Santa Ana Holidays from £696

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Your Santa Ana Holiday

Come and discover this wonderful city for yourself with a Santa Ana holiday package. Consider spending some time in the neighbourhood of Villa Nueva, which is great for history and culture, and your time here will be nothing short of unforgettable. Every trip to Santa Ana needs a well-planned itinerary. Fill yours with famous sights like Casa Santo Domingo Museum, Central Park and Santa Catalina Arch. Check out Expedia's extensive range of travel options and begin planning your perfect holiday to Santa Ana today.

Price found within the past 48 hours. Click for updated prices.
Hotel Las Americas

Hotel Las Americas

4 out of 5
Zona 13
Price was £773, price is now £696 per person
£696
per person
28 Jun - 1 Jul
found 1 day ago
Return direct flight included
Port of Spain (POS) to Guatemala City (GUA)
8.4/10 Very Good! (1,011 reviews)
The location is amazing. Thngs look very worn. The price seems decent for a hotel with a pool. The pool is more kept up than the rest of the hotel.

Reviewed on 20 Apr 2026

Good Hotel Guatemala City

Good Hotel Guatemala City

3 out of 5
Zona 4
Price was £788, price is now £698 per person
£698
per person
28 Jun - 1 Jul
found 1 day ago
Return direct flight included
Port of Spain (POS) to Guatemala City (GUA)
9.4/10 Exceptional! (317 reviews)
Clean room. Very helpful staff. Supermarket and plenty of restaurants/whiskey bar walking distance . Safe location close to the airport. Bed was very comfortable. The only con - No refrigerator in the room to keep drinks cold.

Reviewed on 17 Apr 2026

Hotel Mayestic

Hotel Mayestic

2.5 out of 5
Zona 9
Price was £2,394, price is now £2,134 per person
£2,134
per person
28 Jun - 1 Jul
found 1 day ago
Return direct flight included
Port of Spain (POS) to Guatemala City (GUA)
No reviews
Adriatika Hotel & Residence

Adriatika Hotel & Residence

4.5 out of 5
Zona 14
Price was £810, price is now £733 per person
£733
per person
28 Jun - 1 Jul
found 1 day ago
Return direct flight included
Port of Spain (POS) to Guatemala City (GUA)
9.4/10 Exceptional! (1,008 reviews)
This hotel is nestled in one of the safest neighborhoods in Guatemala city, being maybe some 3 kilometers from the ore commercial and touristic areas of it. It is still close to some excellent restaurants, high end shopping malls and very close to the airport. Rooms are large, clean and bright. I’d stay here again and again(which i have). Very recommended if your goal is staying in a quiet, yet accessible place.

Reviewed on 18 Apr 2026

Hotel Vista Quince

Hotel Vista Quince

5 out of 5
Zona 15
Price was £831, price is now £755 per person
£755
per person
28 Jun - 1 Jul
found 1 day ago
Return direct flight included
Port of Spain (POS) to Guatemala City (GUA)
8.6/10 Excellent! (254 reviews)
Excellent service. Breakfast was not good. Besides that great stay

Reviewed on 28 Mar 2026

Top hotels in Santa Ana

Casa Buho B&B

Casa Buho B&B

3 out of 5
77 Calle del Agua Antigua Guatemala Guatemala
The price is £59 per night from 24 Apr to 25 Apr
£59
24 Apr - 25 Apr
includes taxes & fees
9.2/10 Wonderful! (51 reviews)
Beautiful hotel with clean rooms and friendly staff. The only downsides are the distance to the center (a 30-minute walk) and the chickens and peacocks screaming early in the morning

Reviewed on 28 Feb 2026

Casa Buho B&B
Barceló Guatemala City

Barceló Guatemala City

4.5 out of 5
7 Avenida 15-45, Zona 9 Guatemala City Guatemala
Fully refundableReserve now, pay when you stay
The price is £99 per night from 13 May to 14 May
£99
13 May - 14 May
includes taxes & fees
9.2/10 Wonderful! (3,300 reviews)
NA

Reviewed on 21 Apr 2026

Barceló Guatemala City
Wyndham Garden Guatemala City

Wyndham Garden Guatemala City

4 out of 5
1a Avenida 12-46 Zona 10 Guatemala City Guatemala
Fully refundableReserve now, pay when you stay
The price is £90 per night from 10 May to 11 May
£90
10 May - 11 May
includes taxes & fees
9.2/10 Wonderful! (1,782 reviews)
Room is clean. Great breakfast.

