Title: Cheap Flights to Santo Tomé Department - Expedia.co.uk ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £82 Cheap Flights to Santo Tomé Department [View £82 flight on Sat, 12 Dec 2026](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:AEP,to:PSS,departure:12/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:81.10&airProductToken=AQotCisIwaQBEgQxNzY0GIB5IM-UASj3zZ8DMNvOnwM4SEAAWAFqAkVCcgRIVUVCEgoIARABGAEqAkFSGAEiBAgBEAEoAigDKAQwAQ) [Santo Tomé Department Hotels](https://expedia.co.uk/Destinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations)[Holiday Rentals in Santo Tomé Department](https://expedia.co.uk/Destinations-In-Santo-Tome-Department.d553248635975751431.Holiday-Rental-Destinations)[Santo Tomé Department Car Hire](https://expedia.co.uk/Destinations-In-Santo-Tome-Department.d553248635975751431.Car-Hire-Destinations)[Santo Tomé Department Holidays](https://expedia.co.uk/Santo-Tome-Department.d553248635975751431.Holidays-City-Breaks) ## Popular airlines to Santo Tomé Department - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AR.svg) Aerolineas Argentinas - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_LA.svg) LATAM Airlines Group - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap round-trip flights to Santo Tomé Department Prices were available within the past 7 days and start at £82 for one-way flights and £163 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![Aerolineas Argentinas](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AR.gif) Sun, 10 May - Sat, 16 May AEP Buenos Aires PSS Posadas £163 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:AEP,to:PSS,departure:10/05/2026TANYT&leg2=from:PSS,to:AEP,departure:16/05/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:162.10&airProductToken=AQotCisIwaQBEgQxNzY4GIB5IM-UASj20YwDMNrSjAM4SEAAWAFqAkVCcgRIVUVCCi0KKwjBpAESBDE3NjUYz5QBIIB5KJuUjQMw_5SNAzhIQABYAWoCRUJyBEhVRUISCggBEAEYASoCQVIYASIECAEQASgCKAMoBDAB) ![Aerolineas Argentinas](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AR.gif) Sat, 11 Apr - Mon, 13 Apr AEP Buenos Aires PSS Posadas £164 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:AEP,to:PSS,departure:11/04/2026TANYT&leg2=from:PSS,to:AEP,departure:13/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:163.20&airProductToken=AQotCisIwaQBEgQxNzYwGIB5IM-UASjTh4oDMLeIigM4SEAAWAFqAkVCcgRIVUVCCi0KKwjBpAESBDE3NjkYz5QBIIB5KO2jigMw0aSKAzhIQABYAWoCRUJyBEhVRUISCggBEAEYASoCQVIYASIECAEQASgCKAMoBDAB) ![Aerolineas Argentinas](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AR.gif) Wed, 17 Jun - Wed, 24 Jun AEP Buenos Aires PSS Posadas £166 Return found 4 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:AEP,to:PSS,departure:17/06/2026TANYT&leg2=from:PSS,to:AEP,departure:24/06/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:165.34&airProductToken=AQotCisIwaQBEgQxNzYyGIB5IM-UASjj-I8DMMf5jwM4SEAAWAFqAkVCcgRIVUVCCi0KKwjBpAESBDE3NjkYz5QBIIB5KO3NkAMw0c6QAzhIQABYAWoCRUJyBEhVRUISCggBEAEYASoCQVIYASIECAEQASgCKAMoBDAB) ![Aerolineas Argentinas](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AR.gif) Fri, 12 Jun - Fri, 19 Jun AEP Buenos Aires PSS Posadas £167 Return found 4 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:AEP,to:PSS,departure:12/06/2026TANYT&leg2=from:PSS,to:AEP,departure:19/06/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:166.96&airProductToken=AQotCisIwaQBEgQxNzY4GIB5IM-UASjhxY8DMMXGjwM4SEAAWAFqAkVCcgRIVUVCCi0KKwjBpAESBDE3NjMYz5QBIIB5KK-QkAMwk5GQAzhIQABYAWoCRUJyBEhVRUISCggBEAEYASoCQVIYASIECAEQASgCKAMoBDAB) ![Aerolineas