Title: The 10 Best 5 Star Hotels in Mississippi Gulf Coast - 2026 Updated Prices | Expedia.co.uk [Mississippi Gulf Coast Travel Guide](https://expedia.co.uk/Mississippi-Gulf-Coast.dx6058666)[Hotels in Mississippi Gulf Coast](https://expedia.co.uk/Mississippi-Gulf-Coast-Hotels.d6058666.Travel-Guide-Hotels)[Holiday Rentals in Mississippi Gulf Coast](https://expedia.co.uk/Mississippi-Gulf-Coast-Holiday-Rentals.d6058666.Travel-Guide-HolidayRentals)[Flights to Mississippi Gulf Coast](https://expedia.co.uk/Cheap-Flights-To-Mississippi-Gulf-Coast.d6058666.Travel-Guide-Flights)[Things to do in Mississippi Gulf Coast](https://expedia.co.uk/Things-To-Do-In-Mississippi-Gulf-Coast.d6058666.Travel-Guide-Activities)[Mississippi Gulf Coast Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mississippi-Gulf-Coast.d6058666.Car-Hire-Guide)[Mississippi Gulf Coast Holidays](https://expedia.co.uk/Mississippi-Gulf-Coast.d6058666.Holidays-City-Breaks) ![Hattiesburg showing an administrative building](https://images.trvl-media.com/place/6058670/2e3b1482-dc9b-43a3-ace3-83f541dd5e96.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Mississippi Gulf Coast, Mississippi - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mississippi Gulf Coast 5 Star Hotels Tonight [17 Dec - 18 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058666&startDate=2025-12-17&endDate=2025-12-18&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [18 Dec - 19 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058666&startDate=2025-12-18&endDate=2025-12-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058666&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058666&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mississippi-Gulf-Coast-Hotels.s50-0-d6058666.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mississippi-Gulf-Coast-Hotels.s50-0-d6058666.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mississippi Gulf Coast. ![Hard Rock Hotel & Casino Biloxi](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731566/7e1bb110_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hard Rock Hotel & Casino Biloxi 777 Beach Blvd. Biloxi MS [Get rates](https://expedia.co.uk/Hotel-Search?startDate=31%2F12%2F2025&endDate=01%2F01%2F2026&selected=1731566&PinnedHotelID=1731566&HadPinnedHotel=true®ionId=6058666) 8.2/10 Very Good! (3,695 reviews) [](https://expedia.co.uk/Biloxi-Hotels-Hard-Rock-Hotel-Casino-Biloxi.h1731566.Hotel-Information) ![Palace Casino Resort](https://images.trvl-media.com/lodging/2000000/1660000/1652900/1652862/6049152a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Palace Casino Resort 158 Howard Ave Biloxi MS £58 12 Jan - 13 Jan 2026 includes taxes & fees 9.2/10 Wonderful! (3,008 reviews) [](https://expedia.co.uk/Biloxi-Hotels-Palace-Casino-Resort.h1652862.Hotel-Information) ![IP Casino Resort Spa - Biloxi](https://images.trvl-media.com/lodging/1000000/90000/85100/85080/e0a1ead8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### IP Casino Resort Spa - Biloxi 850 Bayview Ave Biloxi MS £81 18 Dec - 19 Dec includes taxes & fees 8.4/10 Very Good! (5,186 reviews) [](https://expedia.co.uk/Biloxi-Hotels-IP-Casino-Resort-Spa-Biloxi.h85080.Hotel-Information) Still don't see what you're looking for? [See all properties in Mississippi Gulf Coast.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=18%2F12%2F2025&endDate=19%2F12%2F2025®ionId=6058666&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=18%2F12%2F2025&endDate=19%2F12%2F2025®ionId=6058666&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=18%2F12%2F2025&endDate=19%2F12%2F2025®ionId=6058666&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=18%2F12%2F2025&endDate=19%2F12%2F2025®ionId=6058666&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=18%2F12%2F2025&endDate=19%2F12%2F2025®ionId=6058666&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=18%2F12%2F2025&endDate=19%2F12%2F2025®ionId=6058666&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Mississippi Gulf Coast White sand beaches stretch for miles, inviting you to relax and unwind. Explore coastal towns like Biloxi and Gulfport, where you can find entertainment venues including casinos, enjoy fresh seafood, and discover historic lighthouses during your visit. [See all hotels in Mississippi Gulf Coast](https://www.expedia.co.uk/Hotel-Search?startDate=2025-12-31&endDate=2026-01-01&adults=2®ionId=6058666) ![Biloxi featuring a lighthouse and night scenes](https://images.trvl-media.com/place/603259/b5fbd0cd-abad-4665-9fe3-f5a5344cf939.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) Photo by Mississippi Gulf Coast Convention & Visitors Bureau ## Top Mississippi Gulf Coast Hotel Reviews ## Find out more about Mississippi Gulf Coast ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Mississippi Gulf Coast? > - Search for the lowest price per night from £58 ### What makes a hotel 5 stars in Mississippi Gulf Coast? ### Are there any 5-star all-inclusive resorts in Mississippi Gulf Coast? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [5 Star Hotels in Ship Island ](https://www.expedia.co.uk/5Star-Ship-Island-Hotels.s50-0-d717459043476299776.Travel-Guide-Filter-Hotels) - 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