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Check prices for these dates

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3 Oct - 4 Oct
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4 Oct - 5 Oct
Next weekend
9 Oct - 11 Oct
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16 Oct - 18 Oct

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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
A living room with a sofa, armchair, coffee table, fireplace, and large windows.
A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.
A covered outdoor seating area with wicker furniture and a wooden railing.

1. Louisville Bourbon Inn

Louisville Bourbon Inn
Old Louisville, 1.8 mi from 21c Museum Hotel
United States
Roy
£245
includes taxes & fees
5 Oct - 6 Oct
Louisville Bourbon Inn
A wooden staircase with a balustrade leading to a landing.
A two-story brick building with a white porch and a sign reading "Hotel".
A brick building with a covered porch, columns, and potted plants.
A dining area with brick walls, wooden shelves, and tables set for a meal.

2. Market Street Inn

Market Street Inn
1.3 mi from 21c Museum Hotel
United States
Holly
£167
includes taxes & fees
12 Oct - 13 Oct
Market Street Inn
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling, large windows, and classic furniture.
A grand lobby with ornate ceiling, multiple seating areas, and a staircase.
A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

3. The Brown Hotel

The Brown Hotel
Downtown Louisville, 0.8 mi from 21c Museum Hotel
United States
Meghan
£119
includes taxes & fees
28 Oct - 29 Oct
The Brown Hotel
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
A bar with shelves of liquor bottles and a bartender preparing drinks.
A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

4. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville, 0.5 mi from 21c Museum Hotel
United States
Anthony
£210
includes taxes & fees
29 Oct - 30 Oct
Hotel Distil, Autograph Collection
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.
A room with a red velvet sofa, a blue armchair, and a small round table with books.
A living room with a sofa, a fireplace, a staircase, and a chandelier.

5. DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
Old Louisville, 1.7 mi from 21c Museum Hotel
United States
Casey
£125
includes taxes & fees
1 Nov - 2 Nov
DuPont Mansion Bed & Breakfast
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.
A building with a sign reading "THE GRADY" at the entrance.
A modern restaurant interior with a staircase, round tables, and a brick wall.

6. The Grady

The Grady
Downtown Louisville, < 0.1 mi from 21c Museum Hotel
United States
Bruce
£155
includes taxes & fees
11 Oct - 12 Oct
The Grady
A modern bar area with a circular bar, multiple seating options, and a large screen.
A modern lobby with a fireplace, seating area, and a reception desk.
A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.
A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

7. Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
Downtown Louisville, 0.7 mi from 21c Museum Hotel
United States
Erin
£92
includes taxes & fees
25 Oct - 26 Oct
Cambria Hotel Louisville Downtown-Whiskey Row
A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.
A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.
A swimming pool with lounge chairs and a view of the city.
A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

8. Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
Downtown Louisville, < 0.1 mi from 21c Museum Hotel
United States
Kelly
£107
includes taxes & fees
25 Oct - 26 Oct
Homewood Suites by Hilton Louisville Downtown, KY
An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.
A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.
A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.
A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

9. Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
Phoenix Hill, 1.3 mi from 21c Museum Hotel
United States
Addison
£109
includes taxes & fees
18 Oct - 19 Oct
Tempo By Hilton Louisville Downtown Nulu
A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.
A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.
A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.
A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

10. Stellar Suites

Stellar Suites
East Market District, 1.4 mi from 21c Museum Hotel
United States
Kevin
£126
includes taxes & fees
5 Oct - 6 Oct
Stellar Suites
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A steam fountain in a brick alleyway.
A cozy room with a geometric-patterned ceiling, a sofa, and a chair.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

11. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville, < 0.1 mi from 21c Museum Hotel
United States
Matt
£154
includes taxes & fees
25 Oct - 26 Oct
21c Museum Hotel Louisville
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern hotel room with a large bed, a city view, and a unique headboard design.
A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

12. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville, 0.5 mi from 21c Museum Hotel
United States
Cameron
£160
includes taxes & fees
11 Oct - 12 Oct
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.
A modern interior with a fireplace, bookshelves, and seating areas.
A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

13. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville, 0.5 mi from 21c Museum Hotel
United States
Samantha
£226
includes taxes & fees
30 Oct - 31 Oct
Omni Louisville Hotel
A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.
A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.
A cozy living room with a fireplace, a black leather sofa, and a patterned rug.
A modern living room with a sofa, ottomans, a coffee table, and a rug.

14. Moxy Louisville Downtown

Moxy Louisville Downtown
Downtown Louisville, 0.5 mi from 21c Museum Hotel
United States
Bryan
£114
includes taxes & fees
18 Oct - 19 Oct
Moxy Louisville Downtown
An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.
A modern coffee shop interior with a central island, wooden counter, and large windows.
A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.
A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

15. Aloft by Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown
Downtown Louisville, 0.5 mi from 21c Museum Hotel
United States
Angela
£128
includes taxes & fees
25 Oct - 26 Oct
Aloft by Marriott Louisville Downtown
An outdoor seating area with wicker furniture and a fire pit.
A modern lounge area with seating, tables, and a view of the city through large windows.
An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.
A modern living room with a sofa, armchairs, a coffee table, and a TV.

16. Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
Downtown Louisville, 0.2 mi from 21c Museum Hotel
United States
Barbara
£98
includes taxes & fees
25 Oct - 26 Oct
Towneplace Suites By Marriott Louisville Downtown
A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.
A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.
A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.
A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

17. AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
East Market District, 1.3 mi from 21c Museum Hotel
United States
Jen
£127
includes taxes & fees
25 Oct - 26 Oct
AC Hotel Louisville Downtown
A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.
A brightly lit grocery store with yellow shelving and a central checkout counter.
A yellow coffee shop counter with a menu board above, displaying various coffee and food items.
A bedroom with a bed, a chair, a TV, and a window with curtains.

18. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
East Market District, 1.3 mi from 21c Museum Hotel
United States
Tyler
£135
includes taxes & fees
26 Oct - 27 Oct
Hotel Genevieve part of JdV by Hyatt
A covered patio with a stone wall, a glass table, and a bench.
A grand room with a fireplace, a staircase, and a chandelier.
A garden pathway with a lantern, potted plants, and a white fence.
A stone house with a balcony, a front door, and a staircase leading to the entrance.

19. Central Park Bed & Breakfast

Central Park Bed & Breakfast
Old Louisville, 1.8 mi from 21c Museum Hotel
United States
Brittany
£138
includes taxes & fees
6 Oct - 7 Oct
Central Park Bed & Breakfast
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A balcony with a view of a river, a bridge, and a cityscape.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.
A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

20. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville, 0.3 mi from 21c Museum Hotel
United States
Saud
£129
includes taxes & fees
25 Oct - 26 Oct
Galt House Hotel Trademark Collection by Wyndham
View all properties

Compare popular hotels close to 21c Museum Hotel

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
Louisville Bourbon Inn
10.0
Exceptional
25 reviews
View
A wooden staircase with a balustrade leading to a landing.
Market Street Inn
9.8
Exceptional
125 reviews
View
A grand lobby with ornate columns, plush seating, and a chandelier.
The Brown Hotel
9.4
Exceptional
1,330 reviews
View
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
Hotel Distil, Autograph Collection
9.6
Exceptional
507 reviews
View
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
DuPont Mansion Bed & Breakfast
9.6
Exceptional
147 reviews
View

Top 21c Museum Hotel Hotel Reviews

Aloft by Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown

10/10 Excellent
"Great place to stay. Room was super clean. Enjoyed the bar and restaurant. Staff were super friendly. And even had live music one night. Close to bourbon row and 4th st."
Gary 2-night trip
Posted 1 hour ago
Aloft by Marriott Louisville Downtown
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent
"Clean room very friendly staff and a super bar!"
William 2-night trip
Posted 1 hour ago
Cambria Hotel Louisville Downtown-Whiskey Row
Omni Louisville Hotel

Omni Louisville Hotel

10/10 Excellent
"An incredible place."
James 2-night trip
Posted 3 hours ago
Omni Louisville Hotel
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent
"Suite was very large and nice. Like others have said there was a little odd smell but great hotel."
Jacob 2-night trip
Posted 4 hours ago
Galt House Hotel Trademark Collection by Wyndham
The Brown Hotel

The Brown Hotel

10/10 Excellent
"We loved the hotel decor, rooms were big and comfortable and the parking was convenient."
Lorraine 1-night trip
Posted 7 hours ago
The Brown Hotel
The Grady

The Grady

10/10 Excellent
"Great place to stay in downtown Louisville. Staff is always friendly and helpful."
Ralph 1-night trip
Posted 1 day ago
The Grady
Hyatt Regency Louisville

Hyatt Regency Louisville

10/10 Excellent
"Gorgeous atrium style hotel just steps away from convention center. Lots to do and see near hotel."
Victoria 1-night trip
Posted 2 days ago
Hyatt Regency Louisville
Holiday Inn Louisville Downtown by IHG

Holiday Inn Louisville Downtown by IHG

10/10 Excellent
"No commo"
Ed 5-night trip
Posted 2 days ago
Holiday Inn Louisville Downtown by IHG
Louisville Marriott Downtown

Louisville Marriott Downtown

8/10 Good
"Didn’t like the many homeless people right outside on the sidewalk."
Paul 3-night trip
Posted 2 days ago
Louisville Marriott Downtown

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A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)
Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.
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The Kentucky Center for the Performing Arts building facade with large glass windows and a prominent sign.

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)
Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.
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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)
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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)
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Golden Statue of David

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Kentucky Museum of Art and Craft

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)
You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.
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SAR Genealogical Research Library: NSSAR Library

You can spend time exploring the galleries in SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.
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Frequently asked questions

What's the area like around 21c Museum Hotel?
21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 292 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay near 21c Museum Hotel?
Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.
How many hotels are there near 21c Museum Hotel?
Expedia has 292 hotels and other accommodation options within a mile from 21c Museum Hotel.
If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?
Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.
What can I see and do near 21c Museum Hotel?
You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.