Title: Cayos Zapatilla Holidays 2026 from £667 | Expedia.co.uk [Cayos Zapatilla Travel Guide](https://expedia.co.uk/Cayos-Zapatilla.dx6286134)[Hotels in Cayos Zapatilla](https://expedia.co.uk/Cayos-Zapatilla-Hotels.d6286134.Travel-Guide-Hotels)[Holiday Rentals in Cayos Zapatilla](https://expedia.co.uk/Cayos-Zapatilla-Holiday-Rentals.d6286134.Travel-Guide-HolidayRentals)[Flights to Cayos Zapatilla](https://expedia.co.uk/Cheap-Flights-To-Cayos-Zapatilla.d6286134.Travel-Guide-Flights)[Cayos Zapatilla Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Cayos-Zapatilla.d6286134.Car-Hire-Guide) ![](https://images.trvl-media.com/place/6286134/443bad9e-c57b-4b6d-aec8-29e5bf3e9898.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Cayos Zapatilla Holidays from £667 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected ## Top Cayos Zapatilla Flight + Hotel Deals Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista £667 per person 24 Mar - 30 Mar found 22 hours ago Return flight included Kingston (KIN) to Panama City (PTY) 9/10 Wonderful! (4,515 reviews) Everything and everyone were excellent staff and room will Highly recommend and looking forward to another stay there Reviewed on 21 Feb 2026 ![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Mahogany Suites £746 per person 5 May - 12 May found 1 day ago Return direct flight included London (LON) to Panama City (PTY) 10/10 Exceptional! (1 review) Excellent apartment on a golf resort. 5 Star. Reviewed on 28 Jan 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo Save 100% on your flight £1,209 per person 5 May - 12 May found 1 day ago Return direct flight included London (LON) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) The beds and bedding were bad. The duvet wasn’t clean, the pillows overstuffed and hard and the bed was squeaky. I’d say the beds were a 2 star hotel level. Reviewed on 19 Feb 2026 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco £1,156 per person 5 May - 12 May found 1 day ago Return direct flight included London (LON) to Panama City (PTY) 8.4/10 Very Good! (1,204 reviews) clean room, friendly staff, reasonably priced Reviewed on 20 Feb 2026 ![Casa Mallet by Wynwood House](https://images.trvl-media.com/lodging/100000000/99780000/99778900/99778891/dfb3f761_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Mallet by Wynwood House Casco Viejo £1,223 per person 5 May - 12 May found 1 day ago Return direct flight included London (LON) to Panama City (PTY) 9.8/10 Exceptional! (24 reviews) Beautiful apartment definitely recommend staying here if you are coming to Panama Reviewed on 29 Nov 2025 ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=PKG_SPRING_PROMO_6286134) ## Cayos Zapatilla Essential Information | Language | Spanish | | --------------- | --------------------------- | | Currency | Panamanian balboas | | Local Welcome | ¡Hola! | | Local Goodbye | Adiós | | Closest Airport | Tocumen Intl. Airport (PTY) | ## Top hotels in Cayos Zapatilla ![Tropical Suites Hotel](https://images.trvl-media.com/lodging/4000000/3610000/3608200/3608197/0dde6095_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Tropical Suites Hotel First Street, Bocas Town Bocas del Toro Fully refundableReserve now, pay when you stay £148 23 Mar - 24 Mar includes taxes & fees 9.2/10 Wonderful! (301 reviews) Tropical Suits has bed bugs, and the staff did nothing to resolve the problem. They repeatedly told us that they spray Lysol. What a joke! 200.00 a night for nothing. Reviewed on 12 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=23%2F03%2F2026&endDate=24%2F03%2F2026&selected=3608197&PinnedHotelID=3608197&HadPinnedHotel=true®ionId=6286134) ![Cosmic Crab Resort](https://images.trvl-media.com/lodging/19000000/18920000/18918800/18918788/699d1e4d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cosmic Crab Resort Carenero Island Trail Bocas del Toro Bocas del Toro £58 3 Mar - 4 Mar includes taxes & fees 8/10 Very Good! (130 reviews) Room was in fairly good condition. Staff did not appear to be happy! Reviewed on 18 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=03%2F03%2F2026&endDate=04%2F03%2F2026&selected=18918788&PinnedHotelID=18918788&HadPinnedHotel=true®ionId=6286134) ![Bocas Paradise Hotel](https://images.trvl-media.com/lodging/9000000/8130000/8124800/8124781/f0ebf030_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Bocas Paradise Hotel Bocas Town Bocas del Toro Fully refundableReserve now, pay when you stay £72 5 Mar - 6 Mar includes taxes & fees 8.8/10 Excellent! (127 reviews) to much noise!! Reviewed