Santa Cruz de la Sierra Holidays from £229
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Top Santa Cruz de la Sierra Flight + Hotel Deals
Price found within the past 48 hours. Click for updated prices.
Hotel Exe Moncloa
Chamberí
£229
per person
30 Nov - 3 Dec
found 1 day ago
Return flight included
London (LON) to Madrid (MAD)
8.2/10 Very good! (988 reviews)
Nice property. Across the street from the Moncloa Metro Terminal which made it very convenient for travel.
Room was clean and quiet.
Breakfast in their restaurant was very good but cost 15 euros. It would have been nice if it was included.
Reviewed on 8 Sept 2026
Nômade Temple Madrid
Madrid Centro
£423
per person
4 Dec - 7 Dec
found 1 day ago
Return flight included
London (LGW) to Madrid (MAD)
9.6/10 Exceptional! (80 reviews)
Gorgeous gorgeous gorgeous.
Truly beautiful stay - the staff is so friendly helpful and accommodating. The design is next level, a real treat. Wonderful location for walking around the city.
Reviewed on 13 Sept 2026
Main Street Madrid
Madrid Centro
£439
per person
15 Oct - 19 Oct
found 1 day ago
Return flight included
London (LHR) to Madrid (MAD)
8.6/10 Excellent! (277 reviews)
We loved our stay. It was clean, simple, beautiful, quiet, and just what we needed. Everyone was so kind and helpful! Yay! We definitely recommend! ❤️
Reviewed on 10 Jul 2026
Santa Cruz de la Sierra Essential Information
Language | Spanish |
|---|---|
Currency | Euros |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Population | 310 |
Max Temp Winter | 13ºC |
Max Temp Summer | 32ºC |
Top Sights | Trujillo Castle, Palace of the Dukes of San Carlos and Juan Pizarro de Orellana Palace |
Top hotels in Santa Cruz de la Sierra
Rural house (full rental) El Olivar del Marqués for 26 people
Santa Cruz de la Sierra Cáceres
Hotel Izan Trujillo
Plaza del Campillo, 1 Trujillo Caceres
£77
17 Sept - 18 Sept
includes taxes & fees
8.6/10 Excellent! (216 reviews)
"Nice hotel with a secure room for cycles for those on tour like me. Nice rooms and good facilities. Restaurant is good but also great places to eat on the Plaza."
Reviewed on 25 Aug 2026
Eurostars Palacio Santa Marta
Calle Ballesteros 6 Trujillo Caceres
Fully refundableReserve now, pay when you stay
£68
23 Sept - 24 Sept
includes taxes & fees
9.2/10 Wonderful! (352 reviews)
"We had a wonderful stay at Eurostars Palacio Santa Marta. The hotel is set inside a beautifully restored historic building just steps from Plaza Mayor, making it perfect for exploring Trujillo on foot. Our room was spacious, comfortable, and very quiet. Alba was warm, welcoming, and made everything ..."
Reviewed on 13 Jun 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santa Cruz de la Sierra travel package cost?
Cross off another part of the world with our Santa Cruz de la Sierra travel packages, which start from a low £229. Choose the hotels and flights that match your travel style. Then, add on some sightseeing tours to round off your unique getaway.
If I'm not able to travel, can I cancel my Santa Cruz de la Sierra travel package?
Certainly, and we'll help you every step of the way. You may be able to cancel or change your Santa Cruz de la Sierra travel package for free if you booked in the last 24 hours. But you may incur a fee from your hotel, airline or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, take a look at our Customer Service Portal for more information.
How do I get a cheap travel package to Santa Cruz de la Sierra?
One of the simplest ways to save money (and time) is to combine your bookings with Expedia. Hotels, flights, activities and rental cars — we've got it all. Choose a combination that best fits you and watch your savings pile up. We know a travel package is never one-size-fits-all. That's why we offer over 550 air carriers and 1,000,000 properties across the globe, which lets you customize your Santa Cruz de la Sierra getaway.
Does Expedia offer Book Now, Pay Later Santa Cruz de la Sierra holidays?
We certainly do. Expedia has joined forces with online lender Klarna to help you easily pay for your trip in manageable instalments. Simply choose the payment plan that suits best during the checkout process and take the stress out of budgeting for your trip. Don't forget to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your holiday buck. Check out our flexible payment options below:
- Pay monthly holidays: Make your holiday dreams a reality sooner with Klarna's easy monthly instalment plans. If paying just a small amount each month sounds right for you, pick this option during the checkout process.
- Pay in instalments holidays: If you'd prefer to pay off your escape across multiple transactions, holidays paid in instalments might be right for your Book Now, Pay Later holiday through Klarna.
- Low deposit holidays: Clicking on the "book now" button is easier with this plan. Put down a small deposit on your escape and then start working on your travel plans.
What are the top hotels in Santa Cruz de la Sierra?
Get your escape off to a good start by reserving a room at Hotel Izan Trujillo. It's one of most sought-after properties in Santa Cruz de la Sierra. Another top option is Eurostars Palacio Santa Marta.
How far in advance should I book my Santa Cruz de la Sierra holiday?
To bag rock-bottom prices, book early. Air carriers typically begin selling tickets, along with some of the lowest fares, around 12 months prior to departure. Hotels, experiences and car rental should also be booked well in advance so you can have the pick of the bunch. If you're in need of a last-minute getaway in Santa Cruz de la Sierra, there are always lots of great deals on Expedia. Book your escape today!
What does an Expedia Santa Cruz de la Sierra travel package include?
Packages include hotels, rental cars and flights, but you can mix and match them to create your dream Santa Cruz de la Sierra holiday. You can also add on a few tours and activities once you've made your booking. You're the boss! When you bundle your bookings with Expedia, you'll enjoy deals you won't find anywhere else.
What should I know before booking a Santa Cruz de la Sierra travel package?
We already have low prices. However, you'll score even more savings when you book your hotels, flights and car rentals together. With an Expedia package, you'll always get transparent pricing and tons of choice.
Can I choose my airline with a Santa Cruz de la Sierra Expedia travel package?
Definitely. Expedia has more than 550 airline partners to choose from around the world. With so many choices, finding the right carrier to fly you to Santa Cruz de la Sierra shouldn't be hard.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.
