Santa Ana Holidays from £364

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    Save up to £750 when you book a flight and hotel together*

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    Packages with flights are ATOL protected

Your Santa Ana Holiday

With a Santa Ana holiday package, say goodbye to endless planning and hello to an effortless adventure. Every detail of your escape has been taken care of before you go, so you can enjoy each moment discovering this awesome city. During your trip to Santa Ana, set aside some time for sightseeing. A popular place to begin is Río Tamuja. Check out Expedia's extensive range of travel options and begin planning your ultimate holiday to Santa Ana now.

Top Santa Ana Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Dorma Casa de los Linajes

Dorma Casa de los Linajes

3 out of 5
Segovia Old Town
Save 100% on your flight
Price was £653, price is now £364 per person
£364
per person
4 Sept - 11 Sept
found 1 day ago
Return flight included
Manchester (MAN) to Madrid (MAD)
8.8/10 Excellent! (551 reviews)
Excellent parking nice staff clean throughout

Reviewed on 19 Jun 2026

Main Street Madrid

Main Street Madrid

3 out of 5
Madrid Centro
Price was £1,047, price is now £488 per person
£488
per person
8 Sept - 12 Sept
found 16 hours ago
Return flight included
Manchester (MAN) to Madrid (MAD)
8.6/10 Excellent! (267 reviews)
Excellent for a brief stay, we needed 1 night in Madrid and this was perfect, VERY central and nice and clean and quiet. The lady that showed us round was absolutely lovely and couldn't have been more helpful.

Reviewed on 29 Jun 2026

Hotel Atlantico Madrid

Hotel Atlantico Madrid

4 out of 5
Madrid Centro
Save 100% on your flight
Price was £786, price is now £428 per person
£428
per person
20 Aug - 25 Aug
found 1 day ago
Return flight included
Birmingham (BHX) to Madrid (MAD)
9.8/10 Exceptional! (2,200 reviews)
Very spacious and comfortable room on one of the main streets in Madrid…easy to get around the city. Highly recommend this hotel.

Reviewed on 30 Jun 2026

Hotel Riu Plaza España

Hotel Riu Plaza España

4 out of 5
Madrid Centro
Save 100% on your flight
Price was £887, price is now £500 per person
£500
per person
20 Aug - 25 Aug
found 1 day ago
Return flight included
Birmingham (BHX) to Madrid (MAD)
9.4/10 Exceptional! (4,987 reviews)
Best rooftop of Madrid!!!

Reviewed on 3 Jul 2026

Aerotel Madrid Airport - Terminal 4

Aerotel Madrid Airport - Terminal 4

3.5 out of 5
Barajas
Price was £896, price is now £505 per person
£505
per person
19 Sept - 23 Sept
found 1 day ago
Return flight included
Birmingham (BHX) to Madrid (MAD)
7.8/10 Good! (83 reviews)

Santa Ana Essential Information

Language
Spanish
Currency
Euros
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
330
Max Temp Winter
13ºC
Max Temp Summer
32ºC
Top Sights
Trujillo Castle, Palace of the Dukes of San Carlos and Juan Pizarro de Orellana Palace

Top hotels in Santa Ana

Eurostars Palacio Santa Marta

Eurostars Palacio Santa Marta

4 out of 5
Calle Ballesteros 6 Trujillo Caceres
Fully refundableReserve now, pay when you stay
The price is £68 per night from 12 Jul to 13 Jul
£68
12 Jul - 13 Jul
includes taxes & fees
9.2/10 Wonderful! (348 reviews)
"We had a wonderful stay at Eurostars Palacio Santa Marta. The hotel is set inside a beautifully restored historic building just steps from Plaza Mayor, making it perfect for exploring Trujillo on foot. Our room was spacious, comfortable, and very quiet. Alba was warm, welcoming, and made everything ..."