Argentinas](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AR.gif) Sat, 11 Apr - Mon, 13 Apr AEP Buenos Aires PSS Posadas £172 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:AEP,to:PSS,departure:11/04/2026TANYT&leg2=from:PSS,to:AEP,departure:13/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:171.36&airProductToken=AQotCisIwaQBEgQxNzY0GIB5IM-UASiviYoDMJOKigM4SEAAWAFqAkVCcgRIVUVCCi0KKwjBpAESBDE3NjkYz5QBIIB5KO2jigMw0aSKAzhIQABYAWoCRUJyBEhVRUISCggBEAEYASoCQVIYASIECAEQASgCKAMoBDAB) ![Aerolineas Argentinas](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AR.gif) Wed, 1 Apr - Fri, 17 Apr AEP Buenos Aires PSS Posadas £185 Return found 6 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:AEP,to:PSS,departure:01/04/2026TANYT&leg2=from:PSS,to:AEP,departure:17/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:184.27&airProductToken=AQotCisIwaQBEgQxNzYyGIB5IM-UASjplYkDMM2WiQM4S0AAWAFqAkVCcgRLVUVCCi0KKwjBpAESBDE3NjMYz5QBIIB5KM_LigMws8yKAzhIQABYAWoCRUJyBEhVRUISCggBEAEYASoCQVIYASIECAEQASgCKAMoBDAB) ![Aerolineas Argentinas](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AR.gif) Wed, 18 Mar - Mon, 23 Mar AEP Buenos Aires PSS Posadas £192 Return found 8 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:AEP,to:PSS,departure:18/03/2026TANYT&leg2=from:PSS,to:AEP,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:191.99&airProductToken=AQotCisIwaQBEgQxNzYyGIB5IM-UASiB-IcDMOX4hwM4SEAAWAFqAkVCcgRIVUVCCi0KKwjBpAESBDE3NjkYz5QBIIB5KLy2iAMwoLeIAzhIQABYAWoCRUJyBEhVRUISCggBEAEYASoCQVIYASIECAEQASgCKAMoBDAB) ![Aerolineas Argentinas](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AR.gif) Thu, 2 Apr - Fri, 10 Apr AEP Buenos Aires PSS Posadas £197 Return found 2 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:AEP,to:PSS,departure:02/04/2026TANYT&leg2=from:PSS,to:AEP,departure:10/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:196.57&airProductToken=AQotCisIwaQBEgQxNzY4GIB5IM-UASiLp4kDMO-niQM4S0AAWAFqAkVCcgRLVUVCCi0KKwjBpAESBDE3NjMYz5QBIIB5KO_8iQMw0_2JAzhIQABYAWoCRUJyBEhVRUISCggBEAEYASoCQVIYASIECAEQASgCKAMoBDAB) ![Aerolineas Argentinas](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AR.gif) Fri, 27 Mar - Sat, 28 Mar AEP Buenos Aires PSS Posadas £200 Return found 3 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:AEP,to:PSS,departure:27/03/2026TANYT&leg2=from:PSS,to:AEP,departure:28/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:199.70&airProductToken=AQotCisIwaQBEgQxNzYyGIB5IM-UASjs3YgDMNDeiAM4SEAAWAFqAkVCcgRIVUVCCi0KKwjBpAESBDE3NjMYz5QBIIB5KIvriAMw7-uIAzhVQABYAWoCRUJyBFVVRUISCggBEAEYASoCQVIYASIECAEQASgCKAMoBDAB) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Mon, 9 Mar - Thu, 12 Mar CWB Curitiba PSS Posadas £578 Return found 9 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:CWB,to:PSS,departure:09/03/2026TANYT&leg2=from:PSS,to:CWB,departure:12/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:577.50&airProductToken=AQp5CjoIzIIBEgQ1OTM1GMINIIB5KJqUhwMwsJWHAzhLQABYAWoCU0xyCEtMRVNMWjBFegoIwaQBEgQ1OTM1CjsIzIIBEgQ4NDAwGIB5IM-UASjcl4cDMMCYhwM4S0ABWAFqAlNMcghLTEVTTFowRXoKCMGkARIEODQwMAqfAQo7CMyCARIEODQyNBjPlAEggHkorLaHAzCQt4cDOEtAAFgBagJTTHIIS0xFU0xaMEV6CgjBpAESBDg0MjQKLwjMggESBDgxNDMYgHkgpqQBKNO4hwMw5LmHAzhLQAFYAWoCU0xyCEtMRVNMWjBFCi8IzIIBEgQzMjg0GKakASDCDSjewIcDMJ_BhwM4S0ABWAFqAlNMcghLTEVTTFowRRIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=FTG_SPRING_PROMO_) ## Frequently asked questions ### How do I find cheap flights to Santo Tomé Department that have flexible change policies? ### How can I find cheap tickets to Santo Tomé Department? ### How much is a flight to Santo Tomé Department? ### When is the cheapest time to fly to Santo Tomé Department? ### How much is a plane ticket to Santo Tomé Department? ### What months are the cheapest to book a flight to Santo Tomé Department? ## Book with confidence # Top tips for booking flights to Santo Tomé Department from UK ### Get ready to fly to Santo Tomé Department Prepare your luggage and book your flights to Santo Tomé Department with Expedia. We offer a seamless flight booking experience, with a wide range of Santo Tomé Department plane tickets to choose from. If you need help finding some of the best deals for cheap flights to Santo Tomé Department in 2026, we are always available to assist you. Book your flights to Santo Tomé Department today and let the adventure begin! ### Find the best tickets to Santo Tomé Department To find some of the best tickets to Santo Tomé Department in 2026, use Expedia's powerful search engine to compare dates and the different departure and arrival airports for your trip. Whether you're after direct flights to Santo Tomé Department or last-minute flights to Santo Tomé Department, you can filter and sort your search results, making it easy to find the ideal flight to Santo Tomé Department. ### Airlines fly to Santo Tomé Department There are 20 different airlines that fly to Santo Tomé Department including some of the most trusted names in the business. To book flights to Santo Tomé Department with your favourite airline, take a look at Expedia's flight listings and try out different dates to find some of the best Santo Tomé Department plane tickets. ### Find the cheapest flights to Santo Tomé Department By booking early you may find some of the best deals for Santo Tomé Department flights from the UK, including Santo Tomé Department direct flights. You can usually find affordable and cheap flights to Santo Tomé Department, whether one-way from £82 or round-trip from £163, with Expedia if you book your trip far enough in advance. ### Find the best airports for cheap flights to Santo Tomé Department Try searching for different Santo Tomé Department airports with Expedia to find some of the cheapest flights to Santo Tomé Department. Flights from Buenos Aires (AEP) to Posadas (PSS) usually have the lowest price from £82. ### Why book your flights to Santo Tomé Department with Expedia Expedia offers great deals on Santo Tomé Department air fares from £82 to cater to every budget. Not only is Expedia one of the top platforms to book flights to Santo Tomé Department from the UK, it is also your one-stop shop for booking hotels, car rentals, and more. \*Prices and availability are subject to change. Additional terms apply. ## Travel information # Santo Tomé Department Flights Information | Airlines serving | Aerolineas Argentinas, LATAM Airlines Group | | ---------------- | ------------------------------------------- | | Roundtrip price | from £163 | ## Explore a world of travel with Expedia - Top Flights Destinations - Top Santo Tomé Department Hotels - Related Airlines ### Top Flight Destinations In Santo Tomé Department - [Flights to Iberá Provincial Reserve ](https://expedia.co.uk/Cheap-Flights-To-Ibera-Provincial-Reserve.d6096857.Travel-Guide-Flights) - [Flights to Mesopotamia ](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights) ### Top