Title: Top Hotels in La Serena - Compare La Serena Hotels | Expedia.co.uk [Holiday Rentals in La Serena](https://expedia.co.uk/Destinations-In-La-Serena.d553248635942949504.Holiday-Rental-Destinations)[La Serena Car Hire](https://expedia.co.uk/Destinations-In-La-Serena.d553248635942949504.Car-Hire-Destinations)[La Serena Holidays](https://expedia.co.uk/La-Serena.d553248635942949504.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [16 Feb - 17 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635942949504&startDate=2026-02-16&endDate=2026-02-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [17 Feb - 18 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635942949504&startDate=2026-02-17&endDate=2026-02-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635942949504&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [27 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635942949504&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for La Serena hotels ![Smart TV, fireplace](https://images.trvl-media.com/lodging/76000000/76000000/75990600/75990503/df9ca377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, travel cot, free WiFi](https://images.trvl-media.com/lodging/76000000/76000000/75990600/75990503/53beb2e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/76000000/76000000/75990600/75990503/41728992.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/76000000/76000000/75990600/75990503/d146d46e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### El Palomeque Rural House [](https://www.expedia.co.uk/Sancti-Spiritus-Hotels-Vrbo-Property.h75990503.Hotel-Information) Sancti Spiritus 10/10 Exceptional (1 review) "En general todo ha sido sobresaliente" ![Spain](https://a.travel-assets.com/egds/marks/flags/es.svg) EPHRAIM W. £146 includes taxes & fees 28 Feb - 1 Mar [](https://www.expedia.co.uk/Sancti-Spiritus-Hotels-Vrbo-Property.h75990503.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/27000000/26830000/26826000/26825966/f98081e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, 4 Bedrooms | Living area | Flat-screen TV, fireplace](https://images.trvl-media.com/lodging/27000000/26830000/26826000/26825966/c43f186c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, 4 Bedrooms | Living area | Flat-screen TV, fireplace](https://images.trvl-media.com/lodging/27000000/26830000/26826000/26825966/16ab7e6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach](https://images.trvl-media.com/lodging/27000000/26830000/26826000/26825966/eba7c27d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Rural Casas De Las Regatas [](https://www.expedia.co.uk/Castuera-Hotels-Casa-Rural-Casas-De-Las-Regatas.h26825966.Hotel-Information) Castuera [](https://www.expedia.co.uk/Castuera-Hotels-Casa-Rural-Casas-De-Las-Regatas.h26825966.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-02&endDate=2026-03-03®ionId=553248635942949504&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_SPRING_PROMO_553248635942949504) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-La-Serena.d553248635942949504.Hotel-Destinations)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-La-Serena.d553248635942949504.Hotel-Destinations) ## Top La Serena Hotel Reviews ![Hostal San Francisco](https://images.trvl-media.com/lodging/14000000/13240000/13232100/13232029/fab59292_y.jpg) ### Hostal San Francisco 6/10 Okay "Very cold, no breakfast and no dinner offer in the accompanied restaurant. For non spanish speaking people a real challenge. The cleaning staff was most helpful to support our stay. For spanish speaking it might be much easier. Any flyers or door inscripts for the workflow would be helpful. Anyhow, price and tidyness was very ok !! " [](https://expedia.co.uk/Granja-De-Torrehermosa-Hotels-Hostal-San-Francisco.h13232029.Hotel-Information) ![Hotel Rural La Sinforosa](https://images.trvl-media.com/lodging/25000000/24320000/24315800/24315721/aa5f39cc_y.jpg) ### Hotel Rural La Sinforosa 10/10 Excellent "Very friendly staff, nice courtyard for a drink, room was spacious and comfortable. We didn’t try the jacuzzi bath! Breakfast