Title: Cheap Flights to Santa Cruz - Expedia.co.uk ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £79 Cheap Flights to Santa Cruz [View £79 flight on Fri, 27 Mar 2026](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:PTY,to:DAV,departure:27/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:78.20&airProductToken=AQozCjEIw5oBEgIxNRjvxAEgg6gBKPXiiAMwx-OIAzhTQABYAWoFQkFTSUNyCFNMQUFPWjJTEgoIARABGAEqAkNNGAEiBAgBEAEoAigDKAQwAQ) [Hotels in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Hotels.d829296801610752000.Travel-Guide-Hotels)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d829296801610752000.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d829296801610752000.Holidays-City-Breaks) ## Popular airlines to Santa Cruz - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Cruz, San Félix District, Chiriquí Province, Panama,departure:14/03/2026TANYT&leg2=from:Santa Cruz, San Félix District, Chiriquí Province, Panama,to:CMH,departure:21/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Cruz, San Félix District, Chiriquí Province, Panama,departure:14/03/2026TANYT&leg2=from:Santa Cruz, San Félix District, Chiriquí Province, Panama,to:CMH,departure:21/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"UA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AV.svg) Avianca [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Cruz, San Félix District, Chiriquí Province, Panama,departure:14/03/2026TANYT&leg2=from:Santa Cruz, San Félix District, Chiriquí Province, Panama,to:CMH,departure:21/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AV"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Cruz, San Félix District, Chiriquí Province, Panama,departure:14/03/2026TANYT&leg2=from:Santa Cruz, San Félix District, Chiriquí Province, Panama,to:CMH,departure:21/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DL"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_CM.svg) Copa [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Cruz, San Félix District, Chiriquí Province, Panama,departure:14/03/2026TANYT&leg2=from:Santa Cruz, San Félix District, Chiriquí Province, Panama,to:CMH,departure:21/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"CM"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AM.svg) Aeromexico [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Cruz, San Félix District, Chiriquí Province, Panama,departure:14/03/2026TANYT&leg2=from:Santa Cruz, San Félix District, Chiriquí Province, Panama,to:CMH,departure:21/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AM"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_KL.svg) KLM [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Cruz, San Félix District, Chiriquí Province, Panama,departure:14/03/2026TANYT&leg2=from:Santa Cruz, San Félix District, Chiriquí Province, Panama,to:CMH,departure:21/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"KL"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap round-trip flights to Santa Cruz Prices were available within the past 7 days and start at £79 for one-way flights and £101 for round trip, for the period specified. Be sure to select the 'Direct flights only' box above if you are looking for a non stop route. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Fri, 24 Apr - Sat, 25 Apr PTY Panama City DAV David £101 Return found 16 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:PTY,to:DAV,departure:24/04/2026TANYT&leg2=from:DAV,to:PTY,departure:25/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:100.80&airProductToken=AQozCjEIw5oBEgIyNhjvxAEgg6gBKLGdiwMwhp6LAzhBQABYAWoFQkFTSUNyCEFMQTNUWjJTCjMKMQjDmgESAjMwGIOoASDvxAEoj6uLAzDSq4sDOEFAAFgBagVCQVNJQ3IIQUxBM1RaMlMSCggBEAEYASoCQ00YASIECAEQASgCKAMoBDAB) ![Euroairlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/q4.gif) Sun, 14 Jun - Sun, 21 Jun PAC Panama City BOC Bocas del Toro £252 Return found 16 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:PAC,to:BOC,departure:14/06/2026TANYT&leg2=from:BOC,to:PAC,departure:21/06/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:251.40&airProductToken=AQonCiUI0WgSAzEwOBiPECDBEyjU2o8DMJXbjwM4WUAAWAFyBVlGVFJUCicKJQjRaBIDMTA1GMETII8QKNqokAMwlqmQAzhZQABYAXIFWUZUUlQSCggBEAEYASoCUTQYASIECAEQASgCKAMoBDAB) ![Hahn Air Technologies](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/x1.gif) Sun, 1 Mar - Mon, 2 Mar PAC Panama City BOC Bocas del Toro £262 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:PAC,to:BOC,departure:01/03/2026TANYT&leg2=from:BOC,to:PAC,departure:02/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:261.60&airProductToken=AQogCh4I2GISAzIzMhiPECDBEyiAvIYDMLy8hgM4WUAAWAEKIQofCNhiEgQ1NzczGMETII8QKIrGhgMwxsaGAzhRQABYARIKCAEQARgBKgJIUhgBIgQIARABKAgoBDAB) ![KLM](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/KL.gif) Thu, 