South America Adults Only Holidays

Book a Adults Only Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Packages with flights are ATOL protected

Top flight + Adults Only hotel deals in South America

Price found within the past 48 hours. Click for updated prices.
Casa del Arzobispado Hotel
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3 Night Adults Only holidays in South America

Price found within the past 48 hours. Click for updated prices.
Casa del Arzobispado Hotel
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See all available trips from Miami to South America
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Top Adults Only South America Hotels

Hotel Nirvana

Hotel Nirvana

3 out of 5
Paseo de la Republica 6315 Lima Lima
Stay at this hotel in Lima. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Larcomar Shopping Center and John F. Kennedy Park are located ...
6.6/10 (13 reviews)
"Inexpensive and clean, little to no hot water in bathroom."

Reviewed on 7 Sept 2018

Hotel Nirvana
84 DC Bogotá By OxoHotel

84 DC Bogotá By OxoHotel

4 out of 5
Calle 84 No 9-67 Bogotá Distrito Capital
The price is £62 per night from 14 Nov to 15 Nov
£62
14 Nov - 15 Nov
additional charges may apply
Stay at this business-friendly hotel in Bogotá. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular ...
8.8/10 Excellent! (720 reviews)
"Cleanliness Cozy Comfortable Smart Service Helpful Staff Excellent"

Reviewed on 30 Oct 2026

84 DC Bogotá By OxoHotel
Alfiz Hotel Boutique

Alfiz Hotel Boutique

3 out of 5
Calle Cochera del Gobernador, 33-28 Cartagena Bolivar
Stay at this historic hotel in Cartagena. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Our guests praise the helpful staff in their reviews. Popular ...
9.6/10 Exceptional! (199 reviews)
"Notch to really like but it did have a good location"

Reviewed on 10 Aug 2026

Alfiz Hotel Boutique
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.