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Check prices for these dates

Tonight
13 Oct - 14 Oct
Tomorrow
14 Oct - 15 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for Lake Issaqueena hotels

A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
A hotel lobby with a long corridor, seating areas, and a reception desk.
A modern restaurant with a marble-top dining table, blue upholstered chairs, and a variety of food items displayed in the background.
A brick building with a sign reading "The Inn at Patrick Square".

1. The Inn at Patrick Square

The Inn at Patrick Square
5.7 mi from Lake Issaqueena
United States
Jennifer
£125
includes taxes & fees
19 Oct - 20 Oct
The Inn at Patrick Square
A white, two-story house with a front porch, surrounded by trees and shrubs.
A two-story building with a white exterior, a front door, and a balcony.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.
A bedroom with two beds, a TV, and a fireplace.

2. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
8.1 mi from Lake Issaqueena
United States
Christine
£95
includes taxes & fees
30 Oct - 31 Oct
Liberty Hall Bed and Breakfast
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.

3. The Abernathy of Clemson

The Abernathy of Clemson
4.1 mi from Lake Issaqueena
United States
Amy
£125
includes taxes & fees
19 Oct - 20 Oct
The Abernathy of Clemson
A golf course with a water body, trees, and a distant view of a bridge.
An outdoor patio with tables and chairs, surrounded by trees and a view of a body of water.
A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.
A modern building with a central entrance, surrounded by a well-maintained lawn and trees.

4. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
5.4 mi from Lake Issaqueena
United States
Lilllian
£125
includes taxes & fees
14 Oct - 15 Oct
Clemson University's James F. Martin Inn
An outdoor patio area with a fire pit, seating, and string lights.
A food court with a beverage display, seating area, and a Clemson University sign.
A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.

5. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
3.6 mi from Lake Issaqueena
United States
Melissa
£89
includes taxes & fees
8 Nov - 9 Nov
Tru by Hilton Seneca Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.2 mi from Lake Issaqueena
United States
Laurrie
£154
includes taxes & fees
28 Oct - 29 Oct
The Shepherd Hotel Downtown Clemson
A modern bar area with a menu board, bar stools, and a countertop with various items.
A Courtyard Marriott hotel with a brick facade, multiple floors, and a covered entrance area.
An outdoor patio with a circular fire pit surrounded by wicker furniture and a pergola overhead.
A modern lobby with a reception desk, a seating area with three chairs, a round table, and a bookshelf with books.

7. Courtyard Marriott Clemson

Courtyard Marriott Clemson
4.5 mi from Lake Issaqueena
United States
kim
£87
includes taxes & fees
18 Oct - 19 Oct
Courtyard Marriott Clemson
A modern kitchen area with a bar counter and seating.
A modern living room with a grey sofa, purple and orange cushions, a coffee table with magazines, and a large window with patterned curtains.
A Hampton Inn with a modern design, featuring a prominent entrance and outdoor seating area.
A modern bar area with high stools and a poolside view.

8. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
3.4 mi from Lake Issaqueena
United States
Blaise
£92
includes taxes & fees
30 Oct - 31 Oct
Hampton Inn Clemson-University Area
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.

9. Lakeside Lodge Clemson

Lakeside Lodge Clemson
3.5 mi from Lake Issaqueena
United States
Lori
£102
includes taxes & fees
14 Oct - 15 Oct
Lakeside Lodge Clemson
A Holiday Inn Express hotel with a stone facade, large windows, and a parking lot.
A spacious lobby with a reception desk, seating area, and a large glass door entrance.
A hotel room with a large bed, a desk, a chair, a mirror, and a framed picture on the wall.
A laundry room with a Samsung washer and dryer, a white shelf, and a tiled floor.

10. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
4.4 mi from Lake Issaqueena
United States
John
£108
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express & Suites Clemson by IHG
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A wooden interior with a table, chair, and a hanging lantern.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.
A cabin in a forest with a small deck and outdoor seating area.

11. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
9.8 mi from Lake Issaqueena
United States
Sebastian
£111
includes taxes & fees
11 Nov - 12 Nov
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.
A wall with a decorative design featuring a building, trees, and a sky with clouds.
A hotel room with two beds, a desk, a television, and a clock on the wall.
A dining area with a brick floor, wooden tables, and chairs, a kitchen counter with appliances, and large windows offering a view of the outside.

