Title: The 10 Best 5 Star Hotels in Mississippi Gulf Coast - 2025 Updated Prices | Expedia.co.uk [Mississippi Gulf Coast Travel Guide](https://expedia.co.uk/Mississippi-Gulf-Coast.dx6058666)[Hotels in Mississippi Gulf Coast](https://expedia.co.uk/Mississippi-Gulf-Coast-Hotels.d6058666.Travel-Guide-Hotels)[Holiday Rentals in Mississippi Gulf Coast](https://expedia.co.uk/Mississippi-Gulf-Coast-Holiday-Rentals.d6058666.Travel-Guide-HolidayRentals)[Flights to Mississippi Gulf Coast](https://expedia.co.uk/Cheap-Flights-To-Mississippi-Gulf-Coast.d6058666.Travel-Guide-Flights)[Things to do in Mississippi Gulf Coast](https://expedia.co.uk/Things-To-Do-In-Mississippi-Gulf-Coast.d6058666.Travel-Guide-Activities)[Mississippi Gulf Coast Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mississippi-Gulf-Coast.d6058666.Car-Hire-Guide)[Mississippi Gulf Coast Holidays](https://expedia.co.uk/Mississippi-Gulf-Coast.d6058666.Holidays-City-Breaks) # Compare and book 5 Star hotels in Mississippi Gulf Coast, Mississippi ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mississippi Gulf Coast 5 Star Hotels Tonight [28 Oct - 29 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058666&startDate=2025-10-28&endDate=2025-10-29&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [29 Oct - 30 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058666&startDate=2025-10-29&endDate=2025-10-30&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [31 Oct - 2 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058666&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [7 Nov - 9 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058666&startDate=2025-11-07&endDate=2025-11-09&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mississippi Gulf Coast 5 Star Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mississippi-Gulf-Coast-Hotels.s50-0-d6058666.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mississippi-Gulf-Coast-Hotels.s50-0-d6058666.Travel-Guide-Filter-Hotels) ## Learn more about Mississippi Gulf Coast White sand beaches stretch for miles, inviting you to relax and unwind. Explore coastal towns like Biloxi and Gulfport, where you can find entertainment venues including casinos, enjoy fresh seafood, and discover historic lighthouses during your visit. [See all hotels in Mississippi Gulf Coast](https://www.expedia.co.uk/Hotel-Search?startDate=2025-11-11&endDate=2025-11-12&adults=2®ionId=6058666) ![Biloxi featuring a lighthouse and night scenes](https://images.trvl-media.com/place/603259/b5fbd0cd-abad-4665-9fe3-f5a5344cf939.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) Photo by Mississippi Gulf Coast Convention & Visitors Bureau ## Top Mississippi Gulf Coast Hotel Reviews ## Find out more about Mississippi Gulf Coast ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Mississippi Gulf Coast? > How much you pay for a 5-star hotel in Mississippi Gulf Coast can vary based on when you prefer to travel and how long you plan to be away, among other factors. Use our price per night filter and other search tools to land the best deal on a luxurious stay. > > > > - Search for the lowest price per night ### What makes a hotel 5 stars in Mississippi Gulf Coast? > In Mississippi Gulf Coast, a hotel is required to offer a specific number of high-end amenities to earn 5 stars. These can include on-site gyms, spas and saunas, gourmet restaurants, luxury toiletries, premium bedding and more. What also sets 5-star hotels apart is their exceptional service. You'll enjoy things like nightly turn-down services, in-room massages and concierge services. Some may even offer thoughtful touches such as a welcome gift. ### Are there any 5-star all-inclusive resorts in Mississippi Gulf Coast? > Use our filter tool to find an upscale escape in Mississippi Gulf Coast where most of what you need is included. After your initial search, narrow your results for properties that have a 5-star rating and are described as "All inclusive." The main thing on the agenda at these stays? 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