Title: 21c Museum Hotel in Downtown Louisville | Expedia.co.uk [21c Museum Hotel Hotels](https://expedia.co.uk/21c-Museum-Hotel-Hotels.0-l553248621559724956-0.Travel-Guide-Filter-Hotels)[21c Museum Hotel Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-21c-Museum-Hotel.d553248621559724956.Car-Hire-Guide)[Downtown Louisville Holidays](https://expedia.co.uk/Downtown-Louisville.d6059557.Holidays-City-Breaks) # 21c Museum Hotel ## Visit 21c Museum Hotel Activities --- --- ### Popular places to visit ![Louisville Science Center](https://images.trvl-media.com/place/6062647/6cb62b46-d29e-4c5d-8366-afc3a5f9c466.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Louisville Science Center Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages. [](https://expedia.co.uk/Louisville-Science-Center-Louisville.d6062647.Attraction) ![Kentucky Center for the Performing Arts](https://images.trvl-media.com/place/6062653/8b326703-a711-4dce-a0ec-21ab55344b9a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Kentucky Center for the Performing Arts Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville. [](https://expedia.co.uk/Kentucky-Center-For-The-Performing-Arts-Louisville.d6062653.Attraction) ![Muhammad Ali Center](https://images.trvl-media.com/place/6062649/37bc13aa-c0fa-4731-9dbc-637f0a6b0590.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Muhammad Ali Center One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him. [](https://expedia.co.uk/Muhammad-Ali-Center-Downtown-Louisville.d6062649.Attraction) ![Louisville Slugger Museum](https://images.trvl-media.com/place/6062643/cda9eeeb-8ec5-448c-8a77-ca9140c3b310.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Louisville Slugger Museum Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible. [](https://expedia.co.uk/Louisville-Slugger-Museum-Downtown-Louisville.d6062643.Attraction) ![Frazier International History Museum](https://images.trvl-media.com/place/6062645/9c629e58-7648-447d-9f56-6b3e71da3c6b.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Frazier International History Museum Get to know Louisville with a visit to this esteemed museum. It’s a great spot for social interaction as well. [](https://expedia.co.uk/Frazier-International-History-Museum-Louisville.d6062645.Attraction) ![Belle of Louisville](https://images.trvl-media.com/place/6062661/82d9e190-2642-48eb-ad34-140ee14798af.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Belle of Louisville For a nostalgic trip, cruise down a mighty river on this authentic steamboat that has carried tourists, tradesmen and cattle for over a century. [](https://expedia.co.uk/Belle-Of-Louisville-Louisville.d6062661.Attraction) --- ## Top Hotel Deals ## Check availability on hotels close to 21c Museum Hotel [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621559724956&startDate=2026-03-29&endDate=2026-03-30)[29 Mar - 30 Mar](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621559724956&startDate=2026-03-29&endDate=2026-03-30) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621559724956&startDate=2026-03-30&endDate=2026-03-31)[30 Mar - 31 Mar](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621559724956&startDate=2026-03-30&endDate=2026-03-31) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621559724956&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026)[3 Apr - 5 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621559724956&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026) ![Galt House Hotel Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/aa5bcd07_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Galt House Hotel Trademark Collection by Wyndham 140 North Fourth Street Louisville KY [](https://expedia.co.uk/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Homewood Suites by Hilton Louisville Downtown, KY](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599840/2c34bd2f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Homewood Suites by Hilton Louisville Downtown, KY 635 W Market St Louisville KY [](https://expedia.co.uk/Louisville-Hotels-Homewood-Suites-By-Hilton-Louisville-Downtown.h21599840.Hotel-Information) ![Holiday Inn Express & Suites Louisville Downtown by IHG](https://images.trvl-media.com/lodging/13000000/12560000/12552800/12552757/40953e5e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Express & Suites Louisville Downtown by IHG 800 W Market St Louisville KY [](https://expedia.co.uk/Louisville-Hotels-Holiday-Inn-Express-Suites-Louisville-Downtown.h12552757.Hotel-Information) ![Embassy Suites Louisville Downtown](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/5bea9d61_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Embassy Suites Louisville Downtown 501 South Fourth Street Louisville KY [](https://expedia.co.uk/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information) ![21c Museum Hotel Louisville](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 21c Museum Hotel Louisville 700 W Main Street Louisville KY [](https://expedia.co.uk/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![The Grady](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/e116c623_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Grady 601 W Main St Louisville KY [](https://expedia.co.uk/Louisville-Hotels-The-Grady.h61215907.Hotel-Information) ![Towneplace Suites By Marriott Louisville Downtown](https://images.trvl-media.com/lodging/65000000/64700000/64696100/64696084/22942c94_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Towneplace Suites By Marriott Louisville Downtown 801 WEST JEFFERSON STREET Louisville KY [](https://expedia.co.uk/Louisville-Hotels-Towneplace-Suites-By-Marriott-Louisville-Downtown.h64696084.Hotel-Information) ![Hyatt Regency Louisville](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/e017e8a5_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hyatt Regency Louisville 320 West Jefferson Street Louisville KY [](https://expedia.co.uk/Louisville-Hotels-Hyatt-Regency-Louisville.h326983.Hotel-Information) ![Louisville Marriott Downtown](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/c5a6934a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Louisville Marriott Downtown 280 West Jefferson Street Louisville KY [](https://expedia.co.uk/Louisville-Hotels-Louisville-Marriott-Downtown.h1111358.Hotel-Information) [See all 1,958 properties in 21c Museum Hotel](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=553248621559724956) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. 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