Title: Lazzaretto of Ancona in Ancona | Expedia.co.uk [Lazzaretto of Ancona Hotels](https://expedia.co.uk/Lazzaretto-Of-Ancona-Hotels.0-l6104258-0.Travel-Guide-Filter-Hotels)[Flights to Ancona](https://expedia.co.uk/Cheap-Flights-To-Ancona.d394.Travel-Guide-Flights)[Things to do in Ancona](https://expedia.co.uk/Things-To-Do-In-Ancona.d394.Travel-Guide-Activities)[Lazzaretto of Ancona Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Lazzaretto-Of-Ancona.d6104258.Car-Hire-Guide)[Ancona Holidays](https://expedia.co.uk/Ancona.d394.Holidays-City-Breaks) # Lazzaretto of Ancona ![Mole Vanvitelliana featuring a sunset, a marina and general coastal views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/296000/296755-Mole-Vanvitelliana.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mole Vanvitelliana which includes general coastal views, landscape views and a sunset](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/295000/295761-Italy.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mole Vanvitelliana showing a bay or harbour](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/296000/296748-Mole-Vanvitelliana.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Lazzaretto of Ancona](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/295000/295938-Marche.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mole Vanvitelliana showing heritage elements, a square or plaza and street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/295000/295937-Marche.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Lazzaretto of Ancona Activities [Ancona travel guide](https://expedia.co.uk/Ancona.dx394) * * * * * * #### The historical purpose of Ancona’s pentagonal building is as interesting as its architecture. It originally served as a quarantine station for contagious visitors. Mole Vanvitelliana, also known as the Lazaretto, is one of the most distinctive buildings in Ancona. Rising out of the port like a massive stone pentagon, the building has had a striking appeal for centuries. Explore the premises and learn more about why the quarantine station was built. Note the unique placement of Mole Vanvitelliana, which sits on an artificial island in the harbor. Given Ancona’s role as a strategic port city, it was crucial that any contagious diseases brought in by ship did not infect the rest of the city. To address this, Pope Clement XII commissioned a quarantine station in the 18th century. Famed architect Luigi Vanvitelli designed the complex to detain infected people, store goods and defend the harbor. The cross-functional structure was built between 1733 and 1743. Although it originally had no link to the mainland, today you can access Mole Vanvitelliana via three small bridges. The structure has served many purposes throughout Ancona’s history. In the latter half of the 19th century, its primary role shifted from quarantine station to military citadel. Look for the fortifications, cannon holes and sentry boxes that bear testament to this. After that, it served as a sugar refinery and tobacco processing site. Today, it hosts cultural events and exhibits. The Lazaretto was built to house about 2,000 people at any given time. Stroll through the open courtyard inside. Note the neoclassical temple at its center, with a modest cross atop its domed roof. The temple was dedicated to St. Roch, the patron of plague victims. Check out the Omero Tactile Museum, located inside Mole Vanvitelliana. This unique art museum is tailored toward visitors with vision impairments. Instead of relying on sight, you are invited to experience the museum’s exhibits through touch. Feel sculptures dating back to ancient Roman times up until present day. Check out the architecture section, which features scale models of many of Italy’s most famous structures. Mole Vanvitelliana is in the heart of Ancona’s port. With its central location, you can easily walk from here to the sights, shops and restaurants in the city’s Old Town. ## Plan a trip to see Lazzaretto of Ancona Price found within the past 48 hours. Click for updated prices. ![Nun Assisi Relais Spa Museum](https://images.trvl-media.com/lodging/5000000/4030000/4024200/4024167/7cf68211_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Nun Assisi Relais Spa Museum Assisi Historic Center Save 100% on your flight £942 per person 25 Dec - 28 Dec found 1 day ago Return flight included London (LON) to Ancona (AOI) 9.8/10 Exceptional! (186 reviews) It's a beautiful property overall Reviewed on 16 Sept 2025 [](https://expedia.co.uk/go/package/search/FlightHotel/2025-12-25/2025-12-28/?FromAirport=LON&Destination=AOI&NumRoom=1&NumAdult=2&NumChild=0&hotelId=4024167&paandie=true&dealMarker=zMUE98aHhciS2o537lMyr2MuE8Sn627dzaztqlM6qV_0przqdZ8nUie6FHbbI2vW) ### Popular places to visit ![Porto di Ancona](https://mediaim.expedia.com/destination/2/b2b02fa9b7759a1f0f2ad4f7628d7d32.