Distrito Santa Isabel Holidays
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Top Distrito Santa Isabel Flight + Hotel Deals
Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
Price was £1,605, price is now £1,129 per person
£1,129
per person
15 Jul - 24 Jul
found 9 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
8.4/10 Very Good! (1,825 reviews)
Room was in need of updating but very clean and reasonable price. The property has a great pool area and restaurant on property. I had a great meal there.
Reviewed on 9 Jun 2026
Megapolis Hotel Panamá
San Francisco
Save 100% on your flight
Price was £3,253, price is now £1,688 per person
£1,688
per person
15 Jul - 24 Jul
found 9 hours ago
Return direct flight included
London (LON) to Panama City (PTY)
8.4/10 Very Good! (1,553 reviews)
This was absolutely fabulous! The buffet in the mornings were the best part to start your day with fresh omelets and freshly squeezed juices with all of the bells and whistles of a buffet. I would definitely come back to stay.
Reviewed on 10 Jun 2026
Central Hotel Panama Casco Viejo
Casco Viejo
Price was £3,188, price is now £1,954 per person
£1,954
per person
28 Aug - 6 Sept
found 1 day ago
Return direct flight included
Birmingham (BHX) to Panama City (PTY)
9.2/10 Wonderful! (1,011 reviews)
We thoroughly enjoyed our stay. Relaxing, clean and sophisticated vibe there. Central location can’t be beat. So comfortable! We liked the breakfast buffet as well. Staff was friendly. Would stay again! Very pleased :)
Reviewed on 7 Jun 2026
Casa Mallet by Wynwood House
Casco Viejo
Price was £2,726, price is now £2,106 per person
£2,106
per person
28 Aug - 6 Sept
found 1 hour ago
Return direct flight included
Birmingham (BHX) to Panama City (PTY)
9.8/10 Exceptional! (27 reviews)
In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.
Reviewed on 12 Mar 2026
Distrito Santa Isabel Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Top hotels in Distrito Santa Isabel
Caribbean Haven Of Nature 'Preci Beach'
Nombre de Dios Colon
10/10 Exceptional! (31 reviews)
Beautiful
"This place is special. The inside of the house could use a deep cleaning. But the outdoor area and beach area are incredible. We explored tide pools and snorkeled open areas and crevices all week long. Our one negative experience was fishing with some young men from the nearby town; they did not ..."
Reviewed on 17 Mar 2025
BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES
Santa Isabel Colon
10/10 Exceptional! (31 reviews)
"This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful ..."
Reviewed on 1 Jan 2026
Caribbean getaway: beach cottage just on the sand
Palenque Provincia de Colón
8.8/10 Excellent! (3 reviews)
"It’s nice directly on the beach. The street to the cottage is not paved. Tv wasn’t working and no hot water the 2nd day."
Reviewed on 21 Apr 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.
