Title: Cheap American Airlines flights from Des Moines to Orange County (DSM→SNA) - Expedia.co.uk ![Lyon Air Museum which includes an airport and aircraft](https://images.trvl-media.com/place/6159109/f797c590-51c7-44ea-8258-cd8934ac252e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6159109/f797c590-51c7-44ea-8258-cd8934ac252e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Cheap American Airlines flights from Des Moines to Orange County (DSM→SNA) - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only - ## Plan, book, fly with confidence - ### Be in the know Get alerts if flight prices drop or rise\* - ### Book smarter Save up to 25% on select hotels after you book a flight\* - ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Frequently asked questions ### How much is an American Airlines flight from Des Moines Intl. Airport (DSM) to John Wayne Airport (SNA)? > Landing cheap one-way American Airlines flights from DSM to SNA on Expedia is a cinch — just filter by "Price (lowest to highest)." Or check out our affordable round-trip fares for your next exciting getaway.\**\*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.* ### What is the cheapest month to fly from DSM to SNA with American Airlines? > January is one of the least expensive months to travel to Santa Ana with American Airlines. You could also find fantastic deals on one-way and round-trip tickets in April. ### Does American Airlines fly nonstop from Des Moines Intl. Airport (DSM) to John Wayne Airport (SNA)? > Use the "Nonstop" filter when searching for direct American Airlines flights from DSM to SNA. It's also a good way to compare other airlines offering the same direct trip. ### What airports does American Airlines fly into in Santa Ana? > John Wayne Airport (SNA) is the primary Santa Ana hub for American Airlines flights from Des Moines Intl. Airport (DSM). ### Can I change or cancel my American Airlines flight from Des Moines Intl. Airport (DSM) to John Wayne Airport (SNA)? > Depending on your fare type, a fee generally applies if you cancel or reschedule your flight more than 24 hours after it's confirmed. To secure flexible fares, select our "No cancel fee" or "Changes included" filter while searching for flights. For more details on cancelling or changing your reservation, visit "[Trips](https://www.expedia.co.uk/trips)," select your flight and tick "Manage Booking." ## Travel information | Origin airport | Des Moines Intl. | | --- | --- | | Destination airport | John Wayne | | Airlines serving | Alaska Airlines | | Popular airline | Alaska Airlines | | Distance | 2281 km | ## Explore a world of travel with Expedia - Flights - [Aer Lingus Dublin (DUB) to San Diego (SAN) flights](https://www.expedia.co.uk/lp/flight-routes/aer-lingus-from-dublin-to-san-diego-intl/ei/dub/san) - [Aer Lingus Edinburgh (EDI) to Los Angeles (LAX) flights](https://www.expedia.co.uk/lp/flight-routes/aer-lingus-from-edinburgh-to-los-angeles-intl/ei/edi/lax) - [Aer Lingus Leeds (LBA) to Los Angeles (LAX) flights](https://www.expedia.co.uk/lp/flight-routes/aer-lingus-from-leeds-bradford-to-los-angeles-intl/ei/lba/lax) - [Aeroflot-Russian Airlines Moscow (SVO) to Los Angeles (LAX) flights](https://www.expedia.co.uk/lp/flight-routes/aeroflot-russian-airlines-from-sheremetyevo-to-los-angeles-intl/su/svo/lax) - [Air Canada Calgary (YYC) to Los Angeles (LAX) flights](https://www.expedia.co.uk/lp/flight-routes/air-canada-from-calgary-intl-to-los-angeles-intl/ac/yyc/lax) - [Air Canada St. John's (YYT) to San Diego (SAN) flights](https://www.expedia.co.uk/lp/flight-routes/air-canada-from-st-johns-intl-to-san-diego-intl/ac/yyt/san) - [Air Canada Vancouver (YVR) to Los Angeles (LAX) flights](https://www.expedia.co.uk/lp/flight-routes/air-canada-from-vancouver-intl-to-los-angeles-intl/ac/yvr/lax) - [Air France Rome (FCO) to Los Angeles (LAX) flights](https://www.expedia.co.uk/lp/flight-routes/air-france-from-fiumicino-leonardo-da-vinci-intl-to-los-angeles-intl/af/fco/lax) - [Air Tahiti Nui Paris (CDG) to Los Angeles (LAX) flights](https://www.expedia.co.uk/lp/flight-routes/air-tahiti-nui-from-roissy-charles-de-gaulle-to-los-angeles-intl/tn/cdg/lax) - [Alaska Airlines Guadalajara (GDL) to Los Angeles (LAX) flights](https://www.expedia.co.uk/lp/flight-routes/alaska-airlines-from-don-miguel-hidalgo-y-costilla-intl-to-los-angeles-intl/as/gdl/lax) - [Alaska Airlines Las Vegas (LAS) to Los Angeles (LAX) flights](https://www.expedia.co.uk/lp/flight-routes/alaska-airlines-from-harry-reid-intl-to-los-angeles-intl/as/las/lax) - [Alaska Airlines Harry Reid Intl. to QLA-All Airports flights](https://www.expedia.co.uk/lp/flight-routes/alaska-airlines-from-harry-reid-intl-to-qla-all-airports/as/las/qla) - [Alaska Airlines Newark Liberty Intl. 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