£66 Cheap Flights to Santa Isabel

View £66 flight on Mon, 6 Jul 2026Opens in a new window

Popular airlines to Santa Isabel

  • LATAM Airlines Group

  • Avianca

  • Delta

  • Aeromexico

  • Iberia

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Cheap round-trip flights to Santa Isabel

Prices were available within the past 7 days and start at £66 for one-way flights and £127 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Mon, 6 Jul - Tue, 7 Jul
GYE
Guayaquil
CUE
Cuenca
£127 Return, found 2 days ago
£127
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Mon, 6 Jul from Guayaquil to Cuenca, returning Tue, 7 Jul, priced at £127 found 2 days ago
LATAM Airlines Group
Sun, 7 Jun - Sun, 14 Jun
GYE
Guayaquil
CUE
Cuenca
£128 Return, found 2 days ago
£128
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Sun, 7 Jun from Guayaquil to Cuenca, returning Sun, 14 Jun, priced at £128 found 2 days ago
LATAM Airlines Group
Sun, 7 Jun - Mon, 8 Jun
GYE
Guayaquil
CUE
Cuenca
£138 Return, found 6 days ago
£138
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Sun, 7 Jun from Guayaquil to Cuenca, returning Mon, 8 Jun, priced at £138 found 6 days ago
LATAM Airlines Group
Sun, 7 Jun - Sun, 14 Jun
GYE
Guayaquil
CUE
Cuenca
£141 Return, found 2 days ago
£141
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Sun, 7 Jun from Guayaquil to Cuenca, returning Sun, 14 Jun, priced at £141 found 2 days ago
LATAM Airlines Group
Sun, 7 Jun - Sun, 14 Jun
GYE
Guayaquil
CUE
Cuenca
£141 Return, found 2 days ago
£141
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Sun, 7 Jun from Guayaquil to Cuenca, returning Sun, 14 Jun, priced at £141 found 2 days ago
LATAM Airlines Group
Mon, 6 Jul - Tue, 7 Jul
GYE
Guayaquil
CUE
Cuenca
£148 Return, found 2 days ago
£148
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Mon, 6 Jul from Guayaquil to Cuenca, returning Tue, 7 Jul, priced at £148 found 2 days ago
avianca
Sun, 29 Nov - Thu, 3 Dec
UIO
Quito
CUE
Cuenca
£150 Return, found 20 hours ago
£150
Return
found 20 hours ago
Select avianca flight, departing Sun, 29 Nov from Quito to Cuenca, returning Thu, 3 Dec, priced at £150 found 20 hours ago
Air Europa
Wed, 11 Nov - Tue, 24 Nov
LGW
London
CUE
Cuenca
£1,084 Return, found 23 hours ago
£1,084
Return
found 23 hours ago
Select Air Europa flight, departing Wed, 11 Nov from London to Cuenca, returning Tue, 24 Nov, priced at £1,084 found 23 hours ago
Air France
Thu, 19 Nov - Wed, 9 Dec
LHR
London
CUE
Cuenca
£1,203 Return, found 6 days ago
£1,203
Return
found 6 days ago
Select Air France flight, departing Thu, 19 Nov from London to Cuenca, returning Wed, 9 Dec, priced at £1,203 found 6 days ago
Iberia
Tue, 5 Jan - Tue, 2 Mar
LGW
London
CUE
Cuenca
£1,205 Return, found 1 day ago
£1,205
Return
found 1 day ago
Select Iberia flight, departing Tue, 5 Jan from London to Cuenca, returning Tue, 2 Mar, priced at £1,205 found 1 day ago
Book with confidence

Top tips for booking flights to Santa Isabel from UK

Get ready to fly to Santa Isabel

Prepare your luggage and book your flights to Santa Isabel with Expedia. We offer a seamless flight booking experience, with a wide range of Santa Isabel plane tickets to choose from. If you need help finding some of the best deals for cheap flights to Santa Isabel in 2026, we are always available to assist you. Book your flights to Santa Isabel today and let the adventure begin!

Find the best tickets to Santa Isabel

To find some of the best tickets to Santa Isabel in 2026, use Expedia's powerful search engine to compare dates and the different departure and arrival airports for your trip. Whether you're after direct flights to Santa Isabel or last-minute flights to Santa Isabel, you can filter and sort your search results, making it easy to find the ideal flight to Santa Isabel.

Airlines fly to Santa Isabel

There are 20 different airlines that fly to Santa Isabel including some of the most trusted names in the business. To book flights to Santa Isabel with your favourite airline, take a look at Expedia's flight listings and try out different dates to find some of the best Santa Isabel plane tickets.

Find the cheapest flights to Santa Isabel

By booking early you may find some of the best deals for Santa Isabel flights from the UK, including Santa Isabel direct flights. You can usually find affordable and cheap flights to Santa Isabel, whether one-way from £66 or round-trip from £127, with Expedia if you book your trip far enough in advance.

