Title: Cheap Car Hire in Santa Ysabel, USA - Expedia.co.uk [Santa Ysabel Travel Guide](https://expedia.co.uk/Santa-Ysabel.dx6264931)[Hotels in Santa Ysabel](https://expedia.co.uk/Santa-Ysabel-Hotels.d6264931.Travel-Guide-Hotels)[Flights to Santa Ysabel](https://expedia.co.uk/Cheap-Flights-To-Santa-Ysabel.d6264931.Travel-Guide-Flights)[Santa Ysabel Holidays](https://expedia.co.uk/Santa-Ysabel.d6264931.Holidays-City-Breaks) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_car.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rentals in Santa Ysabel, USA ## Search and Compare from Car Companies in Santa Ysabel ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXUK-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car hire - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car hire [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Rental Car Deals in Santa Ysabel \* Price found within the past 6 days. Click for updated prices. Mon, 9 Feb - Tue, 10 Feb ### Midsize SUV Mazda CX-50 or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 42.52 mi from Santa Ysabel city centre ![Mazda CX-50](//mediaim.expedia.com/cars/41/1a0f38a4-52e7-4a61-b150-c14146efeab8.jpg) #### £103 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=09/02/2026&date2=10/02/2026&pprfrr=null&tprfrr=103.4&cvrfrr=ZI&ctrfrr=IF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) Mon, 9 Feb - Tue, 10 Feb ### Standard SUV Chevrolet Equinox or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 42.52 mi from Santa Ysabel city centre ![Chevrolet Equinox](//mediaim.expedia.com/cars/41/65921521-2af6-4b5d-a2f3-4cb300dbe8b4.jpg) #### £110 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=09/02/2026&date2=10/02/2026&pprfrr=null&tprfrr=109.6&cvrfrr=ZI&ctrfrr=SF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) Mon, 9 Feb - Tue, 10 Feb ### Compact Kia Soul or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 42.52 mi from Santa Ysabel city centre ![Kia Soul](//mediaim.expedia.com/cars/41/e7c1fd21-3564-4890-a4ed-2f7ca59d757f.jpg) #### £115 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=09/02/2026&date2=10/02/2026&pprfrr=null&tprfrr=115.0&cvrfrr=ZI&ctrfrr=CC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22compact%22]) Mon, 9 Feb - Tue, 10 Feb ### Economy Hyundai Venue or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 42.52 mi from Santa Ysabel city centre ![Hyundai Venue](//mediaim.expedia.com/cars/41/8790b76e-3028-4f1e-b3ff-9c11cf788d03.jpg) #### £115 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=09/02/2026&date2=10/02/2026&pprfrr=null&tprfrr=114.8&cvrfrr=ZI&ctrfrr=EC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22economy%22]) Mon, 9 Feb - Tue, 10 Feb ### Standard Elite SUV Ford Explorer or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 42.52 mi from Santa Ysabel city centre ![Ford Explorer](//mediaim.expedia.com/cars/41/c92cbd55-45b2-4fbe-b152-5ae503cf5057.jpg) #### £120 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=09/02/2026&date2=10/02/2026&pprfrr=null&tprfrr=120.4&cvrfrr=ZI&ctrfrr=RF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) Mon, 9 Feb - Tue, 10 Feb ### Full Size Toyota Camry or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 42.52 mi from Santa Ysabel city centre ![Toyota Camry](//mediaim.expedia.com/cars/41/f8359e2f-1f3f-4c65-ac4c-bc85e53c01f5.jpg) #### £130 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=09/02/2026&date2=10/02/2026&pprfrr=null&tprfrr=130.2&cvrfrr=ZI&ctrfrr=FC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22fullsize%22]) Mon, 9 Feb - Tue, 10 Feb ### Mini Van Chrysler Pacifica or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 42.52 mi from Santa Ysabel city centre ![Chrysler Pacifica](//mediaim.expedia.com/cars/41/830d8f5e-8263-4790-b5a6-1a9c6632576b.jpg) #### £200 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=09/02/2026&date2=10/02/2026&pprfrr=null&tprfrr=199.85&cvrfrr=ZI&ctrfrr=MV&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22minivan%22]) Mon, 9 Feb - Tue, 10 Feb ### Premium SUV Ford Expedition Max or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 2745 Otay Pacific Dr, Ste #6, Cross Border Xpress Cbx, San Diego, California 92154, USA 42.52 mi from Santa Ysabel city centre ![Ford Expedition Max](//mediaim.expedia.com/cars/41/be025142-68fb-4aed-a655-fa7c713513a4.jpg) #### £201 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=32.548230&olon=-116.974830&date1=09/02/2026&date2=10/02/2026&pprfrr=null&tprfrr=200.8&cvrfrr=ZI&ctrfrr=PF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car hire in Santa Ysabel [View all cars](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Ysabel,%20California,%20United%20States%20of%20America&dpln=6264931&date1=14/02/2026&date2=16/02/2026&crfrr=defaultFlex&SearchType=Place) ## Frequently asked questions ### How much is a rental car per day in Santa Ysabel? ### Can I hire a car from San Diego, CA (SEE-Gillespie Field)? ### What happens if I need to cancel my Santa Ysabel car reservation? ### What types of cars can I rent in Santa Ysabel? ### Where can I go on a road trip from Santa Ysabel? > - Anaheim is around 85 miles from Santa Ysabel. Top-rated tourist spots like Disneyland® Resort should be at the top of your list here. > - Your next stop? Make it Los Angeles, which is around 110 miles away. Universal Studios Hollywood is one local draw card you shouldn't miss. > - Lotusland is approximately 190 miles from Santa Ysabel and is one of the region's most breathtaking nature spots. Pack a picnic lunch and enjoy the fresh air. ### How do I find the best car hire deals in Santa Ysabel with Expedia? ### How old do you have to be to hire a car in Santa Ysabel? ### What do you need to rent a car in Santa Ysabel? ### What is the cheapest car hire in Santa Ysabel? ### Can I hire a car for a month or longer in Santa Ysabel? ### Where can I find a Santa Ysabel hire car if I am younger than 25? ### Can I drive in Santa Ysabel with my current driver's license? > - Age restrictions: You must be at least 25 in many states to hire a car, although in some places, the minimum age is 21 years. We recommend checking local regulations, as well as the car hire website before you go to understand additional terms and conditions. > - Driving limitations: Read the fine print before you drive off the lot so you can avoid any unnecessary fees. When hiring a car in the U.S, you usually can't cross country borders into Mexico or Canada, use car ferries or go off-roading with your hire vehicle. Please read the details before you book! ### Why should I rent a Santa Ysabel car with Expedia? ## Car Hire Information | Popular car types: | [SUV](https://www.expedia.co.uk/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.co.uk/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.co.uk/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | £103 | | Our second best deal of the day: | £110 | | Our third best deal of the day: | £115 | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.co.uk/ground-transfers?rfrr=car.table.AirportTransportation) | ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app