stay away from the centre is another good way to save.

Explore a world of travel with Expedia