Title: Cheap Car Hire in Isla Grande, PAN - Expedia.co.uk [Isla Grande Travel Guide](https://expedia.co.uk/Isla-Grande.dx6053183)[Hotels in Isla Grande](https://expedia.co.uk/Isla-Grande-Hotels.d6053183.Travel-Guide-Hotels)[Flights to Isla Grande](https://expedia.co.uk/Cheap-Flights-To-Isla-Grande.d6053183.Travel-Guide-Flights)[Things to do in Isla Grande](https://expedia.co.uk/Things-To-Do-In-Isla-Grande.d6053183.Travel-Guide-Activities)[Isla Grande Holidays](https://expedia.co.uk/Isla-Grande.d6053183.Holidays-City-Breaks) ![](https://images.trvl-media.com/place/6053183/3ddb22e8-2245-453b-b3ca-3467e9b3943f.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rentals in Isla Grande, PAN ## Search and Compare from Car Companies in Isla Grande ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXUK-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car hire - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car hire [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Rental Car Deals in Isla Grande \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people Isla Grande, Colón, PAN ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Isla%20Grande,%20Col%C3%B3n,%20Panama&dpln=6053183&date1=14/03/2026&date2=16/03/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people Isla Grande, Colón, PAN ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Isla%20Grande,%20Col%C3%B3n,%20Panama&dpln=6053183&date1=14/03/2026&date2=16/03/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people Isla Grande, Colón, PAN ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Isla%20Grande,%20Col%C3%B3n,%20Panama&dpln=6053183&date1=14/03/2026&date2=16/03/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people Isla Grande, Colón, PAN ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Isla%20Grande,%20Col%C3%B3n,%20Panama&dpln=6053183&date1=14/03/2026&date2=16/03/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car hire in Isla Grande [View all cars](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Isla%20Grande,%20Col%C3%B3n,%20Panama&dpln=6053183&date1=14/03/2026&date2=16/03/2026&crfrr=defaultFlex&SearchType=Place) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=CTG_SPRING_PROMO_6053183) ## Frequently asked questions ### How much is a rental car per day in Isla Grande? ### Can I hire a car from Colon (ONX-Enrique Adolfo Jimenez)? ### What happens if I need to cancel my Isla Grande car reservation? ### What types of cars can I rent in Isla Grande? ### Where can I go on a road trip from Isla Grande? > - Roughly 40 miles from Isla Grande, San Miguelito is on the to-do list of many travellers. With sights like Metromall Panama, there's no shortage of things to keep you busy here. > - Another city that's a hit with travellers is Penonome, around 95 miles away. 8 de Diciembre Park is just one of many reasons why people love this place. > - After all that time behind the wheel, treat yourself to a dose of nature at Venao Beach. It's approximately 160 miles from Isla Grande. ### How do I find the best car hire deals in Isla Grande with Expedia? ### What do you need to rent a car in Isla Grande? ### What is the cheapest car hire in Isla Grande? ### Can I hire a car for a month or longer in Isla Grande? ### Where can I find an Isla Grande hire car if I am younger than 25? ### Why should I rent an Isla Grande car with Expedia? ## Car Hire Information | Popular car types: | [SUV](https://www.expedia.co.uk/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.co.uk/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.co.uk/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | | | Our second best deal of the day: | | | Our third best deal of the day: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.co.uk/ground-transfers?rfrr=car.table.AirportTransportation) | ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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