A white monument with a tall column and a statue of a man on a horse. Flags are flying on the monument.

£536 Cheap Flights from Panama City (PTY) to Santiago (STI)

View £536 flight on Thu, 13 Aug 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Cibao Intl. Airport (STI)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 25% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap Flights from Panama City (PTY) to Santiago (STI)

Prices were available within the past 7 days and start at £536 for one-way flights and £448 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, 22 Oct - Mon, 26 Oct
PTY
Panama City
STI
Santiago de los Caballeros
£448 Return, found 6 days ago
£448
Return
found 6 days ago
Select Copa flight, departing Thu, 22 Oct from Panama City to Santiago de los Caballeros, returning Mon, 26 Oct, priced at £448 found 6 days ago
Copa
Mon, 24 Aug - Mon, 31 Aug
PTY
Panama City
STI
Santiago de los Caballeros
£451 Return, found 18 hours ago
£451
Return
found 18 hours ago
Select Copa flight, departing Mon, 24 Aug from Panama City to Santiago de los Caballeros, returning Mon, 31 Aug, priced at £451 found 18 hours ago
Copa
Thu, 22 Oct - Mon, 26 Oct
PTY
Panama City
STI
Santiago de los Caballeros
£536 Return, found 6 days ago
£536
Return
found 6 days ago
Select Copa flight, departing Thu, 22 Oct from Panama City to Santiago de los Caballeros, returning Mon, 26 Oct, priced at £536 found 6 days ago
Copa
Thu, 13 Aug - Thu, 20 Aug
PTY
Panama City
STI
Santiago de los Caballeros
£540 Return, found 2 days ago
£540
Return
found 2 days ago
Select Copa flight, departing Thu, 13 Aug from Panama City to Santiago de los Caballeros, returning Thu, 20 Aug, priced at £540 found 2 days ago
Copa
Thu, 22 Oct - Mon, 26 Oct
PTY
Panama City
STI
Santiago de los Caballeros
£751 Return, found 6 days ago
£751
Return
found 6 days ago
Select Copa flight, departing Thu, 22 Oct from Panama City to Santiago de los Caballeros, returning Mon, 26 Oct, priced at £751 found 6 days ago
Copa
Thu, 13 Aug - Thu, 20 Aug
PTY
Panama City
STI
Santiago de los Caballeros
£756 Return, found 2 days ago
£756
Return
found 2 days ago
Select Copa flight, departing Thu, 13 Aug from Panama City to Santiago de los Caballeros, returning Thu, 20 Aug, priced at £756 found 2 days ago
Copa
Thu, 13 Aug - Thu, 20 Aug
PTY
Panama City
STI
Santiago de los Caballeros
£1,013 Return, found 2 days ago
£1,013
Return
found 2 days ago
Select Copa flight, departing Thu, 13 Aug from Panama City to Santiago de los Caballeros, returning Thu, 20 Aug, priced at £1,013 found 2 days ago
Copa
Thu, 13 Aug - Thu, 20 Aug
PTY
Panama City
STI
Santiago de los Caballeros
£1,048 Return, found 2 days ago
£1,048
Return
found 2 days ago
Select Copa flight, departing Thu, 13 Aug from Panama City to Santiago de los Caballeros, returning Thu, 20 Aug, priced at £1,048 found 2 days ago

Frequently asked questions

How much does a flight from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) cost?
You can find one-way and return flights from PTY to STI with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when PTY to STI ticket fares go up or down.
What is the cheapest month to fly from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
The cheapest months to fly from PTY to STI are typically during off-peak season when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you are able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
Only one airline offers direct flights from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.). Copa operates 7 direct flights from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) every week.
What is the cheapest airline that flies from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
Copa is one of the cheapest airlines offering nonstop return flights from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.), with tickets starting from around £259 for flights that can be booked for departure within the next year. American Airlines offers one of the cheapest connecting return flights on this route, with tickets starting from around £538. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.
How do I find cheap flights from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
To find a cheap flight from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
The best airline to fly with from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) will differ from traveler to traveler. If you like to fly early, Copa offers early morning flights. If price is the most important factor, Copa typically offers the lowest fares. Avianca offers the most daily flights from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
There are approximately 3 connecting flights per day from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.). Some common connection points include Liberty Intl. (EWR), Miami Intl. (MIA), and Hartsfield-Jackson Atlanta Intl. (ATL).
What is the earliest flight from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
The earliest flight from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) typically departs around 7:55 AM. This service is operated by Copa. This is a seasonal service active in March, April, and June. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
You'll generally find the most flights from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) on a Tuesday, with around 5 flights available. This gives you a good selection of options for your journey. Major airlines on this route include United, American Airlines, and Copa. Flight schedules are quite consistent throughout the week, so you'll find similar options on most days.
What are the most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
The most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) are between 9am and 12pm. Many major carriers, including Copa and United, offer flights during this window. Many travellers prefer this time because it allows for a morning departure and an early afternoon arrival, giving you plenty of time to settle in at your destination.
How long does it take to fly from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
A direct flight from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) typically takes around 2 hours 30 minutes. This route covers a distance of approximately 1,489 kilometres. If you opt for a one-stop flight, the journey will be significantly longer, usually around 12 hours 18 minutes. Flights with two or more stops take even longer, with a typical travel time of about 20 hours 48 minutes. Keep in mind that actual flight times can vary due to factors like wind patterns and air traffic, so it's always a good idea to allow for some extra time when planning your trip.
Can you fly business or first class from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
Yes, you can fly business class between PTY and STI. Airlines that offer business class service on this route include:
  • Copa
  • United
  • American Airlines
How do I earn miles on a Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) flight with Expedia?
It's easy to earn miles on a Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Santiago (STI) from Panama City (PTY)?
If you're planning to travel to Santiago from Tocumen Intl. (PTY), you can fly directly into Cibao Intl. (STI). Some flights may connect through major hubs like Hartsfield-Jackson Atlanta Intl. (ATL) before reaching Santiago. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) at the last minute?
Typically, booking a last minute flight from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) flight and hotel package?
Securing a Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.)?
If you booked your Panama City (PTY-Tocumen Intl.) to Santiago (STI-Cibao Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Tocumen Intl.
Destination airport
Cibao Intl.
Airlines serving
Copa
Return price
£448
Distance
1479 km
Average flight time
2 hours 33 mins

Book with confidence

Compare flights from Panama City to Santiago easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Panama City to Santiago. Operating between them flights per day, 9 airlines cover the route. And fly direct, getting you to Cibao Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Tocumen Intl. to Cibao Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Tocumen Intl. (PTY) to Cibao Intl. (STI)

The easiest way to view the best deals on flights from Panama City to Santiago today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Tocumen Intl. to Cibao Intl. start at just £448 and range up to £1,048.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Panama City and Santiago
  • booking your flight during October, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Panama City to Santiago flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Tocumen Intl. to Cibao Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Panama City to Santiago easily and book with confidence

Explore a world of travel with Expedia

*Available to Expedia members.