was a little disappointing apart from the diy freshly squeezed orange juice. Good overnight stop. " [](https://expedia.co.uk/Alange-Hotels-Hotel-Rural-La-Sinforosa.h24315721.Hotel-Information) ![Mesón-Hostal La Cabaña](https://images.trvl-media.com/lodging/54000000/53170000/53164900/53164889/b2f047a6_y.jpg) ### Mesón-Hostal La Cabaña 10/10 Excellent "Great spot ! Beautiful view !" [](https://expedia.co.uk/Medellin-Hotels-Meson-Hostal-La-Cabana.h53164889.Hotel-Information) ![Lantigua Casa Rural](https://images.trvl-media.com/lodging/20000000/19570000/19565600/19565533/621f7b9d_y.jpg) ### Lantigua Casa Rural 10/10 Excellent " “Una estancia maravillosa. La casa es muy acogedora, perfectamente cuidada y con un ambiente tranquilo. La habitación estaba impecable y muy cómoda. El desayuno fue delicioso y preparado con mucho cariño. Los anfitriones son encantadores, siempre atentos y dispuestos a ayudar. Sin duda, un lugar para volver y recomendar.”" [](https://expedia.co.uk/Hinojosa-Del-Duque-Hotels-Lantigua-Casa-Rural.h19565533.Hotel-Information) ![Hotel Varinia Serena - Balneario de Alange](https://images.trvl-media.com/lodging/23000000/22230000/22224800/22224741/512f16d8_y.jpg) ### Hotel Varinia Serena - Balneario de Alange 6/10 Okay "Good place." [](https://expedia.co.uk/Alange-Hotels-Hotel-Varinia-Serena-Balneario-De-Alange.h22224741.Hotel-Information) ![Hospedium Hotel Cortijo Santa Cruz](https://images.trvl-media.com/lodging/4000000/3490000/3486800/3486729/43696b66_y.jpg) ### Hospedium Hotel Cortijo Santa Cruz 10/10 Excellent "Beautiful hotel, with its own style, it has a 360 beautiful view and has everything you would need. It is worth to drive and extra kilometer!" [](https://expedia.co.uk/Villanueva-De-La-Serena-Hotels-Hospedium-Hotel-Cortijo-Santa-Cruz.h3486729.Hotel-Information) ![Hotel Sol](https://images.trvl-media.com/lodging/47000000/46950000/46940400/46940390/0eb9a638_y.jpg) ### Hotel Sol 2/10 Terrible "I canceled the booking. Hotel was closed when we arrived. I have to spend the night in the car with my 98 year father and two sisters. I want a refund. " [](https://expedia.co.uk/Penarroya-Pueblonuevo-Hotels-HOTEL-SOL.h46940390.Hotel-Information) ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in La Serena - [Castuera Hotels ](https://expedia.co.uk/Castuera-Hotels.d6357079.Travel-Guide-Hotels) - [Cabeza del Buey Hotels ](https://expedia.co.uk/Cabeza-Del-Buey-Hotels.d6357075.Travel-Guide-Hotels) - [Monterrubio de la Serena Hotels ](https://expedia.co.uk/Monterrubio-De-La-Serena-Hotels.d553248633901378679.Travel-Guide-Hotels) - [Campanario Hotels ](https://expedia.co.uk/Campanario-Hotels.d6357080.Travel-Guide-Hotels) - [Benquerencia de la Serena Hotels ](https://expedia.co.uk/Benquerencia-De-La-Serena-Hotels.d553248633901349609.Travel-Guide-Hotels) - [Quintana de la Serena Hotels ](https://expedia.co.uk/Quintana-De-La-Serena-Hotels.d553248633901344591.Travel-Guide-Hotels) - [Valle de la Serena Hotels ](https://expedia.co.uk/Valle-De-La-Serena-Hotels.d553248633901344764.Travel-Guide-Hotels) - [Zalamea de la Serena Hotels ](https://expedia.co.uk/Zalamea-De-La-Serena-Hotels.d3000389506.Travel-Guide-Hotels) - [Higuera de la Serena Hotels ](https://expedia.co.uk/Higuera-De-La-Serena-Hotels.d6357144.Travel-Guide-Hotels) - [Magacela Hotels ](https://expedia.co.uk/Magacela-Hotels.d6357083.Travel-Guide-Hotels) - [La Coronada Hotels ](https://expedia.co.uk/La-Coronada-Hotels.d553248633901348155.Travel-Guide-Hotels) - [Zarza Capilla Hotels ](https://expedia.co.uk/Zarza-Capilla-Hotels.d553248633901346812.Travel-Guide-Hotels) - [Peñalsordo Hotels ](https://expedia.co.uk/Penalsordo-Hotels.d553248633901344836.Travel-Guide-Hotels) - [Esparragosa de la Serena Hotels ](https://expedia.co.uk/Esparragosa-De-La-Serena-Hotels.d553248633901370780.Travel-Guide-Hotels) - [Malpartida de la Serena Hotels ](https://expedia.co.uk/Malpartida-De-La-Serena-Hotels.d553248633901348048.Travel-Guide-Hotels) - [Capilla Hotels ](https://expedia.co.uk/Capilla-Hotels.d553248633901348216.Travel-Guide-Hotels) ### Hotels near popular Attractions - [Hotels near