Downtown South San Francisco Holidays from £644

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Your Downtown South San Francisco Holiday

From its culture to its dining, there are so many things to love about Downtown South San Francisco. Book a Downtown South San Francisco holiday package and prepare to experience the charms of this neighbourhood. Get your trip to Downtown South San Francisco off to the best start possible with visits to some of its nearby attractions, such as Sees Candies and K1 Speed San Francisco. Don't just think about it — turn it into a reality! Secure your ultimate Downtown South San Francisco holiday with Expedia and get to where you're going your way.

Price found within the past 48 hours. Click for updated prices.
Hotel EPIK

Hotel EPIK

4 out of 5
Downtown San Francisco
Save 100% on your flight
Price was £1,036, price is now £644 per person
£644
per person
5 Oct - 12 Oct
found 1 day ago
Return direct flight included
London (LHR) to San Francisco (SFO)
7/10 Good! (443 reviews)
Like the boutique hotel feel. Rooms are clean, bathrooms modern, beds comfortable. Much better than other hotels in the area at the same price point.

Reviewed on 25 Aug 2025

Nob Hill Hotel

Nob Hill Hotel

4 out of 5
Downtown San Francisco
Save 100% on your flight
Price was £1,509, price is now £862 per person
£862
per person
5 Oct - 12 Oct
found 1 day ago
Return direct flight included
London (LHR) to San Francisco (SFO)
7.8/10 Good! (1,003 reviews)
Great place, except when you walk out the door.

Reviewed on 11 Aug 2025

1 Hotel San Francisco

1 Hotel San Francisco

5 out of 5
Downtown San Francisco
Save 100% on your flight
Price was £2,927, price is now £1,700 per person
£1,700
per person
6 Oct - 13 Oct
found 1 day ago
Return flight included
London (LON) to San Francisco (SFO)
9.2/10 Wonderful! (440 reviews)
I really enjoyed my stay at 1 Hotel San Francisco. The property is chic, stylish, and perfectly located close to the water with STK conveniently right across the street. The hotel feels thoughtfully designed, ergonomically friendly, and incredibly comfortable. One of the best parts for me was how pet-friendly it is—without any extra charges or hidden fees. They even provided my puppy with a cozy bed and dishes, which was such a thoughtful touch. While it is definitely on the pricier side, the experience is absolutely worth it—I would definitely stay here again with no hesitation.

Reviewed on 16 Aug 2025

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
Fisherman's Wharf
Save 100% on your flight
Price was £1,352, price is now £814 per person
£814
per person
5 Oct - 12 Oct
found 1 day ago
Return direct flight included
London (LHR) to San Francisco (SFO)
9/10 Wonderful! (6,695 reviews)
LOCATION, LOCATION, LOCATION ... Just about anything that anyone might want to do is very close by and very walkable... restaurants, the wharf, the piers, Alcatraz excursion. That is why we chose it ... LOCATION!!!

Reviewed on 26 Aug 2025

Hotel Zetta San Francisco

Hotel Zetta San Francisco

4 out of 5
Downtown San Francisco
Save 100% on your flight
Price was £1,066, price is now £674 per person
£674
per person
5 Oct - 12 Oct
found 1 day ago
Return direct flight included
London (LHR) to San Francisco (SFO)
8.8/10 Excellent! (1,000 reviews)
We enjoyed our 3day stay at Hotel Zetta, and loved the location as well as the games/arcade available for guests! There was complimentary coffee and donuts, and hotel was very clean. We weren’t able to check in early but they held our bags til our rooms were ready.

Reviewed on 4 Aug 2025

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about Downtown South San Francisco
Fisherman\'s Wharf featuring a bay or harbour

Fisherman's Wharf

1 out of top 10 points of interest in this area
5/5(4 area reviews)

This waterfront neighborhood dates back to the gold rush era and is a hub for tourist activities, sea lions and seafood restaurants.

Find hotels in Fisherman's Wharf

Top hotels in Downtown South San Francisco

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd, South San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is £109 per night from 1 Sept to 2 Sept
£109
1 Sept - 2 Sept
includes taxes & fees
8/10 Very Good! (2,012 reviews)
"I've stayed at this property a few times, as it fits my budget, is kinda close to SFSU, and has parking. The rooms are clean & comfortable, the showerheads are tall enough for a 6'3" person. Never used the pool. The breakfast is edible, but won't win any awards. There are a couple of nagging issues. ..."

Reviewed on 22 Aug 2025

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St, San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is £125 per night from 27 Aug to 28 Aug
£125
27 Aug - 28 Aug
includes taxes & fees
8.8/10 Excellent! (6,706 reviews)
"Excellent location, easily walkable to all the places we wanted to visit. Felt safe and easy parking. We were concerned our car may have been over height, there is a 6ft limit but we got in fine. However you can also use the parking in the hotel opposite which has a greater height allowance. Staff ..."

