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12 Nov - 13 Nov
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13 Nov - 14 Nov
This weekend
13 Nov - 15 Nov
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20 Nov - 22 Nov

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Our top choices for Biomuseo hotels

A spacious indoor courtyard with tiled flooring, multiple seating areas, and hanging plants.

1. La Isabela Suites

La Isabela Suites
3.5 star property
San Felipe, 1.5 mi from Biomuseo
9.8 out of 10, Exceptional, (214 reviews)
"Location in old town, across from Plaza Simon Bolivar, is the perfect place to venture around old town and the new city. Great restaurants and shops within easy walking distance. I relied on recommendations from the staff for a couple of things and their selections exceeded my expectations. Highly recommend staying if visiting Panama City."
United States
David
The price is £117
includes taxes & fees
1 Dec - 2 Dec
La Isabela Suites
A restaurant with multiple dining tables, chairs, and a central water feature.

2. Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
5.0 star property
San Felipe, 1.5 mi from Biomuseo
9.8 out of 10, Exceptional, (378 reviews)
"Location was perfect"
United States
Graham
The price is £270
includes taxes & fees
1 Dec - 2 Dec
Hotel La Compañía Casco Antiguo
A balcony with a table, chairs, and a view of a city skyline across a body of water.

3. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
San Felipe, 1.6 mi from Biomuseo
9.8 out of 10, Exceptional, (773 reviews)
"Amazing service and beautiful hotel"
United States
Jose
The price is £360
includes taxes & fees
17 Nov - 18 Nov
Sofitel Legend Casco Viejo, Panama City
A multi-story building with ornate balconies, large windows, and decorative moldings.

4. Hotel Plaza Herrera

Hotel Plaza Herrera
4.0 star property
San Felipe, 1.5 mi from Biomuseo
9.8 out of 10, Exceptional, (54 reviews)
"A small old world style hotel. Beautifully restored (the woodwork is beautiful too ) The staff is lovely and extremely helpful. Immaculate. Breakfast downstairs was delicious. Very low key, relaxed place and very conveniently located."
United States
Sharon
The price is £211
includes taxes & fees
16 Nov - 17 Nov
Hotel Plaza Herrera
A grand, illuminated building with a symmetrical facade, multiple balconies, and a prominent entrance.

5. La Concordia Boutique Hotel

La Concordia Boutique Hotel
4.0 star property
San Felipe, 1.5 mi from Biomuseo
9.6 out of 10, Exceptional, (244 reviews)
"Such a beautiful and highly curated and very helpful staff."
United States
Jadah
The price is £185
includes taxes & fees
26 Nov - 27 Nov
La Concordia Boutique Hotel
A spacious outdoor patio with wicker furniture, potted plants, and umbrellas providing shade.

6. Hotel San Felipe

Hotel San Felipe
4.0 star property
San Felipe, 1.5 mi from Biomuseo
9.4 out of 10, Exceptional, (476 reviews)
"Loved our stay! Central, clean, wonderful staff"
United States
RoseMarie
The price is £130
includes taxes & fees
15 Nov - 16 Nov
Hotel San Felipe
A restaurant interior with checkered flooring, wooden tables, wicker chairs, and hanging wicker lamps.

7. Amarla Boutique Hotel Casco Viejo Adults Only

Amarla Boutique Hotel Casco Viejo Adults Only
3.0 star property
San Felipe, 1.6 mi from Biomuseo
9.6 out of 10, Exceptional, (152 reviews)
"It was a great place to stay, right in the center of old Panama City. Even though it is small it is very quaint and efficiently run. It is also convenient that they have a restaurant in-house. Just making stuff convenient"
United States
Glenn
The price is £171
includes taxes & fees
22 Nov - 23 Nov
Amarla Boutique Hotel Casco Viejo Adults Only
A spacious indoor area with high ceilings, large windows, and multiple dining tables.

