Title: The 10 Best 5 Star Hotels in São Tomé Island - 2025 Updated Prices | Expedia.co.uk [São Tomé Island Travel Guide](https://expedia.co.uk/Sao-Tome-Island.dx3486)[Hotels in São Tomé Island](https://expedia.co.uk/Sao-Tome-Island-Hotels.d3486.Travel-Guide-Hotels)[Holiday Rentals in São Tomé Island](https://expedia.co.uk/Sao-Tome-Island-Holiday-Rentals.d3486.Travel-Guide-HolidayRentals)[Flights to São Tomé Island](https://expedia.co.uk/Cheap-Flights-To-Sao-Tome-Island.d3486.Travel-Guide-Flights)[Things to do in São Tomé Island](https://expedia.co.uk/Things-To-Do-In-Sao-Tome-Island.d3486.Travel-Guide-Activities)[São Tomé Island Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Sao-Tome-Island.d3486.Car-Hire-Guide)[São Tomé Island Holidays](https://expedia.co.uk/Sao-Tome-Island.d3486.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/1/6bd54b7b17061af058501372a92d6b86.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in São Tomé Island, São Tomé and Príncipe ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on São Tomé Island 5 Star Hotels Tonight [21 Sept - 22 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=3486&startDate=2025-09-21&endDate=2025-09-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [22 Sept - 23 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=3486&startDate=2025-09-22&endDate=2025-09-23&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=3486&startDate=2025-09-26&endDate=2025-09-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=3486&startDate=2025-10-03&endDate=2025-10-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top São Tomé Island 5 Star Hotels ## Our top choices for São Tomé Island 5-star hotels ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/ea6ea619.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, minibar, in-room safe, free WiFi](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/bab15252.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside views, open daily](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/b432c63a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/495e994b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pestana São Tomé Vila Maria 8.0/10 Very good (73) "Good choice in São Tomé city." £197 includes taxes & fees 22 Sept - 23 Sept [](https://www.expedia.co.uk/Sao-Tome-Island-Hotels-Pestana-Sao-Tome.h2150447.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Sao-Tome-Island-Hotels.s50-0-d3486.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Sao-Tome-Island-Hotels.s50-0-d3486.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in São Tomé Island. ![Omali São Tomé – Principe Collection](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/d1688203_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Omali São Tomé – Principe Collection Praia Lagarto, São Tomé £175 25 Sept - 26 Sept includes taxes & fees 9.2/10 Wonderful! (59 reviews) [](https://expedia.co.uk/Sao-Tome-Island-Hotels-Omali-Sao-Tome.h6762264.Hotel-Information) Still don't see what you're looking for? [See all properties in São Tomé Island.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=22%2F09%2F2025&endDate=23%2F09%2F2025®ionId=3486&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=22%2F09%2F2025&endDate=23%2F09%2F2025®ionId=3486&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=22%2F09%2F2025&endDate=23%2F09%2F2025®ionId=3486&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=22%2F09%2F2025&endDate=23%2F09%2F2025®ionId=3486&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=22%2F09%2F2025&endDate=23%2F09%2F2025®ionId=3486&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=22%2F09%2F2025&endDate=23%2F09%2F2025®ionId=3486&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about São Tomé Island Venture to sights like São Nicolau Waterfall and Pico São Tomé as you discover São Tomé Island. [See all hotels in São Tomé Island](https://www.expedia.co.uk/Hotel-Search?startDate=2025-10-05&endDate=2025-10-06&adults=2®ionId=3486) ![](https://mediaim.expedia.com/destination/1/6bd54b7b17061af058501372a92d6b86.jpg?impolicy=fcrop&w=899&h=520&p=1&q=high) ## Top São Tomé Island Hotel Reviews ![Pestana São Tomé](//images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/ea6ea619_y.jpg) ### Pestana São Tomé 8/10 Good "Good choice in São Tomé city." [](https://expedia.co.uk/Sao-Tome-Island-Hotels-Pestana-Sao-Tome.h2150447.Hotel-Information) ## Find out more about São Tomé Island ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in São Tomé Island? > You'll find a range of pricing options for 5-star hotels in São Tomé Island on Expedia. How much you'll pay will depend on your travel dates, length of your trip and other factors. Compare available properties for your chosen dates and use our pricing and other filters to lock in the ideal luxury stay. > > > > - Search for the lowest price per night from £175 ### What makes a hotel 5 stars in São Tomé Island? > In São Tomé Island, a hotel is required to offer a certain number of upscale amenities to be designated 5 stars. These may include saunas and spas, on-site gyms, gourmet restaurants, premium bedding, luxury toiletries and more. What also sets 5-star hotels apart is their guest-focused standard of service. You'll enjoy things like nightly turn-down services, in-room massages and concierge services. Some may also offer additional touches like welcome gifts. ### Are there any 5-star all-inclusive resorts in São Tomé Island? > Use our handy filters to find a high-end getaway in São Tomé Island where everything you need is included. Next, narrow your results for hotels that have a rating of 5 stars and are deemed "All inclusive." The most important thing on the agenda at these stays? Pure enjoyment and indulgence. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - [Sports Hotels in São Tomé and Príncipe](https://www.expedia.co.uk/Destinations-In-Sao-Tome-And-Principe-Adventure-Sport-Hotel.0-0-d156-tAdventureSportHotel.Hotel-Filter-Destinations) - [All-Inclusive Hotels in São Tomé and Príncipe](https://www.expedia.co.uk/Destinations-In-Sao-Tome-And-Principe-All-Inclusive-Hotel.0-0-d156-tAllInclusiveHotel.Hotel-Filter-Destinations) - [Beach Resorts & in São Tomé and Príncipe](https://www.expedia.co.uk/Destinations-In-Sao-Tome-And-Principe-Beach-Hotels.0-0-d156-tBeachHotels.Hotel-Filter-Destinations) - [Boutique Hotels in São Tomé and Príncipe](https://www.expedia.co.uk/Destinations-In-Sao-Tome-And-Principe-Boutique-Hotel.0-0-d156-tBoutiqueHotel.Hotel-Filter-Destinations) - [Business Hotels in São Tomé and Príncipe](https://www.expedia.co.uk/Destinations-In-Sao-Tome-And-Principe-Business-Hotel.0-0-d156-tBusinessHotel.Hotel-Filter-Destinations) - 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