Calle 50

Photo by Fabiola Tile
Photo by Fabiola Tile
Photo by Fabiola Tile
Photo by Fabiola Tile
Photo by Journey Of A Nomadic Family
Photo by Journey Of A Nomadic Family
Photo by Simon Gerald
Photo by Simon Gerald
Photo by Stefan Messing
Photo by Stefan Messing

Plan a trip to see Calle 50

Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Punta Paitilla
Price was £807, price is now £683 per person
£683
per person
23 Oct - 26 Oct
found 17 hours ago
Return flight included
George Town (GCM) to Panama City (PTY)
8.4/10 Very Good! (1,045 reviews)
The pool is amazing! Bars and drinks were great. Love the rooms and how spacious it was.

Reviewed on 3 Sep 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was £1,110, price is now £845 per person
£845
per person
23 Oct - 26 Oct
found 17 hours ago
Return flight included
George Town (GCM) to Panama City (PTY)
9/10 Wonderful! (976 reviews)
The hotel is so beautiful, the people are very friendly and helpful!

Reviewed on 2 Sep 2025

Hotel La Compania, in the Unbound Collection by Hyatt

Hotel La Compania, in the Unbound Collection by Hyatt

4.5 out of 5
Casco Viejo
Price was £1,015, price is now £849 per person
£849
per person
23 Oct - 26 Oct
found 17 hours ago
Return flight included
George Town (GCM) to Panama City (PTY)
9.8/10 Exceptional! (229 reviews)
Beautiful hotel in the center of a beautiful old city

Reviewed on 31 Aug 2025

Tours & day trips

See all 53 activities
City Sightseeing Panama City Hop-On Hop-Off Bus Tour

City Sightseeing Panama City Hop-On Hop-Off Bus Tour

Activity duration is 1 day
8.0 out of 10 with 141 reviews
Free cancellation available
Price is £22 per adult
City Sightseeing Panama City Hop-On Hop-Off Bus TourOpens in new tab

Private & custom tours

See all 9 activities
Private Half-Day Panama City Tour And Panama Canal

Private Half-Day Panama City Tour And Panama Canal

Activity duration is 5 hours
10.0 out of 10 with 2 reviews
Free cancellation available
Price is £33 per adult
Private Half-Day Panama City Tour And Panama CanalOpens in new tab

Cruises & boat tours

See all 7 activities
Panama Canal Partial Transit

Panama Canal Partial Transit

Activity duration is 7 hours
8.4 out of 10 with 95 reviews
Free cancellation available
Price is £112 per adult
Panama Canal Partial TransitOpens in new tab

Popular places to visit

Soho City Center

Soho City Center

You can enjoy retail therapy at Soho City Center during your trip to Panama City. Discover the area's casinos or seek out its local tours.

Soho City Center
Multiplaza Pacific Mall

Multiplaza Pacific Mall

4.5/5(8 reviews)

During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Avenida Balboa

Avenida Balboa

3.5/5(9 reviews)

You can browse for the perfect souvenirs at Avenida Balboa during your stay in Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa
Uruguay Street

Uruguay Street

4/5(2 reviews)

During your visit to Panama City, you can search for that perfect souvenir at Uruguay Street. While in this family-friendly area, you can savour the top-notch restaurants.

Uruguay Street

Bingo 90

Why not roll the dice with a visit to Bingo 90 during your travels in Panama City? Visit the casinos and shops in this vibrant area.

Bingo 90

National Shrine of the Heart of Mary

You can learn about the history of Panama City with a trip to National Shrine of the Heart of Mary. Stroll along the seaside or visit the casinos in this vibrant area.

National Shrine of the Heart of Mary

Top Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Hotel Riu Plaza Panama
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
Waymore Hotel Spa & Casino
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
Megapolis Hotel Panamá
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina, Panama City, Panama
Principe Hotel and Suites
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
Las Americas Golden Tower Panama
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons, El Cangre, Bella Vista, Panama City, Panama
Novotel Panama City
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Decapolis Hotel Panama City
The Executive Hotel

The Executive Hotel

3.5 out of 5
Calle 52, Aquilino de La Guardia, Panama City, Panama
The Executive Hotel
AC Hotel by Marriott Panama City

AC Hotel by Marriott Panama City

3.5 out of 5
Calle Ricardo Arias 14, Campo Alegre Area Bancaria, Panama City
AC Hotel by Marriott Panama City
See all 1,484 properties in Calle 50
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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