8. American Trade Hotel

American Trade Hotel
4.5 star property
San Felipe, 1.5 mi from Biomuseo
9.4 out of 10, Exceptional, (828 reviews)
"Beautiful property in great location. Excellent facilities"
United States
Lesley
The price is £183
includes taxes & fees
23 Nov - 24 Nov
American Trade Hotel
A multi-story building with balconies, large windows, and a clear blue sky.

9. Las Clementinas

Las Clementinas
3.5 star property
San Felipe, 1.6 mi from Biomuseo
9.4 out of 10, Exceptional, (208 reviews)
"Beautiful property and great restaurant! Also awesome customer service"
United States
Denise
The price is £121
includes taxes & fees
13 Dec - 14 Dec
Las Clementinas
A hotel room with a bed, a desk with a computer, a chair, a mirror, and a staircase.

10. Hotel Bardot Boutique

Hotel Bardot Boutique
3.0 star property
San Felipe, 1.6 mi from Biomuseo
9.0 out of 10, Wonderful, (66 reviews)
"Excellent location to walk around, visit local attractions and restaurants in the old city."
United States
Luz
The price is £72
includes taxes & fees
6 Dec - 7 Dec
Hotel Bardot Boutique
A multi-story building with balconies, arched windows, and decorative railings.

11. Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 1.5 mi from Biomuseo
9.0 out of 10, Wonderful, (1,004 reviews)
"Great location."
United States
Brian
The price is £135
includes taxes & fees
18 Nov - 19 Nov
Central Hotel Panama Casco Viejo
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

12. Casco View Life Residences

Casco View Life Residences
4.0 star property
Santa Ana, 1.5 mi from Biomuseo
9.0 out of 10, Wonderful, (114 reviews)
"Amazing location and comfort"
United States
Ruben
The price is £82
includes taxes & fees
19 Nov - 20 Nov
Casco View Life Residences
A spacious living room with blue sofas, a marble coffee table, and framed pictures on the walls.

13. Hotel Magnolia Boutique

Hotel Magnolia Boutique
2.0 star property
San Felipe, 1.5 mi from Biomuseo
8.8 out of 10, Excellent, (545 reviews)
"Great check in experience. Clean and comfortable rooms. Recommend to stay here!"
Canada
Cathy
The price is £82
includes taxes & fees
17 Nov - 18 Nov
Hotel Magnolia Boutique
A rooftop bar with a city skyline view, outdoor seating, and a bar area with bottles and glasses.

14. Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 1.6 mi from Biomuseo
8.8 out of 10, Excellent, (343 reviews)
"The location is great."
United States
Israel
The price is £85
includes taxes & fees
6 Dec - 7 Dec
Tantalo Hotel
A glass-top table with wicker chairs in an outdoor setting with greenery and a thatched roof structure.

15. The Balboa Inn

The Balboa Inn
3.0 star property
Balboa, 1.7 mi from Biomuseo
8.8 out of 10, Excellent, (162 reviews)
"Nice room, great AC. Convenient to town."
United States
Rhonda
The price is £61
includes taxes & fees
13 Nov - 14 Nov
The Balboa Inn
A resort with a pool area, lounge chairs, and a view of a bridge at night.

16. Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador, 0.9 mi from Biomuseo
8.6 out of 10, Excellent, (1,015 reviews)
"The best beds of Panama and an extensive breakfast to start the day with"
United States
Hanspeter
The price is £64
includes taxes & fees
25 Nov - 26 Nov
Radisson Hotel Panama Canal
Restaurant

17. Corcho

Corcho
3.0 star property
San Felipe, 1.5 mi from Biomuseo
8.8 out of 10, Excellent, (40 reviews)
"Great room and location. "
Canada
Ashley
The price is £90
includes taxes & fees
23 Nov - 24 Nov
Corcho
A cozy indoor seating area with wooden chairs and tables, surrounded by shelves with plants and books.

