Calle 50

A cityscape with modern skyscrapers and lush green trees.
A cityscape with modern skyscrapers, including a distinctive twisting tower.
A modern, spiraling skyscraper with a unique design, surrounded by other buildings in an urban setting.
A harbor with several boats docked in the foreground and a city skyline in the background.
A city skyline with tall buildings and palm trees.

Plan a trip to see Calle 50

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was £1,280, price is now £963 per person
£963
per person
25 Sept - 30 Sept
found 14 hours ago
Return direct flight included
Philipsburg (SXM) to Panama City (PTY)
8.4/10 Very good! (1,814 reviews)

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was £1,788, price is now £1,089 per person
£1,089
per person
25 Sept - 30 Sept
found 14 hours ago
Return direct flight included
Philipsburg (SXM) to Panama City (PTY)
8.4/10 Very good! (1,628 reviews)
Room was clean. Hotel smells amazing.breakfast great. All amenities are close by. Will definitely stay here again. Ubers to wherever you need to go was cheap as hotel is centrally close to attractions and old Panama.

Reviewed on 19 Aug 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Bella Vista
Price was £1,388, price is now £1,094 per person
£1,094
per person
25 Sept - 30 Sept
found 14 hours ago
Return direct flight included
Philipsburg (SXM) to Panama City (PTY)
9.6/10 Exceptional! (398 reviews)
Hotel is very clean and safe.

Reviewed on 19 Aug 2026

Tours & day trips

See all 54 activities
City Sightseeing Panama City Hop-On Hop-Off Bus Tour

City Sightseeing Panama City Hop-On Hop-Off Bus Tour

Activity duration is 2 days
8.2 out of 10 with 179 reviews
Free cancellation available
Price is £27 per adult
City Sightseeing Panama City Hop-On Hop-Off Bus TourOpens in new tab

Adventure & outdoor

See all 17 activities
All included - Day tour in San Blas Islands - No extra fees

All included - Day tour in San Blas Islands - No extra fees

Activity duration is 14 hours
2.0 out of 10 with 1 review
Free cancellation available
Price is £81 per adult
All included - Day tour in San Blas Islands - No extra feesOpens in new tab

Private & custom tours

See all 14 activities
PRIVATE NIGHT TOUR in Ciudad PANAMA + 360° POIN views

PRIVATE NIGHT TOUR in Ciudad PANAMA + 360° POIN views

Activity duration is 4 hours
10.0 out of 10 with 39 reviews
Free cancellation available
The previous price was £64 and current price is £58 per adult
PRIVATE NIGHT TOUR in Ciudad PANAMA + 360° POIN viewsOpens in new tab

Cruises & boat tours

See all 6 activities
Panama Canal Partial Transit

Panama Canal Partial Transit

Activity duration is 7 hours
8.6 out of 10 with 105 reviews
Free cancellation available
Price is £111 per adult
Panama Canal Partial TransitOpens in new tab

Food, drink & nightlife

See all 4 activities
E-Tickets Emotions Dinner Live Show Admission

E-Tickets Emotions Dinner Live Show Admission

Activity duration is 2 hours
9.0 out of 10 with 22 reviews
Price is £55 per adult
E-Tickets Emotions Dinner Live Show AdmissionOpens in new tab

Stay near popular Calle 50 attractions

Calle 50

You can find out about the history of Panama City when you stop by Calle 50. Discover the area's casinos or seek out its local tours.
See properties

Top Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Hotel Riu Plaza Panama
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Megapolis Hotel Panamá
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
Courtyard by Marriott Panama Multiplaza Mall
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina Panama City Panama
Principe Hotel and Suites
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Waymore Hotel Spa & Casino
Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama

3.5 out of 5
Calle 53 Marbella y Avenida 5a B sur Panama City Panama
Hospedium Princess Hotel Panama
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Las Americas Golden Tower Panama
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Decapolis Hotel Panama City
The Executive Hotel

The Executive Hotel

3.5 out of 5
Calle 52 Panama City Panama
The Executive Hotel
See all 1,768 properties in Calle 50
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.