Title: Mississippi Spa Hotels, United States of America: Mississippi Hotel Guide | Expedia.co.uk [Mississippi Travel Guide](https://expedia.co.uk/Mississippi.dx226)[Mississippi Hotels](https://expedia.co.uk/Destinations-In-Mississippi.d226.Hotel-Destinations)[Holiday Rentals in Mississippi](https://expedia.co.uk/Destinations-In-Mississippi.d226.Holiday-Rental-Destinations)[Mississippi Flights](https://expedia.co.uk/Destinations-In-Mississippi.d226.Flight-Destinations)[Mississippi Car Hire](https://expedia.co.uk/Destinations-In-Mississippi.d226.Car-Hire-Destinations)[Mississippi Holidays](https://expedia.co.uk/Mississippi.d226.Holidays-City-Breaks) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/483000/483399-biloxi.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Spa Hotels in Mississippi ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Mississippi Accommodation: Most Popular Cities to Stay ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/419000/419453-Mississippi-Gulf-Coast.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Hattiesburg [](https://expedia.co.uk/Hattiesburg-Hotels-Spa-Hotels.0-0-d6058670-tSpaHotels.Travel-Guide-Filter-Hotels) ![Natchez featuring signage](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/146000/146997-Natchez.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Natchez [](https://expedia.co.uk/Natchez-Hotels-Spa-Hotels.0-0-d7671-tSpaHotels.Travel-Guide-Filter-Hotels) ## Check availability on Mississippi Spa Hotels Tonight [20 Sept - 21 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2025-09-20&endDate=2025-09-21&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [21 Sept - 22 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2025-09-21&endDate=2025-09-22&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2025-09-26&endDate=2025-09-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mississippi Spa Hotels ## Our top choices for Mississippi hotels with a spa ![Reception](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/7c3027e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/6cab3dab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/f28c478e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/89dcbeb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Jackson Downtown Jackson 9.2/10 Wonderful (795) "Its a very nice upscale hotel. " £163 includes taxes & fees 26 Sept - 27 Sept [](https://www.expedia.co.uk/Jackson-Hotels-The-Westin-Jackson.h18411003.Hotel-Information) ![Couples treatment room(s), body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/e7ff60a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/364a95a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 7:30 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/b66654c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 bars/lounges, sports bar](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/fb7837f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beau Rivage Downtown Biloxi 9.2/10 Wonderful (1414) "Fantastic place to stay " £125 includes taxes & fees 1 Oct - 2 Oct [](https://www.expedia.co.uk/Biloxi-Hotels-Beau-Rivage.h199634.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/8419c524.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/b0ef1168.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub (Hearing) | Blackout curtains, bed sheets](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/819e1941.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/ceef32e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Tupelo Tupelo 9.2/10 Wonderful (574) "Great place to stay." £78 includes taxes & fees 5 Oct - 6 Oct [](https://www.expedia.co.uk/Tupelo-Hotels-Tru-By-Hilton-Tupelo.h72278514.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/abb81802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/151c8939.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/6266d921.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/7cef7a36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Memphis/Southaven, MS Southaven 8.6/10 Excellent (1002) "Great hotel!" £84 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/Memphis-Hotels-Hilton-Garden-Inn-MemphisSouthaven.h1598927.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/969f44da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/bca898d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/f3830c25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/f9830ccb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Jackson/Flowood (Airport Area) MS Flowood 9.0/10 Wonderful (1000) "solid, clean place, great value" £94 includes taxes & fees 6 Oct - 7 Oct [](https://www.expedia.co.uk/Jackson-Hotels-Hampton-Inn-JacksonFlowood.h2958793.Hotel-Information) ![3 restaurants, breakfast, lunch, dinner served; seafood ](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/86740aab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/0d77dc8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, Smoking | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/3923ebb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/5c21d6dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Silver Slipper Casino & Hotel - Adults Only Bay St Louis 8.6/10 Excellent (1001) "Great place" [](https://www.expedia.co.uk/Biloxi-Hotels-Silver-Slipper-Casino-Hotel.h12685296.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/783375ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast ](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/9485a76d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/d71c754f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/86aa793b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites by Hilton Jackson/Pearl, MS Pearl 8.8/10 Excellent (812) "We loved our stay at this property, our room was comfortable and quite large, the staff was so kind and the breakfast options were great! We’ll totally be staying here again!" £90 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/Jackson-Hotels-Home2-Suites-By-Hilton-JacksonPearl.h45764716.