Santa Ana Holidays

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Your Santa Ana Holiday

Come and discover this wonderful city for yourself with a Santa Ana holiday package. Consider spending some time in the neighbourhood of Villa Nueva, which is great for history and culture, and your time here will be nothing short of unforgettable. Every trip to Santa Ana needs a well-planned itinerary. Fill yours with famous sights like Casa Santo Domingo Museum, Central Park and Santa Catalina Arch. Check out Expedia's extensive range of travel options and begin planning your perfect holiday to Santa Ana today.

Top hotels in Santa Ana

Barceló Guatemala City

Barceló Guatemala City

4.5 out of 5
7 Avenida 15-45, Zona 9, Guatemala City, Guatemala
Fully refundableReserve now, pay when you stay
The price is £64 per night from 10 Aug to 11 Aug
£64
10 Aug - 11 Aug
includes taxes & fees
9/10 Wonderful! (2,940 reviews)
"Food can be better"

Reviewed on 30 Jul 2025

Barceló Guatemala City
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

4.5 out of 5
3a Calle Oriente No 28 A, Antigua Guatemala, Sacatepequez
Fully refundableReserve now, pay when you stay
9.2/10 Wonderful! (1,000 reviews)
"El hotel es uno de los más completos que he visitado en el mundo. Todo muy bueno excepto: El maletero no nos llevo el equipaje a la habitación y que El cuarto no contaba con cafetera"

Reviewed on 29 Jul 2025

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Hotel Museo Spa Casa Santo Domingo
Wyndham Garden Guatemala City

Wyndham Garden Guatemala City

4 out of 5
1a Avenida 12-46 Zona 10, Guatemala City, Guatemala
Fully refundableReserve now, pay when you stay
The price is £88 per night from 1 Aug to 2 Aug
£88
1 Aug - 2 Aug
includes taxes & fees
9/10 Wonderful! (1,488 reviews)
"Very nice and clean property"

Reviewed on 19 Jul 2025

Wyndham Garden Guatemala City
See all 1,127 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Ana travel package cost?
We make it simple to travel somewhere new, with Santa Ana packages starting from just . You'll have the flexibility to bundle your preferred hotels, airlines and car rental. For the ultimate getaway, why not add some experiences and tours to your itinerary?
If I'm not able to travel, can I cancel my Santa Ana travel package?
It's hard to predict what the future holds, so it's good to know that you can cancel or change your Santa Ana travel package. If you made your booking in the last 24 hours, you may be entitled to a refund. If it's an older booking, your airline, hotel or car rental company may charge a fee. Check our Customer Service Portal for more information.
How do I get a cheap travel package to Santa Ana?
Bundle your flight and hotel bookings, toss in extras such as activities, and save with a Santa Ana holiday package. You won't just score exciting discounts on your trip — you'll have a world of choice within your reach too. When you book through Expedia, you can choose from more than 550 airlines and 1,000,000 properties worldwide. Your next epic adventure begins right here, right now!
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Your bank balance shouldn't get in the way of escaping on holiday, so Expedia has devised a solution to help. Now that we've joined forces with online lender Klarna, it's easier than ever to book a fantastic getaway without drying up your savings. Klarna offers flexible payment options at checkout that take the stress out of budgeting for your trip. Check out these flexible payment options:

  • Pay monthly holidays: Klarna has manageable monthly payment plans that work for all budgets, so you can take that well-earned holiday now.
  • Pay in instalments holidays: Like the idea of paying for your holiday in multiple transactions? Then select this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Clicking the "book now" button is easier with this option. Put down a small deposit on your holiday and then start working on your travel plans.

Where should I stay in Santa Ana?
You'll want to stay where the action is. Many visitors book hotels around popular sights, like La Merced Church, Casa Santo Domingo Museum and Antigua Guatemala Cathedral.
What are the top hotels in Santa Ana?
Hotel Museo Spa Casa Santo Domingo and Hotel Soleil La Antigua are among the most well-known hotels in Santa Ana. Why not look up the rates and amenities at each and then make a decision?
How far in advance should I book my Santa Ana holiday?
The earlier, the better. Air carriers typically advertise flights up to 12 months in advance, and this is your chance to pick up some of the cheapest prices. Just been told you should take some holiday time next month? No need to worry. Expedia are never short on fantastic deals to help you have the getaway of your dreams, at a price you can afford.
What does an Expedia Santa Ana travel package include?
Car rentals, flights and hotels — we connect you to the very best deals. All you'll have to do is decide on your ideal combination. After you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it simple to create an unforgettable Santa Ana trip.
What should I know before booking a Santa Ana travel package?
You'll pick up excellent savings when you combine your hotels, flights and rental cars into a package. Not only that, booking everything in one spot just makes things easier. So why waste time or money? Whether you're putting together a ritzy city getaway or a budget family adventure, have a look at our travel packages today.
Can I choose my airline with a Santa Ana Expedia travel package?
With a travel package, you're the boss. Whether you'd like to fly to Santa Ana in first class or coach, simply select from the available airline options. Expedia has access to over 550 partner airlines across the world.

Popular places to visit

Antigua Guatemala Colonial Art Museum

You can study the exhibits at Antigua Guatemala Colonial Art Museum, a museum with a story of its own, during your travels to Antigua Guatemala. Discover the area's volcano viewpoints or seek out its local tours.

Antigua Guatemala Colonial Art Museum

Iglesia y Convento de Santo Domingo

You can learn about the history of Antigua Guatemala with a stop at Iglesia y Convento de Santo Domingo. Discover the area's shops or seek out its local tours.

Iglesia y Convento de Santo Domingo

House of the Giants

You can browse the exhibits at House of the Giants, a museum with a story of its own, during your trip to Antigua Guatemala. Discover the volcano viewpoints and shops in this family-friendly area.

House of the Giants

Things to do

Lake Atitlan One Day Tour from Antigua

Lake Atitlan One Day Tour from Antigua

£68
per adult
96% of travellers recommend
Lake Atitlan One Day Tour from Antigua
From Antigua: Pacaya Volcano Trek

From Antigua: Pacaya Volcano Trek

£17
per adult
86% of travellers recommend
From Antigua: Pacaya Volcano Trek
Tour in Hobbitenango on ATV or UTV

Tour in Hobbitenango on ATV or UTV

£55
per adult
100% of travellers recommend
Tour in Hobbitenango on ATV or UTV
See all activities in Antigua Guatemala

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.