Panama Holidays from £1,071

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    Save up to £750 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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    Packages with flights are ATOL protected

Top Panama Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was £1,247, price is now £1,071 per person
£1,071
per person
7 Sept - 12 Sept
found 1 day ago
Return flight included
London (LGW) to St. Louis (STL)
8.8/10 Excellent! (1,061 reviews)
Nice staff and nice hotel

Reviewed on 13 Jul 2026

The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
Central West End
Price was £1,362, price is now £1,136 per person
£1,136
per person
7 Sept - 12 Sept
found 1 day ago
Return flight included
London (LGW) to St. Louis (STL)
9/10 Wonderful! (1,011 reviews)
We loved our stay at the Royal Sonesta, we can't wait to visit again

Reviewed on 13 Jul 2026

Moonrise Hotel

Moonrise Hotel

4 out of 5
Delmar Loop
Price was £1,307, price is now £1,096 per person
£1,096
per person
7 Sept - 12 Sept
found 1 day ago
Return flight included
London (LGW) to St. Louis (STL)
9/10 Wonderful! (1,984 reviews)
.

Reviewed on 10 Jul 2026

The Cheshire

The Cheshire

4 out of 5
Price was £1,258, price is now £1,074 per person
£1,074
per person
7 Sept - 12 Sept
found 1 day ago
Return flight included
London (LGW) to St. Louis (STL)
8.8/10 Excellent! (1,001 reviews)
A majority of the staff was friendly and helpful. Love the literary themes. Had a great stay and would definitely visit again.

Reviewed on 12 Jul 2026

Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch

4 out of 5
Downtown St. Louis
Price was £1,301, price is now £1,127 per person
£1,127
per person
7 Sept - 12 Sept
found 1 day ago
Return flight included
London (LGW) to St. Louis (STL)
8.8/10 Excellent! (1,096 reviews)
Not much good to say other than location to Busch stadium. Carpets were dirty, room was dirty. Anything you wanted was extra. Paid to park and if you wanted breakfast it was extra. Since it was game night the rooms were sky high! Staff was just ho hum. If you can find somewhere else.

Reviewed on 13 Jul 2026

Panama Essential Information

Language
English
Currency
U.S dollars
Max Temp Winter
4ºC
Max Temp Summer
27ºC

Top hotels in Panama

Baymont by Wyndham Litchfield

Baymont by Wyndham Litchfield

2.5 out of 5
1405 W Hudson Dr Litchfield IL
Fully refundableReserve now, pay when you stay
The price is £81 per night from 25 Jul to 26 Jul
£81
25 Jul - 26 Jul
includes taxes & fees
8.2/10 Very good! (1,008 reviews)
"Staff was so nice and place was clean love the place will definitely stay again"

Reviewed on 12 Jul 2026

Baymont by Wyndham Litchfield
Holiday Inn Express & Suites Litchfield West by IHG

Holiday Inn Express & Suites Litchfield West by IHG

2.5 out of 5
4 Thunderbird Circle Litchfield IL
Fully refundable
The price is £94 per night from 21 Jul to 22 Jul
£94
21 Jul - 22 Jul
includes taxes & fees
9.4/10 Exceptional! (638 reviews)
"Great room"

Reviewed on 11 Jul 2026

Holiday Inn Express & Suites Litchfield West by IHG
Comfort Inn & Suites Greenville I-70

Comfort Inn & Suites Greenville I-70

2.5 out of 5
2265 S. State Route 127 Greenville IL
Fully refundable
The price is £90 per night from 19 Jul to 20 Jul
£90
19 Jul - 20 Jul
includes taxes & fees
8.4/10 Very good! (451 reviews)
"Breakfast was good. Well stocked and appetizing."

Reviewed on 2 Jul 2026

Comfort Inn & Suites Greenville I-70
See all 47 properties in Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Panama travel package cost?
From as low as £1,071. Yes, you read that correctly. Our Panama packages are a simple way to make your dollar go further. Combine your favourite hotels, flights and rental car and explore this lively destination.
If I'm not able to travel, can I cancel my Panama travel package?
It's good to know that you can cancel your Panama booking if your plans have changed. Whether you'll incur a fee or not depends on your hotel, airline or car rental company. You may be able to cancel or change your booking for free if you booked in the last 24 hours. Head to our Customer Service Portal to learn more.
How do I get a cheap travel package to Panama?
One of the simplest ways to save money (and time) is to bundle your bookings with Expedia. Flights, rental cars, hotels and activities — we've got them all covered. Pick and choose the combination that suits your style and watch your savings pile up. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 partner airlines and 1,000,000 hotels around the globe, which lets you customize your Panama holiday.
Does Expedia offer Book Now, Pay Later Panama holidays?
Your bank balance shouldn't get in the way of taking a holiday, so Expedia has come up with a solution to help. Thanks to our partnership with online lender Klarna, it's easier than ever to book an incredible getaway without using up all your savings. Klarna offers flexible payment options during the checkout process that take the worry out of budgeting for your escape. Consider one of these flexible payment options:

  • Pay monthly holidays: Make your holiday dreams a reality sooner with Klarna's manageable monthly instalment plans. If paying just a little each month sounds right for you, choose this option at checkout.
  • Pay in instalments holidays: With this Book Now, Pay Later option, Klarna makes it possible to pay off your trip over multiple transactions.
  • Low deposit holidays: Clicking on the "book now" button is much easier with this payment plan. Simply put down a small deposit on your escape and then start packing your suitcase.

What are the top hotels in Panama?
Get your escape off to a flying start by reserving a room at Baymont by Wyndham Litchfield. It's one of most sought-after properties in Panama. Another cosy option is Holiday Inn Express & Suites Litchfield West, an IHG Hotel.
How far in advance should I book my Panama holiday?
It's difficult to pick the best time for airfares, but we usually say the earlier, the better. Most international flights on Expedia become available up to 12 months in advance. If you can't book early, don't fret. Low prices occasionally appear just weeks before departure dates.
What does an Expedia Panama travel package include?
Flights, rental cars and hotels — we've got them covered. With Expedia, you can create your Panama package the way you like it. All you have to do is work out just what you need. Once you've made your booking, you can add extras like activities and tours. The more you bundle, the more you save!
What should I know before booking a Panama travel package?
Whether it's adventure or relaxation you're chasing, a Panama travel package lets you plan your escape your way. Plus, you'll get access to great discounts when you combine your hotel with your rental car and flights. The more you bundle, the bigger the savings!
Can I choose my airline with a Panama Expedia travel package?
With a travel package, you're the boss. Whether you want to fly to Panama in economy or business class, simply pick from the available airline options. Expedia has access to more than 550 airline partners worldwide.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.