18. Viajero Casco Viejo Hostel

Viajero Casco Viejo Hostel
2.0 star property
San Felipe, 1.6 mi from Biomuseo
8.6 out of 10, Excellent, (79 reviews)
"Great location, heaps of activities offered, friendly staff and great amenities. We loved our stay here!"
Australia
Ashleigh
The price is £28
includes taxes & fees
29 Nov - 30 Nov
Viajero Casco Viejo Hostel
A modern kitchen with a dining area, large windows, and a view of the city.

19. La Cuadra by Wynwood House

La Cuadra by Wynwood House
3.0 star property
El Chorrillo, 1.4 mi from Biomuseo
8.8 out of 10, Excellent, (61 reviews)
"Great location and all you need with a lovely view"
United States
Lise Jane
The price is £81
includes taxes & fees
16 Nov - 17 Nov
La Cuadra by Wynwood House
A balcony with a view of a cityscape, including a river and a bridge.

20. Oasis Hotel

Oasis Hotel
3.0 star property
San Felipe, 1.6 mi from Biomuseo
8.6 out of 10, Excellent, (166 reviews)
"I enjoyed everything about my stay,the view was amazing and the location was perfect!! I would definitely stay here in the future!!"
United States
Charles
The price is £53
includes taxes & fees
7 Dec - 8 Dec
Oasis Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Compare popular hotels close to Biomuseo

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious indoor courtyard with tiled flooring, multiple seating areas, and hanging plants.
La Isabela Suites
3.5 star property
9.8
Exceptional
214 reviews
View
A restaurant with multiple dining tables, chairs, and a central water feature.
Hotel La Compañía Casco Antiguo
5.0 star property
9.8
Exceptional
378 reviews
View
A balcony with a table, chairs, and a view of a city skyline across a body of water.
Sofitel Legend Casco Viejo, Panama City
5.0 star property
9.8
Exceptional
773 reviews
View
A multi-story building with ornate balconies, large windows, and decorative moldings.
Hotel Plaza Herrera
4.0 star property
9.8
Exceptional
54 reviews
View
A grand, illuminated building with a symmetrical facade, multiple balconies, and a prominent entrance.
La Concordia Boutique Hotel
4.0 star property
9.6
Exceptional
244 reviews
View

Other attractions near Biomuseo

Amador Causeway

9.0/10 (1,902 reviews)
You can learn about the history of Ancon with a visit to Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.
See properties

Top Biomuseo Hotel Reviews

A multi-story building with ornate balconies, large windows, and decorative moldings.
Hotel Plaza Herrera

Hotel Plaza Herrera

Hotel Plaza Herrera
Casco Viejo

10/10 Excellent

Excellent all round. Lovely hotel, location, staff and their helpfulness. I got an upgrade also which was a bonus
United Kingdom
Qurat-ul-ain
Reviewed August 27, 2026
Hotel Plaza Herrera

Frequently Asked Questions

What's the area like around Biomuseo?

Biomuseo is located in a vibrant area of Ancon known for its array of dining options and major shopping area. You'll find 1260 hotels and other accommodations within a few miles for a convenient home base.

What's the best hotel to stay near Biomuseo?

Radisson Hotel Panama Canal is one of the top choices for your stay based on our traveller data, and this hotel offers 2 outdoor pools and 2 restaurants. It's located just a short 0.9 mi (1.5 km) from Biomuseo. Another good choice is La Palma Experience, located just 0.7 mi (1.1 km) away.

How many hotels are there near Biomuseo?

Expedia has 1260 hotels and other accommodation options a few miles from Biomuseo.

If I need to cancel the hotel reservation for my stay near Biomuseo, will I receive a refund?

Yes, you'll find most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before check in. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view the best deals near Biomuseo.

What can I see and do near Biomuseo?

Interoceanic Canal Museum, Mola Museum and Museum of History Panama feature a variety of fascinating exhibits to see while you're in town. Sights like Panama Canal Railway, Iglesia del Carmen and Paseo de Las Bovedas are must-sees while exploring the area. You can catch a show at National Theater, Anita Villalaz Theater and Amador Theater.