Title: The 10 Best 4 Star Hotels in Southern Indiana - 2025 Updated Prices | Expedia.co.uk [Southern Indiana Travel Guide](https://expedia.co.uk/Southern-Indiana.dx6059635)[Hotels in Southern Indiana](https://expedia.co.uk/Southern-Indiana-Hotels.d6059635.Travel-Guide-Hotels)[Holiday Rentals in Southern Indiana](https://expedia.co.uk/Southern-Indiana-Holiday-Rentals.d6059635.Travel-Guide-HolidayRentals)[Flights to Southern Indiana](https://expedia.co.uk/Cheap-Flights-To-Southern-Indiana.d6059635.Travel-Guide-Flights)[Things to do in Southern Indiana](https://expedia.co.uk/Things-To-Do-In-Southern-Indiana.d6059635.Travel-Guide-Activities)[Southern Indiana Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southern-Indiana.d6059635.Car-Hire-Guide)[Southern Indiana Holidays](https://expedia.co.uk/Southern-Indiana.d6059635.Holidays-City-Breaks) ![Belle of Louisville featuring a ferry and a bay or harbour as well as a small group of people](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 4 Star hotels in Southern Indiana, United States of America - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Indiana 4 Star Hotels Tonight [24 Nov - 25 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059635&startDate=2025-11-24&endDate=2025-11-25&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [25 Nov - 26 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059635&startDate=2025-11-25&endDate=2025-11-26&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [28 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059635&startDate=2025-11-28&endDate=2025-11-30&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6059635&startDate=2025-12-05&endDate=2025-12-07&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southern Indiana 4 Star Hotels ![4 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/594caae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/23521baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9c82234b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville 9.0/10 Wonderful (3794) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tia £84 includes taxes & fees 29 Nov - 30 Nov [](https://www.expedia.co.uk/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Sauna, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/4c7c479b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast served](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/w5757h3840x3y0-b0a2f211.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/9798709f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/e108d0ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Louisville Hotel Downtown Louisville 9.2/10 Wonderful (1696) "Wonderful property and staff. Would love to stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hanna £179 includes taxes & fees 25 Nov - 26 Nov [](https://www.expedia.co.uk/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) ![Dinner served](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/e02820b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/4e79a8f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/c4d1fb67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/f30004bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Louisville Downtown Downtown Louisville 9.0/10 Wonderful (1087) "Clean, hotel was amazing, great breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alana £100 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/3c2671ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/f0221042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/4fd8456f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Brown Hotel Downtown Louisville 9.4/10 Exceptional (1128) "Wonderful hotel with lots of history; clean rooms; Nice lounge and restaurants." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim £106 includes taxes & fees 25 Nov - 26 Nov [](https://www.expedia.co.uk/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/w2665h3837x3y3-e015ca48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, rooftop bar](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/w3837h2557x3y3-a4aae381.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, rooftop bar](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/8178d3c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, dinner served, American cuisine](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/91dde8b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Genevieve part of JdV by Hyatt Downtown Louisville 9.2/10 Wonderful (1009) "Room was OK. Staff was nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ted £121 includes taxes & fees 27 Nov - 28 Nov [](https://www.expedia.co.uk/Louisville-Hotels-Hotel-Genevieve.h90942141.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone) | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/cef338e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville 9.2/10 Wonderful (1004) " Loved our stay, would definitely plan to come back if we are ever in the area again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erica £165 includes taxes & fees 25 Nov - 26 Nov [](https://www.expedia.co.uk/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/f8482687.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/e017e8a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/0e69db21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed | Premium bedding, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/db453fbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Louisville Downtown Louisville 8.8/10 Excellent (1008) "Enjoyed our stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jedediah £104 includes taxes & fees 27 Nov - 28 Nov [](https://www.expedia.co.uk/Louisville-Hotels-Hyatt-Regency-Louisville.h326983.Hotel-Information) ![Deluxe Single Room, 1 King Bed, River View | View from room](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/f322db40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/f5558cfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/c35cecf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/15339a2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Grady Downtown Louisville 9.4/10 Exceptional (1011) "The location was outstanding and atmosphere was very nice." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Malcolm £131 includes taxes & fees 25 Nov - 26 Nov [](https://www.expedia.co.uk/Louisville-Hotels-The-Grady.h61215907.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/6dbe73d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/23bf82e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/e1a9281b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/9fbac853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Louisville Marriott Downtown Downtown Louisville 9.0/10 Wonderful (1002) "Room was great, but the service by the attendant that wait on me was exceptional in what she done for me." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £154 includes taxes & fees 29 Nov - 30 Nov [](https://www.expedia.co.uk/Louisville-Hotels-Louisville-Marriott-Downtown.h1111358.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/8fba23fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/10c56810.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/159d1a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/cf849375.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Distil, Autograph Collection Downtown Louisville 9.6/10 Exceptional (424) "Really a nice place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeanie £157 includes taxes & fees 14 Dec - 15 Dec [](https://www.expedia.co.uk/Louisville-Hotels-Hotel-Distil.h37765616.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/16000000/15410000/15401700/15401694/b1976648.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/16000000/15410000/15401700/15401694/dc7e2fa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15410000/15401700/15401694/1eebe4a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/16000000/15410000/15401700/15401694/a3bd3284.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Evansville Downtown Evansville 8.6/10 Excellent (1002) "The staff were extremely friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jill £86 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Evansville-Hotels-DoubleTree-By-Hilton-Evansville.h15401694.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/108000000/107080000/107072800/107072728/5c616865.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/108000000/107080000/107072800/107072728/cb95631e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room](https://images.trvl-media.com/lodging/108000000/107080000/107072800/107072728/334c8ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/108000000/107080000/107072800/107072728/662aebc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Bourré Bonne Louisville, Curio Collection by Hilton Downtown Louisville 9.0/10 Wonderful (48) "Lovely hotel in downtown Louisville. Well appointed room, comfy bed and outstanding dining. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle £154 includes taxes & fees 1 Dec - 2 Dec [](https://www.expedia.co.uk/Louisville-Hotels-Canopy-By-Hilton-Louisville-Downtown.h107072728.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/3d017cc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/aa5a75a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/e898c223.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/12e6fe89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Seelbach Hilton Louisville Downtown Downtown Louisville 8.6/10 Excellent (1004) "This was a lovely stay and we will definitely return. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dolorse £114 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/Louisville-Hotels-The-Seelbach-Hilton-Louisville.h25958.Hotel-Information) ![Signature Suite, 1 Queen Bed, Non Smoking | 2 bedrooms, premium bedding, down duvets, memory-foam beds](https://images.trvl-media.com/lodging/91000000/90960000/90953600/90953532/e9ed9b4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/91000000/90960000/90953600/90953532/56c60394.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/91000000/90960000/90953600/90953532/af58ac58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Suite, 1 King Bed with Sofa bed, Kitchen, City View | Private kitchen | Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/91000000/90960000/90953600/90953532/b3a591d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stellar Suites Downtown Louisville 9.6/10 Exceptional (114) "Clean and great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Greg £132 includes taxes & fees 8 Dec - 9 Dec [](https://www.expedia.co.uk/Louisville-Hotels-Stellar-Suites.h90953532.Hotel-Information) ![Deluxe Room, 1 King Bed (Culbertson Suite) | Balcony](https://images.trvl-media.com/lodging/17000000/16890000/16881700/16881647/298a5147.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/17000000/16890000/16881700/16881647/a3d5e65f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/17000000/16890000/16881700/16881647/033ac7bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/17000000/16890000/16881700/16881647/8a916a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Pepin Mansion Historic B&B New Albany 9.8/10 Exceptional (645) "Have stayed here once before. Accommodations are wonderful and the sit down breakfast is lovely. Highly recommend this beautiful property." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathy £76 includes taxes & fees 26 Nov - 27 Nov [](https://www.expedia.co.uk/Louisville-Hotels-The-Pepin-Mansion-Historic-BB.h16881647.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/103000000/102320000/102311400/102311340/6034e55c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/103000000/102320000/102311400/102311340/f7ac1a50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, 2 Bedrooms, Non Smoking | 1 bedroom, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/103000000/102320000/102311400/102311340/48d338aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 1 Bedroom, Non Smoking | Terrace/patio](https://images.trvl-media.com/lodging/103000000/102320000/102311400/102311340/w2493h1667x0y0-491d9ec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### CozySuites at Nulu Downtown Louisville 8.2/10 Very good (26) "The unit was clean, all communications were timely, the property has all the amenities, and NULU is very walkable. A perfect stay! My only regret is that I wasn't able to extend the stay. Highly recommended if you're in the Louisville area " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William £153 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Louisville-Hotels-CozySuites-At-Nulu.h102311340.Hotel-Information) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/103000000/102200000/102190400/102190334/23d6a049.