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/d13387bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/3a39ccbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/5d17839d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/74bb001a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel DeSoto Olive Branch 9.0/10 Wonderful (1158) "Very nice property reasonable rates was great for overnight. Stay as we were traveling back to Georgia would stay again I recommend." [](https://www.expedia.co.uk/Olive-Branch-Hotels-Hotel-DeSoto.h57787752.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/46d9ec38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/97317942.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/5c34c1ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/d46b15da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Oxford Oxford 9.2/10 Wonderful (849) "Excellent customer service at the front desk! Great stay!" £83 includes taxes & fees 29 Sept - 30 Sept [](https://www.expedia.co.uk/Oxford-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Oxford.h39577074.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/bff72e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds | Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/435a39d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/9718006a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/4ca21e3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express and Suites Winona North by IHG Winona 8.2/10 Very good (654) "Breakfast, location, clean" £97 includes taxes & fees 5 Oct - 6 Oct [](https://www.expedia.co.uk/Grenada-Hotels-Holiday-Inn-Express-And-Suites-Winona-North.h3557655.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-04&endDate=2025-10-05®ionId=226&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-Spa-Hotels.0-0-d226-tSpaHotels.Hotel-Filter-Destinations)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-Spa-Hotels.0-0-d226-tSpaHotels.Hotel-Filter-Destinations) ## Top Mississippi Hotel Reviews ![Palace Casino Resort](//images.trvl-media.com/lodging/2000000/1660000/1652900/1652862/6049152a_y.jpg) ### Palace Casino Resort 10/10 Excellent "Bed and pillows are not comfortable. Pillows are too soft and flat, bed cushion gives me body ache." [](https://expedia.co.uk/Biloxi-Hotels-Palace-Casino-Resort.h1652862.Hotel-Information) ![IP Casino Resort Spa - Biloxi](//images.trvl-media.com/lodging/1000000/90000/85100/85080/e0a1ead8_y.jpg) ### IP Casino Resort Spa - Biloxi 10/10 Excellent "Very clean" [](https://expedia.co.uk/Biloxi-Hotels-IP-Casino-Resort-Spa-Biloxi.h85080.Hotel-Information) ![Margaritaville Resort Biloxi](//images.trvl-media.com/lodging/16000000/15610000/15602500/15602500/b9c2b2c6_y.jpg) ### Margaritaville Resort Biloxi 10/10 Excellent "Our group is a regular at Margaritaville for a few reasons, those being we can park on arrival and never have to leave the site. Everything is onsite, coffee shop restaurants huge gameroom, pool/slides/and lazy river and much more. The Staff is great in all areas!" [](https://expedia.co.uk/Biloxi-Hotels-Margaritaville-Resort-Biloxi.h15602500.Hotel-Information) ![Hyatt Place Biloxi](//images.trvl-media.com/lodging/17000000/16130000/16127500/16127483/482651a7_y.jpg) ### Hyatt Place Biloxi 10/10 Excellent "Great spot. Clean and comfortable. Great friendly staff. Enjoyed happy hour drinks at the beautiful pool." [](https://expedia.co.uk/Biloxi-Hotels-Hyatt-Place-Biloxi.h16127483.Hotel-Information) ![Best Western Oak Manor](//images.trvl-media.com/lodging/1000000/10000/6300/6236/2de17d27_y.jpg) ### Best Western Oak Manor 10/10 Excellent "Very clean. Staff very helpful." [](https://expedia.co.uk/Biloxi-Hotels-Best-Western-Oak-Manor.h6236.Hotel-Information) ![Motel 6 Biloxi, MS - Beach](//images.trvl-media.com/lodging/1000000/1000000/996200/996160/c051e826_y.jpg) ### Motel 6 Biloxi, MS - Beach 10/10 Excellent "Loved the ability to walk across the street to the beach." [](https://expedia.co.uk/Biloxi-Hotels-Motel-6-Biloxi.h996160.Hotel-Information) ![Best Western Seaway Inn](//images.trvl-media.com/lodging/1000000/10000/2300/2257/b670a344_y.jpg) ### Best Western Seaway Inn 10/10 Excellent "Great comfy hotel. Location is nice very convenient. Front desk clerk was very sweet! Love how it’s pet friendly. " [](https://expedia.co.uk/Biloxi-Hotels-Best-Western-Seaway-Inn.h2257.Hotel-Information) ![Hard Rock Hotel & Casino Biloxi](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731566/7e1bb110_y.jpg) ### Hard Rock Hotel & Casino Biloxi 10/10 Excellent "At-a-glance, everything was great. Then we discovered things were falling apart - the toilet handle, the inside door handle and deadbolt lock were both falling apart - screws fell out or were coming out & the curtain pull rod fell off. The mattress was meh….felt like we rolled to the middle. The “view” would’ve been better if the windows weren’t so filthy on the outside and we could’ve seen a little better. The parking was easy; the staff was friendly, helpful and receptive; the decor was awesome, the music was awesome, the elevators worked well and quickly, the signage was clear, and the rate was a fair price. We would stay here again." [](https://expedia.co.uk/Biloxi-Hotels-Hard-Rock-Hotel-Casino-Biloxi.h1731566.Hotel-Information) ![Golden Nugget Biloxi](//images.trvl-media.com/lodging/1000000/30000/22300/22267/0e82f306_y.jpg) ### Golden Nugget Biloxi 10/10 Excellent "Casino. 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