Reviewed on 21 Apr 2026

Wyndham Garden Guatemala City
See all 1,232 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Ana travel package cost?
We make it simple to travel somewhere new, with Santa Ana packages starting from just £696. You'll have the flexibility to bundle your preferred hotels, airlines and car rental. For the ultimate getaway, why not add some experiences and tours to your itinerary?
If I'm not able to travel, can I cancel my Santa Ana travel package?
It's hard to predict what the future holds, so it's good to know that you can cancel or change your Santa Ana travel package. If you made your booking in the last 24 hours, you may be entitled to a refund. If it's an older booking, your airline, hotel or car rental company may charge a fee. Check our Customer Service Portal for more information.
How do I get a cheap travel package to Santa Ana?
Bundle your flight and hotel bookings, toss in extras such as activities, and save with a Santa Ana holiday package. You won't just score exciting discounts on your trip — you'll have a world of choice within your reach too. When you book through Expedia, you can choose from more than 550 airlines and 1,000,000 properties worldwide. Your next epic adventure begins right here, right now!
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Your bank balance shouldn't get in the way of escaping on holiday, so Expedia has devised a solution to help. Now that we've joined forces with online lender Klarna, it's easier than ever to book a fantastic getaway without drying up your savings. Klarna offers flexible payment options at checkout that take the stress out of budgeting for your trip. Check out these flexible payment options:

  • Pay monthly holidays: Klarna has manageable monthly payment plans that work for all budgets, so you can take that well-earned holiday now.
  • Pay in instalments holidays: Like the idea of paying for your holiday in multiple transactions? Then select this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Clicking the "book now" button is easier with this option. Put down a small deposit on your holiday and then start working on your travel plans.

Where should I stay in Santa Ana?
You'll want to stay where the action is. Many visitors book hotels around popular sights, like La Merced Church, Casa Santo Domingo Museum and Antigua Guatemala Cathedral.
What are the top hotels in Santa Ana?
Hotel Museo Spa Casa Santo Domingo and Hotel Soleil La Antigua are among the most well-known hotels in Santa Ana. Why not look up the rates and amenities at each and then make a decision?
How far in advance should I book my Santa Ana holiday?
The earlier, the better. Air carriers typically advertise flights up to 12 months in advance, and this is your chance to pick up some of the cheapest prices. Just been told you should take some holiday time next month? No need to worry. Expedia are never short on fantastic deals to help you have the getaway of your dreams, at a price you can afford.
What does an Expedia Santa Ana travel package include?
Car rentals, flights and hotels — we connect you to the very best deals. All you'll have to do is decide on your ideal combination. After you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it simple to create an unforgettable Santa Ana trip.
What should I know before booking a Santa Ana travel package?
You'll pick up excellent savings when you combine your hotels, flights and rental cars into a package. Not only that, booking everything in one spot just makes things easier. So why waste time or money? Whether you're putting together a ritzy city getaway or a budget family adventure, have a look at our travel packages today.
Can I choose my airline with a Santa Ana Expedia travel package?
With a travel package, you're the boss. Whether you'd like to fly to Santa Ana in first class or coach, simply select from the available airline options. Expedia has access to over 550 partner airlines across the world.

Popular places to visit

Antigua Guatemala Colonial Art Museum

You can study the exhibits at Antigua Guatemala Colonial Art Museum, a museum with a story of its own, during your travels to Antigua Guatemala. Discover the area's volcano viewpoints or seek out its local tours.

Antigua Guatemala Colonial Art Museum

Iglesia y Convento de Santo Domingo

After visiting Iglesia y Convento de Santo Domingo, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's shops or seek out its local tours.

Iglesia y Convento de Santo Domingo

Tanque La Unión

Explore the great outdoors at Tanque La Unión, a lovely green space in Antigua Guatemala.

Tanque La Unión

Things to do

Picture 5 for Activity From Antigua: Pacaya Volcano Trek

From Antigua: Pacaya Volcano Trek

£18
per adult
90% of travellers recommend
From Antigua: Pacaya Volcano Trek
Antigua: ATV Guided Sunset Tour

Antigua: ATV Guided Sunset Tour

£49
per adult
100% of travellers recommend
Antigua: ATV Guided Sunset Tour
Lake Atitlan One Day Tour from Antigua

Lake Atitlan One Day Tour from Antigua

£68
per adult
86% of travellers recommend
Lake Atitlan One Day Tour from Antigua
See all activities in Antigua Guatemala

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.