28 May - Fri, 5 Jun LHR London DAV David £787 Return found 17 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LHR,to:DAV,departure:28/05/2026TANYT&leg2=from:DAV,to:LHR,departure:05/06/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:786.75&airProductToken=AQqcAQozCMuYARIEMTAwMhjriQEggJMBKIyWjgMw3JaOAzhMQABYAWoFTElHSFRyCEdHTDZUSExBCjIIy5gBEgM3NTcYgJMBIO_EASjPl44DMN6cjgM4R0ABWAFqBUxJR0hUcghHR0w2VEhMQQoxCMOaARICMTMY78QBIIOoASiSo44DMNujjgM4TEABWAFqBUxJR0hUcghHR0w2VEhMQQqaAQoxCMOaARICMjIYg6gBIO_EASjI944DMIz4jgM4TEAAWAFqBUxJR0hUcghHR0w2VEhMQQoxCMGMARIDNDkxGO_EASDiMCiP-Y4DMID-jgM4R0ABWAFqBUxJR0hUcghHR0w2VEhMQQoyCMGMARIEMTE4MBjiMCDriQEor_-OAzD__44DOExAAVgBagVMSUdIVHIIR0dMNlRITEESCggBEAEYASoCS0wYASIECAEQASgCKAMoBDAB) ![Air Europa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UX.gif) Wed, 8 Apr - Wed, 15 Apr LGW London DAV David £928 Return found 6 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LGW,to:DAV,departure:08/04/2026TANYT&leg2=from:DAV,to:LGW,departure:15/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:927.20&airProductToken=AQqiAQo1CNWwARIEMTAxNBjLsQEgjBgonOSJAzCy5YkDOE5AAFgBaghTVEFOREFSRHIITkxZUkVBTkUKMwjVsAESAjU1GIwYIO_EASiR5okDMIzriQM4TkABWAFqCFNUQU5EQVJEcghOTFlSRUFORQo0CMOaARICMTMY78QBIIOoASjS8IkDMJvxiQM4TEABWAFqCFNUQU5EQVJEcghOTFlSRUFORQqiAQo0CMOaARICMTgYg6gBIO_EASjptYoDMKO2igM4TEAAWAFqCFNUQU5EQVJEcghBWVlSUFVORQozCNWwARICNTYY78QBIIwYKNW6igMwo7-KAzhBQAFYAWoIU1RBTkRBUkRyCEFZWVJQVU5FCjUI1bABEgQxMDE1GIwYIMuxASiMwIoDMJ3BigM4QUABWAFqCFNUQU5EQVJEcghBWVlSUFVORRIKCAIQARgCKgJVWBgBIgQIARABKAIoAygEMAE) ## Find the cheapest month to fly from Columbus (CMH) to Panama City (PTY) ### October is typically the cheapest month to fly From £273 - £812 per traveller. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=FTG_SPRING_PROMO_) ## Book with confidence # Expedia flights to Santa Cruz Searching for cheap flights to Santa Cruz? No travel company presents more choices than Expedia if you're looking to compare flights to Santa Cruz. With more airlines, cheaper flights, fewer stops, and more departure and arrival times travellers should ensure they search on Expedia before any holiday to Chiriquí Province. Expedia provides the cheapest flights to many destinations in Chiriquí Province and you may find even greater savings if you combine your flight with a hotel stay in Santa Cruz. Expedia is the largest online travel agency which means that Expedia have access to cheap flights. So make sure you check Expedia regularly for these bargain flights because the cheapest airline tickets sell out fast. Expedia is not only free for everyone to use but it quick and easy to use. Find the lowest flight prices guaranteed and book directly through Expedia. Browse through hundreds of cheap flight offers to find the one that suits your budget by simply inputting your travel dates. Expedia will then find the cheapest flights to Santa Cruz for that period and let you choose your preferred time and airline. If you need additional assistance, Expedia Customer Service representatives are available from 8am - 10pm Monday to Friday, and 9am - 10pm at weekends. Our capable staff will be able to help you with any questions regarding your Santa Cruz flight, or other booking questions that may arise. When you book flights with Expedia you can rest assured that you have booked the best flight at the lowest price. ## Travel information | Destination airport | Enrique Malek Intl. | | ----------------------------- | ------------------- | | Destination airport IATA code | DAV | | Destination city name | David | | Return price | £101 | ## Trending flights to Santa Cruz Prices were available within the past 7 days and start at £79 for one-way flights and £101 for round trip, for the period specified. Be sure to select the 'Direct flights only' box above if you are looking for a non stop route. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![KLM](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/KL.gif) Thu, 28 May - Fri, 5 Jun LHR London DAV David £787 Return found 17 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LHR,to:DAV,departure:28/05/2026TANYT&leg2=from:DAV,to:LHR,departure:05/06/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:786.75&airProductToken=AQqcAQozCMuYARIEMTAwMhjriQEggJMBKIyWjgMw3JaOAzhMQABYAWoFTElHSFRyCEdHTDZUSExBCjIIy5gBEgM3NTcYgJMBIO_EASjPl44DMN6cjgM4R0ABWAFqBUxJR0hUcghHR0w2VEhMQQoxCMOaARICMTMY78QBIIOoASiSo44DMNujjgM4TEABWAFqBUxJR0hUcghHR0w2VEhMQQqaAQoxCMOaARICMjIYg6gBIO_EASjI944DMIz4jgM4TEAAWAFqBUxJR0hUcghHR0w2VEhMQQoxCMGMARIDNDkxGO_EASDiMCiP-Y4DMID-jgM4R0ABWAFqBUxJR0hUcghHR0w2VEhMQQoyCMGMARIEMTE4MBjiMCDriQEor_-OAzD__44DOExAAVgBagVMSUdIVHIIR0dMNlRITEESCggBEAEYASoCS0wYASIECAEQASgCKAMoBDAB) \*Available to Expedia members.