Title: The 10 Best 5 Star Hotels in San Domino - 2026 Updated Prices | Expedia.co.uk

[San Domino Travel Guide](https://expedia.co.uk/San-Domino.dx6125738)[Hotels in San Domino](https://expedia.co.uk/San-Domino-Hotels.d6125738.Travel-Guide-Hotels)[Holiday Rentals in San Domino](https://expedia.co.uk/San-Domino-Holiday-Rentals.d6125738.Travel-Guide-HolidayRentals)[Flights to San Domino](https://expedia.co.uk/Cheap-Flights-To-San-Domino.d6125738.Travel-Guide-Flights)[San Domino Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-San-Domino.d6125738.Car-Hire-Guide)[San Domino Holidays](https://expedia.co.uk/San-Domino.d6125738.Holidays-City-Breaks)

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# Compare and book 5 Star hotels in San Domino, Italy

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## Check availability on San Domino 5 Star Hotels

Tonight

[15 Dec - 16 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6125738&startDate=2025-12-15&endDate=2025-12-16&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[16 Dec - 17 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6125738&startDate=2025-12-16&endDate=2025-12-17&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6125738&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6125738&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Top San Domino Hotel Reviews

## Find out more about San Domino

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