Title: Top Hotels in Antofagasta de la Sierra Department - Compare Antofagasta de la Sierra Department Hotels | Expedia.co.uk [Holiday Rentals in Antofagasta de la Sierra Department](https://expedia.co.uk/Destinations-In-Antofagasta-De-La-Sierra-Department.d553248635975749483.Holiday-Rental-Destinations)[Antofagasta de la Sierra Department Car Hire](https://expedia.co.uk/Destinations-In-Antofagasta-De-La-Sierra-Department.d553248635975749483.Car-Hire-Destinations)[Antofagasta de la Sierra Department Holidays](https://expedia.co.uk/Antofagasta-De-La-Sierra-Department.d553248635975749483.Holidays-City-Breaks) ![Salar or Salt Desert of Antofalla in La Puna de Atacama, in the province of Catamarca in the department of Antofagasta de la Sierra. Argentina, South America, America](https://images.trvl-media.com/place/553248635975749483/23517b45-75d9-415f-936e-1a8925f481d0.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635975749483/23517b45-75d9-415f-936e-1a8925f481d0.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Antofagasta de la Sierra Department Accommodation: Most Popular Cities to Stay ![This area is of an incredible diversity, it is part of the Argentine Puna. #roadtrip](https://images.trvl-media.com/place/6348231/b8d035fc-a159-4a83-8987-4fe3b3c3e54e.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Antofagasta de la Sierra [](https://expedia.co.uk/Antofagasta-De-La-Sierra-Hotels.d6348231.Travel-Guide-Hotels) ## Check prices for these dates Tonight [2 Mar - 3 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749483&startDate=2026-03-02&endDate=2026-03-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [3 Mar - 4 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749483&startDate=2026-03-03&endDate=2026-03-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749483&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749483&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. 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[Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_SPRING_PROMO_553248635975749483) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Antofagasta-De-La-Sierra-Department.d553248635975749483.Hotel-Destinations)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Antofagasta-De-La-Sierra-Department.d553248635975749483.Hotel-Destinations) ## Top Antofagasta de la Sierra Department Hotel Reviews ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Antofagasta de la Sierra Department - [Antofagasta de la Sierra Hotels ](https://expedia.co.uk/Antofagasta-De-La-Sierra-Hotels.d6348231.Travel-Guide-Hotels) - [El Peñón Hotels ](https://expedia.co.uk/El-Penon-Hotels.d3000409898.Travel-Guide-Hotels) ### Explore more hotels - [Hosteria Pucara ](https://expedia.co.uk/Antofagasta-De-La-Sierra-Hotels-Hosteria-Pucara.h42527742.Hotel-Information) - [Hacienda de Molinos ](https://expedia.co.uk/Molinos-Hotels-Hacienda-De-Molinos.h9028723.Hotel-Information) [See a list of all hotels in Antofagasta de la Sierra Department](https://expedia.co.uk/All-Antofagasta-De-La-Sierra-Department-Hotels.d553248635975749483.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Antofagasta de la Sierra Department on Expedia.com.ar ](https://www.expedia.com.ar/Destinos-En-Departamento-Antofagasta-De-La-Sierra.d553248635975749483.Destinos-con-Hoteles) ### Expedia's Latest Trends Hotels - [York Accommodation](https://expedia.co.uk/York-Hotels.d5489.Travel-Guide-Hotels) - [Grace Hotel, Auberge Collection](https://expedia.co.uk/Santorini-Hotels-Grace-Hotel-Santorini.h5005550.Hotel-Information) - [Hakone Retreat Före](https://expedia.co.uk/Hakone-Hotels-Hakone-Retreat-Fore-Adults-Only.h16074097.Hotel-Information) - [Hostels Rio de Janeiro](https://expedia.co.uk/Rio-De-Janeiro-Hostels.d178301-aaHostels.Travel-Guide-Accommodation) - 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