Title: The 10 Best 5 Star Hotels in San Domino - 2025 Updated Prices | Expedia.co.uk [San Domino Travel Guide](https://expedia.co.uk/San-Domino.dx6125738)[Hotels in San Domino](https://expedia.co.uk/San-Domino-Hotels.d6125738.Travel-Guide-Hotels)[Holiday Rentals in San Domino](https://expedia.co.uk/San-Domino-Holiday-Rentals.d6125738.Travel-Guide-HolidayRentals)[Flights to San Domino](https://expedia.co.uk/Cheap-Flights-To-San-Domino.d6125738.Travel-Guide-Flights)[San Domino Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-San-Domino.d6125738.Car-Hire-Guide)[San Domino Holidays](https://expedia.co.uk/San-Domino.d6125738.Holidays-City-Breaks) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in San Domino, Italy ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on San Domino 5 Star Hotels Tonight [31 Oct - 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