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South America Adults Only Holidays

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Packages with flights are ATOL protected

Top Adults Only holiday packages in South America

Price found within the past 48 hours. Click for updated prices.
  • 8 Sept - 13 Sept

    GHL BIOXURY HOTEL + Flight

    Zona T
    5 nights
    4.0 star property
    9.6/10 - Exceptional (1,001 reviews)
    "Great location, clean and very kind and helpful staff."
    Reviewed August 2, 2026
    Return San José (SJO) - Bogotá (BOG)
    SJO - BOG1 stop BOG - SJO1 stop
    £698
    £596
    per traveller
    found 3 hours agoAdditional charges may apply
    GHL BIOXURY HOTEL
  • 25 Oct - 31 Oct

    Casa del Arzobispado Hotel + Flight

    Cartagena Walled City
    5 nights
    4.0 star property
    9.4/10 - Exceptional (345 reviews)
    Return London (LON) - Cartagena (CTG)
    LHR - CTG2 stops CTG - LHR2 stops
    £1,483
    £1,137
    per traveller
    found 1 hour agoAdditional charges may apply
    Casa del Arzobispado Hotel
  • 25 Oct - 31 Oct

    Privado Designer Boutique Hotel + Flight

    Cartagena Walled City
    5 nights
    4.0 star property
    9.6/10 - Exceptional (173 reviews)
    Return London (LON) - Cartagena (CTG)
    LHR - CTG2 stops CTG - LHR2 stops
    £1,320
    £1,027
    per traveller
    found 1 hour agoAdditional charges may apply
    Privado Designer Boutique Hotel

Discover the most popular places to visit in South America

Top Adults Only South America Hotels

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

Why should I book my South America holiday with Expedia?

Choose Expedia to organise your next break simply and all in the same place. Our insider tip for getting the best deal on a South America retreat? Bundle your accommodation, airfares and/or car hire into a package holiday. Then throw in some exciting tours and activities. Many bookings also come with flexible cancellation policies, so there's no need to stress if you have to switch up your travel itinerary. Round-the-clock help with making tweaks to your trip is available via our Customer Service Portal link.

How do I get a cheap holiday to South America?

Browse and lock in everything in the one place with our South America holidays. You'll discover deals on flights, hotels and more that'll keep your hip pocket happy and your adventurous spirit alive. And, with more than 400 air carriers and 321,000 hotels globally to pick from, you'll have the flexibility to mix and match as you please. Learn more about how you can save money on your next holiday when you combine your flight and hotel bookings with Expedia.

Do I need a visa for my South America holiday?

Official government websites will have all the information you need on visa requirements, application procedures and any supporting documentation. Your nationality and the purpose of your visit, whether it be for tourism or business, will determine if you need a visa for South America. Also double-check that your passport is up to date and has a minimum of six months validity remaining beyond your intended return date. Do all your travel planning well in advance to avoid any nasty last-minute surprises.

What should I wear on my South America holiday?

Do a little research into the sorts of things people in South America wear, and consider browsing style blogs for some fashion inspiration. Try to create a versatile travel wardrobe filled with pieces that suit your destination and show off your unique sense of style.

What does an Expedia South America holiday include?

It comes down to what type of trip you have in mind. South America travel deals can include hotels, car hires and flights. You can mix and match to find the bundle that suits your style and budget. You can also add on activities and experiences after you've booked to pick up even bigger discounts. You'll always have the flexibility and freedom to tailor-make your holiday any way you please with Expedia.

Does Expedia offer Book Now, Pay Later South America holidays?

Your bank balance shouldn't prevent you from taking a holiday, so Expedia has come up with a solution to help. Now that we've partnered with online lender Klarna, it's easier than ever to book a fabulous getaway without making a dent in your savings. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your trip. Consider one of these flexible payment options:

  • Pay monthly holidays: Make your holiday dreams a reality sooner with Klarna's manageable instalment plans. If paying in multiple instalments sounds right for you, choose this option at checkout.
  • No-deposit holidays: When you want to jump on an unbeatable deal but your budget doesn't quite cover it yet, Klarna's no-deposit holiday plan will allow you to Book Now, Pay Later to get what you want.

Can I choose my airline with a South America Expedia holiday?

With a holiday package, the choice is in your hands. Whether you're looking to fly to South America in first class or coach, simply select from the available airline options. Expedia has access to over 400 partner airlines globally.