Title: The 10 Best 5 Star Hotels in São Tomé Island - 2026 Updated Prices | Expedia.co.uk [São Tomé Island Travel Guide](https://expedia.co.uk/Sao-Tome-Island.dx3486)[Hotels in São Tomé Island](https://expedia.co.uk/Sao-Tome-Island-Hotels.d3486.Travel-Guide-Hotels)[Holiday Rentals in São Tomé Island](https://expedia.co.uk/Sao-Tome-Island-Holiday-Rentals.d3486.Travel-Guide-HolidayRentals)[Flights to São Tomé Island](https://expedia.co.uk/Cheap-Flights-To-Sao-Tome-Island.d3486.Travel-Guide-Flights)[Things to do in São Tomé Island](https://expedia.co.uk/Things-To-Do-In-Sao-Tome-Island.d3486.Travel-Guide-Activities)[São Tomé Island Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Sao-Tome-Island.d3486.Car-Hire-Guide)[São Tomé Island Holidays](https://expedia.co.uk/Sao-Tome-Island.d3486.Holidays-City-Breaks) ![Nice place, good food... Quite difficult to reach, you need a good car...](https://images.trvl-media.com/place/553248621565299214/edf5448a-52b1-44ed-852d-bc5327dd1c36.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Fabrice Récalt # Compare and book 5 Star hotels in São Tomé Island, São Tomé and Príncipe - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on São Tomé Island 5 Star Hotels Tonight [22 Dec - 23 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=3486&startDate=2025-12-22&endDate=2025-12-23&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [23 Dec - 24 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=3486&startDate=2025-12-23&endDate=2025-12-24&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=3486&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [2 Jan - 4 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=3486&startDate=2026-01-02&endDate=2026-01-04&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for São Tomé Island 5-star hotels ![Pool](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/4b0f9c44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, sun-loungers, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/bb670e49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside views, open daily](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/b432c63a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, in-room safe, free WiFi](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/bab15252.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pestana São Tomé [](https://www.expedia.co.uk/Sao-Tome-Island-Hotels-Pestana-Sao-Tome.h2150447.Hotel-Information) Vila Maria 8.0/10 Very good (78) "Wonderful stay, great staff, easy, relaxing delightful." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) alexander £167 includes taxes & fees 23 Dec - 24 Dec [](https://www.expedia.co.uk/Sao-Tome-Island-Hotels-Pestana-Sao-Tome.h2150447.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Sao-Tome-Island-Hotels.s50-0-d3486.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Sao-Tome-Island-Hotels.s50-0-d3486.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in São Tomé Island. ![Omali São Tomé – Principe Collection](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/d1688203_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Omali São Tomé – Principe Collection Praia Lagarto São Tomé £172 5 Jan - 6 Jan 2026 includes taxes & fees 9.4/10 Exceptional! (62 reviews) [](https://expedia.co.uk/Sao-Tome-Island-Hotels-Omali-Sao-Tome.h6762264.Hotel-Information) Still don't see what you're looking for? [See all properties in São Tomé Island.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F12%2F2025&endDate=24%2F12%2F2025®ionId=3486&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F12%2F2025&endDate=24%2F12%2F2025®ionId=3486&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F12%2F2025&endDate=24%2F12%2F2025®ionId=3486&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F12%2F2025&endDate=24%2F12%2F2025®ionId=3486&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F12%2F2025&endDate=24%2F12%2F2025®ionId=3486&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=23%2F12%2F2025&endDate=24%2F12%2F2025®ionId=3486&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about São Tomé Island Venture to sights like Pico São Tomé and Estadio Nacional 12 de Julho as you discover São Tomé Island. [See all hotels in São Tomé Island](https://www.expedia.co.uk/Hotel-Search?startDate=2026-01-05&endDate=2026-01-06&adults=2®ionId=3486) ![Nice place, good food... Quite difficult to reach, you need a good car...](https://images.trvl-media.com/place/553248621565299214/edf5448a-52b1-44ed-852d-bc5327dd1c36.jpg?impolicy=fcrop&w=225&h=400&p=1&q=high) Photo by Fabrice Récalt ## Top São Tomé Island Hotel Reviews ![Pestana São Tomé](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/ea6ea619_y.jpg) ### Pestana São Tomé 10/10 Excellent "Wonderful stay, great staff, easy, relaxing delightful." [](https://expedia.co.uk/Sao-Tome-Island-Hotels-Pestana-Sao-Tome.h2150447.Hotel-Information) ## Find out more about São Tomé Island ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in São Tomé Island? > - Search for the lowest price per night from £172 ### What makes a hotel 5 stars in São Tomé Island? ### Are there any 5-star all-inclusive resorts in São Tomé Island? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - [Sports Hotels in São Tomé and Príncipe ](https://www.expedia.co.uk/Destinations-In-Sao-Tome-And-Principe-Adventure-Sport-Hotel.0-0-d156-tAdventureSportHotel.Hotel-Filter-Destinations) - [All-Inclusive Hotels in São Tomé and Príncipe ](https://www.expedia.co.uk/Destinations-In-Sao-Tome-And-Principe-All-Inclusive-Hotel.0-0-d156-tAllInclusiveHotel.Hotel-Filter-Destinations) - [Beach Resorts & in São Tomé and Príncipe ](https://www.expedia.co.uk/Destinations-In-Sao-Tome-And-Principe-Beach-Hotels.0-0-d156-tBeachHotels.Hotel-Filter-Destinations) - 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