Title: Mississippi Spa Hotels, United States of America: Mississippi Hotel Guide | Expedia.co.uk [Mississippi Travel Guide](https://expedia.co.uk/Mississippi.dx226)[Mississippi Hotels](https://expedia.co.uk/Destinations-In-Mississippi.d226.Hotel-Destinations)[Holiday Rentals in Mississippi](https://expedia.co.uk/Destinations-In-Mississippi.d226.Holiday-Rental-Destinations)[Mississippi Flights](https://expedia.co.uk/Destinations-In-Mississippi.d226.Flight-Destinations)[Mississippi Car Hire](https://expedia.co.uk/Destinations-In-Mississippi.d226.Car-Hire-Destinations)[Mississippi Holidays](https://expedia.co.uk/Mississippi.d226.Holidays-City-Breaks) ![Jackson, Mississippi, USA Skyline.](https://images.trvl-media.com/place/226/a1e6017b-93a0-48e6-849c-9e1235278e86.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/226/a1e6017b-93a0-48e6-849c-9e1235278e86.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Mississippi Accommodation: Most Popular Cities to Stay ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/419000/419453-Mississippi-Gulf-Coast.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Hattiesburg [](https://expedia.co.uk/Hattiesburg-Hotels-Spa-Hotels.0-0-d6058670-tSpaHotels.Travel-Guide-Filter-Hotels) ![Natchez featuring signage](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/146000/146997-Natchez.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Natchez [](https://expedia.co.uk/Natchez-Hotels-Spa-Hotels.0-0-d7671-tSpaHotels.Travel-Guide-Filter-Hotels) ## Check availability on Mississippi Spa Hotels Tonight [3 Feb - 4 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2026-02-03&endDate=2026-02-04&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [4 Feb - 5 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2026-02-04&endDate=2026-02-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [6 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2026-02-06&endDate=2026-02-08&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2026-02-13&endDate=2026-02-15&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mississippi hotels with a spa ![Reception](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/7c3027e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/b29acf51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/54467fc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/e79685f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Jackson [](https://www.expedia.co.uk/Jackson-Hotels-The-Westin-Jackson.h18411003.Hotel-Information) Downtown Jackson 9.2/10 Wonderful (865 reviews) "Slept great and enjoyed the bar and restaurant! Staff was extremely friendly and we were so please we could bring our dog with us. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Molly £124 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Jackson-Hotels-The-Westin-Jackson.h18411003.Hotel-Information) ![Couples treatment room(s), body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/e7ff60a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 7:30 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/591c81d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 bars/lounges, sports bar](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/fb7837f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/364a95a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beau Rivage [](https://www.expedia.co.uk/Biloxi-Hotels-Beau-Rivage.h199634.Hotel-Information) Downtown Biloxi 9.2/10 Wonderful (1,424 reviews) "Beautiful stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) zoltan £123 includes taxes & fees 5 Feb - 6 Feb [](https://www.expedia.co.uk/Biloxi-Hotels-Beau-Rivage.h199634.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/50d63d1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/eda0cd99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/27a1c79d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/46ee23a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Tupelo [](https://www.expedia.co.uk/Tupelo-Hotels-Tru-By-Hilton-Tupelo.h72278514.Hotel-Information) Tupelo 9.2/10 Wonderful (673 reviews) "Clean, easy check-in, good area with dining options close." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Suzette £78 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Tupelo-Hotels-Tru-By-Hilton-Tupelo.h72278514.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/abb81802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/6266d921.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/4e43e467.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/5dd6a265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Memphis/Southaven, MS [](https://www.expedia.co.uk/Memphis-Hotels-Hilton-Garden-Inn-MemphisSouthaven.h1598927.Hotel-Information) Southaven 8.6/10 Excellent (1,002 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angel £84 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Memphis-Hotels-Hilton-Garden-Inn-MemphisSouthaven.h1598927.