Title: Mississippi Spa Hotels, United States of America: Mississippi Hotel Guide | Expedia.co.uk [Mississippi Travel Guide](https://expedia.co.uk/Mississippi.dx226)[Mississippi Hotels](https://expedia.co.uk/Destinations-In-Mississippi.d226.Hotel-Destinations)[Holiday Rentals in Mississippi](https://expedia.co.uk/Destinations-In-Mississippi.d226.Holiday-Rental-Destinations)[Mississippi Flights](https://expedia.co.uk/Destinations-In-Mississippi.d226.Flight-Destinations)[Mississippi Car Hire](https://expedia.co.uk/Destinations-In-Mississippi.d226.Car-Hire-Destinations)[Mississippi Holidays](https://expedia.co.uk/Mississippi.d226.Holidays-City-Breaks) ![Jackson, Mississippi, USA Skyline.](https://images.trvl-media.com/place/226/a1e6017b-93a0-48e6-849c-9e1235278e86.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Spa Hotels in Mississippi - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Mississippi Accommodation: Most Popular Cities to Stay ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/419000/419453-Mississippi-Gulf-Coast.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Hattiesburg [](https://expedia.co.uk/Hattiesburg-Hotels-Spa-Hotels.0-0-d6058670-tSpaHotels.Travel-Guide-Filter-Hotels) ![Natchez featuring signage](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/146000/146997-Natchez.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Natchez [](https://expedia.co.uk/Natchez-Hotels-Spa-Hotels.0-0-d7671-tSpaHotels.Travel-Guide-Filter-Hotels) ## Check availability on Mississippi Spa Hotels Tonight [19 Dec - 20 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2025-12-19&endDate=2025-12-20&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [20 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2025-12-20&endDate=2025-12-21&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2025-12-19&endDate=2025-12-21&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=226&startDate=2025-12-26&endDate=2025-12-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mississippi hotels with a spa ![Reception](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/7c3027e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/f28c478e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/b29acf51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/19000000/18420000/18411100/18411003/54467fc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Jackson [](https://www.expedia.co.uk/Jackson-Hotels-The-Westin-Jackson.h18411003.Hotel-Information) Downtown Jackson 9.2/10 Wonderful (829) "Nice stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jonvonta £127 includes taxes & fees 23 Dec - 24 Dec [](https://www.expedia.co.uk/Jackson-Hotels-The-Westin-Jackson.h18411003.Hotel-Information) ![Couples treatment room(s), body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/e7ff60a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/364a95a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/de1dcc4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 7:30 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/200000/199700/199634/591c81d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beau Rivage [](https://www.expedia.co.uk/Biloxi-Hotels-Beau-Rivage.h199634.Hotel-Information) Downtown Biloxi 9.2/10 Wonderful (1418) "Great stay, friendly staff overall very enjoyable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jerrell £126 includes taxes & fees 22 Dec - 23 Dec [](https://www.expedia.co.uk/Biloxi-Hotels-Beau-Rivage.h199634.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/50d63d1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/eda0cd99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/46ee23a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/73000000/72280000/72278600/72278514/ceef32e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Tupelo [](https://www.expedia.co.uk/Tupelo-Hotels-Tru-By-Hilton-Tupelo.h72278514.Hotel-Information) Tupelo 9.2/10 Wonderful (643) "Very clean room and staff very attentive and friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Emily £75 includes taxes & fees 28 Dec - 29 Dec [](https://www.expedia.co.uk/Tupelo-Hotels-Tru-By-Hilton-Tupelo.h72278514.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/abb81802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/5dd6a265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/6266d921.