Distrito Santa Isabel Holidays
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- Better togetherSave up to £750 when you book a flight and hotel together*
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Top destinations in Distrito Santa Isabel
Palenque
Nombre de Dios
Playa Chiquita
Santa Isabel
Miramar
The Latest Distrito Santa Isabel Holiday Packages
Price found within the past 48 hours. Click for updated prices.
- Decapolis Hotel Panama City
2 Oct - 8 OctDecapolis Hotel Panama City + Flight
San Francisco6 nights4.0 star property8.6/10 - Excellent (1,716 reviews)"Our stay at Decapolis Hotel was absolutely amazing from start to finish. The hotel is modern, clean, and in a fantastic location with easy access to restaurants, shopping, and attractions. The rooms were spacious, comfortable, and always kept spotless by the housekeeping staff. What really made our stay memorable was the outstanding customer service. Every member of staff we encountered was friendly, professional, and eager to help. They made us feel welcome from the moment we checked in until..."Reviewed July 30, 2026Return • Georgetown (GEO) - Panama City (PTY)GEO - PTY • 1 stop PTY - GEO • 1 stop£894£622found 1 day agoper traveller - Central Hotel Panama Casco Viejo
2 Oct - 8 OctCentral Hotel Panama Casco Viejo + Flight
Casco Viejo6 nights4.0 star property9.2/10 - Wonderful (1,003 reviews)"The hotel's location is excellent, right in the heart of the lively Casco Viejo district. Museums, restaurants, shops, and the waterfront are all within easy walking distance. There was always something happening in the square across from the hotel entrance, from live music to graduation celebrations and photography sessions, making the area feel vibrant and full of energy. The breakfast staff were outstanding—friendly, attentive, and very accommodating. The breakfast buffet offered a wide..."Reviewed July 30, 2026Return • Georgetown (GEO) - Panama City (PTY)GEO - PTY • 1 stop PTY - GEO • 1 stop - Megapolis Hotel Panamá
2 Oct - 8 OctMegapolis Hotel Panamá + Flight
San Francisco6 nights4.5 star property8.4/10 - Very good (1,626 reviews)"good place to stay with family."Reviewed July 30, 2026Return • Georgetown (GEO) - Panama City (PTY)GEO - PTY • 1 stop PTY - GEO • 1 stop - Riande Aeropuerto Hotel & Casino
2 Oct - 8 OctRiande Aeropuerto Hotel & Casino + Flight
Tocumen6 nights4.0 star property8.4/10 - Very good (1,804 reviews)Return • Georgetown (GEO) - Panama City (PTY)GEO - PTY • 1 stop PTY - GEO • 1 stop£1,013£626found 1 day agoper traveller - Hyatt Regency Panama City
2 Oct - 8 OctHyatt Regency Panama City + Flight
Bella Vista6 nights5.0 star property9.6/10 - Exceptional (389 reviews)"Clean, nice staff"Reviewed July 30, 2026Return • Georgetown (GEO) - Panama City (PTY)GEO - PTY • 1 stop PTY - GEO • 1 stop£989£705found 1 day agoper traveller
Frequently Asked Questions
How do I get a cheap travel package to Distrito Santa Isabel?
One of the simplest ways to save money (and time) is to combine your bookings with Expedia. Flights, hotels, rental cars and activities — we've got it all. Pick and choose the combination that suits you and watch your savings grow. Of course, a package deal is never one-size-fits-all. That's why Expedia offers over 550 partner airlines and 1,000,000 hotel options globally, which lets you customize your Distrito Santa Isabel adventure.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.