Title: The 10 Best 5 Star Hotels in Cayos Zapatilla - 2025 Updated Prices | Expedia.co.uk [Cayos Zapatilla Travel Guide](https://expedia.co.uk/Cayos-Zapatilla.dx6286134)[Hotels in Cayos Zapatilla](https://expedia.co.uk/Cayos-Zapatilla-Hotels.d6286134.Travel-Guide-Hotels)[Holiday Rentals in Cayos Zapatilla](https://expedia.co.uk/Cayos-Zapatilla-Holiday-Rentals.d6286134.Travel-Guide-HolidayRentals)[Flights to Cayos Zapatilla](https://expedia.co.uk/Cheap-Flights-To-Cayos-Zapatilla.d6286134.Travel-Guide-Flights)[Cayos Zapatilla Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Cayos-Zapatilla.d6286134.Car-Hire-Guide)[Cayos Zapatilla Holidays](https://expedia.co.uk/Cayos-Zapatilla.d6286134.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/2/8239fa41f2c289b46d39bd2f79231511.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Isa # Compare and book 5 Star hotels in Cayos Zapatilla, Bocas del Toro Province ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Cayos Zapatilla 5 Star Hotels Tonight [14 Oct - 15 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6286134&startDate=2025-10-14&endDate=2025-10-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [15 Oct - 16 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6286134&startDate=2025-10-15&endDate=2025-10-16&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6286134&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6286134&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Cayos Zapatilla 5 Star Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Cayos-Zapatilla-Hotels.s50-0-d6286134.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Cayos-Zapatilla-Hotels.s50-0-d6286134.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Cayos Zapatilla. ![Red Frog Beach Island Resort](https://images.trvl-media.com/lodging/5000000/4030000/4027300/4027252/312e0903_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Red Frog Beach Island Resort Isla Bastimentos, Bocas Town, Bocas del Toro, Bastimentos, Bocas del Toro £240 18 Oct - 19 Oct includes taxes & fees 8.8/10 Excellent! (82 reviews) [](https://expedia.co.uk/Isla-Bastimentos-Hotels-Red-Frog-Beach-Island-Resort.h4027252.Hotel-Information) ![NAYARA Bocas del Toro](https://images.trvl-media.com/lodging/52000000/51310000/51300100/51300004/605d473e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### NAYARA Bocas del Toro Subdivision of Bocas del toro, Isla Frangipani, Bocas del Toro [Get rates](https://expedia.co.uk/Hotel-Search?startDate=28%2F10%2F2025&endDate=29%2F10%2F2025&selected=51300004&PinnedHotelID=51300004&HadPinnedHotel=true®ionId=6286134) 10/10 Exceptional! (55 reviews) [](https://expedia.co.uk/Bocas-Del-Toro-Hotels-Bocas-Bali.h51300004.Hotel-Information) ![Akwaba Lodge](https://images.trvl-media.com/lodging/97000000/96320000/96311700/96311639/8b07e3db_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Akwaba Lodge isla solarte, Bastimentos, bocas del toro £60 15 Oct - 16 Oct includes taxes & fees 9.6/10 Exceptional! (12 reviews) [](https://expedia.co.uk/Bastimentos-Hotels-Akwaba-Lodge.h96311639.Hotel-Information) Still don't see what you're looking for? [See all properties in Cayos Zapatilla.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6286134&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6286134&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6286134&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6286134&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6286134&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=15%2F10%2F2025&endDate=16%2F10%2F2025®ionId=6286134&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Cayos Zapatilla Venture to sights like Zapatilla Island as you discover the local area in Cayos Zapatilla. [See all hotels in Cayos Zapatilla](https://www.expedia.co.uk/Hotel-Search?startDate=2025-10-28&endDate=2025-10-29&adults=2®ionId=6286134) ![](https://mediaim.expedia.com/destination/2/8239fa41f2c289b46d39bd2f79231511.jpg?impolicy=fcrop&w=899&h=600&p=1&q=high) Photo by Isa ## Top Cayos Zapatilla Hotel Reviews ## Find out more about Cayos Zapatilla ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - [1 Star Hotels in Isla Popa](https://www.expedia.co.uk/1Star-Isla-Popa-Hotels.s10-0-d6144989.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Isla Colon](https://www.expedia.co.uk/3Star-Isla-Colon-Hotels.s30-0-d6347742.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Isla Colon](https://www.expedia.co.uk/5Star-Isla-Colon-Hotels.s50-0-d6347742.Travel-Guide-Filter-Hotels) - [Bastimentos Hotels](https://www.expedia.co.uk/Bastimentos-Hotels.d829296964305711104.Travel-Guide-Hotels) - [Hostels in Bocas del Toro](https://www.expedia.co.uk/Bocas-Del-Toro-Hostels.d6023445-aaHostels.Travel-Guide-Accommodation) - 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