Title: Cheap Flights to Santa Isabel - Expedia.co.uk ![Santa Isabel, Chihuahua, Mexico](https://images.trvl-media.com/place/553248635640632170/e78afccd-0d19-4066-ae9e-63a36721ea86.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635640632170/e78afccd-0d19-4066-ae9e-63a36721ea86.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £46 Cheap Flights to Santa Isabel [View £46 flight on Mon, 18 May 2026](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:NLU,to:CUU,departure:18/05/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:45.65&airProductToken=AQpgCi4I2WgSBDMyOTcY7aIBIJNKKLSvjQMwhrGNAzhBQABYAWoEWmVyb3IGQUxDU1MyCi4I2WgSBDMyOTAYk0oggqUBKL6zjQMwrrSNAzhBQAFYAWoEWmVyb3IGQUxDU1MyEgoIARABGAEqAlk0GAEiBAgBEAEoAigDKAQwDQ) [Hotels in Santa Isabel](https://expedia.co.uk/Santa-Isabel-Hotels.d553248635640632170.Travel-Guide-Hotels)[Santa Isabel Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Isabel.d553248635640632170.Car-Hire-Guide)[Santa Isabel Holidays](https://expedia.co.uk/Santa-Isabel.d553248635640632170.Holidays-City-Breaks) ## Popular airlines to Santa Isabel - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AM.svg) Aeromexico [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Isabel, Chihuahua, Mexico,departure:21/04/2026TANYT&leg2=from:Santa Isabel, Chihuahua, Mexico,to:CMH,departure:28/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AM"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_VB.svg) Viva Aerobus [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Isabel, Chihuahua, Mexico,departure:21/04/2026TANYT&leg2=from:Santa Isabel, Chihuahua, Mexico,to:CMH,departure:28/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"VB"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_Y4.svg) Volaris [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Isabel, Chihuahua, Mexico,departure:21/04/2026TANYT&leg2=from:Santa Isabel, Chihuahua, Mexico,to:CMH,departure:28/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"Y4"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Isabel, Chihuahua, Mexico,departure:21/04/2026TANYT&leg2=from:Santa Isabel, Chihuahua, Mexico,to:CMH,departure:28/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Isabel, Chihuahua, Mexico,departure:21/04/2026TANYT&leg2=from:Santa Isabel, Chihuahua, Mexico,to:CMH,departure:28/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DL"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_F9.svg) Frontier Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Isabel, Chihuahua, Mexico,departure:21/04/2026TANYT&leg2=from:Santa Isabel, Chihuahua, Mexico,to:CMH,departure:28/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"F9"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AF.svg) Air France [](https://www.expedia.co.uk/Flights-Search?leg1=from:CMH,to:Santa Isabel, Chihuahua, Mexico,departure:21/04/2026TANYT&leg2=from:Santa Isabel, Chihuahua, Mexico,to:CMH,departure:28/04/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AF"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap round-trip flights to Santa Isabel Prices were available within the past 7 days and start at £46 for one-way flights and £91 for round trip, for the period specified. Be sure to select the 'Direct flights only' box above if you are looking for a non stop route. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![Aeromexico](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/am.gif) Fri, 24 Apr - Mon, 27 Apr GDL Guadalajara CUU Chihuahua £91 Return found 2 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:GDL,to:CUU,departure:24/04/2026TANYT&leg2=from:CUU,to:GDL,departure:27/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:90.80&airProductToken=AQpnCjEIwZoBEgMyMDUY5lggjLkBKI2aiwMw65qLAzhWQABYAWoFTElHSFRyCFJOTksyQUxSCjIIwZoBEgMxNDAYjLkBIIKlASjPm4sDMOSciwM4VkABWAFqBUxJR0hUcghSTk5LMkFMUgpnCjIIwZoBEgMxMzkYgqUBIIy5ASi_u4sDMMG8iwM4VkAAWAFqBUxJR0hUcghSTk5LMkFMUgoxCMGaARIDMjE2GIy5ASDmWCiWvYsDMPK9iwM4VkABWAFqBUxJR0hUcghSTk5LMkFMUhIKCAEQARgBKgJBTRgBIgQIARABKAIoAygEMAE6JDY2NGUzYThmLTM0ZTEtNDAyNi1iYmE1LTJjYWNjZWVjNzlkNg) ![Volaris](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/Y4.gif) Fri, 15 May - Fri, 22 May GDL Guadalajara CUU Chihuahua £101 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:GDL,to:CUU,departure:15/05/2026TANYT&leg2=from:CUU,to:GDL,departure:22/05/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:100.23&airProductToken=AQovCi0I2WgSBDEyMjAY5lgggqUBKLKGjQMwnoeNAzhBQABYAWoEWmVyb3IFQUxTUzQSCggBEAEYASoCWTQYASIECAEQASgCKAMoBDAN) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Mon, 4 May - Fri, 15 May BZE Belize City CUU Chihuahua £980 