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/969f44da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/4d32e8cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![One king dlx sofa bed non smoking | Down duvets, in-room safe, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/053c94ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/bca898d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Jackson/Flowood (Airport Area) MS [](https://www.expedia.co.uk/Jackson-Hotels-Hampton-Inn-JacksonFlowood.h2958793.Hotel-Information) Flowood 9.0/10 Wonderful (1,003 reviews) "I had a nice stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer £87 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Jackson-Hotels-Hampton-Inn-JacksonFlowood.h2958793.Hotel-Information) ![3 restaurants, breakfast, lunch, dinner served; seafood ](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/86740aab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, white sand](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/b646a50a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/3d56d639.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/b9e2395e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Silver Slipper Casino & Hotel - Adults Only [](https://www.expedia.co.uk/Biloxi-Hotels-Silver-Slipper-Casino-Hotel.h12685296.Hotel-Information) Bay St Louis 8.6/10 Excellent (1,002 reviews) "Very clean room, nice view from our room, excellent buffet." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Terrie Jo £57 includes taxes & fees 10 Feb - 11 Feb [](https://www.expedia.co.uk/Biloxi-Hotels-Silver-Slipper-Casino-Hotel.h12685296.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/86aa793b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/a48924fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/783375ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/06827afb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites by Hilton Jackson/Pearl, MS [](https://www.expedia.co.uk/Jackson-Hotels-Home2-Suites-By-Hilton-JacksonPearl.h45764716.Hotel-Information) Pearl 8.8/10 Excellent (913 reviews) "Yes, very clean and warm needful experience at this hotel. Will definitely stay here again! Close to many great restaurants too! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) DIANE £86 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Jackson-Hotels-Home2-Suites-By-Hilton-JacksonPearl.h45764716.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/09dec653.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/d13387bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/5d17839d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/82cc7f29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel DeSoto [](https://www.expedia.co.uk/Olive-Branch-Hotels-Hotel-DeSoto.h57787752.Hotel-Information) Olive Branch 9.0/10 Wonderful (1,127 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim [](https://www.expedia.co.uk/Olive-Branch-Hotels-Hotel-DeSoto.h57787752.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/46d9ec38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/ab684708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/8c5783f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/ef67498d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Oxford [](https://www.expedia.co.uk/Oxford-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Oxford.h39577074.Hotel-Information) Oxford 9.2/10 Wonderful (944 reviews) "The breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen £127 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/Oxford-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Oxford.h39577074.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/4a82aa7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/bff72e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/9718006a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Accessible (Accessible Tub) | Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/e7b8601d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express and Suites Winona North by IHG [](https://www.expedia.co.uk/Grenada-Hotels-Holiday-Inn-Express-And-Suites-Winona-North.h3557655.Hotel-Information) Winona 8.2/10 Very good (687 reviews) "The room was clean and the staff was very friendly and helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Raymond £103 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Grenada-Hotels-Holiday-Inn-Express-And-Suites-Winona-North.h3557655.