Calle 50

A cityscape with modern skyscrapers and lush green trees.
A cityscape with modern skyscrapers, including a distinctive twisting tower.
A modern, spiraling skyscraper with a unique design, surrounded by other buildings in an urban setting.
A harbor with several boats docked in the foreground and a city skyline in the background.
A city skyline with tall buildings and palm trees.

Plan a trip to see Calle 50

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Tocumen Airport
Save 100% on your flight
Price was £1,205, price is now £688 per person
£688
per person
16 Dec - 23 Dec
found 1 day ago
Return flight included
Bridgetown (BGI) to Panama City (PTY)
8.6/10 Excellent! (1,819 reviews)
Me quedé solo una noche por una escala, pero lo recomiendo 100%

Reviewed on 6 Oct 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was £2,319, price is now £826 per person
£826
per person
17 Dec - 23 Dec
found 1 day ago
Return flight included
Bridgetown (BGI) to Panama City (PTY)
8.6/10 Excellent! (1,743 reviews)
Nice place, great pool area and great central location..

Reviewed on 6 Oct 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was £2,502, price is now £1,017 per person
£1,017
per person
17 Dec - 23 Dec
found 1 day ago
Return flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (1,006 reviews)
Great location and excellent hotel. Breakfast is fantastic with many choices and great service. Highly recommend for anyone visiting Panama City. Hotel staff are wonderful.

Reviewed on 6 Oct 2026

Tours & day trips

See all 55 activities
City Sightseeing Panama City Hop-On Hop-Off Bus Tour

City Sightseeing Panama City Hop-On Hop-Off Bus Tour

Activity duration is 1 day
8.2 out of 10 with 191 reviews
Free cancellation available
Price is £23 per adult
City Sightseeing Panama City Hop-On Hop-Off Bus TourOpens in new tab

Adventure & outdoor

See all 17 activities
All included - Day tour in San Blas Islands - No extra fees

All included - Day tour in San Blas Islands - No extra fees

Activity duration is 14 hours
2.0 out of 10 with 1 review
Free cancellation available
Price is £82 per adult
All included - Day tour in San Blas Islands - No extra feesOpens in new tab

Cruises & boat tours

See all 6 activities
Panama Canal Partial Transit

Panama Canal Partial Transit

Activity duration is 7 hours
8.4 out of 10 with 107 reviews
Free cancellation available
Price is £113 per adult
Panama Canal Partial TransitOpens in new tab

Food, drink & nightlife

See all 4 activities
E-Tickets Emotions Dinner Live Show Admission

E-Tickets Emotions Dinner Live Show Admission

Activity duration is 2 hours
9.0 out of 10 with 22 reviews
Price is £57 per adult
E-Tickets Emotions Dinner Live Show AdmissionOpens in new tab

Shows & concerts

See all 3 activities
E-Tickets Emotions Dinner Live Show Admission

E-Tickets Emotions Dinner Live Show Admission

Activity duration is 2 hours
9.0 out of 10 with 22 reviews
Price is £57 per adult
E-Tickets Emotions Dinner Live Show AdmissionOpens in new tab

Stay near popular Calle 50 attractions

Calle 50

You can find out about the history of Panama City when you stop by Calle 50. Discover the area's shops or seek out its local tours.
See properties

Top Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Hotel Riu Plaza Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Megapolis Hotel Panamá
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Ramada Plaza by Wyndham Panama Punta Pacifica
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina Panama City Panama
Principe Hotel and Suites
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
Courtyard by Marriott Panama Multiplaza Mall
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Decapolis Hotel Panama City
The Executive Hotel

The Executive Hotel

3.5 out of 5
Calle 52 Panama City Panama
The Executive Hotel
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Las Americas Golden Tower Panama
See all 1,748 properties in Calle 50
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.