Title: Santa Maria Holidays 2026 | Expedia.co.uk [Hotels in Santa Maria](https://expedia.co.uk/Santa-Maria-Hotels.d553248635976397555.Travel-Guide-Hotels)[Flights to Guayaquil](https://expedia.co.uk/Cheap-Flights-To-Guayaquil.d1414.Travel-Guide-Flights)[Things to do in Guayaquil](https://expedia.co.uk/Things-To-Do-In-Guayaquil.d1414.Travel-Guide-Activities)[Santa Maria Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Maria.d553248635976397555.Car-Hire-Guide) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Santa Maria Holidays ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected ### Your Santa Maria Holiday Discover all the amazing things this neighbourhood has to offer with a customized Santa Maria holiday package. However you imagine yourself spending your days here, you'll find endless opportunities for adventure, relaxation and fun. Start your trip to Santa Maria with a visit to nearby attractions such as [Banco Pichincha Monumental Stadium](https://www.expedia.co.uk/Banco-Pichincha-Monumental-Stadium-Guayaquil.d6112418.Attraction), [Mall del Sol Commercial Centre](https://www.expedia.co.uk/Mall-Del-Sol-Commercial-Center-Simon-Bolivar.d6160670.Attraction) and [City Mall](https://www.expedia.co.uk/City-Mall-Guayaquil.d6214252.Attraction). Expedia can put your travel plans into action. Book your ultimate Santa Maria holiday now. ## Where to stay in Santa Maria Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. [Learn more about Santa Maria](https://expedia.co.uk/Guayaquil-Santa-Maria.dx553248635976397555) ![Fachada colorida de estilo colonial, barrio de Santa Ana, Guayaquil, Ecuador](https://images.trvl-media.com/place/553248635976397513/63317c37-23f5-4437-8dce-9baf7ec279e3.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Ecuador Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out. [Find hotels in Ecuador](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Dest.PKG.Neighborhoods®ionId=553248635976397513) ![Important monument here in Guayaquil ](https://images.trvl-media.com/place/6337570/ec818446-c148-43bd-834f-eee037c6cfc5.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown Guayaquil Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Central Market and Sports Federation of Guayas while you're in town. [Find hotels in Downtown Guayaquil](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Dest.PKG.Neighborhoods®ionId=6337572) ![Vista panorámica de las favelas de cerro santa ana, guayaquil, ecuador](https://images.trvl-media.com/place/6338310/7d2e991e-9428-4fdb-b585-549f29a51fa9.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Puerto Santa Ana Restaurants and river views are some things travellers note about Puerto Santa Ana. Check out Santa Ana Hill or Botanical Garden while you're familiarising yourself with the larger area. [Find hotels in Puerto Santa Ana](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Dest.PKG.Neighborhoods®ionId=6338310) ![Cityscape from Malecón 2000, the boardwalk overlooking the Guayas River in Guayaquil, Ecuador's largest city and economic capital.](https://images.trvl-media.com/place/553248633981744623/4b429326-1b45-4f96-a199-253791852ff3.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Kennedy 1 out of top 10 points of interest in this area Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area. [Find hotels in Kennedy](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Dest.PKG.Neighborhoods®ionId=553248633981744623) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Bolívar While Bolívar may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Malecon Mall and Central Market. [Find hotels in Bolívar](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Dest.PKG.Neighborhoods®ionId=916425151487365120) ## Top hotels in Santa Maria ![Oro Verde Guayaquil](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/104d895f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Oro Verde Guayaquil 9 De Octubre Y Garcia Moreno Guayaquil Guayas Fully refundableReserve now, pay when you stay £74 27 Feb - 28 Feb 9.4/10 Exceptional! (1,004 reviews) Staff great, room clean Reviewed on 19 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=27%2F02%2F2026&endDate=28%2F02%2F2026&selected=23682&PinnedHotelID=23682&HadPinnedHotel=true®ionId=553248635976397555) ![Holiday