Find the best airports for cheap flights to Santa Isabel

Try searching for different Santa Isabel airports with Expedia to find some of the cheapest flights to Santa Isabel. Flights from Guayaquil (GYE) to Cuenca (CUE) usually have the lowest price from £66.

Why book your flights to Santa Isabel with Expedia

Expedia offers great deals on Santa Isabel air fares from £66 to cater to every budget. Not only is Expedia one of the top platforms to book flights to Santa Isabel from the UK, it is also your one-stop shop for booking hotels, car rentals, and more.

 

*Prices and availability are subject to change. Additional terms apply.

Trending flights to Santa Isabel

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Europa
Wed, 11 Nov - Tue, 24 Nov
LGW
London
CUE
Cuenca
£1,084 Return, found 23 hours ago
£1,084
Return
found 23 hours ago
Select Air Europa flight, departing Wed, 11 Nov from London to Cuenca, returning Tue, 24 Nov, priced at £1,084 found 23 hours ago

Frequently asked questions

How do I find cheap flights to Santa Isabel that have flexible change policies?
At Expedia, we've been channeling our inner Olympic gymnast to provide you with the most flexible fares on the market. Simply click on "No change fee" directly underneath the "Flexible change policies" subheading to find your ideal flight to Santa Isabel.
How can I find cheap tickets to Santa Isabel?
You'll always nab an awesome deal with Expedia, but our "flexible dates" search function makes it even easier. Enter your preferred flight date, then check the flexible dates box above to compare prices for nearby days. £127 was the cheapest price for a flight to Santa Isabel in the last seven days.
How much is a flight to Santa Isabel?
In the last seven days, return flights to Santa Isabel sold for as low as £127 and peaked at £1,205. For one-way journeys departing from Guayaquil (GYE), the cheapest seat during this time was only £66.
When is the cheapest time to fly to Santa Isabel?
If you'd prefer to spend your holiday money on having fun in Santa Isabel rather than on getting there, jet off earlier in the week. The most economical day to fly is usually Tuesday, followed by Monday. With many folks travelling over the weekend, Saturday often has the most expensive airfares.
How much is a plane ticket to Santa Isabel?
Fares to Santa Isabel ranged from £127 to £1,205 in the last seven days. Usually, the sooner you make a reservation, the bigger the bargain.
What months are the cheapest to book a flight to Santa Isabel?
February is the most affordable month to book a seat for your Santa Isabel trip. Tickets cost the most during December, so keep clear of this time if possible.

Book with confidence

Top tips for booking flights to Santa Isabel from UK

Get ready to fly to Santa Isabel

Prepare your luggage and book your flights to Santa Isabel with Expedia. We offer a seamless flight booking experience, with a wide range of Santa Isabel plane tickets to choose from. If you need help finding some of the best deals for cheap flights to Santa Isabel in 2026, we are always available to assist you. Book your flights to Santa Isabel today and let the adventure begin!

Find the best tickets to Santa Isabel

To find some of the best tickets to Santa Isabel in 2026, use Expedia's powerful search engine to compare dates and the different departure and arrival airports for your trip. Whether you're after direct flights to Santa Isabel or last-minute flights to Santa Isabel, you can filter and sort your search results, making it easy to find the ideal flight to Santa Isabel.

Airlines fly to Santa Isabel

There are 20 different airlines that fly to Santa Isabel including some of the most trusted names in the business. To book flights to Santa Isabel with your favourite airline, take a look at Expedia's flight listings and try out different dates to find some of the best Santa Isabel plane tickets.

Find the cheapest flights to Santa Isabel

By booking early you may find some of the best deals for Santa Isabel flights from the UK, including Santa Isabel direct flights. You can usually find affordable and cheap flights to Santa Isabel, whether one-way from £66 or round-trip from £127, with Expedia if you book your trip far enough in advance.

Find the best airports for cheap flights to Santa Isabel

Try searching for different Santa Isabel airports with Expedia to find some of the cheapest flights to Santa Isabel. Flights from Guayaquil (GYE) to Cuenca (CUE) usually have the lowest price from £66.

Why book your flights to Santa Isabel with Expedia

Expedia offers great deals on Santa Isabel air fares from £66 to cater to every budget. Not only is Expedia one of the top platforms to book flights to Santa Isabel from the UK, it is also your one-stop shop for booking hotels, car rentals, and more.

 

*Prices and availability are subject to change. Additional terms apply.

Top tips for booking flights to Santa Isabel from UK

Travel information

Santa Isabel Flights Information

Airlines serving
LATAM Airlines Group, avianca, Iberia, Air Europa, Air France
Roundtrip price
from £127
Santa Isabel Flights Information
*Available to Expedia members.