Santa Ana Holidays from £822

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Your Santa Ana Holiday

Come and discover this wonderful city for yourself with a Santa Ana holiday package. Consider spending some time in the neighbourhood of Villa Nueva, which is great for history and culture, and your time here will be nothing short of unforgettable. Every trip to Santa Ana needs a well-planned itinerary. Fill yours with famous sights like Casa Santo Domingo Museum, Central Park and Santa Catalina Arch. Check out Expedia's extensive range of travel options and begin planning your perfect holiday to Santa Ana today.

Price found within the past 48 hours. Click for updated prices.
Good Hotel Guatemala City

Good Hotel Guatemala City

3 out of 5
Zona 4
Price was £954, price is now £822 per person
£822
per person
15 Sept - 19 Sept
found 23 hours ago
Return flight included
London (LON) to Guatemala City (GUA)
9.4/10 Exceptional! (357 reviews)
Its an Exellent Hotel to stay. Staff is professional, friendly and helpful. It has all the needs and more. Im very content with my experience at this hotel.. Only one suggestion;; television.

Reviewed on 13 Jul 2026

Hotel Vista Quince

Hotel Vista Quince

5 out of 5
Zona 15
Price was £1,029, price is now £906 per person
£906
per person
15 Sept - 19 Sept
found 23 hours ago
Return flight included
London (LON) to Guatemala City (GUA)
8.8/10 Excellent! (283 reviews)
Everything was beautiful, service and staff were top tier.

Reviewed on 9 Jul 2026

Hotel Las Americas

Hotel Las Americas

4 out of 5
Zona 13
Price was £933, price is now £830 per person
£830
per person
15 Sept - 19 Sept
found 23 hours ago
Return flight included
London (LON) to Guatemala City (GUA)
8.4/10 Very good! (1,004 reviews)
Very noisy but close to airport. We saw employees swimming with their clothes in the pool. It's really there for decoration only.

Reviewed on 11 Jul 2026

InterContinental Real Guatemala by IHG

InterContinental Real Guatemala by IHG

5 out of 5
Zona 10
Price was £1,095, price is now £974 per person
£974
per person
15 Sept - 19 Sept
found 23 hours ago
Return flight included
London (LON) to Guatemala City (GUA)
9.2/10 Wonderful! (1,000 reviews)

Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center

4.5 out of 5
Zona 11
Price was £965, price is now £867 per person
£867
per person
15 Sept - 19 Sept
found 23 hours ago
Return flight included
London (LON) to Guatemala City (GUA)
9.2/10 Wonderful! (1,008 reviews)
me gustó mucho este hotel sin duda este boy elegir en mi próximo viaje a la cuidad de Guatemala ...el personal exelente sigan así porfabor

Reviewed on 13 Jul 2026

Top hotels in Santa Ana

Barceló Guatemala City

Barceló Guatemala City

4.5 out of 5
7 Avenida 15-45, Zona 9 Guatemala City Guatemala
The price is £91 per night from 28 Jul to 29 Jul
£91
28 Jul - 29 Jul
includes taxes & fees
9.2/10 Wonderful! (3,315 reviews)
"Pretty much my whole stay was excellent. Property was very clean and they always give you great customer service."

Reviewed on 13 Jul 2026

Barceló Guatemala City
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

4.5 out of 5
3a Calle Oriente No 28 A Antigua Guatemala Sacatepequez
Fully refundableReserve now, pay when you stay
The price is £248 per night from 16 Jul to 17 Jul
£248
16 Jul - 17 Jul
includes taxes & fees
9.2/10 Wonderful! (1,081 reviews)
"Gym should improve, too little for the hotel. Spa is great"

Reviewed on 14 Jul 2026

Hotel Museo Spa Casa Santo Domingo
Wyndham Garden Guatemala City

Wyndham Garden Guatemala City

4 out of 5
1a Avenida 12-46 Zona 10 Guatemala City Guatemala
Fully refundableReserve now, pay when you stay
The price is £96 per night from 19 Jul to 20 Jul
£96
19 Jul - 20 Jul
includes taxes & fees
9.2/10 Wonderful! (1,885 reviews)
"Honestly this hotel was so well kept and clean. Very comfortable the staff was helpful and I enjoyed every minute of it with my family and close to everything such a good location. This was a lovely stay."

