Sanctuary Holidays from £1,244

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Your Sanctuary Holiday

Whatever your style of travel, you can discover it all with a tailor-made Sanctuary holiday package. Spend your break enjoying this neighbourhood's golfing and its other charms. Kick off your trip to Sanctuary by checking out nearby attractions such as Bowmans Beach, Turner Beach and Blind Pass Beach. Don't just imagine it — make it a reality! Book your ideal Sanctuary holiday with Expedia and enjoy travelling your way.

Price found within the past 48 hours. Click for updated prices.
The Perry Hotel Naples

The Perry Hotel Naples

4.5 out of 5
Price was £1,825, price is now £1,244 per person
£1,244
per person
22 May - 29 May
found 1 day ago
Return direct flight included
London (LHR) to Fort Myers (RSW)
9.6/10 Exceptional! (725 reviews)
Kev and bellmen Jon gave my family and I so much kindness and compassion during my stay and I will be forever grateful to them and all the staff at this property

Reviewed on 11 Apr 2026

South Seas

South Seas

3.5 out of 5
Price was £2,527, price is now £1,934 per person
£1,934
per person
22 May - 29 May
found 1 day ago
Return direct flight included
London (LHR) to Fort Myers (RSW)
8.4/10 Very Good! (1,001 reviews)
On site dining was just average. But price was high. The resort was very nice and had a very nice beach area and the pools were great as well. If you like seclusion. It’s a good place to go.

Reviewed on 10 Apr 2026

Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3 out of 5
Price was £1,633, price is now £1,271 per person
£1,271
per person
22 May - 29 May
found 1 day ago
Return direct flight included
London (LHR) to Fort Myers (RSW)
9.4/10 Exceptional! (1,008 reviews)
Bar was priced way to high as were most bars on fort myer beach.

Reviewed on 10 Apr 2026

Sanibel Inn

Sanibel Inn

3 out of 5
East End
Price was £2,365, price is now £1,880 per person
£1,880
per person
22 May - 29 May
found 1 day ago
Return direct flight included
London (LHR) to Fort Myers (RSW)
9.2/10 Wonderful! (1,006 reviews)
The Sanibel Inn was absolutely amazing! My wife and i went here to celebrate our 20th Anniversary and from the time we booked the staff was amazing! Once we arrived they checked in on us regularly to make sure we had everything we needed! Our room was completely updated and very clean,had all of the amenities, free coffee, coffee machine, toaster , plates, bowls, cups, and silverware. The Sanibel inn has literally everything u could want, stunning landscaping on the entire property, every room has great views of the pool area or the gulf or of both! The beach is very private and they provide beach lounge chairs and umbrellas! They have a tiki bar with full food menu and play music all day at the pool. They have corn hole boards, pickleball courts, free bikes to ride, they provide all of the pool and beach towels, they 4 built in grills for all to use, firepits to hang out by. They also have Dantes Italian kitchen on site which is a very nice restaraunt with great food. I literally cant say enough great things about the Sanibel Inn, they made us feel very welcome and we would reccomend to book a stay at the Sanibel Inn to any of our friends, family and to all of you trying to find a place in Sanibel! You will be happy that you did!

Reviewed on 10 Apr 2026

Waterfront Pink House With Private Dock Pool

Waterfront Pink House With Private Dock Pool

2 out of 5
Save 100% on your flight
Price was £4,363, price is now £3,510 per person
£3,510
per person
22 May - 29 May
found 1 day ago
Return direct flight included
London (LHR) to Fort Myers (RSW)
No reviews

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most. Learn more about Sanctuary
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Mid Island

2 out of top 10 points of interest in this area

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

Find hotels in Mid Island

Top hotels in Sanctuary

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 out of 5
1538 Cape Coral Pkwy E Cape Coral FL
Fully refundableReserve now, pay when you stay
The price is £80 per night from 11 May to 12 May
£80
11 May - 12 May
includes taxes & fees
9.2/10 Wonderful! (1,386 reviews)
Room was neat, clean and tidy. Staff was friendly, breakfast was good and filling. Able to park easily.

Reviewed on 11 Apr 2026

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
9/10 Wonderful! (2,003 reviews)
Beautiful beach, clean hotel, friendly staff, felt like a little too long distances to walk and multiple levels to go up and down between the road that splits the property and safety layout. Totally understandable, but could be annoying for people with strollers or handicapped.

Reviewed on 11 Apr 2026

Get rates
Margaritaville Beach Resort Fort Myers
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3 out of 5
1231 Middle Gulf Dr Sanibel FL
Fully refundableReserve now, pay when you stay
The price is £299 per night from 19 Apr to 20 Apr
£299
19 Apr - 20 Apr
includes taxes & fees
9.2/10 Wonderful! (1,769 reviews)
Great place to vacation! The beach was so close we could just stroll to it everyday. The staff was very amenable and prompt. The property is slightly old but rooms were clean and quiet. We got our best sleep in a long time! Thanks folks!

