Santa Cruz de la Sierra Holidays from £332

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    Save up to £750 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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    Packages with flights are ATOL protected

Top Santa Cruz de la Sierra Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Montera Center Madrid

Montera Center Madrid

2 out of 5
Madrid Centro
Save 100% on your flight
Price was £575, price is now £332 per person
£332
per person
24 Sept - 27 Sept
found 21 hours ago
Return flight included
London (LON) to Madrid (MAD)
6.4/10 (42 reviews)
Horrible place, no signs of the name and impossible to check in

Reviewed on 29 Jul 2026

Main Street Madrid

Main Street Madrid

3 out of 5
Madrid Centro
Price was £963, price is now £472 per person
£472
per person
10 Sept - 13 Sept
found 1 day ago
Return flight included
London (LON) to Madrid (MAD)
8.6/10 Excellent! (274 reviews)
We loved our stay. It was clean, simple, beautiful, quiet, and just what we needed. Everyone was so kind and helpful! Yay! We definitely recommend! ❤️

Reviewed on 10 Jul 2026

Hotel Pinar Plaza

Hotel Pinar Plaza

4 out of 5
Ciudad Lineal
Price was £1,922, price is now £1,021 per person
£1,021
per person
10 Sept - 15 Sept
found 17 hours ago
Return flight included
Birmingham (BHX) to Madrid (MAD)
9.6/10 Exceptional! (146 reviews)
:-)

Reviewed on 25 Jul 2026

Hotel Riu Plaza España

Hotel Riu Plaza España

4 out of 5
Madrid Centro
Price was £1,732, price is now £938 per person
£938
per person
10 Oct - 16 Oct
found 21 hours ago
Return direct flight included
Birmingham (BHX) to Madrid (MAD)
9.4/10 Exceptional! (5,044 reviews)

Dorma Casa de los Linajes

Dorma Casa de los Linajes

3 out of 5
Segovia Old Town
Save 100% on your flight
Price was £677, price is now £375 per person
£375
per person
5 Sept - 12 Sept
found 24 hours ago
Return flight included
Birmingham (BHX) to Madrid (MAD)
8.8/10 Excellent! (561 reviews)
A superb small hotel in a quiet, gorgeous location. I would definitely go back

Reviewed on 29 Jul 2026

Santa Cruz de la Sierra Essential Information

Language
Spanish
Currency
Euros
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
310
Max Temp Winter
13ºC
Max Temp Summer
32ºC
Top Sights
Trujillo Castle, Palace of the Dukes of San Carlos and Juan Pizarro de Orellana Palace

Top hotels in Santa Cruz de la Sierra

Rural house (full rental) El Olivar del Marqués for 26 people

Rural house (full rental) El Olivar del Marqués for 26 people

Santa Cruz de la Sierra Cáceres
Get rates
Rural house (full rental) El Olivar del Marqués for 26 people
Parador de Trujillo

Parador de Trujillo

4 out of 5
Santa Beatriz de Silva 1 Trujillo Caceres
Fully refundableReserve now, pay when you stay
The price is £70 per night from 24 Aug to 25 Aug
£70
24 Aug - 25 Aug
includes taxes & fees
9.2/10 Wonderful! (239 reviews)
"Just at the outskirts of the historical center with easy access with a car and a short walk to the attractions, this hotel offers a comfortable and tranquil place to stay. Rooms are generous in size with comfortable beds. Breakfast is generous with cooked to order eggs."

Reviewed on 18 Jun 2026

Parador de Trujillo
Hotel Izan Trujillo

Hotel Izan Trujillo

4 out of 5
Plaza del Campillo, 1 Trujillo Caceres
Fully refundableReserve now, pay when you stay
The price is £65 per night from 18 Aug to 19 Aug
£65
18 Aug - 19 Aug
includes taxes & fees
8.6/10 Excellent! (214 reviews)
"All very good"

Reviewed on 20 Nov 2025

Hotel Izan Trujillo
See all 95 properties in Santa Cruz de la Sierra
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Cruz de la Sierra travel package cost?
Cross off another part of the world with our Santa Cruz de la Sierra travel packages, which start from a low £332. Choose the hotels and flights that match your travel style. Then, add on some sightseeing tours to round off your unique getaway.
If I'm not able to travel, can I cancel my Santa Cruz de la Sierra travel package?
Certainly, and we'll help you every step of the way. You may be able to cancel or change your Santa Cruz de la Sierra travel package for free if you booked in the last 24 hours. But you may incur a fee from your hotel, airline or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, take a look at our Customer Service Portal for more information.
How do I get a cheap travel package to Santa Cruz de la Sierra?
One of the simplest ways to save money (and time) is to combine your bookings with Expedia. Hotels, flights, activities and rental cars — we've got it all. Choose a combination that best fits you and watch your savings pile up. We know a travel package is never one-size-fits-all. That's why we offer over 550 air carriers and 1,000,000 properties across the globe, which lets you customize your Santa Cruz de la Sierra getaway.
Does Expedia offer Book Now, Pay Later Santa Cruz de la Sierra holidays?
We certainly do. Expedia has joined forces with online lender Klarna to help you easily pay for your trip in manageable instalments. Simply choose the payment plan that suits best during the checkout process and take the stress out of budgeting for your trip. Don't forget to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your holiday buck. Check out our flexible payment options below:

  • Pay monthly holidays: Make your holiday dreams a reality sooner with Klarna's easy monthly instalment plans. If paying just a small amount each month sounds right for you, pick this option during the checkout process.
  • Pay in instalments holidays: If you'd prefer to pay off your escape across multiple transactions, holidays paid in instalments might be right for your Book Now, Pay Later holiday through Klarna.
  • Low deposit holidays: Clicking on the "book now" button is easier with this plan. Put down a small deposit on your escape and then start working on your travel plans.

What are the top hotels in Santa Cruz de la Sierra?
Get your escape off to a good start by reserving a room at Hotel Izan Trujillo. It's one of most sought-after properties in Santa Cruz de la Sierra. Another top option is Eurostars Palacio Santa Marta.
How far in advance should I book my Santa Cruz de la Sierra holiday?
To bag rock-bottom prices, book early. Air carriers typically begin selling tickets, along with some of the lowest fares, around 12 months prior to departure. Hotels, experiences and car rental should also be booked well in advance so you can have the pick of the bunch. If you're in need of a last-minute getaway in Santa Cruz de la Sierra, there are always lots of great deals on Expedia. Book your escape today!
What does an Expedia Santa Cruz de la Sierra travel package include?
Packages include hotels, rental cars and flights, but you can mix and match them to create your dream Santa Cruz de la Sierra holiday. You can also add on a few tours and activities once you've made your booking. You're the boss! When you bundle your bookings with Expedia, you'll enjoy deals you won't find anywhere else.
What should I know before booking a Santa Cruz de la Sierra travel package?
We already have low prices. However, you'll score even more savings when you book your hotels, flights and car rentals together. With an Expedia package, you'll always get transparent pricing and tons of choice.
Can I choose my airline with a Santa Cruz de la Sierra Expedia travel package?
Definitely. Expedia has more than 550 airline partners to choose from around the world. With so many choices, finding the right carrier to fly you to Santa Cruz de la Sierra shouldn't be hard.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.