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Porto di Ancona Explore the waterfront in Ancona with a trip to Porto di Ancona. Wander the waterfront and beaches in the area. [](https://expedia.co.uk/Porto-Di-Ancona-Ancona.d553248635544166272.Attraction) ![Chiesa di Santa Maria della Piazza which includes heritage elements and a church or cathedral](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/296000/296646-Chiesa-Di-Santa-Maria-Della-Piazza.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Chiesa di Santa Maria della Piazza Learn about the local history of Ancona when you spend time at Chiesa di Santa Maria della Piazza. Wander the waterfront and beaches in the area. [](https://expedia.co.uk/Chiesa-Di-Santa-Maria-Della-Piazza-Ancona.d6104252.Attraction) ![Piazza del Plebiscito](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/296000/296596-Piazza-Del-Plebiscito.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Piazza del Plebiscito Dominated by the Church of San Domenico and located within walking distance of the port, this bustling square has been the hub of Ancona since medieval times. [](https://expedia.co.uk/Piazza-Del-Plebiscito-Ancona.d6104254.Attraction) ![Arco di Traiano showing heritage elements as well as a couple](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/296000/296757-Arco-Di-Traiano.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Arches of Trajan Amid the very modern hustle and bustle of Ancona’s port, discover a triumphal arch that dates back to ancient Roman times. [](https://expedia.co.uk/Arches-Of-Trajan-Ancona.d6104248.Attraction) ![Cathedral of San Ciriaco featuring heritage architecture and a church or cathedral](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/296000/296639-Cathedral-Of-San-Ciriaco.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Cathedral of San Ciriaco Trek up from Ancona’s Old Town and discover its Roman Catholic cathedral, which has presided over the city for more than 1,000 years. [](https://expedia.co.uk/Cathedral-Of-San-Ciriaco-Ancona.d6104250.Attraction) #### Chiesa San Francesco alle Scale Learn about the local history of Ancona with a stop at Chiesa San Francesco alle Scale. Wander the waterfront and beaches in the area. 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Martino 21, Ancona, AN [](https://expedia.co.uk/Ancona-Hotels-La-Piazza.h114219408.Hotel-Information) [See all 962 properties in Lazzaretto of Ancona](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=6104258) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. 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[Flights to Ancona](https://www.expedia.co.uk/Cheap-Flights-To-Ancona.d394.Travel-Guide-Flights) - [Flights to Marche](https://www.expedia.co.uk/Destinations-In-Marche.d6048667.Flight-Destinations) - [Flights to Province of Ancona](https://www.expedia.co.uk/Destinations-In-Province-Of-Ancona.d6055205.Flight-Destinations) - [Ancona Holidays](https://www.expedia.co.uk/Ancona.d394.Holidays-City-Breaks) - [Visit Ancona](https://www.expedia.co.uk/Ancona.dx394) - [Arches of Trajan](https://www.expedia.co.uk/Arches-Of-Trajan-Ancona.d6104248.Attraction) - [Beach of the Two Sisters](https://www.expedia.co.uk/Beach-Of-The-Two-Sisters-Italy.d553248635975883297.Attraction) - [Carlo Urbani Hospital](https://www.expedia.co.uk/Carlo-Urbani-Hospital-Jesi.d553248635544157473.Attraction) - [Castelfidardo Holidays](https://www.expedia.co.uk/Castelfidardo.d6057378.Holidays-City-Breaks) - [Cathedral of San Ciriaco](https://www.expedia.co.uk/Cathedral-Of-San-Ciriaco-Ancona.d6104250.Attraction) - [Falconara Marittima Holidays](https://www.expedia.co.uk/Falconara-Marittima.d6048907.Holidays-City-Breaks) - [Garibaldi Senigallia Square](https://www.expedia.co.uk/Garibaldi-Senigallia-Square-Senigallia.d553248634499178970.Attraction) - [Jesi Holidays](https://www.expedia.co.uk/Jesi.d6055206.Holidays-City-Breaks) - [La