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-17&endDate=2026-02-18®ionId=226&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-Spa-Hotels.0-0-d226-tSpaHotels.Hotel-Filter-Destinations)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-Spa-Hotels.0-0-d226-tSpaHotels.Hotel-Filter-Destinations) ## Top Mississippi Hotel Reviews ![Margaritaville Resort Biloxi](https://images.trvl-media.com/lodging/16000000/15610000/15602500/15602500/b9c2b2c6_y.jpg) ### Margaritaville Resort Biloxi 10/10 Excellent "Everything just for the people who stay their the rides should be included especially during the time the pools aren’t open !!!!" [](https://expedia.co.uk/Biloxi-Hotels-Margaritaville-Resort-Biloxi.h15602500.Hotel-Information) ![IP Casino Resort Spa - Biloxi](https://images.trvl-media.com/lodging/1000000/90000/85100/85080/e0a1ead8_y.jpg) ### IP Casino Resort Spa - Biloxi 10/10 Excellent "Very clean and nice" [](https://expedia.co.uk/Biloxi-Hotels-IP-Casino-Resort-Spa-Biloxi.h85080.Hotel-Information) ![Hilton Jackson](https://images.trvl-media.com/lodging/1000000/10000/1900/1845/c581281e_y.jpg) ### Hilton Jackson 10/10 Excellent "Great and simple " [](https://expedia.co.uk/Jackson-Hotels-Hilton-Jackson.h1845.Hotel-Information) ![Golden Nugget Biloxi](https://images.trvl-media.com/lodging/1000000/30000/22300/22267/0e82f306_y.jpg) ### Golden Nugget Biloxi 10/10 Excellent "The hotel was beautiful and had so many options for restaurants and shopping. Didn’t really see much of the staff as far as its cleanest concern but the room was spotless. It was beautiful. We had a balcony overlooking the pool that was super nice. We like the layout in the room and all the amenities, a room head to offer. we only ate it one of the hotels restaurants, and it was a brunch for Saturday morning. It was absolutely delicious. I don’t thing had to say is that the casino itself the machines did not pay anything. As I walked around the floors couldn’t see anyone winning anything no bells or whistles going off it just sucked up your money so I may stay there again, but I don’t think I’ll ever play there again" [](https://expedia.co.uk/Biloxi-Hotels-Golden-Nugget-Biloxi.h22267.Hotel-Information) ![Motel 6 Biloxi, MS - Beach](https://images.trvl-media.com/lodging/1000000/1000000/996200/996160/c051e826_y.jpg) ### Motel 6 Biloxi, MS - Beach 10/10 Excellent "Loved it from the front desk clerk to the housekeepers everything was good 5STARS from me." [](https://expedia.co.uk/Biloxi-Hotels-Motel-6-Biloxi.h996160.Hotel-Information) ![Palace Casino Resort](https://images.trvl-media.com/lodging/2000000/1660000/1652900/1652862/6049152a_y.jpg) ### Palace Casino Resort 10/10 Excellent "Room was spotless, staff was courteous and helpful. " [](https://expedia.co.uk/Biloxi-Hotels-Palace-Casino-Resort.h1652862.Hotel-Information) ![White House Hotel](https://images.trvl-media.com/lodging/9000000/8760000/8751700/8751651/w1998h2492x0y8-c9ab34b7_y.jpg) ### White House Hotel 10/10 Excellent "Spotless room. Super clean hotel. Incredible ambiance throughout the property. Courteous and helpful staff. Very grateful for this option while on the MS coast. " [](https://expedia.co.uk/Biloxi-Hotels-White-House-Hotel.h8751651.Hotel-Information) ![The Hotel Legends](https://images.trvl-media.com/lodging/45000000/44560000/44550300/44550296/4393bc4f_y.jpg) ### The Hotel Legends 10/10 Excellent "Rooms were spotless. Staff was good. Rooms were very clean." [](https://expedia.co.uk/Biloxi-Hotels-The-Hotel-Legends.h44550296.Hotel-Information) ![Hard Rock Hotel & Casino Biloxi](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731566/7e1bb110_y.jpg) ### Hard Rock Hotel & Casino Biloxi 10/10 Excellent "The property was beautiful and in a very central location we fell in love with our room the second we walked in!" [](https://expedia.co.uk/Biloxi-Hotels-Hard-Rock-Hotel-Casino-Biloxi.h1731566.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Other - More ways to book - [Bay Springs Hotels ](https://www.expedia.co.uk/Bay-Springs-Hotels.d6354166.Travel-Guide-Hotels) - [Hotels near Bienville National Forest ](https://www.expedia.co.uk/Bienville-National-Forest-Hotels.0-l553248635921053914-0.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Brandon ](https://www.expedia.co.uk/Brandon-Hotels-Gay-Friendly-Hotel.0-0-d6754-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Brandon Hotels ](https://www.expedia.co.uk/Brandon-Hotels.d6754.Travel-Guide-Hotels) - [Carthage Hotels ](https://www.expedia.co.uk/Carthage-Hotels.d7283.Travel-Guide-Hotels) - [Farmstay in Central Mississippi ](https://www.expedia.co.uk/Central-Mississippi-Agritourism.d6058674-aaAgritourism.Travel-Guide-Accommodation) - [Cheap Hotels in Central Mississippi ](https://www.expedia.co.uk/Central-Mississippi-Hotels-Budget-Hotels.0-0-d6058674-tBudgetHotels.Travel-Guide-Filter-Hotels) - 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