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Santiago, the nation's capital, can be found roughly 30 miles to the north of Paine.
Thinking about stopping by the Monticello Grand Casino and Convention Centre? It's the perfect place to blow off some steam are a long day of travelling.
Why don't you check out two of the most visited stretches of coastline? Isla Negra Beach, 60 miles to the northwest, and Rocas de Santo Domingo Beach, 50 miles to the west, are top picks.
Spend a day relaxing amid the splendour of the region's nature reserves. Some nearby locations are San Cristobal Hill (30 miles away) and Santa Lucia Hill (30 miles away).
Sports fans should make the trip to see the Colo-Colo play a home game at Estadio Monumental David Arellano. It's in Santiago, 25 miles north of Paine. Be sure to wear red, white and black, the team colors.
Avid skiers will be thrilled to hear that there are several ski resorts within driving distance, including Valle Nevado Ski Resort and La Parva Ski Resort.
Thermas Internacional and the Santa Rita Winery are just some of the interesting places in Buin, a locality 8 miles from Paine. Alternatively, you should have a look at the Viña Undurraga and the Viña de Martino in Talagante. This destination rests 14 miles out of Paine.
You should head to El Quisco. It's approximately 60 miles northwest of Paine and it contains some fantastic visitor attractions, including Isla Negra House, the Pablo Neruda Museum and Canelo Beach. If you're after more, some other good options are Penguin Island and Pablo Neruda's House.
Be sure to take your taste buds on an exciting adventure through the rich culinary traditions of Santiago.
It's possible you haven't thought a lot about the intricacies of shellfish and quinoa in the past, but you're sure to be an expert on these characteristic ingredients by the end of the trip!
Dine like the local residents do by trying porotos con riendas (bean and pasta soup) and pastel de choclo (corn and meat pie).
Arouse your sweet tooth with some arroz con leche (rice pudding), a truly tempting dessert.
Relax with an Austral Pale Ale, a much-loved beer.
Whether you prefer red, white or anything in between, wine is a wonderful beverage to accompany a tasty meal. Try the regional favorites, Colchagua Valley Malbec and Casablanca Valley Carmenere.
After you have spent your last Chilean pesos and it's time to depart, remember to say a last Adiós to Paine.
Once you're ready to catch your flight, keep in mind that the nearest airport is 30 miles to the north.
Situated in Rancagua, this hotel is 1.6 mi (2.5 km) from Estadio El Teniente and within 16 miles (25 km) of Mostazal Square and Saint Francis of Assisi Church. Reserva Nacional Rio de los Cipreses is 24.7 mi (39.8 km) away.
Situated in Mostazal, this spa resort is 5.4 mi (8.6 km) from Mostazal Square and 5.5 mi (8.9 km) from Saint Francis of Assisi Church. Andean Museum and Estadio El Teniente are also within 20 miles (32 km).
Located in the heart of Rancagua, this hotel is 0.8 mi (1.3 km) from Estadio El Teniente and within 16 miles (25 km) of Mostazal Square and Saint Francis of Assisi Church. Reserva Nacional Rio de los Cipreses is 25.3 mi (40.7 km) away.
Situated in Alto Jahuel, this hotel is 0.5 mi (0.8 km) from Andean Museum and 12 mi (19.3 km) from Concha Y Toro Winery. Estadio Monumental David Arellano and Mall Plaza Oeste are also within 25 miles (40 km).
Located in the heart of Santiago, this aparthotel is within 9 miles (15 km) of Concha Y Toro Winery, Mall Plaza Vespucio and Mirador Interactive Museum. Estadio Monumental David Arellano and Paseo Quilin Mall are also within 12 miles (20 km).
Situated in Pirque, this spa bed & breakfast is 0.1 mi (0.1 km) from Cajon del Maipo and 3.5 mi (5.7 km) from Concha Y Toro Winery. Mall Plaza Vespucio and Mirador Interactive Museum are also within 16 miles (25 km).
Situated in Pirque, this hotel is 0.1 mi (0.1 km) from Cajon del Maipo and 3.1 mi (5 km) from Concha Y Toro Winery. Mall Plaza Vespucio and Mirador Interactive Museum are also within 16 miles (25 km).
Situated in San Jose de Maipo, this lodge is 0.1 mi (0.1 km) from Cajon del Maipo and within 12 miles (20 km) of Concha Y Toro Winery and San Jose de Maipo Square. Mall Plaza Vespucio is 12.3 mi (19.8 km) away.