Spiaggiola](https://www.expedia.co.uk/La-Spiaggiola-Numana.d553248635977472215.Attraction) - [Loreto Holidays](https://www.expedia.co.uk/Loreto.d6123080.Holidays-City-Breaks) - [Marcelli Holidays](https://www.expedia.co.uk/Marcelli.d6143406.Holidays-City-Breaks) - [Marche Holidays](https://www.expedia.co.uk/Marche.d6048667.Holidays-City-Breaks) - [Visit Marche](https://www.expedia.co.uk/Marche.dx6048667) - [Mount Conero](https://www.expedia.co.uk/Mount-Conero-Ancona.d6342674.Attraction) - [Museo Archeologico Nazionale delle Marche](https://www.expedia.co.uk/Museo-Archeologico-Nazionale-Delle-Marche-Ancona.d553248621533001009.Attraction) - [Museo Internazionale della Fisarmonica](https://www.expedia.co.uk/Museo-Internazionale-Della-Fisarmonica-Castelfidardo.d553248621532500588.Attraction) - [Numana Holidays](https://www.expedia.co.uk/Numana.d6046956.Holidays-City-Breaks) - [Palazzo del Duca](https://www.expedia.co.uk/Palazzo-Del-Duca-Senigallia.d6269087.Attraction) - [Piazza Giacomo Leopardi](https://www.expedia.co.uk/Piazza-Giacomo-Leopardi-Recanati.d6169974.Attraction) - [Portici Ercolani](https://www.expedia.co.uk/Portici-Ercolani-Senigallia.d6268972.Attraction) - [Porto Recanati Holidays](https://www.expedia.co.uk/Porto-Recanati.d6025815.Holidays-City-Breaks) - [Portonovo Holidays](https://www.expedia.co.uk/Portonovo.d6342175.Holidays-City-Breaks) - [Province of Ancona Holidays](https://www.expedia.co.uk/Province-Of-Ancona.d6055205.Holidays-City-Breaks) - [Visit Province of Ancona](https://www.expedia.co.uk/Province-Of-Ancona.dx6055205) - [Recanati Holidays](https://www.expedia.co.uk/Recanati.d6050611.Holidays-City-Breaks) - [Rocca Roveresca Castle](https://www.expedia.co.uk/Rocca-Roveresca-Castle-Senigallia.d6268959.Attraction) - [Rocca Roveresca](https://www.expedia.co.uk/Rocca-Roveresca-Senigallia.d553248621562145555.Attraction) - [Sanctuary of San Girio](https://www.expedia.co.uk/Sanctuary-Of-San-Girio-Potenza-Picena.d553248621592064205.Attraction) - [Senigallia Holidays](https://www.expedia.co.uk/Senigallia.d6023971.Holidays-City-Breaks) - [Shrine of Our Lady of the Rose](https://www.expedia.co.uk/Shrine-Of-Our-Lady-Of-The-Rose-Ostra.d553248634029163076.Attraction) - [Sirolo Holidays](https://www.expedia.co.uk/Sirolo.d6129979.Holidays-City-Breaks) - [Car hire Ancona](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Ancona.d394.Car-Hire-Guide) - [Convertible Car Hire in Province of Ancona](https://www.expedia.co.uk/Convertible-Car-Rentals-In-Province-Of-Ancona.d6055205-tConvertible.Car-Rental-Destination-Class) - [Car hire near Marche](https://www.expedia.co.uk/Destinations-In-Marche.d6048667.Car-Hire-Destinations) - [Car hire near Province of Ancona](https://www.expedia.co.uk/Destinations-In-Province-Of-Ancona.d6055205.Car-Hire-Destinations) - [Dollar Rental Cars in Marche](https://www.expedia.co.uk/Dollar-Destinations-In-Marche.d6048667-c1091.Car-Rental-Destination-Suppliers) - [Europcar Rental Cars in Province of Ancona](https://www.expedia.co.uk/Europcar-Destinations-In-Province-Of-Ancona.d6055205-c14.Car-Rental-Destination-Suppliers) - [Hertz Rental Cars in Ancona](https://www.expedia.co.uk/Hertz-Car-Rentals-In-Ancona.d394-c40.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Marche](https://www.expedia.co.uk/Hertz-Destinations-In-Marche.d6048667-c40.Car-Rental-Destination-Suppliers) - [Luxury Car Hire in Marche](https://www.expedia.co.uk/Luxury-Car-Rentals-In-Marche.d6048667-tLuxury.Car-Rental-Destination-Class) - [Luxury Car Hire in Province of Ancona](https://www.expedia.co.uk/Luxury-Car-Rentals-In-Province-Of-Ancona.d6055205-tLuxury.Car-Rental-Destination-Class) - [Sixt Rental Cars in Marche](https://www.expedia.co.uk/Sixt-Destinations-In-Marche.d6048667-c35.Car-Rental-Destination-Suppliers) - [Sports Car Car Hire in Ancona](https://www.expedia.co.uk/Sportscar-Car-Rentals-In-Ancona.d394-tSportscar.Car-Rental-Guide-Class) - [Marche Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Marche.d6048667.Holiday-Rental-Destinations) - [Things to do in Ancona](https://www.expedia.co.uk/Things-To-Do-In-Ancona.d394.Travel-Guide-Activities) - [Things to do in Marche](https://www.expedia.co.uk/Things-To-Do-In-Marche.d6048667.Travel-Guide-Activities) - [Things to do in Province of Ancona](https://www.expedia.co.uk/Things-To-Do-In-Province-Of-Ancona.d6055205.Travel-Guide-Activities)