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A rustic building with a wooden door, a hanging red chili, and a cactus plant.

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    Check prices for these dates, 13 – 14 December 2026

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    Our top choices for Mesilla holiday homes

    1. Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian

    A building entrance with a wooden door, a brick pathway, and a decorative wreath.

    2. Charming 2-bedroom Casita In Mesilla Park Casita Conway #5

    A modern house with a porch, a welcome mat, a small statue, and outdoor furniture.

    3. Unique 1-bedroom casita in Mesilla Park with hot tub

    A narrow hallway with wooden flooring leading to a room with a fireplace.

    4. 2 bed, yard, pet friendly in Historic Mesilla.

    A door with a purple frame and a decorative floral pattern above it.

    5. Charming 1-bedroom house with WiFi, AC Mesilla Park Las Cruces Casita Conway 2

    A closet with two robes hanging on wooden hangers.

    6. 3 bed 2 bath Hacienda near Downtown and NMSU.

    A dining area with a table set for four, a chandelier, a vase with flowers, and a window with curtains.

    7. Modern New Mexico Loft in the heart of Las Cruces.

    A kitchen with granite countertops, a stove, and a dining area with a table and chairs.

    8. Step into a newly renovated two-bed, one-bath haven in Mesilla Casita Conway #4

    A building entrance with a wooden door, a number '306 4' on the wall, and a doormat with a wreath design.

    9. 1 bedroom near NMSU. W/D in unit/pets welcome.

    A small, single-story building with a red door and beige walls, surrounded by a gravel driveway and yellow flowering plants.

    10. 2 bed with W/D, pets ok, 5 min to Farmers Market

    A single-story house with a brown stucco exterior, a grey roof, and a front porch.

    11. Historical 1920s Bungalow Near NMSU & Mesilla

    A stone-paved entrance to a brick building with a green door and a number '1010' sign.

    12. Cozy and Modern Home w/ King Bed and more!

    A laundry room with a ceiling fan, a washing machine, and a dryer. There is a dining table with chairs and a window with blinds.

    13. The New Zen Den- Cozy Private Studio with Kitchenette & Private Entrance

    Wooden planters with cacti against a yellow wall.

    14. Casita! Fully functional kitchen and bathroom!

    A patio with a white door, a wall covered in green foliage, and two metal tables with chairs.

    15. 2 king bds/2.5 bathrooms in the heart of Downtown

    A covered patio area with a pergola, outdoor seating, and a stone wall.

    16. 2 bd/2bth near NMSU and Memorial Medical Center

    A living room with a fireplace, a sofa, a coffee table, and a ceiling fan.

    17. Rock House Retreat, Hot Tub, 2min to Downtown

    A stone wall with a blue door.

    18. 2 bd w/lrg fenced yard 3 mins from farmers market

    Pergola at night

    19. Payne Place 1

    A modern kitchen with stainless steel appliances, wooden cabinets, and a checkered tile backsplash.

    20. 2 bed/2 bath quiet neighborhood

    A house with a tiled roof, a covered porch, and a well-maintained lawn.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Learn more about Mesilla

    Historic adobe buildings surround the plaza where Billy the Kid once stood trial in this charming town. Explore local art galleries and sample authentic Mexican cuisine at La Posta, a restaurant housed in a 19th-century stagecoach stop.

    See all hotels in Mesilla

    A rustic building with a wooden door, a hanging red chili, and a cactus plant.

    Top reviews in Mesilla

    Hampton Inn & Suites Las Cruces I-10

    A spacious lobby with a central dining area, multiple seating options, and a modern chandelier.

    Comfort Inn & Suites Las Cruces Mesilla

    A swimming pool with clear blue water, surrounded by lounge chairs and a tiled wall.

    Best Western Mission Inn

    A buffet area with a variety of baked goods, a coffee station, and a decorative plant.

    Days Inn by Wyndham Las Cruces

    An outdoor patio with wooden benches and a grill area.

    Hotel Encanto de Las Cruces

    A woman sitting at a table with a cup, a decorative fountain, and potted plants in a well-lit indoor space.

    La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain

    A multi-story hotel with a central entrance, balconies, and a parking area.

    Springhill Suites By Marriott Las Cruces

    A hotel room with a large bed, a nightstand, a wall-mounted light, and a window with curtains.

    Home2 Suites by Hilton Las Cruces

    An outdoor seating area with a fire pit, sofas, and chairs.

    Holiday Inn Express & Suites Las Cruces North by IHG

    A Holiday Inn Express & Suites hotel with a brick facade, multiple windows, and a well-lit entrance.

    Staybridge Suites Las Cruces by IHG

    An outdoor patio with stone pillars, green chairs, and a table.