Reviewed on 10 Apr 2026

Sanibel Island Beach Resort
See all 13,089 properties in Sanctuary
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a Sanctuary travel package cost?
Discover the best of Sanctuary from as low as £1,244. Choose from a great selection of flights, rental cars and hotels to suit your travel style. You can score even better deals when you add a few tours or activities to your package.
If I'm not able to travel, can I cancel my Sanctuary travel package?
Your situation can change suddenly, so yes. You may be able to change or cancel your Sanctuary travel package for free if you've booked in the last 24 hours. For bookings older than that, you can still cancel or make changes, but your car rental company, airline or hotel may impose a fee. Need more information? Look up our Customer Service Portal. We're here to help make sure your trip goes off without a hitch.
How do I get a cheap travel package to Sanctuary?
Bundle your hotels and flights with Expedia to save big on your next trip. With over 550 partner airlines and 1,000,000 hotels throughout the world, your Sanctuary travel package can be customized exactly to suit your budget. With all that extra cash, why not throw in some exciting activities and tours? It's an easy way to unlock even more bargains. That holiday you've always dreamed of in Sanctuary is much closer than you thought!
Does Expedia offer Book Now, Pay Later Sanctuary holidays?
Expedia has partnered with online lender Klarna to make your next getaway easier on your budget. Paying in instalments means you can spread the costs of your next dream escape, leaving you with more cash to play with while you're away. Klarna has several payment plans to pick from, so you're sure to find one that fits your budget. Consider these flexible payment options:

  • Pay monthly holidays: Klarna has convenient monthly payment plans that fit all budgets, so you can book that well-deserved holiday sooner.
  • Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: When you want to jump on an awesome deal but your budget doesn't quite go that far, Klarna's low deposit holiday plan will help you get what you want.

Where should I stay in Sanctuary?
With interesting attractions like Bowmans Beach and Sanibel Island Southern Beach in this neighbourhood, try to find a hotel near them. Castaways Marina is another sight in Sanctuary that draws the crowds.
What are the top hotels in Sanctuary?
Lock in a room at Sundial Beach Resort And Spa. It's one of this neighbourhood's most popular hotels. Another top-rated option in Sanctuary is Sanibel Island Beach Resort.
How far in advance should I book my Sanctuary holiday?
It can be hard to know when the best time is to book your Sanctuary holiday. But generally the earlier you book, the more affordable the prices. Sometimes, you can book your flights and hotels up to a year before departure. If you're eager to escape on a last-minute getaway, no need to stress! There are unbeatable deals posted on Expedia every single day.
What does an Expedia Sanctuary travel package include?
Flights, hotels and car rentals — we bring you the best deals. All you have to do is pick your ideal combination. After you've made your booking, you can add on the fun stuff like experiences and tours. Our travel packages make it easy to put together an exciting Sanctuary holiday.
What should I know before booking a Sanctuary travel package?
Bundling your bookings into a Sanctuary travel package is the most convenient way to organise your trip. Not only that, you'll save big when you combine your flights, hotels and car rentals. Once you've booked, why not add on an activity or a tour?
Can I choose my airline with a Sanctuary Expedia travel package?
Yes, you're in control. We have access to over 550 airlines throughout the world, so you can tailor your Sanctuary holiday according to your needs and budget.

Popular places to visit

Sanibel Island Lighthouse

Sanibel Island Lighthouse

4/5(23 reviews)

You can find out about the history of Sanibel with a trip to Sanibel Island Lighthouse. Wander through the beautiful beaches and seaside in this family-friendly area.

Sanibel Island Lighthouse
Causeway Islands Park B

Causeway Islands Park B

If a restful holiday is part of your travel plans, Causeway Islands Park B might be the perfect place to visit during your trip to Sanibel. Wander the seaside or discover the beautiful sunsets in this family-friendly area.

Causeway Islands Park B

Sanibel Island Golf Club

Enjoy a round of golf in Sanibel at Sanibel Island Golf Club. Stroll along the seaside in this family-friendly area or visit its lively bars.

Sanibel Island Golf Club

Things to do

Southwest Florida Sunset Sail

Southwest Florida Sunset Sail

£52
per adult
100% of travellers recommend
Southwest Florida Sunset Sail
Dolphin Wildlife Cruise Fort Myers Beach

Dolphin Wildlife Cruise Fort Myers Beach

£48
per adult
Dolphin Wildlife Cruise Fort Myers Beach
Copacetic Day Sail

Copacetic Day Sail

£52
per adult
100% of travellers recommend
Copacetic Day Sail
See all activities in Sanibel

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.