Reviewed on 13 Jun 2026

Eurostars Palacio Santa Marta
Parador de Trujillo

Parador de Trujillo

4 out of 5
Santa Beatriz de Silva 1 Trujillo Caceres
Fully refundableReserve now, pay when you stay
The price is £77 per night from 28 Jul to 29 Jul
£77
28 Jul - 29 Jul
includes taxes & fees
9.2/10 Wonderful! (238 reviews)
"Just at the outskirts of the historical center with easy access with a car and a short walk to the attractions, this hotel offers a comfortable and tranquil place to stay. Rooms are generous in size with comfortable beds. Breakfast is generous with cooked to order eggs."

Reviewed on 18 Jun 2026

Parador de Trujillo
Hotel Izan Trujillo

Hotel Izan Trujillo

4 out of 5
Plaza del Campillo, 1 Trujillo Caceres
8.6/10 Excellent! (213 reviews)
"All very good"

Reviewed on 20 Nov 2025

Get rates
Hotel Izan Trujillo
See all 102 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Ana travel package cost?
Our Santa Ana packages, which start at just £364, are an awesome way to save precious money. Choose your favourite hotels, flights and rental car to create your ideal getaway.
If I'm not able to travel, can I cancel my Santa Ana travel package?
We totally understand — life sometimes gets in the way of your plans. If you've booked a Santa Ana travel package and need to cancel or change it, we can help. It's always worth taking a look at our Customer Service Portal first for information. But in general, if you've booked your package within 24 hours, you may be able to change your itinerary for free. If it's been more than 24 hours, your hotel, airline or car rental company may impose a fee.
How do I get a cheap travel package to Santa Ana?
Track down flights that fit in with your schedule, add a hotel to your booking and watch how much you save with a Santa Ana travel package. It's as easy as that! From hotels and flights to rental cars and activities, Expedia makes travelling cheaply a cinch. And with more than 550 partner airlines and 1,000,000 properties around the globe to select from, you won't be short of choice.
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Yes. Expedia has joined forces with online lender Klarna to help you easily pay for your trip in instalments. Simply click on the payment plan best suited to your needs during checkout and take the stress out of budgeting for your next trip. Remember to bundle your flights, accommodation and activities with Expedia to get the biggest bang for your buck. Browse our flexible payment options below:

  • Pay monthly holidays: Jet off on that dream holiday sooner with Klarna's easy monthly instalment plans. If paying bite-sized amounts each month sounds right for you, choose this option during the checkout process.
  • Pay in instalments holidays: With this Book Now, Pay Later option, Klarna allows you to pay off your trip in multiple transactions.
  • Low deposit holidays: When you want to jump on an amazing deal but your budget doesn't quite cover it yet, Klarna's low deposit holiday plan will help you get what you want.

What are the top hotels in Santa Ana?
Get your holiday off to a flying start by booking a stay at Gran Hotel Don Manuel. It's one of most sought-after hotels in Santa Ana. Another comfortable option is NH Collection Cáceres Palacio de Oquendo.
How far in advance should I book my Santa Ana holiday?
You'll be rewarded with the biggest variety and the cheapest prices by booking your Santa Ana holiday nice and early. Air carriers typically publish flight tickets around 12 months prior to departure, so start your planning as soon as possible. That being said, Expedia is dedicated to giving you the best bargains around, so it's never a bad time to book your dream holiday!
What does an Expedia Santa Ana travel package include?
Much of that depends on you. You can select from a range of Santa Ana bundles, such as a rental car, flight and hotel. You can also book a flight and a hotel, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like activities and experiences. Whatever your perfect Santa Ana break looks like, you'll save!
What should I know before booking a Santa Ana travel package?
Locking in all the parts of your escape together is a great way to save. Bundle your car rentals, flights and hotels into a tidy little package. But you're not restricted to hotels. Expedia has all sorts of properties, including holiday rentals such as beachfront villas and city residences. The list goes on!
Can I choose my airline with a Santa Ana Expedia travel package?
You can, and with more than 550 airlines to choose from all over the world, it's all about choice. Browse the available options and see which airline suits your budget and needs.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.