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/103000000/102200000/102190400/102190334/e576ef26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/103000000/102200000/102190400/102190334/7b66ec14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/103000000/102200000/102190400/102190334/4f2a9bad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### stayAPT Suites Louisville North-Clarksville Clarksville 9.8/10 Exceptional (43) "Excellent stay. One of my favorite hotels in the area. They never disappoint " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julia £137 includes taxes & fees 26 Nov - 27 Nov [](https://www.expedia.co.uk/Louisville-Hotels-StayAPT-Suites-Louisville-N-Clarksville.h102190334.Hotel-Information) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/a0c5fbcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/2ec829de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/00e4c915.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/97b4a308.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Reserve on Main Downtown Louisville 10/10 Exceptional (1) "Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) georgios £155 includes taxes & fees 25 Nov - 26 Nov [](https://www.expedia.co.uk/Louisville-Hotels-The-Reserve-On-Main.h121877336.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/25000000/24380000/24372500/24372412/360e07d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/25000000/24380000/24372500/24372412/aebabcae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/25000000/24380000/24372500/24372412/aa1a2a19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Multiple Beds | Living area | Flat-screen TV, Netflix, video library](https://images.trvl-media.com/lodging/25000000/24380000/24372500/24372412/b618c806.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb Sellersburg 9.4/10 Exceptional (10) "Very nice house in a nice neighborhood, spacious home environmental, felt more that at home there," ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tammy [](https://www.expedia.co.uk/Sellersburg-Hotels-Spacious-3-BR-Ranch-House-Wpatio-Yard-In-A-Quiet-Suburb.h24372412.Hotel-Information) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/19300/19261/bdbbecb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/19300/19261/98663241.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/19300/19261/66f2648f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Evansville Airport Evansville 8.0/10 Very good (604) "Nice hotel but it doesn’t have a fridge in the room or microwave." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anonymous traveller [](https://www.expedia.co.uk/Evansville-Hotels-Holiday-Inn-Evansville-Airport.h19261.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Southern-Indiana-Hotels.s40-0-d6059635.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Southern-Indiana-Hotels.s40-0-d6059635.Travel-Guide-Filter-Hotels) ## Learn more about Southern Indiana Find lots to see and do in Southern Indiana—live music, sports teams and sights from Patoka Lake Swimming Beach to Patoka Lake. [See all hotels in Southern Indiana](https://www.expedia.co.uk/Hotel-Search?startDate=2025-12-08&endDate=2025-12-09&adults=2®ionId=6059635) ![Belle of Louisville featuring a ferry and a bay or harbour as well as a small group of people](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Southern Indiana Hotel Reviews ![DoubleTree by Hilton Evansville](https://images.trvl-media.com/lodging/16000000/15410000/15401700/15401694/b1976648_y.jpg) ### DoubleTree by Hilton Evansville 10/10 Excellent "Great stay!" [](https://expedia.co.uk/Evansville-Hotels-DoubleTree-By-Hilton-Evansville.h15401694.Hotel-Information) ## Find out more about Southern Indiana ## Frequently asked questions ### What are the best 4-star hotels in Southern Indiana? > Based on reviews by our guests, [Galt House Hotel Trademark Collection by Wyndham](https://www.expedia.co.uk/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) is among the best 4-star hotels in Southern Indiana. Situated in Louisville, it includes massage services and beauty services. [Hyatt Regency Louisville](https://www.expedia.co.uk/Louisville-Hotels-Hyatt-Regency-Louisville.h326983.Hotel-Information) is another sought-after option here. Also with a 4-star rating and offering premium bedding and designer toiletries, you're sure to have a comfortable stay. ### How much does it cost to stay in a 4-star hotel in Southern Indiana? > To book a 4-star hotel in Southern Indiana that's within your budget, take advantage of Expedia's handy filters. Take a look at what's available during your preferred dates and use our pricing filter to set your limit. You can also sort your results by the most budget-friendly option first. > > > > - Search for the lowest price from £76 ### What's the difference between 5-star and 4-star hotels in Southern Indiana? > Give yourself the luxury treatment during your Southern Indiana escape by checking in to a 4-star hotel. As well as featuring upmarket surroundings, these properties are typically packed with amenities such as large beds, bathrobes and plenty more. A 5-star hotel will go the extra mile to make your stay an even more indulgent and memorable one. 24-hour concierge assistance, luxurious spas and world-class dining are a few of the exclusive services and conveniences you'll likely be able to enjoy. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Cottages in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Cottages.d6233674-aaCottages.Travel-Guide-Accommodation) - [Casino Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Casino-Hotel.0-0-d6233674-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Gay-Friendly-Hotel.0-0-d6233674-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Historic-Hotel.0-0-d6233674-tHistoricHotel.Travel-Guide-Filter-Hotels) - 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