12. Inn @ Clemson

Inn @ Clemson
4.1 mi from Lake Issaqueena
United States
Samantha
£61
includes taxes & fees
21 Oct - 22 Oct
Inn @ Clemson
Room
A hotel hallway with a carpeted floor, light-colored walls, and doors on both sides.
A modern kitchen with a microwave, toaster, and coffee maker. There are white bowls and a coffee station.
A spacious room with a large window, a flat-screen TV mounted on the wall, and a seating area with sofas and chairs.

13. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
4.1 mi from Lake Issaqueena
£92
includes taxes & fees
2 Nov - 3 Nov
Comfort Inn & Suites Clemson - University Area
A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.
A spacious indoor area with multiple seating arrangements, a ping pong table, and a bar area with purple accents.
A spacious indoor area with multiple levels of balconies, seating areas, and a central open space.
A lobby with seating areas, a reception desk, and a patterned wall.

14. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
4.2 mi from Lake Issaqueena
United States
David
£92
includes taxes & fees
19 Oct - 20 Oct
Best Western Plus Clemson Hotel & Conference Center
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

15. Best Western Seneca-Clemson

Best Western Seneca-Clemson
6 mi from Lake Issaqueena
United States
Michelle
£85
includes taxes & fees
28 Oct - 29 Oct
Best Western Seneca-Clemson
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

16. Quality Inn Seneca US-123

Quality Inn Seneca US-123
8.4 mi from Lake Issaqueena
United States
Barry
£70
includes taxes & fees
18 Oct - 19 Oct
Quality Inn Seneca US-123
A cozy living room with a fireplace, a dining area with a table and chairs, and a large wooden door.
A room with wooden sliding doors, a small black table with a potted plant, and a circular sign with the words "stay awhile".
A cozy living room with a dining table, sofas, and a chandelier.
A bedroom with a bed, bedside tables, a nightstand, a wooden floor, a door, and a wall-mounted shelf.

17. Clemson Memorabilia House

Clemson Memorabilia House
5.7 mi from Lake Issaqueena
United States
Ashley
£180
includes taxes & fees
18 Oct - 19 Oct
Clemson Memorabilia House
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A reception area with a counter, chairs, and a patterned rug.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

18. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
5.3 mi from Lake Issaqueena
United States
Lloyd
£102
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn & Suites Seneca-Clemson Area
A dining area with a table and chairs, large windows with a view of the outside, and a green sofa.
A hotel room with two beds, a desk, a chair, a TV, and a painting on the wall.
A reception desk with a vase of flowers, framed pictures, and a printer.
A gazebo with a tiled roof and a surrounding gravel area.

19. Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson
4.4 mi from Lake Issaqueena
United States
David
£67
includes taxes & fees
14 Oct - 15 Oct
Days Inn by Wyndham Clemson
A swimming pool with lounge chairs and a covered area with tables and chairs.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a microwave.
A spacious living room with a dark leather sofa, a wooden coffee table, and a dining area with a table and chairs. Large windows provide natural light and views of the outdoors.
A modern bedroom with a large bed, a ceiling fan, and a view of the outdoors through a window.

20. Carolina Camp Cedar

Carolina Camp Cedar
12.6 mi from Lake Issaqueena
United States
Katlynn
£150
includes taxes & fees
20 Oct - 21 Oct
Carolina Camp Cedar
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Compare popular hotels close to Lake Issaqueena

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
The Inn at Patrick Square
9.8
Exceptional
926 reviews
View
A white, two-story house with a front porch, surrounded by trees and shrubs.
Liberty Hall Bed and Breakfast
9.8
Exceptional
104 reviews
View
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
The Abernathy of Clemson
9.6
Exceptional
653 reviews
View
A golf course with a water body, trees, and a distant view of a bridge.
Clemson University's James F. Martin Inn
9.4
Exceptional
1,005 reviews
View
An outdoor patio area with a fire pit, seating, and string lights.
Tru by Hilton Seneca Clemson
9.2
Wonderful
899 reviews
View

Top Lake Issaqueena Hotel Reviews

Lakeside Lodge Clemson

Lakeside Lodge Clemson

10/10 Excellent
"Great place, great location."
JORGE 1-night trip
Posted 9 hours ago
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

10/10 Excellent
"Everything was great. We really enjoyed it. We would definitely stay again"
Stephen 1-night trip
Posted 2 days ago
Tru by Hilton Seneca Clemson
Clemson Barndominium -close to University and lakes