Flight Destinations In World - [Flights to China ](https://expedia.co.uk/Destinations-In-China.d37.Flight-Destinations) - [Flights to Indonesia ](https://expedia.co.uk/Destinations-In-Indonesia.d81.Flight-Destinations) - [Flights to India ](https://expedia.co.uk/Destinations-In-India.d80.Flight-Destinations) - [Flights to Canada ](https://expedia.co.uk/Destinations-In-Canada.d31.Flight-Destinations) - [Flights to Japan ](https://expedia.co.uk/Destinations-In-Japan.d89.Flight-Destinations) - [Flights to Greece ](https://expedia.co.uk/Destinations-In-Greece.d67.Flight-Destinations) - [Flights to Argentina ](https://expedia.co.uk/Destinations-In-Argentina.d8.Flight-Destinations) - [Flights to Sweden ](https://expedia.co.uk/Destinations-In-Sweden.d173.Flight-Destinations) - [Flights to Australia ](https://expedia.co.uk/Destinations-In-Australia.d10.Flight-Destinations) - [Flights to Russia ](https://expedia.co.uk/Destinations-In-Russia.d153.Flight-Destinations) - [Flights to Mexico ](https://expedia.co.uk/Destinations-In-Mexico.d117.Flight-Destinations) - [Flights to Norway ](https://expedia.co.uk/Destinations-In-Norway.d138.Flight-Destinations) - [Flights to Colombia ](https://expedia.co.uk/Destinations-In-Colombia.d38.Flight-Destinations) - [Flights to France ](https://expedia.co.uk/Destinations-In-France.d59.Flight-Destinations) - [Flights to Brazil ](https://expedia.co.uk/Destinations-In-Brazil.d23.Flight-Destinations) - [Flights to Thailand ](https://expedia.co.uk/Destinations-In-Thailand.d178.Flight-Destinations) - [Flights to United States of America ](https://expedia.co.uk/Destinations-In-United-States-Of-America.d201.Flight-Destinations) - [Flights to Philippines ](https://expedia.co.uk/Destinations-In-Philippines.d145.Flight-Destinations) - [Flights to South Korea ](https://expedia.co.uk/Destinations-In-South-Korea.d94.Flight-Destinations) - [Flights to Switzerland ](https://expedia.co.uk/Destinations-In-Switzerland.d174.Flight-Destinations) ### Top Santo Tomé Department Hotels - [Puerto Valle Hotel de Esteros ](https://expedia.co.uk/Ituzaingo-Hotels-Puerto-Valle-Hotel-De-Esteros.h2346397.Hotel-Information) - [Wild Wetlands Lodge ](https://expedia.co.uk/Ituzaingo-Hotels-Wild-Wetlands-Lodge.h103441567.Hotel-Information) - [Howard Johnson Express Inn Ituzaingo ](https://expedia.co.uk/Ituzaingo-Hotels-Howard-Johnson-Express-Inn-Ituzaingo.h2827237.Hotel-Information) ### Related Airlines - [Amber Air ](https://expedia.co.uk/Amber-Air-Flights.c0A.Travel-Guide-Airlines) - [BlueAir ](https://expedia.co.uk/BlueAir-Flights.c0B.Travel-Guide-Airlines) - [Catovair ](https://expedia.co.uk/Cobra-Aviation-Flights.c0C.Travel-Guide-Airlines) - [Darwin Airline SA Lugano ](https://expedia.co.uk/Darwin-Airline-SA-Lugano-Flights.c0D.Travel-Guide-Airlines) - [Evergreen International ](https://expedia.co.uk/Evergreen-International-Flights.c0E.Travel-Guide-Airlines) - [Ghadames Air Transport ](https://expedia.co.uk/Ghadames-Air-Transport-Flights.c0G.Travel-Guide-Airlines) - [Aircompany Kokshetau ](https://expedia.co.uk/AirCompany-Kokshetau-Flights.c0K.Travel-Guide-Airlines) - [Vietnam Air Service Co. ](https://expedia.co.uk/Vietnam-Air-Service-Co-Flights.c0V.Travel-Guide-Airlines) - [West Caribbean Costa Rica ](https://expedia.co.uk/West-Caribbean-Costa-Rica-Flights.c0W.Travel-Guide-Airlines) - [Olympus Airways ](https://expedia.co.uk/Olympus-Airways-Flights.c11.Travel-Guide-Airlines) \*Available to Expedia members.