on 20 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=05%2F03%2F2026&endDate=06%2F03%2F2026&selected=8124781&PinnedHotelID=8124781&HadPinnedHotel=true®ionId=6286134) [See all 303 properties in Cayos Zapatilla](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=22%2F02%2F2026&endDate=23%2F02%2F2026®ionId=6286134) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holidays](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![Holiday in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ## Frequently asked questions ### Can I cancel my flight booking to Cayos Zapatilla due to COVID-19? ### What's the best way to find cheap flights to Cayos Zapatilla that have flexible change policies? ### What are some of the general tips for travellers to Cayos Zapatilla during the COVID-19 outbreak? > - Investigate if any travel restrictions apply to your origin and destination before committing to a flight. Also check if there are any conditions you'll need to follow on arrival, such as installing a contact tracing app. > - You must wear a face mask at the airport, including at security checkpoints. Be prepared to lower your mask for ID verification when asked by a TSA officer. > - Rather than handing a TSA employee your boarding pass, position it directly on the scanner yourself. After that, hold it up for inspection. > - TSA is now allowing passengers to take one container of hand sanitizer, up to 12 oz (350 ml) in size, in carry-on baggage. This will have to be removed from your bag at the X-ray machine for scanning. > - To minimize handling during the screening process, place items such as your phone and loose change into your carry-on instead of into the bins. > - Separate any food you have for screening. Putting it in a clear plastic bag and into a bin reduces the need for a TSA employee to handle and inspect your belongings. ### Which airlines fly to Cayos Zapatilla? ### How can I find cheap tickets to Cayos Zapatilla? ### How much is a flight to Cayos Zapatilla? ### What are the most popular airports to fly into in Cayos Zapatilla? ### When is the cheapest time to fly to Cayos Zapatilla? ### How much is a plane ticket to Cayos Zapatilla? ### Which airlines with flights to Cayos Zapatilla employ COVID-19 cleanliness policies? > - Copa Airlines - this airline is known for conducting passenger temperature checks and electrostatic cleaning. > - United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant. > - American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - [1 Star Hotels in Isla Popa ](https://www.expedia.co.uk/1Star-Isla-Popa-Hotels.s10-0-d6144989.Travel-Guide-Filter-Hotels) - 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[Payless Rental Cars in Isla Loma Partida ](https://www.expedia.co.uk/Payless-Car-Rentals-In-Isla-Loma-Partida.d3000419307-c38.Car-Rental-Guide-Suppliers) - [Rentmotors Rental Cars in Isla Bastimentos ](https://www.expedia.co.uk/RentMotors-Car-Rentals-In-Isla-Bastimentos.d6238840-c1138.Car-Rental-Guide-Suppliers) - [Right Cars Rental Cars in Water Cay ](https://www.expedia.co.uk/Right-Cars-Car-Rentals-In-Water-Cay.d3000665402-c1070.Car-Rental-Guide-Suppliers) - [Sports Car Car Hire in Bocas del Toro ](https://www.expedia.co.uk/Sportscar-Car-Rentals-In-Bocas-Del-Toro.d6023445-tSportscar.Car-Rental-Guide-Class) - [Sports Car Car Hire in Water Cay ](https://www.expedia.co.uk/Sportscar-Car-Rentals-In-Water-Cay.d3000665402-tSportscar.Car-Rental-Guide-Class) - [Thrifty Car Rental Rental Cars in Bocas del Toro ](https://www.expedia.co.uk/Thrifty-Car-Rental-Car-Rentals-In-Bocas-Del-Toro.d6023445-c45.Car-Rental-Guide-Suppliers) - [Bocas del Toro Holiday Rentals ](https://www.expedia.co.uk/Bocas-Del-Toro-Holiday-Rentals.d6023445.Travel-Guide-HolidayRentals) - [Isla Bastimentos Holiday Rentals ](https://www.expedia.co.uk/Isla-Bastimentos-Holiday-Rentals.d6238840.Travel-Guide-HolidayRentals) - [Isla Loma Partida Holiday Rentals ](https://www.expedia.co.uk/Isla-Loma-Partida-Holiday-Rentals.d3000419307.Travel-Guide-HolidayRentals) - [Isla Solarte Holiday Rentals ](https://www.expedia.co.uk/Isla-Solarte-Holiday-Rentals.d6344114.Travel-Guide-HolidayRentals) - [Things to do in Bocas del Toro ](https://www.expedia.co.uk/Things-To-Do-In-Bocas-Del-Toro.d6023445.Travel-Guide-Activities) - [Things to do in Isla Bastimentos ](https://www.expedia.co.uk/Things-To-Do-In-Isla-Bastimentos.d6238840.Travel-Guide-Activities) \* Savings based on package bookings compared to the price of the same components booked separately. 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