Inn Guayaquil Airport by IHG](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/15d3bf82_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Guayaquil Airport by IHG Av. de Las Américas,junto al Aeropuerto Guayaquil Guayas Fully refundable £73 20 Mar - 21 Mar 9.4/10 Exceptional! (1,015 reviews) Everyone was very welcoming and friendly. The hotel is clean and have all amenities needed for your stay, I definitely recommend staying there Reviewed on 21 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=20%2F03%2F2026&endDate=21%2F03%2F2026&selected=5959068&PinnedHotelID=5959068&HadPinnedHotel=true®ionId=553248635976397555) ![Wyndham Guayaquil Puerto Santa Ana](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/79b2b000_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Wyndham Guayaquil Puerto Santa Ana Calle Numa Pompilio Llona S N Guayaquil Guayas Fully refundableReserve now, pay when you stay £79 1 Mar - 2 Mar 9.2/10 Wonderful! (1,005 reviews) Staff was very friendly, food spectacular, and the infrastructure was amazing! Spa was a plus... Reviewed on 5 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=01%2F03%2F2026&endDate=02%2F03%2F2026&selected=6312483&PinnedHotelID=6312483&HadPinnedHotel=true®ionId=553248635976397555) [See all 423 properties in Santa Maria](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=24%2F02%2F2026&endDate=25%2F02%2F2026®ionId=553248635976397555) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holidays](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![Holiday in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ## Frequently asked questions ### How much does a Santa Maria travel package cost? ### If I'm not able to travel, can I cancel my Santa Maria travel package? ### How do I get a cheap travel package to Santa Maria? ### Does Expedia offer Book Now, Pay Later Santa Maria holidays? > - Pay monthly holidays: Make your holiday dreams come true sooner with Klarna's manageable monthly instalment plans. If paying a little each month sounds right for you, choose this option during the checkout process. > - Pay in instalments holidays: With this Book Now, Pay Later option, Klarna makes it easy to pay off your trip across multiple transactions. > - Low deposit holidays: When you spot an unbeatable deal but your budget doesn't quite go that far, Klarna's low deposit holiday plan will help you lock it in. ### Where should I stay in Santa Maria? ### What are the top hotels in Santa Maria? ### How far in advance should I book my Santa Maria holiday? ### What does an Expedia Santa Maria travel package include? ### What should I know before booking a Santa Maria travel package? ### Can I choose my airline with a Santa Maria Expedia travel package? ### Popular places to visit #### Dr. Teodoro Maldonado Carbo Hospital If Dr. Teodoro Maldonado Carbo Hospital is what brings you to town, hopefully you'll have a chance to explore more of Guayaquil. [](https://expedia.co.uk/Dr-Teodoro-Maldonado-Carbo-Hospital-Guayaquil.d6331051.Attraction) ### Things to do ![Half Day Walking Tour of Guayaquil Pearl of the Pacific](https://mediaim.expedia.com/localexpert/44847268/e9f87071-a55f-439d-b9b9-b5b419c4838c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Half Day Walking Tour of Guayaquil Pearl of the Pacific £73 per adult [](https://expedia.co.uk/things-to-do/half-day-walking-tour-of-guayaquil-pearl-of-the-pacific.a44847268.activity-details) ![Guayaquil: Cloud Forest, Hiking & Canyoning Full Day Tour](https://mediaim.expedia.com/localexpert/48063579/553f0dc3-295a-4fe8-b7de-f298f96c097b.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Guayaquil: Cloud Forest, Hiking & Canyoning Full Day Tour £313 per adult [](https://expedia.co.uk/things-to-do/guayaquil-cloud-forest.a48063579.activity-details) ![Making hot Chocolate!](https://mediaim.expedia.com/localexpert/1750558/510bf7ee-5365-4f56-b4a2-cb0eec4c6e29.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Cocoa farm and Chocolate making! £113 per adult [](https://expedia.co.uk/things-to-do/cocoa-farm-and-chocolate-making.a1750558.activity-details) [See all activities in Guayaquil](https://expedia.co.uk/things-to-do/search?rid=553248635976397555) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.