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:BZE,to:CUU,departure:04/05/2026TANYT&leg2=from:CUU,to:BZE,departure:15/05/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:980.00&airProductToken=AQpGCiAIwYIBEgMzMTQYoSYgo7EBKIaNjAMw1Y6MAzhRQABYAQoiCMGCARIENDIxOBijsQEggqUBKOqWjAMw6ZeMAzhRQAFYAQpHCiIIwYIBEgQzMzY5GIKlASCjsQEo3IWNAzDTho0DOFFAAFgBCiEIwYIBEgQyNDUxGKOxASChJii8iI0DMO6JjQM4UUABWAESCggBEAEYASoCQUEYASIECAEQASgIKAQwAQ) ![Air France](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AF.gif) Mon, 14 Sept - Tue, 6 Oct LHR London CUU Chihuahua £1,023 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LHR,to:CUU,departure:14/09/2026TANYT&leg2=from:CUU,to:LHR,departure:06/10/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1022.65&airProductToken=AQqoAQoyCMGMARIEMTE4MRjriQEg4jAoxeWXAzCQ5pcDOExAAFgBagVMSUdIVHIIVlkyREk1TEEKMQjBjAESAzE3OBjiMCCMuQEonu2XAzDf8pcDOFZAAVgBagVMSUdIVHIIVlkyREk1TEEKPwjBjAESBDk5NjQYjLkBIIKlASje9JcDMPH1lwM4VkABWAFqBUxJR0hUcghWWTJESTVMQXoKCMGaARIEOTk2NAqoAQo_CMGMARIEOTk1MBiCpQEgjLkBKKvdmQMwtN6ZAzhWQABYAWoFTElHSFRyCFZZMkRJNUxBegoIwZoBEgQ5OTUwCjEIwYwBEgMxNzkYjLkBIOIwKPffmQMwhuWZAzhWQAFYAWoFTElHSFRyCFZZMkRJNUxBCjIIwYwBEgQxMTgwGOIwIOuJASiP55kDMN_nmQM4TEABWAFqBUxJR0hUcghWWTJESTVMQRIKCAIQARgCKgJBRhgBIgQIARABKAIoAygEMA0) ![British Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/BA.gif) Mon, 14 Sept - Tue, 6 Oct LHR London CUU Chihuahua £1,062 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LHR,to:CUU,departure:14/09/2026TANYT&leg2=from:CUU,to:LHR,departure:06/10/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1061.99&airProductToken=AQqEAQpACMKCARIEMTUyMBjriQEgo7EBKIXjlwMw4ueXAzhPQABYAWoFTk9CQUdyCU9MWDhDMUI0UHoKCMGCARIEMTUyMApACMKCARIENDM5NBijsQEggqUBKPDulwMw7O-XAzhPQAFYAWoFTk9CQUdyCU9MWDhDMUI0UHoKCM2iARIENDM5NAqEAQpACMKCARIEMTg0NhiCpQEgo7EBKPDZmQMw6dqZAzhPQABYAWoFTk9CQUdyCU9MWDhDMUI0UHoKCM2iARIEMTg0NgpACMKCARIEMTUwNRijsQEg64kBKOndmQMwgOKZAzhPQAFYAWoFTk9CQUdyCU9MWDhDMUI0UHoKCMGCARIEMTUwNRIKCAEQARgBKgJCQRgBIgQIARABKAIoAzAN) ## Book with confidence # Expedia flights to Santa Isabel Searching for cheap flights to Santa Isabel? No travel company presents more choices than Expedia if you're looking to compare flights to Santa Isabel. With more airlines, cheaper flights, fewer stops, and more departure and arrival times travellers should ensure they search on Expedia before any holiday to Chihuahua. Expedia provides the cheapest flights to many destinations in Chihuahua and you may find even greater savings if you combine your flight with a hotel stay in Santa Isabel. Expedia is the largest online travel agency which means that Expedia have access to cheap flights. So make sure you check Expedia regularly for these bargain flights because the cheapest airline tickets sell out fast. Expedia is not only free for everyone to use but it quick and easy to use. Find the lowest flight prices guaranteed and book directly through Expedia. Browse through hundreds of cheap flight offers to find the one that suits your budget by simply inputting your travel dates. Expedia will then find the cheapest flights to Santa Isabel for that period and let you choose your preferred time and airline. If you need additional assistance, Expedia Customer Service representatives are available from 8am - 10pm Monday to Friday, and 9am - 10pm at weekends. Our capable staff will be able to help you with any questions regarding your Santa Isabel flight, or other booking questions that may arise. When you book flights with Expedia you can rest assured that you have booked the best flight at the lowest price. ## Travel information | Destination airport | General Roberto Fierro Villalobos Intl. | | ----------------------------- | --------------------------------------- | | Destination airport IATA code | CUU | | Destination city name | Chihuahua | | Return price | £91 | ## Trending flights to Santa Isabel Prices were available within the past 7 days and start at £46 for one-way flights and £91 for round trip, for the period specified. Be sure to select the 'Direct flights only' box above if you are looking for a non stop route. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![Aeromexico](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/am.gif) Mon, 1 Jun - Mon, 8 Jun LHR London CUU Chihuahua £924 Return found 2 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LHR,to:CUU,departure:01/06/2026TANYT&leg2=from:CUU,to:LHR,departure:08/06/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:923.89&airProductToken=AQpoCjEIwZoBEgE4GOuJASCMuQEoysmOAzCGz44DOFZAAFgBagZCQVNJQ0FyCFJLWFNBOUVVCjMIwZoBEgMxNDQYjLkBIIKlASjq1I4DMIDWjgM4VkABWAFqBkJBU0lDQXIIUktYU0E5RVUKaAozCMGaARIDMTQxGIKlASCMuQEo55WPAzDxlo8DOFZAAFgBagZCQVNJQ0FyCFJLWFNBOUVVCjEIwZoBEgE3GIy5ASDriQEov5uPAzDEoI8DOFZAAVgBagZCQVNJQ0FyCFJLWFNBOUVVEgoIARABGAEqAkFNGAEiBAgBEAEoAigDKAQwAQ) \*Available to Expedia members.