TOP Jeffersonville - Clarksville Spa Hotels for 2026 - Spas in Jeffersonville - Clarksville, IN

A large building with a dome and columns, surrounded by trees and a grassy area.

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Our top choices for Jeffersonville - Clarksville hotels with a spa

A restaurant with round tables, chairs, chandeliers, and a bar area.

A casino with multiple gaming tables and slot machines, a red carpet, and ornate chandeliers.

A hot tub with a pool, indoor seating area, and a view of the pool.

A spacious lobby with a geometric chandelier, a reception desk, and a red accent wall.

1. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Elizabeth

Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.

£65

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A modern interior with a fireplace, bookshelves, and seating areas.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A lobby with a marble floor, a reception desk, and a large chandelier.

2. Omni Louisville Hotel

Downtown Louisville

Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.

£111

includes taxes & fees

18 Oct - 19 Oct

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A modern hotel room with a large window, a sofa, a red armchair, and a small table.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

An outdoor patio with black tables and chairs, surrounded by large windows and a row of arches.

3. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville

Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.

£124

includes taxes & fees

8 Nov - 9 Nov

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

A modern bathroom with a shower, a sink, and a large mirror.

4. 21c Museum Hotel Louisville

Downtown Louisville

Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness centre in city centre Louisville.

£139

includes taxes & fees

8 Nov - 9 Nov

A rustic bar area with a wooden bar counter, stools, and a variety of bottles and glasses.

A living room with a sofa, coffee table, and a television mounted on the wall.

A porch with white rocking chairs and a table, a window with blinds, and a view of a green landscape.

A cozy room with a wooden wall, a sofa, and a dining table.

5. Pillow and Paddock B&B

La Grange

Relax in a cosy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.

£263

includes taxes & fees

19 Oct - 20 Oct

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Choose what matters most at spa hotels in Jeffersonville - Clarksville

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Breakfast included

Hot tub

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Top Jeffersonville - Clarksville Hotel Reviews

Drury Inn & Suites Louisville North

10/10 Excellent

"The room was spacious and the bed was very comfortable. Found the room to be a little dark even with the numerus lights. The breakfast was average fair, not disappointing just not memorable. The hotel was well positioned with a major highway nearby for ease of access to the surrounding communities and also a large shopping area almost attached to the property."