Sanibel Isles Holidays from £1,271

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Your Sanibel Isles Holiday

Lock in your holiday package to Sanibel Isles and get ready to experience its views and more. Whether you're craving fun or adventure, it's all waiting for you in this appealing neighbourhood. Not sure what to see and do during your trip to Sanibel Isles? Nearby attractions like Sanibel Island Southern Beach, Sanibel Island Lighthouse and Periwinkle Way are good places to begin. No matter what your ideal Sanibel Isles holiday may look like, you can make it a reality with Expedia.

Price found within the past 48 hours. Click for updated prices.
Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3 out of 5
Price was £1,633, price is now £1,271 per person
£1,271
per person
22 May - 29 May
found 12 hours ago
Return direct flight included
London (LHR) to Fort Myers (RSW)
9.4/10 Exceptional! (1,008 reviews)
Would stay here every time we come to Ft Myers! Loved everything about it. Much happier here than in a huge corporate hotel!

Reviewed on 9 Apr 2026

South Seas

South Seas

3.5 out of 5
Price was £2,527, price is now £1,934 per person
£1,934
per person
22 May - 29 May
found 12 hours ago
Return direct flight included
London (LHR) to Fort Myers (RSW)
8.4/10 Very Good! (1,001 reviews)
Website is deceiving, this is not a resort like advertised. It is individually owned places managed by a resort. You have to come prepared with food and water. Getting towels at pools by the condos were a constant problem. The views were beautiful and lots of great wildlife to enjoy watching.

Reviewed on 4 Apr 2026

Sanibel Inn

Sanibel Inn

3 out of 5
East End
Price was £2,365, price is now £1,880 per person
£1,880
per person
22 May - 29 May
found 12 hours ago
Return direct flight included
London (LHR) to Fort Myers (RSW)
9.2/10 Wonderful! (1,006 reviews)
Room was very clean and ready a little early. Property is close to town and we biked everywhere. Would stay here again for sure!

Reviewed on 8 Apr 2026

Waterfront Pink House With Private Dock Pool

Waterfront Pink House With Private Dock Pool

2 out of 5
Save 100% on your flight
Price was £4,363, price is now £3,510 per person
£3,510
per person
22 May - 29 May
found 12 hours ago
Return direct flight included
London (LHR) to Fort Myers (RSW)
No reviews
Casa Ybel Resort

Casa Ybel Resort

2.5 out of 5
Mid Island
Price was £2,207, price is now £1,783 per person
£1,783
per person
22 May - 29 May
found 12 hours ago
Return direct flight included
London (LHR) to Fort Myers (RSW)
8.8/10 Excellent! (320 reviews)
Nice, quiet, friendly. Spacious unit and pretty beach and pool.

Reviewed on 8 Apr 2026

Where to stay in Sanibel Isles

Find the best Sanibel Isles areas and neighborhoods for the activities you enjoy most. Learn more about Sanibel Isles
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Mid Island

2 out of top 10 points of interest in this area

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

Find hotels in Mid Island

Top hotels in Sanibel Isles

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 out of 5
1538 Cape Coral Pkwy E Cape Coral FL
Fully refundableReserve now, pay when you stay
The price is £81 per night from 30 Apr to 1 May
£81
30 Apr - 1 May
includes taxes & fees
9.2/10 Wonderful! (1,382 reviews)
Very clean room, staff so friendly and amazing, breakfast also plenty of and excellent, parking easy and convenient and location to everything.

Reviewed on 9 Apr 2026

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
The price is £216 per night from 11 May to 12 May
£216
11 May - 12 May
includes taxes & fees
9/10 Wonderful! (2,000 reviews)
Yes

Reviewed on 9 Apr 2026

Margaritaville Beach Resort Fort Myers
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3 out of 5
1231 Middle Gulf Dr Sanibel FL
Fully refundableReserve now, pay when you stay
The price is £211 per night from 3 May to 4 May
£211
3 May - 4 May
includes taxes & fees
9.2/10 Wonderful! (1,763 reviews)
Last minute decision to go to Sanibel and was pleasantly surprised to find available at such a great resort! Updated rooms, great pool and bar, beach front and lunge chairs and hammocks! Would definitely recommend!