Reviewed on 24 Aug 2025

Hotel Riu Plaza Fisherman's Wharf
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center, San Francisco, CA
Fully refundableReserve now, pay when you stay
The price is £175 per night from 28 Aug to 29 Aug
£175
28 Aug - 29 Aug
includes taxes & fees
9.2/10 Wonderful! (1,816 reviews)
"This hotel is very very quiet. I did not hear the neighbors at all. The room was very large with a stunning view on the 17th floor. I stayed over the weekend when the prices were very reasonable, less than $200 a night. The price almost doubled during the week. I discovered this when my flight was ..."

Reviewed on 23 Aug 2025

Hyatt Regency San Francisco
See all 4,683 properties in Downtown South San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Downtown South San Francisco travel package cost?
Our Downtown South San Francisco travel packages, which start from just £644, are the best way to save money. All you have to do is choose your favourite hotels, flights and more to create a personalized escape.
If I'm not able to travel, can I cancel my Downtown South San Francisco travel package?
Because we understand life can throw you a few curveballs, the answer is yes. For more information, head to our Customer Service Portal. But generally speaking, if you've made your booking in the last 24 hours, you may be able to cancel or change it with no penalties. Your hotel, airline or car rental company may impose a fee if your booking is older than that.
How do I get a cheap travel package to Downtown South San Francisco?
Imagine all the amazing things you could do in Downtown South San Francisco with a wad of extra cash in your wallet. Watch your savings stack up when you combine your travel bookings into a Downtown South San Francisco travel package. You have plenty of choice when you book with Expedia too. In fact, you can choose from more than 550 airlines and 1,000,000 hotels globally. Whether you're enjoying a break with the family or embarking on a solo adventure, planning a trip to Downtown South San Francisco is better with a package.
Does Expedia offer Book Now, Pay Later Downtown South San Francisco holidays?
Your bank balance shouldn't get in the way of going on holiday, so Expedia has worked out a solution to help. Now that we've teamed up with online lender Klarna, it's easier than ever to book your dream getaway without hurting your hip pocket. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your trip. Check out these flexible payment options:

  • Pay monthly holidays: If paying bite-sized amounts each month works for you, Klarna can help. Paying in convenient monthly instalments will make your getaway dreams come true.
  • Pay in instalments holidays: With this Book Now, Pay Later option, Klarna makes it easy to pay for your trip over multiple transactions.
  • Low deposit holidays: When you see an awesome deal but your budget doesn't quite go that far, Klarna's low deposit holiday plan will help you get what you want.

Where should I stay in Downtown South San Francisco?
Close to the action. Many visitors book hotels within easy reach of top sights, like South San Francisco Convention Centre, Sees Candies and K1 Speed San Francisco.
What are the top hotels in Downtown South San Francisco?
Get your holiday off to a flying start by reserving a room at Best Western Plus Grosvenor Airport Hotel. It's one of most sought-after hotels in Downtown South San Francisco. Another welcoming option is Travelodge by Wyndham San Francisco Airport North.
How far in advance should I book my Downtown South San Francisco holiday?
It all depends on the airline, but you can usually browse through international fares on Expedia up to a year in advance. While it's advisable to book ahead of time, lucky travellers occasionally nab a cheaper flight just weeks prior to departure dates.
What does an Expedia Downtown South San Francisco travel package include?
From flights and hotels to rental cars, Expedia can help you shape a Downtown South San Francisco package that's ideal for you. Holidaying for a week or two? Give some thought to a hotel, flight and rental car bundle. If you're taking a quick break, a hotel and flight deal may be more your style. Experiences can also be added once you've made your booking. Our travel packages make it simple to save and plan.
What should I know before booking a Downtown South San Francisco travel package?
When you book your flights, hotels and car rentals together, you'll nab amazing discounts. Whether you're planning an outdoor getaway in a chalet or prefer to stay in a convenient hotel in the city, Expedia can help make it happen.
Can I choose my airline with a Downtown South San Francisco Expedia travel package?
Yes, definitely. Expedia has over 550 airline partners to choose from worldwide. With all that choice at your fingertips, finding the perfect carrier to whisk you off to Downtown South San Francisco shouldn't be hard.

Popular places to visit

Golden Gate Park featuring a garden and flowers

Golden Gate Park

This beloved park offers relaxation among trees, flowers and wildlife, right in San Francisco’s backyard.

Golden Gate Park
Pier 39 featuring street scenes, a city and signage

Pier 39

This waterfront attraction offers thrilling rides, innovative street performers and colorful souvenir shops, but it’s the sea lions that win the day.

Pier 39
Golden Gate Bridge featuring a suspension bridge or treetop walkway, night scenes and general coastal views

Golden Gate Bridge

Cars trundle across it and ships sail under it, but the best way to experience this iconic bridge is on foot.

Golden Gate Bridge

Things to do

Golden Gate Bridge at night

San Francisco Night Tour

£39
per adult
78% of travellers recommend
San Francisco Night Tour
San Francisco: Skip-the-Line 1-Hour Bay Cruise by Boat

San Francisco: Skip-the-Line 1-Hour Bay Cruise by Boat

£28
per adult
90% of travellers recommend
San Francisco: Skip-the-Line 1-Hour Bay Cruise by Boat
California Academy of Sciences General Admission

California Academy of Sciences Daytime Admission

£36
per adult
84% of travellers recommend
California Academy of Sciences Daytime Admission
See all activities in San Francisco

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.