A large building with a dome and columns, surrounded by trees and a grassy area.

Find Spa Hotels in Jeffersonville - Clarksville, IN

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Jeffersonville - Clarksville Spa Hotels

Tonight
10 Oct - 11 Oct
Tomorrow
11 Oct - 12 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Our top choices for Jeffersonville - Clarksville hotels with a spa

A restaurant with round tables, chairs, chandeliers, and a bar area.
A large hotel with a prominent 'Caesars' sign, multiple floors, and a symmetrical facade.
A spacious lobby with a geometric chandelier, a reception desk, and a red accent wall.
A hot tub with a pool, indoor seating area, and a view of the pool.

1. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
Elizabeth
  • Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.
Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
An outdoor patio with black tables and chairs, surrounded by large windows and a row of arches.
A balcony with a view of a river, a bridge, and a cityscape.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

2. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville
  • Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.
Galt House Hotel Trademark Collection by Wyndham
A cozy room with a geometric-patterned ceiling, a sofa, and a chair.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.
A modern bathroom with a shower, a sink, and a large mirror.

3. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville
  • Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness centre in city centre Louisville.
21c Museum Hotel Louisville
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.
A modern interior with a fireplace, bookshelves, and seating areas.
A lobby with a marble floor, a reception desk, and a large chandelier.

4. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville
  • Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.
Omni Louisville Hotel
A rustic bar area with a wooden bar counter, stools, and a variety of bottles and glasses.
A modern bathroom with a shower, a vanity with a sink, and a toilet. There are wooden shelves and a vase with flowers on the vanity.
A porch with white rocking chairs and a table, a window with blinds, and a view of a green landscape.
A cozy room with a wooden wall, a sofa, and a dining table.

5. Pillow and Paddock B&B

Pillow and Paddock B&B
La Grange
  • Relax in a cosy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.
Pillow and Paddock B&B
View all properties

Choose what matters most at spa hotels in Jeffersonville - Clarksville

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Jeffersonville - Clarksville Hotel Reviews

Louisville Marriott Downtown

Louisville Marriott Downtown

10/10 Excellent
"The room was clean and the hotel was in a great location."
Veronica 3-night trip
Posted 5 days ago
Louisville Marriott Downtown

Explore a world of travel with Expedia