Title: Top Hotels in Santo Tomé Department - Compare Santo Tomé Department Hotels | Expedia.co.uk [Holiday Rentals in Santo Tomé Department](https://expedia.co.uk/Destinations-In-Santo-Tome-Department.d553248635975751431.Holiday-Rental-Destinations)[Santo Tomé Department Car Hire](https://expedia.co.uk/Destinations-In-Santo-Tome-Department.d553248635975751431.Car-Hire-Destinations)[Santo Tomé Department Holidays](https://expedia.co.uk/Santo-Tome-Department.d553248635975751431.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find the best Santo Tomé Department Hotels - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [28 Nov - 29 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975751431&startDate=2025-11-28&endDate=2025-11-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [29 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975751431&startDate=2025-11-29&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [28 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975751431&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975751431&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Hotels Santo Tomé Department ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_FR-DE-MX-UK_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Save up to 40% on select hotels. [Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_BF_PROMO_553248635975751431) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations) ## Top Santo Tomé Department Hotel Reviews ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Santo Tomé Department - [Gobernador Virasoro Hotels](https://expedia.co.uk/Gobernador-Virasoro-Hotels.d3000428985.Travel-Guide-Hotels) ### Explore more hotels - [Puerto Valle Hotel de Esteros](https://expedia.co.uk/Ituzaingo-Hotels-Puerto-Valle-Hotel-De-Esteros.h2346397.Hotel-Information) - [Wild Wetlands Lodge](https://expedia.co.uk/Ituzaingo-Hotels-Wild-Wetlands-Lodge.h103441567.Hotel-Information) [See a list of all hotels in Santo Tomé Department](https://expedia.co.uk/All-Santo-Tome-Department-Hotels.d553248635975751431.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Santo Tomé Department on Expedia.com.ar](https://www.expedia.com.ar/Destinos-En-Departamento-Santo-Tome.d553248635975751431.Destinos-con-Hoteles) ### Expedia's Latest Trends Hotels - [Caravan Parks Gatwick](https://expedia.co.uk/Gatwick-Caravan-Parks.d182523-aaCaravanParks.Travel-Guide-Accommodation) - [Embleton Spa Hotel](https://expedia.co.uk/Cockermouth-Hotels-Embleton-Spa-Hotel.h4190510.Hotel-Information) - [Orchard Grand Court](https://expedia.co.uk/Singapore-Hotels-Orchard-Grand-Court.h12023352.Hotel-Information) - [The Feathers Holt](https://expedia.co.uk/Holt-Hotels-The-Feathers-Holt.h5506423.Hotel-Information) - [Apartments Hermanus](https://expedia.co.uk/Hermanus-Apartments.d601891-aaApartments.Travel-Guide-Accommodation) - [Holiday Inn Paris Palais de l'Elysée by IHG](https://expedia.co.uk/Paris-Hotels-Holiday-Inn-Paris-Elysees.h109408.Hotel-Information) - [All-Inclusive Hotels in Bangladesh](https://expedia.co.uk/Destinations-In-Bangladesh-All-Inclusive-Hotel.0-0-d15-tAllInclusiveHotel.Hotel-Filter-Destinations) - 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[Baros Island Holidays](https://expedia.co.uk/Baros-Island.d6053755.Holidays-City-Breaks) - [Zanzibar Holidays](https://expedia.co.uk/Zanzibar.d4186.Holidays-City-Breaks) - [Heaton Park](https://expedia.co.uk/Heaton-Park-Manchester.d507970.Attraction) General - [Visit St. Levan](https://expedia.co.uk/St-Levan.dx3000463059) - [Visit Arvonia](https://expedia.co.uk/Arvonia.dx3000355001) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)