Clemson Barndominium -close to University and lakes

10/10 Excellent
"Kim was wonderful! Her place is so cute- very unique space! Much bigger than the pictures lead you to believe! It was perfect for visiting our daughter at Clemson for a game weekend!"
Aimee 2-night trip
Posted 9 days ago
Clemson Barndominium -close to University and lakes
Clemson Game Day Cottage w/ Fire Pit

Clemson Game Day Cottage w/ Fire Pit

10/10 Excellent
"Great place to stay! We were there for a Clemson football game and we couldn't ask for a better place. Very nice place, clean and peaceful."
Rodney D. 2-night trip
Posted 3 weeks ago
Clemson Game Day Cottage w/ Fire Pit
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

10/10 Excellent
"We had everything we needed for the weekend."
Kim C. 2-night trip
Posted 3 weeks ago
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Iroquois Crossroads - 10 min from Clemson & lakes

Iroquois Crossroads - 10 min from Clemson & lakes

10/10 Excellent
"Couldn't have been an easier process. Place was immaculate. Would recommend."
Steve M. 3-night trip
Posted 3 weeks ago
Iroquois Crossroads - 10 min from Clemson & lakes
Family Seneca Stay - 4mi to Clemson Memorial Stadium

Family Seneca Stay - 4mi to Clemson Memorial Stadium

10/10 Excellent
"Rachel was a great host. Planning on coming back again next year."
Daniel L. 2-night trip
Posted 3 weeks ago
Family Seneca Stay - 4mi to Clemson Memorial Stadium
NEW!Lakefront retreat with huge dock, private cove. Perfect for Clemson Football

NEW!Lakefront retreat with huge dock, private cove. Perfect for Clemson Football

10/10 Excellent
"Very clean, lots of space, and great lakefront access! The puzzle and game collection is also impressive. Would stay here again!"
Joni K. 3-night trip
Posted 2 months ago
NEW!Lakefront retreat with huge dock, private cove. Perfect for Clemson Football
Clemson Game Day Villa Near Campus & Lakes

Clemson Game Day Villa Near Campus & Lakes

10/10 Excellent
"Great house"
justin g. 2-night trip
Posted 2 months ago
Clemson Game Day Villa Near Campus & Lakes

Other attractions near Lake Issaqueena

Larry W. Abernathy Waterfront Park

8.6/10 (58 reviews)
Larry W. Abernathy Waterfront Park is just one of the places to see in Clemson, so why not enjoy the other things to explore during your travels? Experience the area's theatre scene or attend a football match.
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Littlejohn Coliseum

9.4/10 (141 reviews)
Catch an event at Littlejohn Coliseum during your trip to Clemson. Amble around the area's lakeside or attend a football match.
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Sloan Tennis Center

Catch an event at Sloan Tennis Center during your trip to Clemson. You can attend a football match while in the area.
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Memorial Stadium

9.6/10 (410 reviews)
Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theatre scene or attend a football match.
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Clemson Area African American Museum

You can spend time exploring the galleries in Clemson Area African American Museum in Clemson. You can attend a football match while in the area.
See properties

Wyndham Plaza

You can search for that perfect souvenir at Wyndham Plaza during your stay in Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area.
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World of Energy

You can spend an afternoon browsing the exhibits at World of Energy in Seneca. Amble around this family-friendly area's lakeside or attend a sporting event.
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Frequently asked questions

What's the area like around Lake Issaqueena?
Lake Issaqueena is located in Central. You'll find 209 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay near Lake Issaqueena?
Lakeside Lodge Clemson is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. It's located 3.5 mi (5.6 km) from Lake Issaqueena. Other good choices within 5 miles include Best Western Plus Clemson Hotel & Conference Center and Comfort Inn & Suites Clemson - University Area.
How many hotels will I find close to Lake Issaqueena?
Expedia has 209 hotels and other accommodation options a few miles from Lake Issaqueena.
If I need to cancel the hotel reservation for my stay near Lake Issaqueena, will I receive a refund?
Yes, most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to get the top deals on offer near Lake Issaqueena.
What can I see and do near Lake Issaqueena?
You'll want to browse the exhibits at Fort Hill and Clemson Area African American Museum. Explore nature at Keowee Reservoir and Larry W. Abernathy Waterfront Park. If you've got some time to explore the area around Lake Issaqueena, you may want to make a stop by Littlejohn Coliseum, Memorial Stadium and Sloan Tennis Center.