Orellana Beach ](https://expedia.co.uk/Orellana-Beach-Hotels.0-l553248626836817887-0.Travel-Guide-Filter-Hotels) ### Explore more hotels - [Vegas Altas ](https://expedia.co.uk/Don-Benito-Hotels-Vegas-Altas.h5089004.Hotel-Information) - [Hotel Sol ](https://expedia.co.uk/Penarroya-Pueblonuevo-Hotels-HOTEL-SOL.h46940390.Hotel-Information) - [Hospedium Hotel Cortijo Santa Cruz ](https://expedia.co.uk/Villanueva-De-La-Serena-Hotels-Hospedium-Hotel-Cortijo-Santa-Cruz.h3486729.Hotel-Information) - [Hotel Rural La Sinforosa ](https://expedia.co.uk/Alange-Hotels-Hotel-Rural-La-Sinforosa.h24315721.Hotel-Information) - [Hotel Veracruz ](https://expedia.co.uk/Don-Benito-Hotels-Hotel-Veracruz.h36065785.Hotel-Information) - [Apartamentos Embalse de Orellana ](https://expedia.co.uk/Orellana-La-Vieja-Hotels-Apartamentos-Embalse-De-Orellana.h30403593.Hotel-Information) - [Hostal San Francisco ](https://expedia.co.uk/Granja-De-Torrehermosa-Hotels-Hostal-San-Francisco.h13232029.Hotel-Information) - [Gran Hotel Aqualange - Balneario de Alange ](https://expedia.co.uk/Alange-Hotels-Gran-Hotel-Aqualange-Balneario-De-Alange.h11898892.Hotel-Information) [See a list of all hotels in La Serena](https://expedia.co.uk/All-La-Serena-Hotels.d553248635942949504.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in La Serena on Expedia.es ](https://www.expedia.es/Destinos-En-La-Serena.d553248635942949504.Destinos-con-hotel) ### Expedia's Latest Trends Hotels - [Hotels in Costa Tropical](https://expedia.co.uk/Destinations-In-Costa-Tropical.d3000692293.Hotel-Destinations) - [Hotels with Parking in Antwerp](https://expedia.co.uk/Antwerp-Hotels-Hotel-With-Parking.0-0-d6179462-thotelwithparking.Travel-Guide-Filter-Hotels) - [Ca' della Loggia](https://expedia.co.uk/Venice-Hotels-Ca-Della-Loggia.h2538234.Hotel-Information) - [Hotels in Costa del Sol Occidental](https://expedia.co.uk/Destinations-In-Costa-Del-Sol-Occidental.d553248635976006689.Hotel-Destinations) - [Apartments Keswick](https://expedia.co.uk/Keswick-Apartments.d4371-aaApartments.Travel-Guide-Accommodation) - 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[Flights to La Marina Alta](https://expedia.co.uk/Destinations-In-La-Marina-Alta.d553248625840561592.Flight-Destinations) - [Flights to Verona](https://expedia.co.uk/Cheap-Flights-To-Verona.d6046582.Travel-Guide-Flights) - [Flights from Tobago to London](https://expedia.co.uk/lp/flights/tab/lgw/tobago-to-london) - [Flights to Costa Tropical](https://expedia.co.uk/Destinations-In-Costa-Tropical.d3000692293.Flight-Destinations) - [Flights to Val d'Aran](https://expedia.co.uk/Destinations-In-Val-DAran.d553248621593726096.Flight-Destinations) - [Hannover Airport Flights](https://expedia.co.uk/lp/airports/haj/flights-from-hannover-airport) - [Flights from London to Verona](https://expedia.co.uk/lp/flights/lcy/vrn/london-to-verona) - [British Airways London (LHR) to Geneva (GVA) flights](https://expedia.co.uk/lp/flight-routes/british-airways-from-heathrow-to-cointrin-intl/ba/lhr/gva) - [Flights from Karachi to London](https://expedia.co.uk/lp/flights/khi/lhr/karachi-to-london) Activities - [Things to do in Costa Tropical](https://expedia.co.uk/Things-To-Do-In-Costa-Tropical.d3000692293.Travel-Guide-Activities) - [Things to do in La Marina Alta](https://expedia.co.uk/Things-To-Do-In-La-Marina-Alta.d553248625840561592.Travel-Guide-Activities) Packages - [La Marina Alta Holidays](https://expedia.co.uk/La-Marina-Alta.d553248625840561592.Holidays-City-Breaks) - [Costa Tropical Holidays](https://expedia.co.uk/Costa-Tropical.d3000692293.Holidays-City-Breaks) - [Las Vegas Holidays](https://expedia.co.uk/Las-Vegas.d553248633958022088.Holidays-City-Breaks) Holiday Rentals - [Devon Holiday Rentals](https://expedia.co.uk/Destinations-In-Devon.d6046196.Holiday-Rental-Destinations) General - [Visit La Marina Alta](https://expedia.co.uk/La-Marina-Alta.dx553248625840561592) - [Visit Central Los Angeles](https://expedia.co.uk/Central-Los-Angeles.dx553248635974578052) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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