Reviewed on 13 Jul 2026

Wyndham Garden Guatemala City
See all 1,265 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Ana travel package cost?
We make it simple to travel somewhere new, with Santa Ana packages starting from just £822. You'll have the flexibility to bundle your preferred hotels, airlines and car rental. For the ultimate getaway, why not add some experiences and tours to your itinerary?
If I'm not able to travel, can I cancel my Santa Ana travel package?
It's hard to predict what the future holds, so it's good to know that you can cancel or change your Santa Ana travel package. If you made your booking in the last 24 hours, you may be entitled to a refund. If it's an older booking, your airline, hotel or car rental company may charge a fee. Check our Customer Service Portal for more information.
How do I get a cheap travel package to Santa Ana?
Bundle your flight and hotel bookings, toss in extras such as activities, and save with a Santa Ana holiday package. You won't just score exciting discounts on your trip — you'll have a world of choice within your reach too. When you book through Expedia, you can choose from more than 550 airlines and 1,000,000 properties worldwide. Your next epic adventure begins right here, right now!
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Your bank balance shouldn't get in the way of escaping on holiday, so Expedia has devised a solution to help. Now that we've joined forces with online lender Klarna, it's easier than ever to book a fantastic getaway without drying up your savings. Klarna offers flexible payment options at checkout that take the stress out of budgeting for your trip. Check out these flexible payment options:

  • Pay monthly holidays: Klarna has manageable monthly payment plans that work for all budgets, so you can take that well-earned holiday now.
  • Pay in instalments holidays: Like the idea of paying for your holiday in multiple transactions? Then select this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Clicking the "book now" button is easier with this option. Put down a small deposit on your holiday and then start working on your travel plans.

Where should I stay in Santa Ana?
You'll want to stay where the action is. Many visitors book hotels around popular sights, like La Merced Church, Casa Santo Domingo Museum and Antigua Guatemala Cathedral.
What are the top hotels in Santa Ana?
Hotel Museo Spa Casa Santo Domingo and Hotel Soleil La Antigua are among the most well-known hotels in Santa Ana. Why not look up the rates and amenities at each and then make a decision?
How far in advance should I book my Santa Ana holiday?
The earlier, the better. Air carriers typically advertise flights up to 12 months in advance, and this is your chance to pick up some of the cheapest prices. Just been told you should take some holiday time next month? No need to worry. Expedia are never short on fantastic deals to help you have the getaway of your dreams, at a price you can afford.
What does an Expedia Santa Ana travel package include?
Car rentals, flights and hotels — we connect you to the very best deals. All you'll have to do is decide on your ideal combination. After you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it simple to create an unforgettable Santa Ana trip.
What should I know before booking a Santa Ana travel package?
You'll pick up excellent savings when you combine your hotels, flights and rental cars into a package. Not only that, booking everything in one spot just makes things easier. So why waste time or money? Whether you're putting together a ritzy city getaway or a budget family adventure, have a look at our travel packages today.
Can I choose my airline with a Santa Ana Expedia travel package?
With a travel package, you're the boss. Whether you'd like to fly to Santa Ana in first class or coach, simply select from the available airline options. Expedia has access to over 550 partner airlines across the world.

Things to do

Picture 5 for Activity From Antigua: Pacaya Volcano Trek

From Antigua: Pacaya Volcano Trek

£18
per adult
90% of travellers recommend
From Antigua: Pacaya Volcano Trek
From Antigua: Pacaya Volcano Tour in English/Spanish

From Antigua: Pacaya Volcano Tour in English/Spanish

£17
per adult
80% of travellers recommend
From Antigua: Pacaya Volcano Tour in English/Spanish
Picture 1 for Activity From Antigua: Adventure, 2-Day Hiking to Acatenango Volcano

From Antigua: Adventure, 2-Day Hiking to Acatenango Volcano

£43
per adult
From Antigua: Adventure, 2-Day Hiking to Acatenango Volcano
See all activities in Antigua Guatemala

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.