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598927/4e43e467.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Memphis/Southaven, MS [](https://www.expedia.co.uk/Memphis-Hotels-Hilton-Garden-Inn-MemphisSouthaven.h1598927.Hotel-Information) Southaven 8.6/10 Excellent (1006) "Everything was great including the breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Damien £75 includes taxes & fees 27 Dec - 28 Dec [](https://www.expedia.co.uk/Memphis-Hotels-Hilton-Garden-Inn-MemphisSouthaven.h1598927.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/969f44da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![One king dlx sofa bed non smoking | Down duvets, in-room safe, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/053c94ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/f3830c25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2960000/2958800/2958793/bca898d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Jackson/Flowood (Airport Area) MS [](https://www.expedia.co.uk/Jackson-Hotels-Hampton-Inn-JacksonFlowood.h2958793.Hotel-Information) Flowood 9.0/10 Wonderful (1000) "Cleanliness of the room and friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marilyn £85 includes taxes & fees 1 Jan - 2 Jan 2026 [](https://www.expedia.co.uk/Jackson-Hotels-Hampton-Inn-JacksonFlowood.h2958793.Hotel-Information) ![3 restaurants, breakfast, lunch, dinner served; seafood ](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/86740aab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/3d56d639.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/b9e2395e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/13000000/12690000/12685300/12685296/dce0a99f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Silver Slipper Casino & Hotel - Adults Only [](https://www.expedia.co.uk/Biloxi-Hotels-Silver-Slipper-Casino-Hotel.h12685296.Hotel-Information) Bay St Louis 8.6/10 Excellent (1002) "Very good at catering to their guests." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Donivan £64 includes taxes & fees 23 Dec - 24 Dec [](https://www.expedia.co.uk/Biloxi-Hotels-Silver-Slipper-Casino-Hotel.h12685296.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/86aa793b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/06827afb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast ](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/9485a76d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/46000000/45770000/45764800/45764716/a48924fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites by Hilton Jackson/Pearl, MS [](https://www.expedia.co.uk/Jackson-Hotels-Home2-Suites-By-Hilton-JacksonPearl.h45764716.Hotel-Information) Pearl 8.8/10 Excellent (880) "Great location, clean rooms, pet friendly,, super fast check in. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Moonika £86 includes taxes & fees 28 Dec - 29 Dec [](https://www.expedia.co.uk/Jackson-Hotels-Home2-Suites-By-Hilton-JacksonPearl.h45764716.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/09dec653.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/3a39ccbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/5d17839d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/58000000/57790000/57787800/57787752/d13387bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel DeSoto [](https://www.expedia.co.uk/Olive-Branch-Hotels-Hotel-DeSoto.h57787752.Hotel-Information) Olive Branch 9.0/10 Wonderful (1144) "Clean rooms and the staff was great 😃" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Catherine [](https://www.expedia.co.uk/Olive-Branch-Hotels-Hotel-DeSoto.h57787752.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/46d9ec38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/ef67498d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/cef987ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/ab684708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Oxford [](https://www.expedia.co.uk/Oxford-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Oxford.h39577074.Hotel-Information) Oxford 9.2/10 Wonderful (923) "Nice place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hilary £64 includes taxes & fees 10 Jan - 11 Jan 2026 [](https://www.expedia.co.uk/Oxford-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Oxford.h39577074.