Title: Top Hotels in Santo Tomé Department - Compare Santo Tomé Department Hotels | Expedia.co.uk [Holiday Rentals in Santo Tomé Department](https://expedia.co.uk/Destinations-In-Santo-Tome-Department.d553248635975751431.Holiday-Rental-Destinations)[Santo Tomé Department Car Hire](https://expedia.co.uk/Destinations-In-Santo-Tome-Department.d553248635975751431.Car-Hire-Destinations)[Santo Tomé Department Holidays](https://expedia.co.uk/Santo-Tome-Department.d553248635975751431.Holidays-City-Breaks) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find the best Santo Tomé Department Hotels ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [6 Oct - 7 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975751431&startDate=2025-10-06&endDate=2025-10-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [7 Oct - 8 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975751431&startDate=2025-10-07&endDate=2025-10-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [10 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975751431&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975751431&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Hotels Santo Tomé Department ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations) ## Top Santo Tomé Department Hotel Reviews ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Santo Tomé Department - [Gobernador Virasoro Hotels](https://expedia.co.uk/Gobernador-Virasoro-Hotels.d3000428985.Travel-Guide-Hotels) ### Explore more hotels - [Wild Wetlands Lodge](https://expedia.co.uk/Ituzaingo-Hotels-Wild-Wetlands-Lodge.h103441567.Hotel-Information) - [Puerto Valle Hotel de Esteros](https://expedia.co.uk/Ituzaingo-Hotels-Puerto-Valle-Hotel-De-Esteros.h2346397.Hotel-Information) [See a list of all hotels in Santo Tomé Department](https://expedia.co.uk/All-Santo-Tome-Department-Hotels.d553248635975751431.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Santo Tomé Department on Expedia.com.ar](https://www.expedia.com.ar/Destinos-En-Departamento-Santo-Tome.d553248635975751431.Destinos-con-Hoteles) ### Expedia's Latest Trends Hotels - [Caravan Parks Gatwick](https://expedia.co.uk/Gatwick-Caravan-Parks.d182523-aaCaravanParks.Travel-Guide-Accommodation) - [Embleton Spa Hotel](https://expedia.co.uk/Cockermouth-Hotels-Embleton-Spa-Hotel.h4190510.Hotel-Information) - 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Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)