Reviewed on 10 Apr 2026

Sanibel Island Beach Resort
See all 15,519 properties in Sanibel Isles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Family Friendly Holidays

Frequently asked questions

How much does a Sanibel Isles travel package cost?
From as little as £1,271. Yes, you read that right. Our Sanibel Isles travel packages are an awesome way to stretch your budget further. Bundle your hotels, flights and rental car and get out and explore this fabulous destination.
If I'm not able to travel, can I cancel my Sanibel Isles travel package?
If your travel plans in Sanibel Isles have been upended, it's comforting to know that you can cancel your booking. If your booking was made in the last 24 hours, you may be eligible to receive a refund. If your booking was made more than 24 hours ago, your hotel, airline or car rental company may charge fees. To learn more, visit our Customer Service Portal.
How do I get a cheap travel package to Sanibel Isles?
Crafting your own Sanibel Isles travel package with Expedia is the easiest way to save. We offer more than 550 airlines and 1,000,000 hotels spread across the globe. With such a fantastic range to choose from, you'll have no trouble pulling together your next dream escape.
Does Expedia offer Book Now, Pay Later Sanibel Isles holidays?
Good news! We do. Expedia has teamed up with online lender Klarna to help you easily pay for your trip in instalments. Simply click on the payment plan best suited to your needs during checkout and take away the stress of budgeting for your next trip. Remember to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your travel buck. Check out our flexible payment options below:

  • Pay monthly holidays: If paying bite-sized amounts each month works for you, Klarna offers just that! Paying in convenient monthly instalments will make your holiday dreams possible.
  • Pay in instalments holidays: If you'd like to pay for your getaway in multiple transactions, holidays paid in instalments might be right for your Book Now, Pay Later holiday through Klarna.
  • Low deposit holidays: Hitting the "book now" button is much easier with this payment plan. Put down a small deposit on your booking and then start working on your travel plans.

Where should I stay in Sanibel Isles?
With loads to explore in Sanibel Isles, it'd be handy for you to lock in a hotel near its attractions. Sanibel Island Lighthouse, Sanibel Island Golf Club and Sanibel Moorings Botanical Gardens are some fascinating ones to put on your itinerary.
What are the top hotels in Sanibel Isles?
Get your trip off to an excellent start by locking in a room at Sundial Beach Resort And Spa. It's one of most sought-after hotels in Sanibel Isles. Another welcoming option is Sanibel Island Beach Resort.
How far in advance should I book my Sanibel Isles holiday?
While not all airlines advertise ticket prices early, it's usually possible to compare international flights on Expedia up to a year in advance. This is the time you can bag some incredible deals. If you're purchasing tickets last minute, you might still be in luck. Low prices sometimes appear just weeks prior to departure.
What does an Expedia Sanibel Isles travel package include?
That depends on what you want. If you're travelling solo, you might decide to combine flights and hotels. Taking the whole family to Sanibel Isles? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the freedom to customize your travel package.
What should I know before booking a Sanibel Isles travel package?
We already have low prices. However, you'll snap up even more savings if you book your hotels, flights and car rentals together. With an Expedia package, you'll always get transparent pricing and lots of choice.
Can I choose my airline with a Sanibel Isles Expedia travel package?
Yes, you sure can. We have more than 550 airline partners all over the world, so go with the carrier that suits your travel preferences.

Popular places to visit

Sanibel Island Lighthouse

Sanibel Island Lighthouse

You can find out about the history of Sanibel with a trip to Sanibel Island Lighthouse. Wander through the beautiful beaches and seaside in this family-friendly area.

Sanibel Island Lighthouse
Causeway Islands Park B

Causeway Islands Park B

If a restful holiday is part of your travel plans, Causeway Islands Park B might be the perfect place to visit during your trip to Sanibel. Wander the seaside or discover the beautiful sunsets in this family-friendly area.

Causeway Islands Park B

Sanibel Island Golf Club

Enjoy a round of golf in Sanibel at Sanibel Island Golf Club. Stroll along the seaside in this family-friendly area or visit its lively bars.

Sanibel Island Golf Club

Things to do

Southwest Florida Sunset Sail

Southwest Florida Sunset Sail

£52
per adult
100% of travellers recommend
Southwest Florida Sunset Sail
Dolphin Wildlife Cruise Fort Myers Beach

Dolphin Wildlife Cruise Fort Myers Beach

£48
per adult
Dolphin Wildlife Cruise Fort Myers Beach
Copacetic Day Sail

Copacetic Day Sail

£52
per adult
100% of travellers recommend
Copacetic Day Sail
See all activities in Sanibel

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.