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/4a82aa7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Accessible (Accessible Tub) | Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/e7b8601d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/bff72e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557655/4ca21e3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express and Suites Winona North by IHG [](https://www.expedia.co.uk/Grenada-Hotels-Holiday-Inn-Express-And-Suites-Winona-North.h3557655.Hotel-Information) Winona 8.2/10 Very good (674) "Will stay there again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) MIKE £90 includes taxes & fees 16 Jan - 17 Jan 2026 [](https://www.expedia.co.uk/Grenada-Hotels-Holiday-Inn-Express-And-Suites-Winona-North.h3557655.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-03&endDate=2026-01-04®ionId=226&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-Spa-Hotels.0-0-d226-tSpaHotels.Hotel-Filter-Destinations)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-Spa-Hotels.0-0-d226-tSpaHotels.Hotel-Filter-Destinations) ## Top Mississippi Hotel Reviews ![Best Western Seaway Inn](https://images.trvl-media.com/lodging/1000000/10000/2300/2257/b670a344_y.jpg) ### Best Western Seaway Inn 10/10 Excellent "As always, the room was clean, staff was friendly and helpful, and the breakfast is expansive and delicious! " [](https://expedia.co.uk/Biloxi-Hotels-Best-Western-Seaway-Inn.h2257.Hotel-Information) ![Palace Casino Resort](https://images.trvl-media.com/lodging/2000000/1660000/1652900/1652862/6049152a_y.jpg) ### Palace Casino Resort 10/10 Excellent "The food options were fantastic! All staff were friendly and helpful. The non smoking casino was larger than I expected and had a nice variety of gaming options. Only sight knock is an oddly firm bed. The room itself was great. " [](https://expedia.co.uk/Biloxi-Hotels-Palace-Casino-Resort.h1652862.Hotel-Information) ![Hard Rock Hotel & Casino Biloxi](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731566/7e1bb110_y.jpg) ### Hard Rock Hotel & Casino Biloxi 10/10 Excellent "Yes some what" [](https://expedia.co.uk/Biloxi-Hotels-Hard-Rock-Hotel-Casino-Biloxi.h1731566.Hotel-Information) ![The Hotel Legends](https://images.trvl-media.com/lodging/45000000/44560000/44550300/44550296/4393bc4f_y.jpg) ### The Hotel Legends 10/10 Excellent "Yes everything was great " [](https://expedia.co.uk/Biloxi-Hotels-The-Hotel-Legends.h44550296.Hotel-Information) ![Best Western Oak Manor](https://images.trvl-media.com/lodging/1000000/10000/6300/6236/2de17d27_y.jpg) ### Best Western Oak Manor 10/10 Excellent "Great stay overall. The property looked nice, the room was clean, check-in was quick and easy, amenities were well maintained, and the breakfast options were good. Would definitely stay again." [](https://expedia.co.uk/Biloxi-Hotels-Best-Western-Oak-Manor.h6236.Hotel-Information) ![Golden Nugget Biloxi](https://images.trvl-media.com/lodging/1000000/30000/22300/22267/0e82f306_y.jpg) ### Golden Nugget Biloxi 10/10 Excellent "Nice clean " [](https://expedia.co.uk/Biloxi-Hotels-Golden-Nugget-Biloxi.h22267.Hotel-Information) ![Harrah’s Gulf Coast – A Caesars Rewards Destination](https://images.trvl-media.com/lodging/1000000/70000/67100/67068/5a7f80d4_y.jpg) ### Harrah’s Gulf Coast – A Caesars Rewards Destination 10/10 Excellent "Love the stay very nice!" [](https://expedia.co.uk/Biloxi-Hotels-Harrahs-Gulf-Coast.h67068.Hotel-Information) ![Gold Strike Casino Resort](https://images.trvl-media.com/lodging/1000000/80000/77900/77838/602ab043_y.jpg) ### Gold Strike Casino Resort 10/10 Excellent "Good" [](https://expedia.co.uk/Robinsonville-Hotels-Gold-Strike-Casino-Resort.h77838.Hotel-Information) ![Motel 6 Biloxi, MS - Beach](https://images.trvl-media.com/lodging/1000000/1000000/996200/996160/c051e826_y.jpg) ### Motel 6 Biloxi, MS - Beach 10/10 Excellent "Small room but everything was clean and right across the street from the beach. 👌" [](https://expedia.co.uk/Biloxi-Hotels-Motel-6-Biloxi.h996160.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Other - More ways to book - [Bay Springs Hotels ](https://www.expedia.co.uk/Bay-Springs-Hotels.d6354166.Travel-Guide-Hotels) - [Hotels near Bienville National Forest ](https://www.expedia.co.uk/Bienville-National-Forest-Hotels.0-l553248635921053914-0.Travel-Guide-Filter-Hotels) - 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